Article
Multidisciplinary Sciences
Svenja Deuchler, Ralf Schubert, Pankaj Singh, Adonis Chedid, Natallia Brui, Ninel Kenikstul, Thomas Kohnen, Hanns Ackermann, Frank Koch
Summary: This study aimed to sample vitreous fluid from patients with diabetic retinopathy (DR) to assess the expression of growth and inflammatory factors (GIF). The results showed that the expression of CD54, IL-8, and PIGF was significantly higher in patients with proliferative DR compared to those with non-proliferative DR, suggesting their potential importance in defining and monitoring the effectiveness of patient therapy.
Article
Ophthalmology
Hassan Elkayal, Ahmed M. Bedda, Hesham El-Goweini, Ahmed A. Souka, Amir Ramadan Gomaa
Summary: The study compared the efficacy of PPV and IVI of RBZ in treating DME with VMIA, finding that visual improvement was more pronounced in the IVI group, although this may have been affected by other confounding factors.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Minho Kim, Soonil Kwon, Sohee Jeon, Byung Ju Jung, Kyu Seop Kim
Summary: Abnormal posterior vitreous detachment (PVD) is speculated to be an important mechanism in the development of epiretinal membrane (ERM). Sphingosine-1-phosphate (S1P) has been found to be expressed in ERM specimens, indicating its potential role in the pathogenesis of ERM during abnormal PVD.
Article
Ophthalmology
David H. W. Steel, Niall Patton, Theodor Stappler, Niral Karia, Hans Hoerauf, Nishal Patel, Joachim Wachtlin, Thomas Raber, Petra Kozma-Wiebe
Summary: The INJECT study demonstrated the effectiveness of ocriplasmin in patients with VMT, including those with MH. The study found that in the overall group, the rate of nonsurgical VMT resolution was 40.7%, with a nonsurgical MH closure rate of 36.0%.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Dimosthenis Mantopoulos, Jonathan L. Prenner, Vishal K. Patel, Daniel B. Roth, Sumit P. Shah, Onoufrios Tsavaris, Howard F. Fine, H. Matthew Wheatley
Summary: The effect of cataract extraction on the vitreomacular interface varies significantly, with Stage 2 or 3 macular hole patients all progressing to Stage 4 macular hole after surgery. The vitreomacular adhesion did not significantly change in diabetic patients' eyes. Larger studies are needed to further understand the impact of cataract extraction on vitreomacular traction.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Medicine, General & Internal
Stefano Ranno, Stela Vujosevic, Manuela Mambretti, Cristian Metrangolo, Micol Alkabes, Giovanni Rabbiolo, Andrea Govetto, Elisa Carini, Paolo Nucci, Paolo Radice
Summary: This study evaluates the role of vitrectomy with or without internal limiting membrane (ILM) peeling in nontractional refractory diabetic macular edema (DME). The results show significant improvements in central macular thickness and visual acuity after vitrectomy. Better outcomes are observed in patients with subfoveal serous retinal detachment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Yi-Ting Hsieh, Chung-May Yang
Summary: This study retrospectively analyzed 30 patients with diabetic retinopathy and concurrent vitreomacular traction (VMT), and found that VMT in diabetic retinopathy had unique characteristics, including thickened posterior hyaloid membrane and multi-layered traction from different directions. Surgical treatment can improve visual acuity and macular structures.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Ruveyde Garip, Ayca K. Cinar, Abdulkadir C. Cinar, Ahmet Kursad Sakallioglu, Hande Guclu, Vuslat Gurlu
Summary: In this study, VMT prevalence was higher in eyes with exudative AMD compared to nonexudative AMD, but spontaneous release rates were similar in both types of AMD, indicating potential factors affecting VMT prognosis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Ophthalmology
Ruveyde Garip, Ayca Kupeli Cinar, Abdulkadir Can Cinar, Vuslat Gurlu
Summary: In patients with diabetic retinopathy and vitreomacular traction (VMT), factors associated with VMT relief were evaluated retrospectively. Spontaneous release of VMT was observed in 37.8% of the eyes, with lower horizontal length, absence of hyperreflective retinal spots, and absence of epiretinal membrane being associated with VMT relief. No significant difference was found in the presence of intravitreal injection or panretinal photocoagulation between eyes with VMT relief and persistent VMT.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Endocrinology & Metabolism
Chunyan Lei, Yun Zhang, Meixia Zhang
Summary: The study shows a significant association between insulin treatment and reduced risks of postoperative DME in Japanese PDR patients with PPV surgery compared with oral medications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Atsushi Fujiwara, Yuki Kanzaki, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Shinichiro Doi, Kosuke Takahashi, Ryo Matoba, Yuki Morizane
Summary: This retrospective study classified diabetic macular edema (DME) based on the localization and area of the fluid, revealing the significant impact of fluid localization and area on visual acuity (VA) in DME patients.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Dilsher S. Dhoot, Hadi Moini, Kimberly Reed, Weiming Du, Robert Vitti, Alyson J. Berliner, Rishi P. Singh
Summary: This study aimed to assess the time to, cumulative incidence of, and functional benefit of achieving sustained improvement in diabetic macular oedema (DMO) in terms of the Diabetic Retinopathy Severity Scale (DRSS). The results showed that patients treated with intravitreal aflibercept injections achieved sustained improvement in DRSS earlier and more frequently compared to laser treatment, and this improvement was associated with greater improvement in visual acuity, independent of central subfield thickness reduction.
