Article
Engineering, Aerospace
Kung-Ming Chung, Yi-Xuan Huang
Summary: This study used pressure-sensitive paint (PSP) to determine the surface pressure distributions for a compressible swept convex-corner flow. It found greater spanwise pressure gradient and curved shocks in the case of shock-induced boundary layer separation. The PSP data agreed with experimental data for subsonic expansion flow but showed significant discrepancy for transonic expansion flow, requiring temperature correction.
Article
Optics
Panqiu Jiang, Jiale Mu, Yuxing Liu, Pinghe Wang, Guohua Shi
Summary: In this study, a new structure is used to enhance the nonlinear effect in the cavity, improving the performance of the 1.3 μm broadband swept source. The proposed method improves the spectral range and optical power of the swept sources without additional accessories.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2023)
Article
Multidisciplinary Sciences
R. Lejoyeux, R. Atia, K. K. Vupparaboina, M. N. Ibrahim, S. Suthaharan, J. A. Sahel, K. K. Dansingani, J. Chhablani
Summary: This study utilized en-face swept source optical coherence tomography (SS-OCT) to analyze the distribution of short posterior ciliary arteries (SPCA) entry sites into the choroid in normal eyes. The mean number of arteries per eye was 13.8, with 36% located in the center of the posterior pole image and 21% in the temporal part. The correlation between two masked observers was fair (0.54), with an accuracy rate of 95-99% for choroidal border segmentation.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Ji-Cai Liu, Viktoriia Savchenko, Victor Kimberg, Michael Odelius, Faris Gel'mukhanov
Summary: Theoretical studies on X-ray absorption and core-ionization spectra of molecules pumped by two coherent infrared pulses with different polarizations have shown a sensitivity to the vibrational profile of X-ray probe spectra. The polarization dependence observed is qualitatively different for X-ray absorption and X-ray photoelectron spectra. This technique can be used to select differences in Franck-Condon distributions and study molecular rotation dynamics.
Article
Biochemical Research Methods
Shuibin Ni, Xiang Wei, Ringo Ng, Susan Ostmo, Michael F. Chiang, David Huang, Yali Jia, J. Peter Campbell, Yifan Jian
Summary: Optical coherence tomography (OCT) and OCT angiography (OCTA) allow noninvasive imaging of eye structures and blood vessels, playing a critical role in diagnosing and monitoring vascular eye diseases. Handheld OCT/OCTA systems offer flexibility and portability in eye imaging, although high image acquisition speed and stability are essential for obtaining quality images.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Optics
Qingrui Li, Tianduo Lai, Zhenyang Ding, Kuiyuan Tao, Fengyu Zhu, Hao Kuang, Peidong Hua, Yin Yu, Tiegen Liu
Summary: This paper compares polarization imaging methods based on Jones matrix and Mueller matrix, finding that Mueller matrix performs better in handling non-coaxial diattenuation. Experimental results show that Mueller matrix with incoherent averaging method has better performance in areas with low signal to noise ratio.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Senyao Liu, Yu Zhu, Peng Wu, Hu Xiong
Summary: LS-NO is a promising diagnostic agent for real-time detection of NO in inflammatory bowel disease and may simultaneously promote inflammatory stool examination.
