Article
Endocrinology & Metabolism
Siying Li, Rui Hua, Zuoqian Jing, Lele Huang, Lei Chen
Summary: This study investigated the correlation between best corrected visual acuity (BCVA) and retinal microstructural parameters detected by optical coherence tomography (OCT) in diabetic retinopathy macular edema (DRME). The results showed that central foveal thickness (CFT), fracture distances of the external limiting membrane (ELM) and junction between the inner and outer segments (IS/OS) were negatively correlated with BCVA. Additionally, there was a significant difference in BCVA among patients with different types of retinal edema.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Huiping Yao, Zijian Yang, Yu Cheng, Xi Shen
Summary: This study investigated the changes in macular status and choroidal thickness following phacoemulsification in patients with mild to moderate nonproliferative diabetic retinopathy. The results showed that the increase in SCP-VD, MT, and CT after surgery was significantly greater in diabetic retinopathy patients compared to the control group.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Cameron D. Haydinger, Genevieve F. Oliver, Liam M. Ashander, Justine R. Smith
Summary: Diabetic retinopathy is a retinal disease associated with hyperglycemia in diabetes patients, affecting both the central and peripheral retina. Its major mechanism involves oxidative stress caused by elevated production of reactive oxygen species, which is particularly harmful to the retina due to its high metabolic activity. This review provides an overview of the role of oxidative stress in diabetic retinopathy, including the formation and effects of advanced glycation end-products, metabolic memory, and non-coding RNA, as well as potential therapeutic strategies.
Article
Medicine, General & Internal
Carolina Arruabarrena, Antonio Rodriguez-Miguel, Fernando de Aragon-Gomez, Purificacion Escamez, Ingrid Rosado, Miguel A. Teus
Summary: The purpose of this study was to establish normative data for macular thickness and volume in a diabetic population. The researchers used spectral-domain optical coherence tomography (SD-OCT) to observe and compare macular thickness and volume between diabetic patients and a reference population. The results showed that diabetic patients had thinner macular thickness and volume compared to the reference population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Article
Medicine, General & Internal
Mikel Garcia Gomez de Segura, Ana Martin-Arroyuelos, Isabel Pinilla, Javier Araiz
Summary: The study assessed differences in macular thickness evolution after uncomplicated cataract surgery between non-diabetic subjects and diabetic patients without diabetic retinopathy using SD-OCT. Results showed that there was no increase in foveal, parafoveal, and perifoveal retinal thickness on postoperative day 7, but thickness values increased on days 30, 90, and 180 after surgery in both groups, peaking at 90 days. There were no differences in macular thickness before or after surgery between diabetic and non-diabetic patients.
Article
Medicine, General & Internal
Xue Bai, Rui Hua
Summary: The study found that fluorescein angiography had a higher accuracy in detecting the severity of diabetic retinopathy and macular leakages compared to optical coherence tomography. Central foveal thickness is not a sensitive parameter for detecting latent DMEs.
FRONTIERS IN MEDICINE
(2021)
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Article
Health Care Sciences & Services
Santosh Gopi Krishna Gadde, Arpita Kshirsagar, Neha Anegondi, Thirumalesh B. Mochi, Stephane Heymans, Arkasubhra Ghosh, Abhijit Sinha Roy
Summary: The study showed that as the severity of diabetic retinopathy increases, the volume of macular edema also increases, with proliferative DR having the largest edema volume. For intravitreal injection treatment, recurrent eyes had the largest edema volume, while the treatment naive group had the smallest.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Qiaowei Wu, Yijun Hu, Baoyi Liu, Zhanjie Lin, Yu Xiao, Xiaomin Zeng, Ying Fang, Ying Yan, Ya Ye, Ming Yan, Zhen Huang, Honghua Yu, Yanping Song, Siwen Zang
Summary: The study found that factors associated with the presence of FB after resolving DME include younger age, better baseline BCVA and lower baseline CFT, as well as better post-treatment BCVA and longer OS length.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Ramon Sagarra, Esther Hervas, Reyes Blasco, Julia Molina, Empar F. Moreno, Eugeni Garcia-Curto
Summary: The study found that during the COVID-19 pandemic, attendance in the diabetes screening program decreased in 2020 and then recovered in 2021. Additionally, there was a slight increase in cases of the most severe forms of diabetic retinopathy starting in 2021.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Chaoyang Zhang, Dawei Luo, Hai Xie, Qian Yang, Dandan Liu, Lei Tang, Jingting Zhang, Weiye Li, Haibin Tian, Lixia Lu, Xiaodong Sun, Guo-Tong Xu, Jingfa Zhang
Summary: Retinal Muller glial dysfunction and intracellular edema in diabetic retinopathy (DR) are associated with down-regulation of Aquaporin 11 (AQP11). AQP11 overexpression alleviates intracellular edema, enhances glutamate metabolism, and reduces cell death. The down-regulation of AQP11 in DR is mediated by the miRNA-AQP11 axis, which is partially reversed by AQP11 overexpression. Targeting AQP11 regulation may provide a new therapeutic strategy for diabetic macular edema (DME).
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Jing Huang, Qiong Zhou
Summary: This study investigates the role of T-helper 17 (Th17) cell-related genes in the progression of diabetic macular edema (DME). It identifies a set of Th17-related genes that can distinguish between different stages of diabetic nephropathy (DN) and diabetic retinopathy (DR). These findings contribute to our understanding of the molecular mechanisms underlying the interaction between Th17 cells in the eye and kidney in diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Chunyan Lei, Yun Zhang, Meixia Zhang
Summary: The study shows a significant association between insulin treatment and reduced risks of postoperative DME in Japanese PDR patients with PPV surgery compared with oral medications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jing Huang, Qiong Zhou
Summary: This study investigates the molecular mechanism of CD8+T cells in the progression of diabetic macular edema (DME) and identifies key CD8+T cell-related genes that play a crucial role in the inflammatory response. Through gene analysis and enrichment analysis, important CD8+T cell-related genes were identified. These findings provide new directions for the treatment of diabetic retinopathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)