Article
Biochemistry & Molecular Biology
Nan-Ni Chen, Chau-Yin Chen, Jin-Jhe Wang, Heng-Chiao Huang, Wei-Dar Chen, Ching-Lung Chen, Yao-Hsu Yang, Meng-Hung Lin, Ting-Yu Kuo, Chien-Hsiung Lai
Summary: This study investigated the outcomes of anti-VEGF treatment in patients with exudative AMD with or without OSA. The results showed that patients with OSA had a higher rate of subretinal fluid resorption compared to patients without OSA, but there were no significant differences in other imaging biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana Rita Fernandes, Aleksandra Zielinska, Elena Sanchez-Lopez, Tiago dos Santos, Maria Luisa Garcia, Amelia M. Silva, Jacek Karczewski, Eliana B. Souto
Summary: This review discusses the latest developments in treatment options for age-related macular degeneration (AMD), including pharmacologic therapies and laser treatments for exudative AMD. However, there are still no successful treatments for nonexudative AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Su Ling Young, Martin J. Anderson, Shyamanga Borooah, Ana-Maria Armbrecht, Peter D. Cackett
Summary: This study assessed the long-term prognosis of patients with exudative AMD treated with an as-needed regime of anti-VEGF injections in the real world, showing a relatively good long-term prognosis in terms of vision and mortality. Although most patients experienced vision loss, the rate of decline was significantly slower than in the pre-anti-VEGF era, and the standardized mortality risk was lower than the national average.
Article
Ophthalmology
Burak Mergen, David J. Ramsey
Summary: The study found a significantly lower rate of diagnosed glaucoma or its suspicion in patients with exudative AMD compared to non-exudative AMD. There was a significant difference in the rates of suspected glaucoma between the two groups. The retrospective application of clinical criteria may help identify potential underdiagnosis of glaucoma in AMD patients.
Article
Ophthalmology
Ryo Terao, Ryo Obata, Atsushi Okubo, Shuichiro Aoki, Keiko Azuma, Tazbir Ahmed, Satoru Inoda, Yuto Hashimoto, Ryota Takahashi, Hana Yoshida, Manami Misawa, Hironori Takahashi, Hidenori Takahashi
Summary: The purpose of this study was to identify the cytokine profile in the aqueous humor of patients with intraocular inflammation after intravitreal administration of brolucizumab for neovascular age-related macular degeneration. The results showed that the levels of inflammatory cytokines were significantly higher in patients with intraocular inflammation compared to those without inflammation. These changes in cytokine levels were associated with type IV hypersensitivity and vascular inflammation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Robyn H. Guymer, Thomas G. Campbell
Summary: Age-related macular degeneration is becoming increasingly important due to aging populations and increased longevity. It affects individuals older than 55 years and threatens high-acuity central vision needed for important tasks. Advances in retinal imaging have identified biomarkers of progression. New treatments for neovascular AMD offer potentially longer-lasting effects, but a treatment for atrophic late-stage AMD is still being developed. An effective intervention for early-stage disease or prevention of late-stage AMD has not been found yet, and our understanding of underlying mechanisms continues to evolve.
