Article
Nutrition & Dietetics
Yuan-Yuei Chen, Ying-Jen Chen
Summary: This study found that higher levels of dietary calcium and potassium were associated with a lower risk of diabetic retinopathy. The assessment of dietary micronutrients may be part of the treatment for patients with diabetic complications.
Review
Public, Environmental & Occupational Health
Yicong Guo, Siyue Liu, Huilan Xu
Summary: This meta-analysis found that uric acid (UA) levels are higher in patients with diabetic retinopathy (DR) compared to controls, especially in those with proliferative DR. UA levels may serve as a potential biomarker for identifying disease severity in patients with DR. More clinical evidence is needed to confirm these findings.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Ophthalmology
Xiao-Wen Hou, Ying Wang, Chen-Wei Pan
Summary: Metabolomics studies have identified potential biomarkers and metabolic pathways for diabetic retinopathy. Metabolites like L-glutamine and L-lactic acid may offer new diagnostic insights into DR. Dysregulation of amino acid and energy metabolism pathways are implicated in the development of this microvascular complication of diabetes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Yanhua Jiang, Huaying Fan, Jing Xie, Yao Xu, Xin Sun
Summary: Diabetic retinopathy (DR) is closely associated with adipocytokines. Previous studies have shown that levels of leptin and chemerin are higher in DR patients compared to controls, while omentin-1 levels are lower. Further high-quality studies are needed to confirm these associations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Maria Olimpia Paz Alvarenga, Giza Hellen Nonato Miranda, Railson Oliveira Ferreira, Miki Taketomi Saito, Nathalia Carolina Fernandes Fagundes, Lucianne Cople Maia, Rafael Rodrigues Lima
Summary: Five studies found a significant relationship between the severity of periodontitis and diabetic retinopathy, but the overall quality of evidence was rated as low. Further large-scale studies with proper adjustment for confounders and prospective analysis are needed to clarify this association.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Endocrinology & Metabolism
Shilia Jacob Kurian, Tejaswini Baral, Mazhuvancherry K. Unnikrishnan, Ruby Benson, Murali Munisamy, Kavitha Saravu, Gabriel Sunil Rodrigues, Mahadev Rao, Amit Kumar, Sonal Sekhar Miraj
Summary: A systematic review showed that DFU patients have lower levels of vitamin D, magnesium, and selenium, suggesting an association between micronutrient status and risk of DFU. Routine monitoring and supplementation of micronutrients are recommended in DFU patients, and personalized nutrition therapy may be considered in DFU management guidelines.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Review
Medicine, General & Internal
Fanwen Jiang, Lin Zhou, Chun Zhang, Hui Jiang, Zhuping Xu
Summary: This systematic review compared circulating malondialdehyde (MDA) levels in people with and without diabetic retinopathy (DR). The results showed that circulating MDA levels were higher in people with DR compared to those without.
CHINESE MEDICAL JOURNAL
(2023)
Review
Nutrition & Dietetics
Drake W. Lem, Dennis L. Gierhart, Pinakin Gunvant Davey
Summary: High blood sugar leads to depletion of endogenous antioxidants in the retina, resulting in neurodegeneration and irreversible vision loss. Lutein and zeaxanthin offer protection for retinal vascular cells and improve visual function, showing potential therapeutic effects for diabetic retinopathy.
Article
Clinical Neurology
Kaiyan Hu, Mengyao Jiang, Qi Zhou, Weiting Zeng, Xuhong Lan, Qianqian Gao, Fan Mei, Li Zhao, Fei Chen, Anhu Wu, Gongcai Tao, Chenghua Mou, Bin Ma
Summary: The presence of diabetic retinopathy is associated with an increased risk of stroke in diabetic patients, particularly in those with type 2 diabetes mellitus. However, the association is uncertain in patients with type 1 diabetes mellitus. Further research is needed to validate the role of diabetic retinopathy in stroke-risk stratification, including studies on the association between the stage of diabetic retinopathy and stroke risk.
FRONTIERS IN NEUROLOGY
(2021)
Review
Ophthalmology
Jocelyn J. Drinkwater, Amy Kalantary, Angus W. Turner
Summary: This article reviewed the current evidence on whether the screening intervals for diabetic retinopathy (DR) can be extended. The findings suggest that in certain circumstances, such as for patients with type 2 diabetes without current DR and optimal management of other risk factors, the screening intervals can be extended to 3-5 years.
ACTA OPHTHALMOLOGICA
(2023)
Review
Nutrition & Dietetics
Agostino Milluzzo, Martina Barchitta, Andrea Maugeri, Roberta Magnano San Lio, Giuliana Favara, Maria Grazia Mazzone, Laura Sciacca, Antonella Agodi
Summary: Diabetic retinopathy is a multifactorial neuro-microvascular disease with high prevalence and severe consequences. There are limited treatment options for early stage or prevention, while advanced stage requires invasive and expensive therapies. A systematic review of observational and interventional studies suggests that certain nutrients, such as vitamins B, D, and E, may have a preventive role in DR. However, further research is needed to determine the clinical application of nutraceuticals in the prevention and treatment of DR.