Review
Pharmacology & Pharmacy
Qiongzhen Yuan, Yanling Liu, Yueqin Gou, Hanyue Xu, Yunxia Gao, Yilin Liu, Yi Chen, Ming Zhang
Summary: This study compared the efficacy and safety of the intravitreal dexamethasone (DEX) implant for the treatment of diabetic macular edema (DME) in vitrectomized and nonvitrectomized eyes. The results showed similar efficacy and safety of the DEX implant in both groups, suggesting that it could be considered as an effective treatment choice for DME in eyes with prior vitrectomy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Andreas Katsanos, Konstantina Gorgoli, Ioannis Asproudis, Maria Stefaniotou
Summary: This case report describes a recurrent vitreomacular traction and macular edema in an 82-year-old male patient who underwent treatment with ocriplasmin injections. Despite initial improvement post-injection, the VMT symptoms recurred. A conservative approach with observation eventually led to resolution of the VMT. More than 3 years after the injection, there is no evidence of VMT, the patient is free of metamorphopsia, and his BCVA is 0.0 logMAR.
OPHTHALMOLOGY AND THERAPY
(2021)
Article
Ophthalmology
Yue Qi, Pengyou Yan, Wenying Fan, Ningli Wang, An Li Duan
Summary: A retrospective study was conducted to compare the outcomes of vitrectomy with and without fovea-sparing internal limiting membrane (ILM) peeling for highly myopic eyes with retinoschisis and foveal detachment. The results showed that fovea-sparing ILM peeling had better anatomical outcomes in resolving foveoschisis and foveal detachment compared to non-ILM peeling, while both procedures had similar visual functional outcomes.
Article
Medicine, Research & Experimental
Adam R. Glassman, Wesley T. Beaulieu, Cynthia R. Stockdale, Roy W. Beck, Neil M. Bressler, Leanne T. Labriola, Michele Melia, Kristina Oliver, Jennifer K. Sun
Article
Ophthalmology
Maureen G. Maguire, Danni Liu, Adam R. Glassman, Lee M. Jampol, Chris A. Johnson, Carl W. Baker, Neil M. Bressler, Thomas W. Gardner, Dante Pieramici, Cynthia R. Stockdale, Jennifer K. Sun
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Adam R. Glassman, Carl W. Baker, Wesley T. Beaulieu, Neil M. Bressler, Omar S. Punjabi, Cynthia R. Stockdale, Charles C. Wykoff, Lee M. Jampol, Jennifer K. Sun
JAMA OPHTHALMOLOGY
(2020)
Review
Medicine, General & Internal
Lee M. Jampol, Adam R. Glassman, Jennifer Sun
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Ophthalmology
Adam R. Glassman, John A. Wells, Kristin Josic, Maureen G. Maguire, Andrew N. Antoszyk, Carl Baker, Wesley T. Beaulieu, Michael J. Elman, Lee M. Jampol, Jennifer K. Sun
Editorial Material
Ophthalmology
Adam R. Glassman
JAMA OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Philipp K. Roberts, Wolf-Dieter Vogl, Bianca S. Gerendas, Adam R. Glassman, Hrvoje Bogunovic, Lee M. Jampol, Ursula M. Schmidt-Erfurth
JAMA OPHTHALMOLOGY
(2020)
Editorial Material
Ophthalmology
Wesley T. Beaulieu, Adam R. Glassman
JAMA OPHTHALMOLOGY
(2020)
Article
Medicine, General & Internal
Andrew N. Antoszyk, Adam R. Glassman, Wesley T. Beaulieu, Lee M. Jampol, Chirag D. Jhaveri, Omar S. Punjabi, Hani Salehi-Had, John A. Wells, Maureen G. Maguire, Cynthia R. Stockdale, Daniel F. Martin, Jennifer K. Sun
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Ophthalmology
David W. Hutton, Adam R. Glassman, Joshua D. Stein, Neil M. Bressler, Jennifer K. Sun
