Article
Ophthalmology
Yoav Nahum, Orly Galor, Maya Atar, Irit Bahar, Eitan Livny
Summary: The study included five males and two females aged 54-82 years with corneal oedema due to Pseudophakic bullous keratopathy (n=5), Fuchs' endothelial dystrophy (n=2). In all cases, the technique allowed proper determination of the graft's orientation.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Harminder S. Dua, Rui Freitas, Youssef Sadek, Darren S. J. Ting, Mario Nubile, Imran Mohammed, Dalia G. Said
Summary: The study aimed to determine the primary axis of Descemet's membrane scrolling and investigate the impact of oval trephination along the axis of least scrolling. Results showed that Descemet's membrane primarily scrolled along the horizontal axis, and vertically oval samples displayed minimal scrolling. Additionally, the degree of scrolling was not influenced by the distribution of elastin.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Giulia Coco, Hannah J. Levis, Alfredo Borgia, Davide Romano, Luca Pagano, Gianni Virgili, Stephen B. Kaye, Vito Romano
Summary: By evaluating the features of anterior segment optical coherence tomography (AS-OCT), it was found that posterior stromal ripples and detachment axial extension are the main risk factors for graft detachment worsening in Descemet's membrane endothelial keratoplasty (DMEK). Patients showing these features should be closely monitored to identify the need for re-bubbling at an early stage, thus improving surgical outcomes.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Naing L. Tint, Kelvin K. W. Cheng, Amritpaul S. Dhillon, Pearse A. Keane, Philip Alexander, David Kennedy, David Y. S. Chau, Felicity R. A. J. Rose, Bruce D. S. Allan
Summary: By exploring the use of a thermoreversible copolymer gel coating, this study found that the gel coating can effectively prevent scrolling of donor tissue in DMEK. The copolymer formulations were characterized using rheological analyses and cytotoxicity assays, and the thickness of the gel coating was analyzed using OCT. The results showed that the copolymer could be easily applied to the endothelium and prevented scrolling of the DMEK graft.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Toshiki Shimizu, Takahiko Hayashi, Atsuyuki Ishida, Akira Kobayashi, Takefumi Yamaguchi, Nobuhisa Mizuki, Kenji Yuda, Satoru Yamagami
Summary: This study evaluated the changes in corneal nerves and dendritic cells in patients undergoing DMEK surgery for BK. The results showed that DMEK can repair and normalize the corneal environment.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Chihiro Sunouchi, Takahiko Hayashi, Toshiki Shimizu, Yusuke Hara, Junki Kurita, Hiroko Kobashigawa, Itaru Oyakawa, Yasutsugu Ida, Akira Kobayashi, Jun Shoji, Satoru Yamagami
Summary: This study compared the central corneal thickness before and after DSAEK and DMEK surgeries, and evaluated the recipient corneal thickness following DSAEK. The results showed that there was no significant difference in central corneal thickness between DSAEK and DMEK eyes before surgery, but the central corneal thickness was slightly greater in DSAEK eyes compared to DMEK eyes at 6 months post-surgery. However, there was no significant difference in recipient corneal thickness following DSAEK and central corneal thickness following DMEK at 6 months.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Burcu Kasim, Yusuf Kocluk
Summary: This retrospective study analyzed the outcomes and risk factors of failure in Descemet's membrane endothelial keratoplasty (DMEK) for graft failure after penetrating keratoplasty (PKP). The study found that DMEK is a feasible option with fast visual recovery and low risk of complications in patients with graft failure after PKP. However, larger studies are needed to analyze intraoperative and donor-related factors.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Annekatrin Rickmann, Silke Wahl, Alisa Katsen-Globa, Andre Schulz, Norbert Puetz, Peter Szurman
Summary: The study investigated the ultrastructure of the cleavage plane of human cornea after liquid-bubble prepared tissue for Descemet's membrane endothelial keratoplasty. The results showed a smooth cleavage plane between the interfacial matrix and posterior stromal collagen lamellae, without significant stromal remnants or demarcation of a distinct pre-DM layer. The conclusion was that the DMEK graft preparation performed by liquid-bubble technique provided a smooth cleavage plane without a distinct pre-DM layer.
ACTA OPHTHALMOLOGICA
(2021)
Review
Medicine, General & Internal
Kai Yuan Tey, Sarah Yingli Tan, Darren S. J. Ting, Jodhbir S. Mehta, Marcus Ang
Summary: This systematic review and meta-analysis found that DMEK surgery has a similar risk of post-operative complications compared to triple DMEK, with comparable visual outcomes and graft survival rates at 6 months postoperative.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Sotaip Nishisako, Takefumi Yamaguchi, Masatoshi Hirayama, Kazunari Higa, Dai Aoki, Chiaki Sasaki, Hisashi Noma, Jun Shimazaki
Summary: This study aims to identify donor-related risk factors associated with graft endothelial failure and postoperative endothelial cell density reduction. The results suggest that donor pseudophakic status and preoperative endothelial folds are significant risk factors for endothelial failure in non-FECD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Pavel Studeny, Katerina Hlozankova, Deli Krizova, Magdalena Netukova, Miroslav Veith, Peter Mojzis, David P. Pinero
Summary: The study evaluated the long-term outcomes of combining cataract surgery, intraocular lens implantation, and DMEK-S, showing that this combined procedure is effective in treating patients with corneal disease and cataract, maintaining visual rehabilitation in the long term. Future efforts should focus on minimizing complications associated with the surgery.