Review
Biochemistry & Molecular Biology
Ana Boned-Murillo, Henar Albertos-Arranz, Maria Dolores Diaz-Barreda, Elvira Orduna-Hospital, Ana Sanchez-Cano, Antonio Ferreras, Nicolas Cuenca, Isabel Pinilla
Summary: Optical coherence tomography angiography (OCTA) is an essential tool for the diagnosis and control of diabetic patients, allowing visualization and analysis of the retinal and choroidal microvasculature, and the detection of diabetic retinopathy and other related diseases.
Article
Multidisciplinary Sciences
Abere Woretaw Azagew, Yeneabat Birhanu Yohanes, Zerko Wako Beko, Yohannes Mulu Ferede, Chilot Kassa Mekonnen
Summary: In this study, co-morbid hypertension, poor glycemic control, and longer duration of diabetes illness were found to be determinant factors of diabetic retinopathy. Aggressive treatment of co-morbid hypertension and blood glucose, and regular eye screening should be implemented to reduce the occurrence of diabetic retinopathy.
Review
Health Care Sciences & Services
Pedro Romero-Aroca, Maribel Lopez-Galvez, Maria Asuncion Martinez-Brocca, Alicia Pareja-Rios, Sara Artola, Josep Franch-Nadal, Joan Fernandez-Ballart, Jose Andonegui, Marc Baget-Bernaldiz
Summary: This study investigated the prevalence and incidence of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients in Spain and its changes over the past 20 years. The study found that the prevalence of DR was higher between 2001 and 2008 and decreased thereafter. Longitudinal studies also determined the annual incidence of DR and sight-threatening diabetic retinopathy (STDR).
Article
Cardiac & Cardiovascular Systems
Elisa Dal Canto, Sharon Remmelzwaal, Adriana Johanne van Ballegooijen, M. Louis Handoko, Stephane Heymans, Vanessa van Empel, Walter J. Paulus, Giel Nijpels, Petra Elders, Joline W. J. Beulens
Summary: This study evaluated the diagnostic performance of echocardiographic markers for HFpEF and LVDD, finding that a multivariable model showed the highest diagnostic performance, left atrial strain had reasonable performance, and adding exercise E/e ' improved the sensitivity of HFpEF diagnostic algorithms. Larger, well-designed studies are needed to further evaluate the potential diagnostic role of novel tools in current diagnostic algorithms.
HEART FAILURE REVIEWS
(2022)
Review
Public, Environmental & Occupational Health
Inge A. T. van de Luitgaarden, Sabine van Oort, Emma J. Bouman, Linda J. Schoonmade, Ilse C. Schrieks, Diederick E. Grobbee, Yvonne T. van der Schouw, Susanna C. Larsson, Stephen Burgess, Adriana J. van Ballegooijen, N. Charlotte Onland-Moret, Joline W. J. Beulens
Summary: This systematic review examined the causal effects of moderate alcohol consumption on cardiometabolic health through Mendelian randomization studies, indicating null associations for cardiovascular disease and diabetes but a detrimental association with all-cause mortality. The variability in methodological quality across included studies currently impedes drawing definitive conclusions on this topic, with further advancements in Mendelian randomization methodology expected to enhance future research in this area.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Isabel A. L. Slurink, Nicolette R. den Braver, Femke Rutters, Nina Kupper, Tom Smeets, Petra J. M. Elders, Joline W. J. Beulens, Sabita S. Soedamah-Muthu
Summary: The highest intake of high fat fermented dairy, cheese and high fat cheese were associated with a lower risk of prediabetes, whereas other dairy types were not associated. Cheese seems to be inversely associated with type 2 diabetes risk, despite high levels of saturated fatty acids and sodium.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Emma A. Vermeulen, Hanne B. T. de Jong, Alexander G. A. Blomjous, Coby Eelderink, Tiny Hoekstra, Petra J. M. Elders, Martin H. de Borst, Marc G. Vervloet, Adriana J. van Ballegooijen, Joline W. Beulens
Summary: This study did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses. Participants with the highest magnesium intake did not show significant differences in various vascular outcomes compared to those with the lowest intake.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Editorial Material
Nutrition & Dietetics
Joline W. J. Beulens, Marc Vervloet
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Josine M. Stuber, Jeroen Lakerveld, Loes W. Kievitsbosch, Joreintje D. Mackenbach, Joline W. J. Beulens
Summary: The effectiveness of nudging healthy food choices in an online supermarket was evaluated in a randomized controlled trial. Information nudges were found to significantly increase healthy product purchases for shoppers in deprived areas, while showing adverse effects for those in non-deprived areas. Further research is needed to explore the real-life effects of online healthy food nudging and its equitability within populations.
