Article
Medicine, General & Internal
Jingyuan Yang, Yi Qu, Jianchun Zhao, Jingwu Cong, Zixi Sun, Yunfeng Du, Gang Yang, Dayong Ding, Youxin Chen, Gangwei Cheng
Summary: In the evaluation of optic disc photographs for morphologic features and glaucoma likelihood, the stereoscopic method showed superiority compared to the monoscopic method for general ophthalmologists. The stereoscopic method is more likely to identify glaucomatous eyes which need medical intervention.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ella Bouris, Tyler Davis, Esteban Morales, Lourdes Grassi, Diana Salazar Vega, Joseph Caprioli
Summary: This study developed a deep CNN using a code-free platform to assess the quality of optic disc photographs. The model achieved high accuracy in both ternary and binary classification systems, with overall accuracies of 91% and 98% respectively. The proposed system has wide clinical and research potential, from providing immediate feedback to photographers to screening large databases before research use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Akshat Tulsani, Preetham Kumar, Sumaiya Pathan
Summary: This paper presents a novel approach for the identification of glaucoma using a segmentation based approach on the optic disc and optic cup, achieving improved accuracy for image classification and segmentation through tuning hyper parameters and using a custom loss function. The model demonstrates state-of-art results for Intersection over Union (IOU) scores and enhances training time efficiency.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Ophthalmology
Eun Jung Lee, Jong Chul Han, Changwon Kee
Summary: This study examined the morphology of the deep optic nerve head in tilted disc syndrome (TDS) and identified factors associated with retinal nerve fiber layer (RNFL) defects. The results showed that a higher baseline IOP, a larger tilt axis, a larger BMO-lamina cribrosa insertion angle, and more lamina cribrosa defects were associated with the presence of RNFL defects in TDS. These findings suggest a mechanism of RNFL defect associated with structural ONH deformation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Mathematics
Jose E. Valdez-Rodriguez, Edgardo M. Felipe-Riveron, Hiram Calvo
Summary: Early detection and treatment of glaucoma are crucial to prevent vision loss. A CNN-based methodology focusing on the extraction of optic disc information from retinal images achieved high accuracy in glaucoma diagnosis. Further exploration with different RGB channels and depth information did not significantly improve classification performance.
Article
Ophthalmology
Fabian A. Braeu, Thanadet Chuangsuwanich, Tin A. Tun, Shamira Perera, Rahat Husain, Alexandre H. Thiery, Tin Aung, George Barbastathis, Michael J. A. Girard
Summary: Using artificial intelligence techniques, the study aims to assess the robustness of the optic nerve head (ONH) by analyzing biomechanical knowledge through optical coherence tomography (OCT). Three AI algorithms were compared to predict ONH robustness and the DGCNN algorithm outperformed the others. The study suggests that ONH robustness can be assessed from a single OCT scan, providing potential insights into identifying fast visual field loss progressors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Vahid Mohammadzadeh, Sean Wu, Tyler Davis, Arvind Vepa, Esteban Morales, Sajad Besharati, Kiumars Edalati, Jack Martinyan, Mahshad Rafiee, Arthur Martynian, Fabien Scalzo, Joseph Caprioli, Kouros Nouri-Mahdavi
Summary: By using a deep learning model based on longitudinal optic disc photographs, we can predict visual field progression with high accuracy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yeon Ju Lim, Jong Wook Bang, Robert N. Weinreb, Linda M. Zangwill, Min Hee Suh
Summary: The clinical characteristics of focal temporal optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) patients were assessed. It was found that focal temporal MvD-D was associated with longer axial length and subsequent morphological changes of the optic disc and parapapillary area.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Yuhao Zhang, Xiangrui Cai, Ying Zhang, Hong Kang, Xin Ji, Xiaojie Yuan
Summary: Glaucoma is the leading cause of blindness globally, and automated detection methods are crucial for intervention and damage reduction. However, due to variations in image capture among different fundus cameras, pretrained models suffer performance degradation on other datasets, and the high cost of manual annotations limits practicality.
KNOWLEDGE-BASED SYSTEMS
(2021)
Article
Computer Science, Artificial Intelligence
Samiksha Pachade, Prasanna Porwal, Manesh Kokare, Luca Giancardo, Fabrice Meriaudeau
Summary: This paper presents a novel segmentation network called NENet, which combines deep learning frameworks with specific network structures to achieve superior performance and generalizability in optic disc and cup segmentation for glaucoma. Experimental results demonstrate that NENet outperforms current state-of-the-art methods in accuracy and detail segmentation.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Ophthalmology
Hosni Al Zoubi, Thomas Riemer, Rowena Simon, Walthard Vilser, Somar Hasan, Daniel Meller, Regine Augsten, Martin Hammer
Summary: The study investigated the haemoglobin concentration and oxygenation in the optic disc of glaucoma patients compared to healthy controls. The results showed that haemoglobin concentration was significantly lower in the optic disc of glaucoma patients, particularly in the rim and the excavation. Oxygenation levels were not significantly different, except in glaucoma patients with ischaemic disc rims. Flicker light stimulation increased haemoglobin concentration in both controls and glaucoma discs, and increased oxygenation only in controls. The study also found a significant correlation between haemoglobin concentration and various clinical measures of glaucoma severity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Mathematics
Zhijie Liu, Yuanqiong Chen, Xiaohua Xiang, Zhan Li, Bolin Liao, Jianfeng Li
Summary: This study proposes a lightweight segmentation algorithm, GlauNet, based on convolutional neural networks, for accurate segmentation of the optic disc and optic cup in the diagnosis of glaucoma. The algorithm achieves high segmentation efficiency and accuracy through an efficient feature-extraction network and a multiscale boundary fusion module.