Article
Medicine, General & Internal
Joanna Ladkowska, Maciej Gawecki, Marek Szolkiewicz
Summary: This study found that the presence of cardiovascular risk factors, especially hypertension, in patients with neovascular age-related macular degeneration negatively impacts visual acuity outcomes following anti-VEGF therapy. Patients with higher total cholesterol levels showed better visual improvement, but this did not significantly affect the percentage of responders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Prem Patel, Veeral Sheth
Summary: AMD is a common cause of vision loss, with two main types, neovascular and non-neovascular, treated primarily through inhibition of VEGF. Discrepancies between clinical trial results and real-world outcomes exist, indicating the potential for new treatments to improve therapeutic efficacy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yun Zhang, Sheng Gao, Xun Li, Xi Huang, Yi Zhang, Tiancong Chang, Zhaolun Cai, Meixia Zhang
Summary: The study evaluated the efficacy and safety of anti-VEGF monotherapy in nAMD patients and concluded that brolucizumab, aflibercept, and ranibizumab are the ideal treatment regimens.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ruth M. Galindo-Camacho, Cristina Blanco-Llamero, Raquel da Ana, Mayra A. Fuertes, Francisco J. Senorans, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: This article reviews the challenges in the treatment of age-related macular degeneration (AMD), innovative nanoformulations, 3D bioprinting, and techniques for monitoring progress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Liangbo L. Shen, Mengyuan Sun, Aneesha Ahluwalia, Michael M. Park, Benjamin K. Young, Eleonora M. Lad, Cynthia Toth, Lucian Del Priore
Summary: This study tracked the progression of eyes with geographic atrophy (GA) involving the central 1 mm diameter zone and found that the central residual effective radius (CRER) declined linearly over approximately 13 years. This finding suggests that CRER could serve as an anatomical endpoint in future clinical trials aiming to preserve the central zone.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Han Joo Cho, Jaemin Kim, Seung Kwan Nah, Jihyun Lee, Chul Gu Kim, Jong Woo Kim
Summary: The development of tiny branching vessels of CNV on OCTA during the nonexudative period was associated with early exudative recurrence, including intraretinal fluid (IRF) or hemorrhage. Identifying these changes on OCTA may help predict exudative recurrence in neovascular AMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Tommaso Bacci, Juliet O. Essilfie, Belinda C. S. Leong, K. Bailey Freund
Summary: The study describes a new clinical phenotype of exudative non-neovascular AMD characterized by intraretinal exudation causing macular edema. It emphasizes the importance of multimodal imaging in differentiating this condition from other manifestations of AMD. Further research is needed to assess the clinical impact and optimal management of exudative non-neovascular AMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Marco Rispoli, Gilda Cennamo, Luca Di Antonio, Marco Lupidi, Mariacristina Parravano, Marco Pellegrini, Daniele Veritti, Stela Vujosevic, Maria Cristina Savastano
Summary: This article provides an overview of current macular imaging techniques and describes the biomarkers that may be useful in the routine management of macular diseases, particularly exudative age-related macular degeneration (AMD). The authors discuss the use of optical coherence tomography (OCT) and OCT angiography (OCTA) in macular imaging, classification of exudative AMD, and biomarkers in structural OCT and OCTA. The integration of technologically-advanced imaging equipment with AI software is expected to enhance patient care in the future.
SURVEY OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Maya Kishi, Akiko Miki, Aya Kamimura, Mina Okuda, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: This retrospective study evaluated the functional and anatomical effects of switching to faricimab for neovascular age-related macular degeneration (nAMD) patients who were refractory to intravitreal aflibercept. The results showed that after switching, the patients experienced a significant decrease in central retinal thickness (CRT), an extended injection interval, and a decrease in the presence of intraretinal fluid and subretinal fluid. However, best-corrected visual acuity (BCVA) and central choroidal thickness (CCT) did not change significantly. The study suggests that switching to faricimab could be an additional treatment option for nAMD patients who are refractory to aflibercept.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Hanyue Xu, Ling Qin, Yifan Zhang, Yinan Xiao, Ming Zhang
Article
Biotechnology & Applied Microbiology
Huili Li, Ming Zhang, Dahong Wang, Guojun Dong, Zhiwei Chen, Suilin Li, Xiaohong Sun, Min Zeng, Haiyang Liao, Huifang Chen, Shengyan Xiao, Xiaodan Li
Summary: The clinical and animal experiments indicate that low-intensity blue light can cause structural and functional damage to the retina, warranting attention to chronic damage caused by low-intensity light.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Ophthalmology
Yifan Zhang, Dan Zhang, Yuzhu Gao, Li Yang, Yunhan Tao, Hanyue Xu, Shulei Man, Ming Zhang, Yanming Xu
Summary: The study demonstrates decreased retinal flow density in early-stage Parkinson's Disease patients, with associations to retinal nerve fiber layer, ganglion cell layer + inner plexiform layer, and internal nuclear layer thickness. Superficial and deep flow parameters could potentially serve as imaging biomarkers for PD diagnosis and staging.