Article
Ophthalmology
Ashok Sharma, Rajan Sharma
Summary: A 78-year-old male underwent ultra-thin DSAEK for PBK (OS) and developed allograft rejection, which was successfully controlled with steroid treatment, leading to no recurrence during 11 months of follow-up.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Philipp Roberts, Miriam Keane, Gink Yang, Elsie G. Chan, Damien Harkin, Natalie McKirdy, Mark Daniell, Australian Corneal Graft Registry
Summary: This study compared the graft survival rates of endothelial keratoplasty (EK) versus penetrating keratoplasty (PK) in patients with iridocorneal endothelial (ICE) syndrome, and identified ocular features associated with graft survival. The results showed that EK had a lower survival rate compared to PK in corneal transplantation for ICE syndrome, and a history of raised intraocular pressure was associated with a higher risk of graft failure.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tim Berger, Berthold Seitz, Elias Flockerzi, Shady Suffo, Fidelis A. Flockerzi, Maximilian Berger, Nora Szentmary, Loay Daas
Summary: This study retrospectively analyzed 18 eyes with complicated Descemet's membrane detachment (DMD) and reported clinical outcomes after surgical intervention. The results showed that in eyes with previous penetrating keratoplasty (PKP), AS-OCT demonstrated rupture of Descemet's membrane (DM) in some cases, but spontaneous reattachment occurred in most cases within 8 weeks. Visual acuity significantly improved after surgical treatments such as PKP. In conclusion, PKP is an effective treatment option for complicated DMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Pranita Sahay, Rajesh Fogla, Namrata Sharma
Summary: This study investigated the preferred surgical technique of Descemet membrane endothelial keratoplasty (DMEK) among corneal surgeons in India, as well as barriers faced by non-DMEK surgeons in performing this procedure. The results showed that DMEK was the most commonly used technique, but lack of training was the main reason for not performing DMEK among non-DMEK surgeons. The study also found that most DMEK surgeons found unrolling the graft in the anterior chamber to be the most difficult step, and they were more comfortable with using DSEK or DSAEK techniques.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
James Myerscough, Harry William Roberts, Angeli Christy Yu, Michael Mimouni, Luca Furiosi, Matteo Mandrioli, Giuseppe Giannaccare, Massimo Busin
Summary: This study aimed to describe the incidence and risk factors of postoperative cystoid macular oedema (CMO) after endothelial keratoplasty (EK). The results showed that older age (>67 years), diabetes mellitus, and DMEK were identified as independent risk factors for CMO following EK.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Angeli Christy Yu, Rossella Spena, Fiorella Fusco, Riccardo Dondi, James Myerscough, Federica Fabbri, Cristina Bovone, Massimo Busin
Summary: Two-piece microkeratome-assisted mushroom keratoplasty can achieve excellent visual rehabilitation for traumatic corneal scars with relatively stable endothelial cell loss and low rates of immunologic rejection and graft failure.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Environmental Sciences
Daniela Mazzuca, Massimiliano Borselli, Santo Gratteri, Giovanna Zampogna, Alessandro Feola, Marcello Della Corte, Francesca Guarna, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: This review describes the role and main applications of telemedicine in ophthalmic clinical practice, as well as the related medico-legal aspects. Telemedicine ensures patient care through information and communication technologies, saving time and costs and avoiding physical contact. However, there are limitations including the absence of physical examinations, the possibility of transmission failure, and potential privacy and confidentiality violations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Ophthalmology
Marco Pellegrini, Angeli Christy Yu, Massimo Busin
Summary: This study reports the outcomes of a modified large-diameter (9 mm) big-bubble deep anterior lamellar keratoplasty (DALK) technique in post-radial keratotomy (RK) eyes with improved success rates of pneumatic dissection. The technique involved a large-diameter (9 mm) deep partial-thickness trephination, air injection, limited stromal clearance, and suturing of an anterior lamellar graft. The success rate of pneumatic dissection, visual acuity improvement, keratometric astigmatism, and complications were recorded. Rating: 7 out of 10.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Harry W. Roberts, Mark R. Wilkins, Mohsan Malik, Melody Talachi-Langroudi, James Myerscough, Marco Pellegrini, Angeli Christy Yu, Massimo Busin
Summary: The study aimed to report the rates of corneal transplant rejection from 2018 to 2022 at Moorfields Eye Hospital UK and Ospedali Privati Forli (OPF) Villa Igea, Italy, and evaluate the association between COVID-19 vaccination and rejection. The results showed no significant increase in rejection rates in 2021 when COVID-19 vaccination was widely implemented, suggesting no causal association between COVID-19 vaccination and corneal graft rejection.
