Article
Ophthalmology
Thibaut Gaboriau, Remi Dubois, Boris Foucque, Florence Malet, Cedric Schweitzer
Summary: The purpose of this study was to compare the 24-hour intraocular pressure (IOP) related fluctuations monitoring between two groups of visual field progression rates in patients with open angle glaucoma (OAG). The results showed that patients with higher visual field progression rates had significantly higher amplitudes and absolute areas under the 24-hour monitoring curve. Therefore, this monitoring method can help adjust the treatment strategy for glaucoma earlier.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Neroev, Tatyana Malishevskaya, Dietmar Weinert, Sergei Astakhov, Sergey Kolomeichuk, Germaine Cornelissen, Yana Kabitskaya, Elena Boiko, Irina Nemtsova, Denis Gubin
Summary: In patients with stable or advanced primary open-angle glaucoma, the 24-hour rhythm of intraocular pressure (IOP) was found to peak during the night, correlating with retinal ganglion cell (RGC) loss, and showing an increasing internal phase shift with disease progression. The phase of IOP in advanced glaucoma tended to occur during the night, progressively delayed relative to the phase of temperature rhythm. The angiotensin converting enzyme Alu-repear deletion/insertion (ACE I/D) emerged as a candidate gene polymorphism influencing the circadian IOP variability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Eamon Sharkawi, Daniel Josef Lindegger, Paul H. Artes, Lydia Lehmann-Clarke, Mohamad El Wardani, Marie Misteli, Jerome Pasquier, Adriano Guarnieri
Summary: This study reported on the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in eyes with pseudoexfoliative glaucoma (PXG) over a 24-month period. The results showed a high success rate, low complication rate, effective reduction in intraocular pressure, and decrease in the number of medications used for treatment.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Huub J. Poelman, Jan Pals, Parinaz Rostamzad, Wichor M. Bramer, Roger C. W. Wolfs, Wishal D. Ramdas
Summary: The study on 221 eyes undergoing XEN-implant surgery confirmed the effectiveness and safety in lowering IOP and reducing the number of IOP-lowering medications. No significant differences were found between standalone and combined procedures. Meta-analysis of 19 studies showed comparable outcomes with a two-years postoperative pooled mean for IOP and IOP-lowering medications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shigeo S. M. Pawiroredjo, Wichor M. Bramer, Noemi D. Pawiroredjo, Jan Pals, Huub J. Poelman, Victor A. de Vries, Roger C. W. Wolfs, Wishal D. Ramdas
Summary: The PRESERFLO MicroShunt has demonstrated effectiveness and safety in reducing intraocular pressure and the need for intraocular pressure-lowering medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Maria Jesus Muniesa, Ivan Benitez, Juan Ezpeleta, Manuel Sanchez de la Torre, Marta Pazos, Elena Milla, Ferran Barbe
Summary: Most severe OSAS patients show significant nocturnal fluctuations in intraocular pressure, with the highest readings at night. CPAP therapy is linked to a more pronounced increase in eye pressure during the initial phase of nocturnal acrophase.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Mandy Oi Man Wong, Isabel S. W. Lai, Poemen Puiman Chan, Noel C. Y. Chan, Alison Y. Y. Chan, Gilda W. K. Lai, Vivian S. M. Chiu, Christopher Kai-Shun Leung
Summary: This study compared the intraocular pressure lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up, and found no significant differences in terms of lowering intraocular pressure and safety between the two methods.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Yipeng Shi, Yan Zhang, Wenying Sun, Alex S. Huang, Shuang Chen, Lixia Zhang, Wei Wang, Like Xie, Xiaobin Xie
Summary: This is a prospective, observer-masked, randomized clinical trial conducted at Eye Hospital, China Academy of Chinese Medical Sciences from December 2018 to June 2021. The trial compared the short-term efficacy of primary single-selective laser trabeculoplasty (SLT) to 0.005% latanoprost eye drops for the treatment of 24-hour intraocular pressure (IOP) in patients with newly diagnosed primary open angle glaucoma (POAG) and ocular hypertension (OHT) in Beijing, China. Both SLT and latanoprost significantly decreased mean 24-hour IOP and peak IOP, with latanoprost showing a more potent effect. The latanoprost eye drops may be better in decreasing mean and peak 24-hour IOP and controlling IOP fluctuation compared to SLT.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Aleksandar Vukmirovic, Jessica Ong, Aqif Mukhtar, Dao-Yi Yu, William H. Morgan
Summary: This study investigated the outcomes of XEN-45 stent surgery, and found that prior cataract or trabeculectomy surgery does not have a negative impact on the results of this surgery. However, compared to trabeculectomy, gelatin stent surgery has a poorer intraocular pressure reduction effect at 2 years.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Multidisciplinary Sciences
Lei Guo, Jun Tao, Yang Tong, Shichao Chen, Xin Zhao, Rui Hua
Summary: This study investigated the morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The results showed significant differences in refractive error, intraocular pressure (IOP), and circumpapillary retinal nerve fibre layer (cpRNFL) thickness between the 3-week and 4-week groups. There were no significant differences in vascular characteristics between the two groups, but a positive correlation was found between total vessel length and cpRNFL thickness, and a negative correlation was found between total vessel length and IOP.
SCIENTIFIC REPORTS
(2022)
Review
Ophthalmology
Shih-Yi Wang, Chu-Yu Yen, Bo- Kuo, Ju-Chuan Yen, Shiow-Wen Liou, Chun-Chen Chen
Summary: A meta-analysis was conducted comparing the efficacy and safety of diode laser transscleral cyclophotocoagulation (TSCPC) and cyclocryotherapy (CCT) in the treatment of intractable glaucoma. The results showed that there was no significant difference in terms of intraocular pressure reduction and other efficacy outcomes between TSCPC and CCT. However, CCT had a better intraocular pressure-lowering effect in non-Asian participants. Both procedures had a comparable safety profile.
ACTA OPHTHALMOLOGICA
(2023)
Article
Medicine, General & Internal
Yumi Shigemoto, Yuka Hasebe, Kazuyoshi Kitamura, Yoshiko Fukuda, Masako Sakamoto, Mio Matsubara, Shinya Minaguchi, Kenji Kashiwagi
Summary: The study aimed to determine the number of tests required to adequately assess diurnal changes in intraocular pressure (IOP) using a self-measuring rebound tonometer among glaucoma patients. Twenty-four patients with primary open-angle glaucoma who successfully measured IOP at least three times per day during the correct time periods for four days were included in the analysis. The results showed that the diurnal IOP rhythm measured by patients was inconsistent, and multiple days of measurements may be necessary to accurately assess diurnal IOP rhythm.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ilka Schmidt, Niklas Plange, Peter Walter, Antonis Koutsonas
Summary: This study investigates the use of implantable telemetric IOP sensors for glaucoma patients. The results show that these sensors demonstrate good long-term safety, tolerability, and functionality, allowing patients to self-measure their IOP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Hsun- Chiu, Huan- Su, Yu-Chieh Ko, Catherine Jui-Ling Liu
Summary: The study aimed to determine long-term outcomes and risk factors for failure after MMC-augmented IT in Taiwanese patients. The results showed that despite satisfactory long-term success rates, most eyes still required medication for IOP control, and eyes with poor preoperative visual acuity had lower qualified success rates, while patients aged >70 years had higher complete success rates.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)