Summary: The study found that similar visual outcomes were obtained on average when managing CI-DME and good baseline VA patients initially with laser or observation strategies compared to the immediate use of aflibercept. While individual circumstances may warrant any of these three strategies, on a societal level, cost savings might be achieved with these first two approaches.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Brandon J. Lujan, Claire T. Calhoun, Adam R. Glassman, Joseph M. Googe, Lee M. Jampol, Michele Melia, Deborah K. Schlossman, Jennifer K. Sun
Summary: This study investigated the quality of OCTA scans in multicenter clinical studies, showing that the majority of scans were of good quality. However, improvements are needed in signal strength and motion artifacts.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Wesley T. Beaulieu, Adam R. Glassman, Carl W. Baker, Maureen G. Maguire, Chris A. Johnson, Michele Melia, Jennifer K. Sun
Summary: The study aimed to describe 2.5% low-contrast visual acuity in eyes with good vision despite center-involved diabetic macular edema and compare changes after different treatments. Results showed no significant difference in low-contrast visual acuity change from baseline to 2 years among treatment groups. However, due to the limited sample size, the study may not have had enough power to detect clinically meaningful benefits between treatment groups.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Clement K. Chan, Calvin E. Mein, Adam R. Glassman, Wesley T. Beaulieu, Claire T. Calhoun, Glenn J. Jaffe, Lee M. Jampol, Mathew W. MacCumber, Maureen G. Maguire, Raj K. Maturi, Hani Salehi-Had, Soraya Rofagha, Jennifer K. Sun, Daniel F. Martin
Summary: Pneumatic vitreolysis (PVL) showed effectiveness in releasing vitreomacular traction (VMT) in most eyes and closing full-thickness macular holes (FTMH) in approximately one third of eyes. However, safety concerns related to retinal detachments and tears led to early termination of the studies.
Article
Ophthalmology
Raj K. Maturi, Adam R. Glassman, Kristin Josic, Andrew N. Antoszyk, Barbara A. Blodi, Lee M. Jampol, Dennis M. Marcus, Daniel F. Martin, Michele Melia, Hani Salehi-Had, Cynthia R. Stockdale, Omar S. Punjabi, Jennifer K. Sun
Summary: The study found that in eyes with moderate to severe NPDR, using aflibercept compared to sham treatment can reduce the proportion of eyes that develop proliferative diabetic retinopathy or non-center involved diabetic macular edema causing vision loss. However, preventive treatment did not confer visual acuity benefit compared with observation plus treatment with aflibercept only after development of PDR or vision-reducing CI-DME within two years.
JAMA OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Adam R. Glassman, Wesley T. Beaulieu, Maureen G. Maguire, Andrew N. Antoszyk, Clement C. Chow, Michael J. Elman, Lee M. Jampol, Hani Salehi-Had, Jennifer K. Sun
Summary: This study compares exploratory outcomes between treatment groups for patients with vitreous hemorrhage due to proliferative diabetic retinopathy, finding that both initial aflibercept injections and vitrectomy with PRP are viable treatment options. Although no overall difference in mean visual acuity was noted between the groups, eyes that underwent vitrectomy with PRP had better visual acuity outcomes in the subgroup with baseline visual acuity worse than 20/800.
JAMA OPHTHALMOLOGY
(2021)