Article
Immunology
Joseph P. Grande, Erika S. Helgeson, Arthur J. Matas
Summary: The size of glomeruli in renal allografts is associated with the severity of injury and transplant outcomes, with glomerular area being linked to microvascular inflammation and affecting long-term graft survival.
Article
Gastroenterology & Hepatology
Abigail Snyder, Lisa Kojima, Yuki Imaoka, Miho Akabane, Allison Kwong, Marc L. Melcher, Kazunari Sasaki
Summary: The current liver allocation system may disadvantage younger adult recipients by not considering the age difference between donors and recipients. This study aimed to investigate the long-term prognostic influence of the donor-recipient age difference in young adult recipients. The results showed that a larger age difference in younger recipients was associated with inferior long-term survival, highlighting the importance of considering age in liver transplantation.
LIVER TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Hon Shing Ong, Nathalie Chiam, Hla Myint Htoon, Ashish Kumar, Anshu Arundhati, Jodhbir S. Mehta
Summary: Corneal transplantations are common surgeries worldwide, with an impetus for eye banks to optimize the use of donor corneas. This study evaluated the effects of donor-recipient sex- and age-matching on the outcomes of eyes that had undergone deep anterior lamellar keratoplasty (DALK) surgeries. The results showed no significant influence of these factors on graft rejection and failure post-DALK.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Takahisa Hiramitsu, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Yutaka Matsuoka, Norihiko Goto, Toshihiro Ichimori, Shunji Narumi, Asami Takeda, Takaaki Kobayashi, Kazuharu Uchida, Yoshihiko Watarai
Summary: This study investigated the impact of age differences between older adult living donors and recipients on kidney transplantation outcomes. The results showed that kidney transplants from older adult donors to older adult recipients had the highest risk of graft loss and mortality, with recipients having lower estimated glomerular filtration rates.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Ophthalmology
Silvia Schrittenlocher, Mario Matthaei, Bjorn Bachmann, Claus Cursiefen
Summary: There is currently a lack of understanding about the impact of donor tissue characteristics on DMEK outcomes, and the upcoming COMEDOS study aims to address this knowledge gap.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
J. M. Duenas-Jurado, P. A. Gutierrez, A. Casado-Adam, F. Santos-Luna, A. Salvatierra-Velazquez, S. Carcel, C. J. C. Robles-Arista, C. Hervas-Martinez
Summary: The study analyzed 404 lung transplants conducted over 23 years in a Spanish hospital and developed a powerful model for donor-recipient matching. Variables predicting increased survival included vital capacity, carbon dioxide pressure, donor ventilation, and ischemia time. The combination of statistical methods and machine learning can enhance decision-making on donor-recipient compatibility and improve transplant outcomes.
Article
Surgery
Sumeet K. Asrani, Giovanna Saracino, Anji Wall, James F. Trotter, Giuliano Testa, Ruben Hernaez, Pratima Sharma, Allison Kwong, Srikanta Banerjee, Gregory McKenna
Summary: Accurate assessment of donor quality at the time of organ offer for liver transplantation candidates may be inadequately captured by the donor risk index. A novel objective and simple model, called the ID(2)EAL score, was developed and validated to assess donor risk using donor level variables available at the time of organ offer. The ID(2)EAL score had better discrimination than the donor risk index and may serve as an important tool for patient discussion about donor risk and decisions regarding offer acceptance.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Zhengtao Liu, Jingting Lyu, Xiang Li, Lu Yu, Shuping Que, Jun Xu, Lei Geng, Shusen Zheng
Summary: This study aimed to investigate the interactions between graft-to-recipient weight ratio (GWRWR) and other risk factors responsible for inferior allograft outcomes. The results showed that the GWRWR had a nonlinear effect on prognosis, and grafts with a volume exceeding 3.0% had an inferior post-transplant prognosis.
FRONTIERS IN SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Abraham Shaked, Bao-Li Loza, Elisabet Van Loon, Kim M. Olthoff, Weihua Guan, Pamala A. Jacobson, Andrew Zhu, Claire E. Fishman, Hui Gao, William S. Oetting, Ajay K. Israni, Giuliano Testa, James Trotter, Goran Klintmalm, Maarten Naesens, Sumeet K. Asrani, Brendan J. Keating
Summary: T2D PRS can identify transplant candidates at high risk of PTDM, aiding in preemptive diabetes management and donor selection.
Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Faisal Jarrar, Karthik K. Tennankore, Amanda J. Vinson
Summary: This study investigates the impact of donor and recipient (DR) obesity on graft outcomes in kidney transplantation. The results suggest that DR obesity pairing is associated with increased risks of graft loss and delayed graft function.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Degong Jia, Shanshan Guo, Zhixing Jia, Zhengjie Gao, Kun You, Jianping Gong, Shengwei Li
Summary: A systematic review and meta-analysis found that N-acetylcysteine (NAC) is effective in treating ischemia-reperfusion injury in transplanted livers, reducing the incidence of primary graft non-function, postoperative complications, and peak enzyme levels. However, NAC increases the requirements for cryoprecipitate and red blood cells during surgery.
Article
Ophthalmology
Raghunandan Byanju, Ram Prasad Kandel, Bimal Poudyal, Sadhan Bhandari, Anju Ligal, Sangita Pradhan, Maria Gautam, Puspa Shrestha, Ranjeet Kumar Sah, John A. Gonzales, Travis C. Porco, John P. Whitcher, Muthiah Srinivasan, Madan Prasad Upadhyay, Thomas M. Lietman, Jeremy David Keenan, Kieran S. O'Brien
Summary: This study examined risk factors for corneal ulcer in a rural and peri-urban setting in Nepal. The findings showed that ocular injury, manual labour, and lower education are strongly associated with the development of corneal ulcer.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Marios Marcou, Matthias Galiano, Anja Tzschoppe, Katja Sauerstein, Sven Wach, Helge Taubert, Bernd Wullich, Karin Hirsch-Koch, Hendrik Apel
Summary: Recognizing risk factors is crucial for decision-making in pediatric kidney transplantation. A retrospective study identified small body surface area (<1 m(2)) as a favorable prognostic factor for long-term graft survival, while adolescents over the age of 12 had poorer outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Ioannis D. Kostakis, Nikolaos Karydis, Theodoros Kassimatis, Nicos Kessaris, Ioannis Loukopoulos
Summary: Kidney transplant recipients with BSAi <= 0.75 from living donors and donors after brain death have higher risk of delayed graft function. Graft survival is significantly reduced in renal transplants from donors after circulatory death with BSAi <= 0.75.
JOURNAL OF NEPHROLOGY
(2021)