CURRENT EYE RESEARCH
(2021)
Article
Ophthalmology
Yunhan Tao, Xiang Ren, Yifan Zhang, Yuzhu Gao, Mengying Tao, Yueqin Gou, Yunxia Gao, Ming Zhang
Summary: The study investigated the clinical outcomes and complications of using the FIHFT technique in patients with Marfan syndrome. Results showed significant improvement in visual acuity postoperatively with no major complications observed during the surgery.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Mengying Tao, Yueqin Gou, Ruijin Ran, Yunhan Tao, Yunxia Gao, Ming Zhang
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
(2022)
Article
Ophthalmology
Yuzhu Gao, William Robert Kwapong, Yifan Zhang, Yuying Yan, Xurui Jin, Yunhan Tao, Hanyue Xu, Bo Wu, Ming Zhang
Summary: This study used SS OCTA to assess the microvascular changes in the macular region and FAZ area in participants with WMHs. The results showed significantly decreased VD in ICP and DCP, and significantly enlarged FAZ area in WMH participants. These findings are important for the early evaluation of WMHs.
Article
Mathematical & Computational Biology
Zhaotian Zhang, Qiang Tang, Qiong Wang, Fulei Nie, Limei Sun, Delun Luo, Wei Chen, Xiaoyan Ding
Summary: The Human Ophthalmic Diseases Database (HODD) contains information on 730 ophthalmic diseases and 653 related genes, collected from various well-known databases. By providing comprehensive information on disease description, gene location, effects, protein-protein interactions, and associated pathways, HODD aims to facilitate studies on ophthalmic diseases.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Yunfeng Lin, Qian Li, Lihua Wang, Quanyi Guo, Shuyun Liu, Shihui Zhu, Yu Sun, Yujiang Fan, Yong Sun, Haihang Li, Xudong Tian, Delun Luo, Sirong Shi
Summary: tFNAs, as versatile DNA nanostructures, have great potential in regenerative medicine with applications in promoting tissue regeneration and treating various diseases, showing positive effects on cellular behaviors and tissue regeneration.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Review
Ophthalmology
Mengying Tao, Guoqing Wang, Yueqin Gou, Ming Zhang
Summary: The study found that the conventional inverted internal limiting membrane (ILM), flap covering technique, and ILM flap filling technique have similar anatomical efficacy in treating idiopathic macular hole (MH). However, the inverted ILM flap covering technique is superior in terms of postoperative best-corrected visual acuity (BCVA) and reconstitution of outer retinal layers compared to the filling technique.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cell Biology
Xiaodi Zhou, Yanting Lai, Xiaoxiao Xu, Qiong Wang, Limei Sun, Limei Chen, Jiajie Li, Rong Li, Delun Luo, Yunfeng Lin, Xiaoyan Ding
Summary: This study aimed to explore the effect and mechanism of tetrahedral framework nucleic acids (tFNAs) in inhibiting pathological retinal neovascularization (RNV) and vaso-obliteration (VO) in ischaemic retinopathy. Cell-based assays showed that tFNAs can enter endothelial cells (ECs) and inhibit angiogenic functions. In vivo experiments confirmed that tFNAs reduce RNV and inhibit VO through the PI3K/AKT/mTOR/S6K pathway. This study provides a theoretical basis for understanding RNV and suggests that tFNAs could be a novel candidate for treating blind-causing RNV.
CELL PROLIFERATION
(2023)
Letter
Infectious Diseases
Yuzhu Gao, Yifan Zhang, Kefan Mou, Shulei Man, Qing Chen, Yilin Liu, Hanyue Xu, Ming Zhang
JOURNAL OF INFECTION
(2023)
Letter
Public, Environmental & Occupational Health
Yifan Zhang, Yilin Liu, Yuzhu Gao, Shulei Man, Kefan Mou, Hanyue Xu, Yi Chen, Ming Zhang
JOURNAL OF TRAVEL MEDICINE
(2023)
Letter
Biochemistry & Molecular Biology
Juanjuan Kang, Sisi Yu, Song Lu, Guohui Xu, Jiang Zhu, Na Yan, Delun Luo, Kai Xu, Zhihui Zhang, Jian Huang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Article
Ophthalmology
Amy S. Babiuch, Mehnaz Khan, Ming Hu, Peter K. Kaiser, Sunil K. Srivastava, Rishi P. Singh, Allison Watts, Jamie L. Reese, Justis P. Ehlers
OPHTHALMOLOGY RETINA
(2018)
Article
Ophthalmology
Justis P. Ehlers, Mehnaz Khan, Daniel Petkovsek, Laura Stiegel, Peter K. Kaiser, Rishi P. Singh, Jamie L. Reese, Sunil K. Srivastava
OPHTHALMOLOGY RETINA
(2018)