期刊
OPTICS EXPRESS
卷 16, 期 20, 页码 16227-16239出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.16.016227
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资金
- National Institute of Health [P41-RR02594, R01-CA97966]
We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity. (c) 2008 Optical Society of America
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