Article
Medicine, General & Internal
Xuemei Liang, Baiyun Shen, Zuguo Ou, Hongmei An, Li Li
Summary: This study compared the efficacy and injection number of IVR monotherapy and IVR + DEX implants for ME secondary to RVO. The results showed no significant differences in BCVA improvement and CFT reduction between the two groups. However, the IVR + DEX implant group had an advantage in reducing the number of injections and prolonging the time between injections.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Thomas Wecker, Bastian Grundel, Milena Grundel, Marie-Christine Bruender, Simon Trick, Clemens Lange, Daniel Boehringer, Hansjuergen Agostini, Andreas Stahl
Summary: In this study evaluating the use of dexamethasone intravitreal implants in patients with ME due to RVO, it was found that most patients maintained stable visual acuity, while central retinal thickness decreased. However, morphologic improvement did not always lead to functional gain, with mean intraocular pressure remaining within normal limits and expected cataract formation in this age group.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Yu-Te Huang, Chun-Ju Lin, Huan-Sheng Chen, Peng-Tai Tien, Chun-Ting Lai, Ding-Yi Hsia, Jane-Ming Lin, Wen-Lu Chen, Yi-Yu Tsai
Summary: This study found that dexamethasone intravitreal implant leads to significant improvements in macular edema and visual acuity, while older age, higher initial CRT, and diabetes are risk factors for requiring multiple injections.
Article
Medicine, General & Internal
Pichai Jirarattanasopa, Sakunjanut Jiranoppasakdawong, Mansing Ratanasukon, Patama Bhurayanontachai, Wantanee Dangboon
Summary: This retrospective study evaluated the efficacy of intravitreal dexamethasone implants for treating macular edema associated with retinal vascular diseases. The results showed improvements in visual acuity and central retinal thickness over a 6-month period. Reinjection may be associated with a higher baseline retinal thickness.
Article
Ophthalmology
Mohamed Kamel Soliman, Javier Zarranz-Ventura, Usha Chakravarthy, Martin McKibbin, Christopher Brand, Geeta Menon, Helena Cilliers, Salim Natha, Adam Ross, Mahmoud Sarhan, Aires Lobo, Victor Chong, Sajjad Mahmood, Niaz Islam, Toks Akerele, Ahmed Shakarchi, Ahmed Sallam
Summary: The study investigated the use of intravitreal dexamethasone implant (IDI) for treating macular edema secondary to retinal vein occlusion. It found that the visual outcomes and safety profile of IDI in real-world settings were comparable to those in clinical trials. The study also observed that additional medical treatment can effectively control increased intraocular pressure in eyes with preexisting ocular hypertension or glaucoma, and phakic eyes are more likely to experience intraocular pressure rise with IDI compared to pseudophakic eyes.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Gonzaga Garay-Aramburu, Angela Gomez-Moreno, Aritz Urcola
Summary: The study confirmed the effectiveness of intravitreal dexamethasone implant in treating macular edema secondary to retinal vein occlusion and identified new predictive factors for different treatment outcomes that include visual and anatomical improvements.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xing Du, Yanjuan Sheng, Yeqiang Shi, Min Du, Yuanyuan Guo, Shanshan Li
Summary: This study confirms that the simultaneous use of dexamethasone implant and ranibizumab is safe and effective for the treatment of macular edema secondary to central retinal vein occlusion. The combination treatment significantly improves visual acuity and reduces macular edema, with minimal adverse reactions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stephanie Baillif, Pascal Staccini, Michel Weber, Marie-Noelle Delyfer, Yannick Le Mer, Vincent Gualino, Laurence Collot, Pierre-Yves Merite, Catherine Creuzot-Garcher, Laurent Kodjikian, Pascale Massin
Summary: In this multicenter retrospective observational study, switching from dexamethasone implant to fluocinolone acetonide implant was found to be effective and safe in treating diabetic macular edema eyes. A short time between the switch was associated with reduced central macular thickness fluctuations and the need for early additional treatments.
Review
Pharmacology & Pharmacy
Qiongzhen Yuan, Yunxia Gao, Yilin Liu, Hanyue Xu, Tong Wang, Ming Zhang
Summary: This meta-analysis demonstrates that switching therapy to DEX implants can significantly improve visual acuity and reduce central macular thickness in patients with refractory macular edema secondary to retinal vein occlusion. The efficacy can last for up to 6 months after a single-dose application.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Ophthalmology
Raymond Pranata, Amelinda Vania, Rachel Vania, Andi Arus Victor
Summary: Intravitreal ranibizumab (RNB) showed superior efficacy in improving best-corrected visual acuity and had a less pronounced effect on intraocular pressure and cataract formation compared to dexamethasone intravitreal implant (DII) for patients with macular edema secondary to branch retinal vein occlusion (BRVO).
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ke Shi, Xiaodong Sun, Jingfa Zhang
Summary: The study identified the crucial role of retinal inflammation in the pathogenesis of RVO in RVO-ME patients. Effective improvement in visual acuity and reduction in macular edema were observed in patients receiving intravitreal dexamethasone implant injections.
