Review
Medicine, General & Internal
Omar M. Raslan, Alejandro Lazo-Langner
Summary: Retinal vein occlusion is a significant cause of vision loss, and current treatment options focus on preventing neovascular complications. Few studies have explored the potential benefits of anticoagulant agents and other interventions targeting the coagulation system.
Review
Medicine, General & Internal
Adrianna Marcinkowska, Slawomir Cisiecki, Marcin Rozalski
Summary: RVO is a complex disorder with multifactorial pathogenesis involving vascular, platelet, and hypercoagulable factors. Platelet function and related markers play key roles in RVO diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Pasquale Loiudice, Giuseppe Covello, Michele Figus, Chiara Posarelli, Maria Sole Sartini, Giamberto Casini
Summary: This study aimed to evaluate the choroidal vascularity change in eyes with central and branch retinal vein occlusion (RVO). By analyzing the records of 47 patients, it was found that RVO eyes had higher choroidal vascularity index, total choroidal area, and luminal area compared to unaffected eyes. The changes varied according to the type of macular edema.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yixiang Zhan, Weipeng Zhao, Kemin Ni, Zhaoce Liu, Yanjun Su, Xichuan Li, Heng Zhang, Chunze Zhang
Summary: Immunotherapy is a revolutionary cancer treatment, but it can lead to rare ocular side effects. This case report highlights a patient who developed central retinal vein occlusion and vitreous hemorrhage, resulting in blindness, after receiving anti-PD-1 therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. Vanveldhuisen, S. Michael, B. A. Blodi
Summary: There is a nonlinear association between central subfield thickness (CST) on spectral-domain OCT and concurrent visual acuity letter score (VALS) in eyes treated initially with afli-bercept or bevacizumab for macular edema associated with central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO). The best expected VALS is observed when post-treatment CST is close to the estimated inflection points.
Review
Hematology
Emanuele Valeriani, Francesco Paciullo, Angelo Porfidia, Pasquale Pignatelli, Matteo Candeloro, Marcello Di Nisio, Marco Paolo Donadini, Claudio Maria Mastroianni, Roberto Pola, Paolo Gresele, Walter Ageno
Summary: Based on the analysis of multiple studies, anticoagulant therapy was found to have better efficacy in terms of visual acuity improvement and recurrent RVO events compared to antiplatelet therapy, but it also carried a certain risk of bleeding complications.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Lasse Jorgensen Cehofski, Anders Kruse, Alexander Norgaard Alsing, Benn Falch Sejergaard, Jonas Ellegaard Nielsen, Anders Schlosser, Grith Lykke Sorensen, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: This study investigated the proteomic changes in the retina following aflibercept intervention in a central retinal vein occlusion (CRVO) model. The findings showed that aflibercept mainly acted through VEGF receptor modulation, and several other proteins also exhibited changes. These results provide insights into the mechanism of action of aflibercept and are of clinical importance for cases with aflibercept-resistant macular edema secondary to CRVO.
Review
Biochemistry & Molecular Biology
Sandrine Laurance, Mickael Marin, Yves Colin
Summary: Central retinal vein occlusion (CRVO) is a common retinal disorder leading to blindness, but the primary cause and treatment remain unidentified. This review aims to provide an overview of CRVO pathophysiology, specifically focusing on the role of red blood cells (RBCs). The review explores the functions of RBCs beyond oxygen transport and their potential involvement in CRVO occurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Maja Lendzioszek, Malgorzata Mrugacz, Anna Bryl, Ewa Poppe, Katarzyna Zorena
Summary: Retinal vein occlusion (RVO) is the second most common retinal disorder and often has a greater psychological impact. There is strong evidence suggesting that cardiovascular diseases are the main risk factors for RVO, and a higher consumption of fish, nuts, fruits, and vegetables can protect against this condition. The review aims to investigate the potential impact of macro- and micronutrients on retinal vein occlusion.
