Simple and efficient phosphine-free Pd(OAc)2 catalyzed urea accelerated Suzuki-Miyaura cross-coupling reactions in iPrOH-H2O at room temperature

A simple, efficient, and less expensive protocol for the phosphine-free Suzuki-Miyaura cross-coupling reactions of aryl halides with different aryl boronic acids in (PrOH)-Pr-i-H2O under aerobic conditions has been developed. The mixture of Pd(OAc)(2) and urea catalyzes the Suzuki-Miyaura cross-coupling of a variety of aryl halides with aryl boronic acids at room temperature, giving generally high yields even under low catalytic loads. The effect of solvent, base, and catalyst loading on the coupling reaction of aryl halide with arylboronic acid is also described. (C) 2014 Elsevier Ltd. All rights reserved.