Article
Public, Environmental & Occupational Health
I. A. T. van de Luitgaarden, A. E. Bardach, N. Espinola, I. C. Schrieks, D. E. Grobbee, J. W. J. Beulens
Summary: Alcohol consumption in Argentina is among the highest in the world, making it a risk factor for cancer. Moderate alcohol consumption contributes the most to cancer-related deaths and DALYs. Implementing population-wide strategies to reduce harmful alcohol use can effectively decrease the burden of cancer.
Review
Peripheral Vascular Disease
Anna G. Hoek, Sabine van Oort, Kenneth J. Mukamal, Joline W. J. Beulens
Summary: There is a clear link between excessive alcohol consumption and cardiovascular disease (CVD), but the effects of moderate alcohol consumption on CVD are still uncertain. Some studies have shown that moderate drinkers have a lower risk of coronary heart disease and myocardial infarction, but there is still ambiguity about the effects of alcohol on other CVDs and all-cause mortality. More research, including long-term randomized controlled trials, studies on genetic polymorphisms, and policy evaluations, is needed to provide the best available evidence.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Review
Endocrinology & Metabolism
Joline W. J. Beulens, Maria G. M. Pinho, Taymara C. Abreu, Nicole R. den Braver, Thao M. Lam, Anke Huss, Jelle Vlaanderen, Tabea Sonnenschein, Noreen Z. Siddiqui, Zhendong Yuan, Jules Kerckhoffs, Alexandra Zhernakova, Milla F. Brandao Gois, Roel C. H. Vermeulen
Summary: Type 2 diabetes is primarily influenced by environmental risks and modifiable factors such as lifestyle choices. The external exposome, including built, social, physico-chemical, and lifestyle/food environments, plays a significant role in the prevention of type 2 diabetes. Air pollution, residential noise, and area-level socioeconomic deprivation have been linked to an increased risk of type 2 diabetes, while neighborhood walkability and green space are associated with a reduced risk. The impact of food environment, social environment, and outdoor temperature on type 2 diabetes risk remains inconclusive and requires further investigation.
Article
Environmental Sciences
Haykanush Ohanyan, Lutzen Portengen, Anke Huss, Eugenio Traini, Joline W. J. Beulens, Gerard Hoek, Jeroen Lakerveld, Roel Vermeulen
Summary: This study investigated the relationship between environmental factors in urban areas and BMI, using multiple statistical methods to analyze the data. The results indicated that neighborhood house values, oxidative potential of air pollution, healthy food outlets, low-income neighborhoods, and one-person households were significantly associated with BMI.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Nicolette R. den Braver, Jeroen Lakerveld, Peter Gozdyra, Tim van de Brug, John S. Moin, Ghazal S. Fazli, Femke Rutters, Johannes Brug, Rahim Moineddin, Joline W. J. Beulens, Gillian L. Booth
Summary: This study developed a novel neighbourhood drivability index that predicts whether local residents drive or use active modes of transportation. The index can be used to investigate the association between drivability, physical activity, and chronic disease risk.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Ehlana Catharina Maria Bartels, Nicolette Roelina den Braver, Karin Johanna Borgonjen-van den Berg, Femke Rutters, Amber van der Heijden, Joline Wilhelma Johanna Beulens
Summary: This study aims to investigate whether adherence to the Dutch Healthy Diet index 2015 (DHD15-index) is associated with change in glycemic control and cardio-metabolic markers in people with type 2 diabetes (T2D). The results show that adherence to the DHD15-index is associated with a decrease in BMI, but not with changes in glycemic control or other cardio-metabolic parameters.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Correction
Nutrition & Dietetics
Jody C. Hoenink, Joline W. J. Beulens, Marjolein C. Harbers, Jolanda M. A. Boer, S. Coosje Dijkstra, Mary Nicolaou, Yvonne T. van der Schouw, Ivonne Sluijs, W. M. Monique Verschuren, Wilma Waterlander, Joreintje D. Mackenbach
Article
Cardiac & Cardiovascular Systems
Michiel T. H. M. Henkens, Anne-Mar van Ommen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A. J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P. M. Empel, Joline W. J. Beulens, Hester M. Ruijter, Stephane R. B. Heymans
Summary: This study aims to identify distinct phenogroups and their associated blood proteome profiles in patients with HF-like symptoms using the HFA-PEFF score. Four different phenogroups were identified and several biomarkers associated with inflammation and extracellular matrix remodeling were found.
Article
Public, Environmental & Occupational Health
Jody C. Hoenink, Wilma Waterlander, Joline W. J. Beulens, Joreintje D. Mackenbach
Summary: This study examined whether material and psychosocial resources can explain the socioeconomic differences in diet quality. The findings suggest that individual-level factors, such as cooking skills, only explain a small proportion of the socioeconomic differences in diet quality, indicating the importance of considering other psychosocial and material resources as well as structural factors outside the individual, such as financial, work and living circumstances.
SSM-POPULATION HEALTH
(2022)