Article
Ophthalmology
Ramesh Venkatesh, Shama Sharief, Chitturi Venkata Sai Prashanti, Nikitha Gurram Reddy, Rubble Mangla, Yash Parmar, Aaditi Anilkumar, Naresh Kumar Yadav, Jay Chhablani
Summary: Aberrant filling of the retinal vein in patients with branch or hemi-central retinal artery occlusions is associated with less severe retinal ischemia and better visual outcomes. This finding may be attributed to altered retinal vascular anatomy or arteriovenous shunts. The presence of aberrant filling of the retinal vein could indicate a better visual prognosis.
Review
Ophthalmology
Dan Calugaru, Mihai Calugaru
Summary: In patients with acute central/hemicentral retinal vein occlusions, intraocular pressure (IOP) may be reduced due to decreased aqueous humor secretion, gradually increasing until 3 months after occlusion onset, while IOP increases can lead to ocular hypertension and glaucoma. The correlations between ocular hypertension/glaucoma and acute RVOs can be classified into three groups based on the sequence of events and age-related vascular alterations.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Adrianna Marcinkowska, Nina Wolska, Boguslawa Luzak, Slawomir Cisiecki, Karol Marcinkowski, Marcin Rozalski
Summary: Platelets contribute to the development of retinal vein occlusion by enhancing procoagulant activity through platelet-derived microvesicles. The direct role of platelets' hyperreactivity in developing RVO is less apparent.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Lasse Jorgensen Cehofski, Anders Kruse, Mads Odgaard Maeng, Benedict Kjaergaard, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: Bevacizumab intervention results in altered levels of retinal proteins, including components of bevacizumab itself. The changes suggest a narrow mechanism of action.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Shin Tanaka, Yui Tanaka, Tatsuya Inoue, Koichi Nagura, Rei Arasaki, Kazuyoshi Okawa, Shohei Kitahata, Kentaro Nakamura, Shiro Kastube, Yasuo Yanagi, Maiko Maruyama-Inoue, Kazuaki Kadonosono
Summary: This study aimed to evaluate the relationship between retinal haemorrhages detected on Ultra-widefield (UWF) red channel images and perfusion status in eyes with acute central retinal vein occlusion (CRVO). The results showed that red channel haemorrhages were significantly correlated with nonperfusion areas, confirming that UWF red channel imaging could be used to identify ischaemia-related haemorrhage in eyes with acute CRVO.
Article
Ophthalmology
Piyush Kohli, Haemoglobin Parida, Renu P. Rajan, Naresh Babu Kannan
Summary: This article reports the management of a neonate with simultaneous bilateral central retinal vein occlusion (CRVO) secondary to septicemia. Apart from systemic treatment, aggressive ocular treatment is needed for severe ischemic ocular injuries.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Sohan Singh Hayreh
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Neurosciences
Sohan Singh Hayreh
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2019)
Review
Ophthalmology
Sohan Singh Hayreh
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Letter
Ophthalmology
Sohan Singh Hayreh
Letter
Ophthalmology
Sohan Singh Hayreh
Article
Clinical Neurology
S. S. Hayreh
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Review
Ophthalmology
Sohan Singh Hayreh
Summary: This article discusses the role of photocoagulation in the treatment of retinal vein occlusion, emphasizing its importance in managing NV and macular edema. Research shows that photocoagulation can prevent and treat NV-related complications in CRVO and BRVO, and recent advancements in treatment options have drastically changed the role and management of photocoagulation in these conditions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Sohan Singh Hayreh
Summary: This case report documents three siblings from northwest India diagnosed with familial giant cell arteritis, which is the first non-Caucasian family reported with the condition.
Letter
Ophthalmology
Sohan Singh Hayreh
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Sohan Singh Hayreh
Summary: Giant cell arteritis is a critical medical emergency in ophthalmology, with visual loss being its most dreaded complication which can be prevented with early diagnosis and aggressive treatment. This review discusses GCA, its ophthalmic manifestations, and strategies for diagnosis and management.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Letter
Ophthalmology
Sohan Singh Hayreh
Letter
Ophthalmology
Sohan Singh Hayreh
Letter
Ophthalmology
Sohan Singh Hayreh
INDIAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Ophthalmology
Sohan Singh Hayreh
OPHTHALMOLOGY RETINA
(2018)
Letter
Ophthalmology
Sohan Singh Hayreh