Article
Ophthalmology
Nisha R. Acharya, Albert T. Vitale, Elizabeth A. Sugar, Janet T. Holbrook, Alyce E. Burke, Jennifer E. Thorne, Michael M. Altaweel, John H. Kempen, Douglas A. Jabs
Summary: This study evaluated the effectiveness of three different intravitreal treatments for persistent or recurrent uveitic macular edema. The results showed that dexamethasone was more effective than methotrexate or ranibizumab in treating uveitic macular edema. However, there was a risk of increased intraocular pressure with dexamethasone treatment.
Article
Ophthalmology
Yoshihito Sakanishi, Koichi Yasuda, Syu Morita, Keitaro Mashimo, Kazunori Tamaki, Toshiro Sakuma, Nobuyuki Ebihara
Summary: The 24-month study on the efficacy of intravitreal aflibercept (IVA) for macular edema due to branch retinal vein occlusion (BRVO-ME) showed significant improvements in visual acuity and central foveal thickness, with a decrease in injection frequency over time and an increase in ME remission rate. The onset period of the disease was found to be significantly associated with the need for reinjection after 12 months.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Oncology
Pradeep Kumar Panigrahi
Summary: A 59-year-old female patient presented with gradual vision loss in the right eye. After receiving Brolucizumab treatment, her vision improved and there was no recurrence of macular edema.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Medicine, General & Internal
Francesco Pignatelli, Annalisa Nacucchi, Alfredo Niro, Samuele Gigliola, Fedele Passidomo, Rossella Donghia, Giuseppe Addabbo
Summary: In this study, we investigated the efficacy and safety of DEX-I combined with silicone oil (SO) removal for the treatment of recalcitrant cystoid macular edema (CME) after successful rhegmatogenous retinal detachment (RRD) repair. The results showed that DEX-I treatment significantly improved CME and visual acuity, and was safe to use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Frank G. Holz, Rodrigo Abreu-Gonzalez, Francesco Bandello, Renaud Duval, Louise O'Toole, Daniel Pauleikhoff, Giovanni Staurenghi, Armin Wolf, Daniel Lorand, Andreas Clemens, Benjamin Gmeiner
Summary: The RAZORBILL study aims to evaluate the impact of AI-based clinical decision support tools on disease activity assessment in nAMD patients. It enriches 3D OCT scans with automated fluid and layer quantification measurements. The study consists of two phases: clinical data collection and OCT enrichment analysis. It will provide insights into the value of AI tools in routine clinical care.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tatiana R. Rosenblatt, Daniel Vail, Cassie A. Ludwig, Ahmad Al-Moujahed, Malini Veerappan Pasricha, Marco H. Ji, Natalia F. Callaway, Darius M. Moshfeghi
Summary: This study aimed to investigate the relationship between pseudophakic monovision and fall risk in the elderly. The results showed that patients with pseudophakic single vision had a higher risk of falls compared to those without cataract surgery, while pseudophakic monovision did not impact fall risk.
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2023)
Review
Ophthalmology
Alessandro Vinciguerra, Antonio Giordano Resti, Andrea Rampi, Mario Bussi, Francesco Bandello, Matteo Trimarchi
Summary: This article reviews the literature of the past 30 years on the use of END-DCR and EXT-DCR in treating DALO, aiming to provide a simple and reproducible treatment algorithm. For primary surgeries, END-DCR is preferred in the presence of intranasal comorbidities, while EXT-DCR is chosen if local anesthesia is needed. In recurrent cases, END-DCR is considered the treatment of choice.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ruben Martin-Pinardel, Jordi Izquierdo-Serra, Sandro De Zanet, Alba Parrado-Carrillo, Gonzaga Garay-Aramburu, Martin Puzo, Carolina Arruabarrena, Laura Sararols, Maximino Abraldes, Laura Broc, Jose Juan Escobar-Barranco, Marta Figueroa, Miguel Angel Zapata, Jose M. Ruiz-Moreno, Aina Moll-Udina, Carolina Bernal-Morales, Socorro Alforja, Marc Figueras-Roca, Laia Gomez-Baldo, Carlos Ciller, Stefanos Apostolopoulos, Agata Mosinska, Ricardo P. Casaroli Marano, Javier Zarranz-Ventura
Summary: This study used artificial intelligence to quantify fluid compartments in OCT images of patients with neovascular age-related macular degeneration (nAMD) and explored their associations with visual outcomes at 12 months. The results showed that the distribution of fluid in the fovea was correlated with baseline and final visual acuity. AI-based fluid dynamics analysis provided baseline characteristics of patients and predicted visual improvements.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Wei-Shan Tsai, Sridevi Thottarath, Sarega Gurudas, Elizabeth Pearce, Andrea Giani, Victor Chong, Chui Ming Gemmy Cheung, Sobha Sivaprasad
Summary: This study investigated the impact of disorganization of the retinal inner layers (DRIL) and ellipsoid zone (EZ) loss on visual function in diabetic macular ischemia (DMI). It found that DRIL had a more significant effect on vision, retinal thickness, and microvascular parameters than EZ loss, and the coexistence of DRIL and EZ loss had the greatest impact on visual acuity.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Sridevi Thottarath, Shruti Chandra, Sarega Gurudas, Wei-Shan Tsai, Andrea Giani, Eduard De Cock, Taffeta Ching Ning Yamaguchi, Sobha Sivaprasad
Summary: The purpose of the study is to estimate the prevalence and incidence of subclinical non-exudative macular neovascularisation (neMNV) in patients with unilateral neovascular age-related macular degeneration (nAMD), and to develop predictive models for conversion to neovascular AMD. The study will recruit 800 patients with new onset nAMD in the first eye, and evaluate the retinal imaging characteristics using OCT and OCTA. The findings will help inform the risk of conversion to neovascular AMD.