Review
Biochemistry & Molecular Biology
Berta Sanz-Morello, Hamid Ahmadi, Rupali Vohra, Sarkis Saruhanian, Kristine Karla Freude, Steffen Hamann, Miriam Kolko
Summary: Evidence suggests that changes in the redox system may contribute to various optic neuropathies, characterized by neurodegeneration of innermost retinal neurons and their axons. Optic neuropathies are often asymptomatic until advanced stages, necessitating further investigation of oxidative stress biomarkers and optimization of study design for more valuable and comparable results. Developing therapeutic strategies targeting the redox system is essential to prevent vision loss in optic neuropathies.
Article
Computer Science, Information Systems
Lingling Fang, Lirong Zhang
Summary: Glaucoma, a chronic eye disease that is difficult to diagnose early, can be aided through the proposed machine learning-based biregional contour evolution model for segmenting the optic disc and the optic cup to assist in glaucoma screening.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Integrative & Complementary Medicine
Tanuj Dada, Brajesh Lahri, Karthikeyan Mahalingam, Jyoti Shakrawal, Atul Kumar, Ramanjit Sihota, Raj Kumar Yadav
Summary: The study demonstrated that MBSR can significantly reduce IOP, increase circumpapillary vessel density and perfusion, as well as improve the Flux Index in patients with POAG, suggesting it as a useful adjunct to standard medical therapy.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Ophthalmology
Nathan Congdon, Augusto Azuara-Blanco, Yoram Solberg, Carlo E. Traverso, Michele Iester, Carlo Alberto Cutolo, Alessandro Bagnis, Tin Aung, Scott J. Fudemberg, Richard Lindstrom, Thomas Samuelson, Kuldev Singh, Eytan Z. Blumenthal, Gus Gazzard
Summary: This study aims to compare the efficacy and non-inferiority of Eagle direct selective laser trabeculoplasty (DSLT) and selective laser trabeculoplasty (SLT) in reducing intraocular pressure (IOP) in patients with open angle glaucoma (OAG). The study is a randomized controlled trial with the primary outcome being the mean change in IOP at 6 months.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ashleigh Kernohan, Tara Homer, Hosein Shabaninejad, Anthony J. King, Jemma Hudson, Gordon Fernie, Augusto Azuara-Blanco, Jennifer Burr, John M. Sparrow, David Garway-Heath, Keith Barton, John Norrie, Graeme Maclennan, Luke Vale
Summary: This study compares medical and surgical management strategies for advanced glaucoma and suggests that medication may be more cost-effective over a 2-year time horizon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Alasdair N. Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Summary: This study describes the grading methods and baseline characteristics for UK Biobank participants who underwent retinal imaging, and characterizes individuals with retinal features suggestive of age-related macular degeneration, glaucoma, and retinopathy. The results provide important insights into both ocular and systemic health.
Article
Ophthalmology
Gus Gazzard, Evgenia Konstantakopoulou, David Garway-Heath, Mariam Adeleke, Victoria Vickerstaff, Gareth Ambler, Rachael Hunter, Catey Bunce, Neil Nathwani, Keith Barton, The LiGHT Trial Study Grp
Summary: After 6 years of treatment, selective laser trabeculoplasty (SLT) has been shown to be a more effective and cost-effective primary treatment for open-angle glaucoma (OAG) and ocular hypertension (OHT) compared to intraocular pressure (IOP)-lowering eye drops. The SLT group had better glaucoma symptom scores and 69.8% of eyes in this group achieved or maintained the target IOP without the need for medical or surgical treatment.
Article
Ophthalmology
Cristina Maltese, Paola Cassottana, Aldo Vagge, Carlo Enrico Traverso, Michele Iester
Summary: Choroidal osteoma is a rare benign ossifying tumor with unknown etiology, typically affecting young females. However, our case report involves bilateral choroidal osteomas in an elderly woman.