ANALYTICAL CHEMISTRY
(2021)
Article
Spectroscopy
Sufang Shao, Deling Zhang, Bin Lin, Yifeng Han
Summary: In this study, a novel fluorescent probe, BCyP, based on benzohemicyanine was synthesized for highly selective and sensitive detection of phosgene in both liquid and gas phases, which has significant application and research significance.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Physics, Applied
Jianfeng Wang, Eric J. Chaney, Edita Aksamitiene, Marina Marjanovic, Stephen A. Boppart
Summary: This report demonstrates the implementation of compressive sensing and sparse sampling in polarization sensitive optical coherence tomography to reduce the number of B-scans required for effective volumetric measurements. The results show that CS could reconstruct reasonably good PS-OCT measurements with a maximum reduced B-scan rate of 50%, thereby accelerating and doubling the rate of volumetric PS-OCT measurements.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Biochemical Research Methods
Shuang Chang, Jessica Handwerker, Giovanna A. Giannico, Sam S. Chang, Audrey K. Bowden
Summary: This study introduces a method for fabricating birefringent tissue phantoms using PDMS and demonstrates its application in mimicking bladder wall layers. PDMS allows precise control of tissue scattering and thickness, and exhibits controllable birefringent properties.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemical Research Methods
Ana Rodriguez-Aramendia, Fernando Diaz-Douton, Jose Fernandez-Trullas, Pol Falgueras, Laura Gonzalez, Jaume Pujol, Ireneusz Grulkowski, Jose Luis Guell
Summary: The study demonstrates a novel SS-OCT system that alternately images the whole anterior segment and retina using a single source and detector, showing the potential for clinical application in describing and detecting early clinical features in patients.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Medicine, General & Internal
Mariko Sato, Takeshi Iwase
Summary: We evaluated the closure of full-thickness macular holes (MHs) the day after surgery to minimize burden and maximize patient outcomes. In total, 93% of eyes achieved closure after 24.7 hours, and confirmation was done using optical coherence tomography. Termination of facedown positioning was possible after closure confirmation, and larger MH size was associated with non-closure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Mingxiu Wang, Feng Zhang, Cai-Qi Wang, Nan Yin, Yuting Wang, Guixin Qin, Qingling Xu, Jianhua Gong, Huizhen Liu, Xinrui Duan
Summary: Abnormal production of H2O2 is associated with cancer. It is crucial to develop fluorescent probes that can selectively image basal H2O2 in tumor cells. We have successfully developed a fluorescent probe, BBHP, which contains benzil as a recognition site for H2O2 and biotin as a target binding motif. BBHP enables a selective fluorescence turn-on response to H2O2 and can sufficiently image basal H2O2 in biotin receptor-positive cancer cells and tumor tissues.
ANALYTICAL CHEMISTRY
(2022)
Article
Optics
Vitaly Sukharenko, Simeon Bikorimana, Roger Dorsinville
Summary: This letter presents a new experimental technique of polarization sensitive quantum optical coherence tomography (PS-QOCT) for imaging and characterization of birefringent materials. The technique has many potential applications in the characterization of micro and nano structures, including biological samples.
Article
Biochemical Research Methods
Di Yang, Zhuoqun Yuan, Muyun Hu, Yanmei Liang
Summary: This paper presents the use of polarization-sensitive optical coherence tomography (PS-OCT) to image the zebrafish brain and monitor the recovery process of a head wound. The results demonstrate that introducing polarization information can display more features of the brain, and the density of pigment in the skull is a critical factor affecting polarization imaging.
JOURNAL OF BIOPHOTONICS
(2022)
Review
Biotechnology & Applied Microbiology
Antonia Lichtenegger, Bernhard Baumann, Yoshiaki Yasuno
Summary: The zebrafish is an established vertebrate model in biomedical research, especially for high-throughput studies. Recently, optical coherence tomography (OCT) has been widely used in zebrafish research. This review article summarizes the relevant literature and provides an outlook for this emerging field.
BIOENGINEERING-BASEL
(2023)
Article
Biochemical Research Methods
Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno
Summary: This article presents a new formulation for the lateral imaging process of point-scanning optical coherence tomography (OCT) and introduces a new differential contrast method based on this formulation. The formulation utilizes a mathematical sample model called the dispersed scatterer model (DSM), where the sample is represented as a material with slowly varying refractive index and randomly distributed scatterers. It is demonstrated that the formulation represents OCT image and speckle as separate mathematical quantities. The new differential contrast method utilizes complex signal processing of OCT images and is validated through experiments on in vivo and in vitro samples.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Rion Morishita, Toshio Suzuki, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Yiheng Lim, Antonia Lichtenegger, Shuichi Makita, Kiriko Tomita, Yuki Yamamoto, Tetsuharu Nagamoto, Yoshiaki Yasuno
Summary: We utilized 3D dynamic optical coherence tomography (DOCT) to observe the intratissue and intracellular activities of hiPSCs-derived alveolar organoids in normal and fibrosis models. The DOCT images revealed cystic structures surrounded by high-intensity borders, potentially representing alveoli with highly dynamic epithelium, as well as mesh-like structures, possibly fibroblasts. Furthermore, the images displayed abnormal repair of the alveolar epithelium.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Engineering, Electrical & Electronic