Article
Ophthalmology
Michele Cavalleri, Beatrice Tombolini, Riccardo Sacconi, Gianpaolo Gatta, Renato Valeri, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to analyze the visual and anatomical outcomes after switching to intravitreal brolucizumab therapy in eyes affected by neovascular age-related macular degeneration (nAMD) previously treated with other anti-vascular endothelial growth factor (VEGF) agents. The results showed that despite persistent residual retinal fluid after frequent anti-VEGF treatment, nAMD eyes can still achieve functional and anatomical improvements after switching to brolucizumab therapy.
Article
Ophthalmology
Alessio Antropoli, Alessandro Arrigo, Lorenzo Bianco, Elena Cavallari, Alessandro Berni, Filippo Casoni, Giacomo Consalez, Francesco Bandello, Ottavio Cremona, Maurizio Battaglia Parodi
Summary: The study aims to describe a continuous hyperreflective band called hyperreflective ganglion cell layer band (HGB) detected in patients with retinitis pigmentosa (RP). Retrospective analysis of OCT images showed that HGB was present in 25.3% of RP patients and associated with poorer visual function.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Enrico Borrelli, Costanza Barresi, Alessandro Feo, Giorgio Lari, Domenico Grosso, Lea Querques, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
Summary: The study aimed to assess the relationship between clinical characteristics and the rate of retinal thinning in eyes with diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF) therapy. The findings showed a significant longitudinal thinning in the inner and outer retina in all analyzed regions. Type 2 diabetes, subfoveal neuroretinal detachment, gender, and diabetic retinopathy stage were associated with different rates of retinal thinning.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Ashish Sharma, Nilesh Kumar, Nikulaa Parachuri, Anat Loewenstein, Francesco Bandello, Baruch D. Kuppermann
Summary: South Asian countries like India, South Korea, and Japan are leading the way in researching and developing biosimilars of anti-VEGF ranibizumab for retinal diseases. This article discusses the current and upcoming biosimilars for ranibizumab and aflibercept, as well as the development status of aflibercept biosimilars.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Article
Ophthalmology
Riccardo Sacconi, Beatrice Tombolini, Ilaria Zucchiatti, Andrea Servillo, Matteo Menean, Giulio Falco Alessandrini, Lea Querques, Francesco Prascina, Peter Charbel Issa, Francesco Bandello, Giuseppe Querques
Summary: This study describes subclinical angioid streaks (AS) as a frequent and peculiar phenotype of age-related macular degeneration (AMD) and compares the features of eyes with subclinical AS to those without AS. Eyes with subclinical AS were found to have a more advanced stage of AMD compared to eyes without subclinical AS.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Paul Mitchell, Jennifer Arnold, Samantha Fraser-Bell, Hyong Kwon Kang, Andrew A. Chang, Jodi Tainton, Susan Simonyi
Summary: This study aimed to evaluate the effectiveness of dexamethasone intravitreal implant 0.7 mg (DEX) monotherapy in the non-responder subgroup of the AUSSIEDEX study, which was defined by diabetic macular oedema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) agents. The results showed that DEX significantly improved anatomical outcomes at 52 weeks without new safety concerns.
BMJ OPEN OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Stela Vujosevic, Emily Chew, Leanne Labriola, Sobha Sivaprasad, Ecosse Lamoureux
Summary: This narrative review assessed the available PROMs used in research on diabetic retinal diseases and highlighted areas for improvement. The most commonly used PROM is NEI VFQ-25, but it lacks the ideal psychometric, responsiveness, and clinical setting digital administration requirements for inclusion in an updated DRD staging system.
OPHTHALMOLOGY SCIENCE
(2024)
Article
Ophthalmology
Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, Maria Pia Manitto, Elisabetta Martina, Emanuela Aragona, Francesco Bandello, Maurizio Battaglia Parodi
Summary: This study reveals significant correlations between genotypes and phenotypes in ABCA4-associated retinopathy, providing valuable insights for prognosis and guiding the design of future clinical trials.
JAMA OPHTHALMOLOGY
(2023)