CASE REPORTS IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Anthony J. King, Jemma Hudson, Augusto Azuara-Blanco, James F. Kirwan, Saurabh Goyal, Kin Sheng Lim, Graeme Maclennan
Summary: This study evaluates the impact of socioeconomic status on treatment outcomes in patients with advanced glaucoma and reports the correlation between socioeconomic status and baseline characteristics. The study found that socioeconomic status is correlated with visual function, quality of life, ethnicity, age, and number of optician visits.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Juliane Matlach, Padraig Mulholland, Marketa Cilkova, Reena Chopra, Nilpa Shah, Tony Redmond, Steven C. Dakin, David F. Garway-Heath, Roger S. Anderson
Summary: This study investigated the age-related changes of outer nuclear layer (ONL) thickness and cone density in healthy participants using a modified narrow scan-angle Heidelberg Retina Angiograph (HRA2). The results showed that both cone density and ONL thickness decreased with age. However, there was no strong correlation between cone density and ONL thickness, suggesting that factors other than cone density contribute to ONL thickness measurements.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Correction
Ophthalmology
Alasdair Warwick, Katie Curran, Barbra Hamill, Kelsey Stuart, Anthony P. Khawaja, Paul J. Foster, Andrew J. Lotery, Michael Quinn, Savita Madhusudhan, Konstantinos Balaskas, Tunde Peto
Article
Ophthalmology
Rogier L. Eggermont, Agnes M. Witteman, Judith A. van Erkelens, Karin Vermeulen, Lydia Vunderink, Nicolaas J. Reus
Summary: There is significant practice variation in performing Nd:YAG laser capsulotomy within 1 year after cataract surgery in the Netherlands. Routinely polishing the posterior capsule, performing bimanual irrigation/aspiration, and using hydrophobic intraocular lenses are associated with lower incidence of Nd:YAG laser capsulotomy.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Kelsey V. Stuart, Robert N. Luben, Alasdair N. Warwick, Kian M. Madjedi, Praveen J. Patel, Mahantesh I. Biradar, Zihan Sun, Mark A. Chia, Louis R. Pasquale, Janey L. Wiggs, Jae H. Kang, Jihye Kim, Hugues Aschard, Jessica H. Tran, Marleen A. H. Lentjes, Paul J. Foster, Anthony P. Khawaja
Summary: The purpose of this study was to examine the associations between alcohol consumption and glaucoma and related traits, assess whether genetic predisposition to glaucoma modified these associations, and perform MR experiments to investigate causal effects. The findings showed consistent and adverse associations between alcohol intake and glaucoma and related traits, even at levels below the current guidelines in the UK and the US.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Nicolas Leveziel, Simon Marillet, Tasanee Braithwaite, Tunde Peto, Pierre Ingrand, Shahina Pardhan, Alain M. Bron, Jost B. Jonas, Serge Resnikoff, Little Julie Anne, Adrian C. Davis, Catherine M. McMahon, Rupert R. A. Bourne
Summary: This study investigated self-reported dual sensory impairment (DSI) in European population and found higher prevalence of DSI in Eastern and southern countries. Social isolation and poor self-rated health status were associated with DSI, while higher income was associated with lower risk. Human Development Index explained almost 38% of the variance of age-adjusted prevalence of DSI.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Petra Eid, Catherine Creuzot-Garcher, Ludwig Serge Aho, Pierre-Henry Gabrielle, Estelle Charpin, Dea Haddad, Laure-Anne Steinberg, Alain Bron, Bruno Verges, Louis Arnould
Summary: This study analyzed retinal vascular parameters in type 1 diabetes patients without diabetic retinopathy using OCT-A and found lower vascular density in the SCP. Additionally, there was a correlation between central vascular density in the DCP and total daily insulin intake, and the use of the FSL device was associated with higher vascular densities in both the SCP and DCP.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Polymer Science
Paola Cassottana, Chiara Toma, Cristina Maltese, Viviana Villa, Roberta Ricciarelli, Carlo Enrico Traverso, Michele Iester
Summary: This study describes a rare case of bilateral choroidal effusion following a XEN45 implantation. The patient experienced choroidal detachment and hypotony in both eyes, which were successfully treated. The case highlights the importance of careful postoperative follow-up and timely intervention in XEN45 implantation cases, as well as the potential risk factor of choroidal effusion in the fellow eye.
Review
Cell Biology
Dimitrios Stavropoulos, Manjot K. K. Grewal, Bledi Petriti, Kai-Yin Chau, Christopher J. J. Hammond, David F. F. Garway-Heath, Gerassimos Lascaratos
Summary: This review aims to provide a better understanding of the emerging role of mitophagy in glaucomatous neurodegeneration, which is the primary cause of irreversible blindness worldwide. Increasing evidence from genetic and other experimental studies suggests that mitophagy-related genes are implicated in the pathogenesis of glaucoma in various populations. The association between polymorphisms in these genes and increased risk of glaucoma is presented.
Article
Nutrition & Dietetics
Jean-Baptiste Bizeau, Mayssa Albouery, Stephane Gregoire, Benedicte Buteau, Lucy Martine, Marine Crepin, Alain M. Bron, Olivier Berdeaux, Niyazi Acar, Benoit Chassaing, Marie-Agnes Bringer
Summary: This study investigated the impact of dietary intake of inulin on the levels of plasmalogens in the mouse cortex. The results showed that inulin supplementation reduced the abundance of ethanolamine plasmalogens in the cortex, but had no effect on enzyme gene expression or fatty acid profile.