Yoshiaki Yasuno
Summary: Jones-matrix optical coherence tomography (JM-OCT) is an extension of polarization-sensitive OCT that provides multiple optical contrasts for biological and clinical samples. It measures the spatial and temporal distribution of the Jones matrix in the sample to compute various contrasts, including intensity, phase retardation, polarization uniformity, diattenuation, signal attenuation, scatterer density, Doppler OCT, OCT angiography, and dynamic OCT. JM-OCT is a generalized version of OCT as it measures the generalized form of sample information, i.e., the Jones matrix sequence. This review summarizes the concept, principles, implementation, processing, and applications of JM-OCT, including noise correction, quantity estimation, and self-calibration.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Biochemical Research Methods
Lida Zhu, Shuichi Makita, Junya Tamaoki, Antonia Lichtenegger, Yiheng Lim, Yiqiang Zhu, Makoto Kobayashi, Yoshiaki Yasuno
Summary: This study proposes a method called multi-focus averaging (MFA) to improve the image contrast of optical coherence tomography (OCT) by suppressing multiple-scattering signals. The MFA method captures multiple OCT volumes with various focal positions and averages them in complex form, effectively reducing multiple-scattering and enhancing image contrast.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Toshihiro Mino, Yoshikiyo Moriguchi, Masato Tamura, Akiko Matsumoto, Atsushi Kubota, Masahiro Akiba, Yunchan Hwang, Shuichi Makita, Yoshiaki Yasuno, Hiroshi Enaida, James G. Fujimoto, Zhenguo Wang
Summary: This study proposes a novel scanning protocol called ammonite scan for widefield optical coherence tomography angiography (OCTA) and relative retinal blood flow velocity imaging in the human retina using variable interscan time analysis (VISTA). The protocol achieved an interscan time of 1.28 ms through a repeated circle scan with a 400 kHz swept-source. The study also eliminated image artifacts caused by eye movement through extra motion-correction processing and explored the microvascular flow parameter in the healthy human eye using the VISTA image.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Multidisciplinary Sciences
Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Thi Hang Tran, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Yiheng Lim, Yoshiaki Yasuno
Summary: This paper presents label-free functional activity imaging of renal tubules in normal and obstructed mouse kidney models using three-dimensional dynamic optical coherence tomography (OCT). The study found that the structure of renal tubules changed and a high dynamics appearance was observed in the perirenal cortex region in the obstructed kidneys. These findings provide a new tool for studying kidney function during kidney diseases.
SCIENTIFIC REPORTS
(2023)
Proceedings Paper
Engineering, Biomedical
Yusong Liu, Shuichi Makita, Masahiro Miura, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi, Yoshiaki Yasuno
Summary: A U-Net shape model was used to synthesize retinal DOPU from OCT with OCTA images. The synthesized DOPU showed high recall and precision for healthy structure, RPE elevation, and RPE thickening. However, improvement is needed for synthesizing RPE defect and hyperreflective retina foci.
OPHTHALMIC TECHNOLOGIES XXXIII
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Lida Zhu, Shuichi Makita, Yiheng Lim, Junya Tamaoki, Yiqiang Zhu, Makoto Kobayashi, Yoshiaki Yasuno
Summary: Optical coherence tomography (OCT) is used to investigate tissue optical properties, while polarization-sensitive OCT (PS-OCT) provides additional contrasts. Multiple scattering (MS) in biological samples hampers OCT and PS-OCT measurements. Various methods, including wavefront shaping, have been proposed to tackle MS. This study presents a method called multi-focus averaging (MFA) to suppress MS and improve image contrast in deep regions. MFA effectively mitigates artifacts caused by MS and improves the accuracy of polarization-sensitive measurements.
OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XXVII
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Yiqiang Zhu, Lida Zhu, Shuichi Makita, Yiheng Lim, Yoshiaki Yasuno
Summary: In this study, a B-scan-wise-multi-focus averaging (B-MFA) method was proposed to suppress multiple scattering noise in optical coherence tomography. This method utilizes multiple B-scans with different focus positions, which are computationally refocused and complex averaged. The results demonstrate the ability of B-MFA in suppressing multiple scattering noise.
OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XXVII
(2023)
Article
Biochemical Research Methods
Shuichi Makita, Masahiro Miura, Shinnoshuke Azuma, Toshihiro Mino, Yoshiaki Yasuno
Summary: Degree of polarization uniformity (DOPU) imaging obtained by polarization-sensitive optical coherence tomography (PS-OCT) has the potential to provide biomarkers for retinal diseases. A neural network-based approach is presented to estimate the DOPU from standard OCT images. DOPU images are synthesized by the neural network and compared with ground truth DOPU images to evaluate the clinical findings. The proposed method demonstrates the potential of extending the features of retinal non-PS OCT.
BIOMEDICAL OPTICS EXPRESS
(2023)
Proceedings Paper
Engineering, Biomedical
Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, Bernhard Baumann
Summary: The zebrafish is a crucial animal model in cancer research, and a polarization sensitive Jones matrix optical coherence tomography prototype is utilized to non-destructively investigate tumor and control tissue differences in adult zebrafish.
OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XXVI
(2022)