Review
Biology
Jessica Maiuolo, Rosa Maria Bulotta, Francesca Oppedisano, Francesca Bosco, Federica Scarano, Saverio Nucera, Lorenza Guarnieri, Stefano Ruga, Roberta Macri, Rosamaria Caminiti, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Antonio Cardamone, Annarita Coppoletta, Martina Nicita, Adriano Carnevali, Vincenzo Scorcia, Vincenzo Mollace
Summary: Eye health is crucial and diseases can greatly impact vision and quality of life. Natural antioxidants and nutraceutical supplementation can counteract oxidative stress in early stages of eye diseases and improve vision. Combining nutraceuticals and antioxidants may be a promising solution for eye protection.
Article
Biology
Amedeo Lucente, Andrea Taloni, Vincenzo Scorcia, Giuseppe Giannaccare
Summary: Diabetic retinopathy (DR) can cause various lesions in the peripheral retina, which may go unnoticed with traditional fundus cameras. Widefield (WF) and Ultra-Widefield (UWF) technologies aim to expand the photographable retinal field. Through geometrical analysis, we found that WF and UWF imaging significantly increase the field of view, allowing detailed visualization of the peripheral retina. This has a significant impact on the diagnosis and management of DR.
Article
Ophthalmology
Andrea Lucisano, Vincenzo Scorcia, Andrea Taloni, Costanza Rossi, Raffaella Gioia, Giuseppe Giannaccare
Summary: In this study, the visual and topographic outcomes of large (9.0 mm) versus conventional (8.0 mm) deep anterior lamellar keratoplasty (DALK) for the treatment of keratoconus (KC) were compared, based on the different localization of corneal ectasia. The results showed that large 9.0-mm DALK provided better anatomical outcomes, particularly in eyes with corneal ectasia extending beyond the central 8.0 mm.
Editorial Material
Ophthalmology
Chiara Vivarelli, Angeli christy Yu, Massimo Busin
Article
Medicine, General & Internal
Rossella Spena, Cristina Bovone, Nicolo Ciarmatori, Marco Pellegrini, Angeli Christy Yu, Giorgio Zauli, Massimo Busin
Summary: The purpose of this paper is to report the clinical manifestations, diagnostic evaluation, management, and outcomes of microsporidial keratitis in post-keratoplasty eyes. The study found that confocal microscopy can be used for the in vivo detection of pathogenic microorganisms and therapeutic keratoplasty with topical fumagillin can lead to a satisfactory visual prognosis for microsporidial stromal keratitis in post-keratoplasty eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Matteo Posarelli, Davide Romano, Davide Tucci, Giuseppe Giannaccare, Vincenzo Scorcia, Andrea Taloni, Luca Pagano, Alfredo Borgia
Summary: The ocular surface is a complex structure that is critical for maintaining visual function. Regeneration therapies have emerged as a promising approach to repair the damaged ocular surface by stimulating cell proliferation and restoring the eye homeostasis and function. This article reviews the different strategies employed in ocular-surface regeneration, including cell-based therapies, growth-factor-based therapies, and tissue-engineering approaches.
Editorial Material
Ophthalmology
Andrea Taloni, Vincenzo Scorcia, Giuseppe Giannaccare
Article
Ophthalmology
Marco Pellegrini, Angeli Christy Yu, Rossella Spena, Cristina Bovone, Giorgio Zauli, Massimo Busin
Summary: This study reports the clinical outcomes of large diameter deep anterior lamellar keratoplasty (DALK) and converted two-piece microkeratome-assisted mushroom keratoplasty (MK) for herpetic corneal scars. The results showed that DALK yields excellent visual and clinical outcomes, and in case of intraoperative complications, DALK can be converted to MK to maximize the refractive benefit and minimize the risk of graft failure.
Review
Oncology
Fabio Casciano, Enrico Zauli, Massimo Busin, Lorenzo Caruso, Saleh AlMesfer, Samar Al-Swailem, Giorgio Zauli, Angeli Christy Yu
Summary: Ocular malignancies have significant impacts on national healthcare systems and can result in significant vision loss. The role of p53 in maintaining ocular homeostasis and its potential as a targeted therapy for managing ocular tumors are discussed in this review.
Article
Health Care Sciences & Services
Daniela Mazzuca, Giuseppe Demarinis, Marcello Della Corte, Fiorella Caputo, Antonello Caruso, Margherita Pallocci, Luigi Tonino Marsella, Filippo Tatti, Emanuele Siotto Pintor, Lorenzo Mangoni, Gabriele Piccoli, Adriano Carnevali, Sabrina Vaccaro, Vincenzo Scorcia, Enrico Peiretti, Carmelo Nobile, Nicola Gratteri, Giuseppe Giannaccare
Summary: This study examined the impact of the COVID-19 pandemic on the management of retinal diseases in Italy, specifically the decreased number of intravitreal injections and the related medico-legal implications. The study found a significant reduction in injections during the lockdown and subsequent phases, leading to delayed treatment of chronic retinal diseases. The lack of management guidelines created ethical and legal issues that need to be addressed in future planning.
