Article
Biochemistry & Molecular Biology
Jing Wu, Jingfa Zhang
Summary: This study compared the progression of neovascular remodeling and subretinal fibrosis in NVAMD patients after anti-VEGF therapy. The results showed that there was no significant difference in visual acuity and vascular density, but the central macular thickness decreased and subretinal fibrosis increased.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Ophthalmology
Assaf Hilely, Adrian Au, K. Bailey Freund, Anat Loewenstein, Eric H. Souied, Dinah Zur, Riccardo Sacconi, Enrico Borrelli, Enrico Peiretti, Claudio Iovino, Yoshimi Sugiura, Abdallah A. Ellabban, Jordi Mones, Nadia K. Waheed, Sengul Ozdek, Duygu Yalinbas, Sarah Thiele, Luisa Salles de Moura Mendonca, Mee Yon Lee, Won Ki Lee, Pierre Turcotte, Vittorio Capuano, Meryem Filali Ansary, Usha Chakravarthy, Albrecht Lommatzsch, Frederic Gunnemann, Daniel Pauleikhoff, Michael S. Ip, Giuseppe Querques, Frank G. Holz, Richard F. Spaide, SriniVas Sadda, David Sarraf
Summary: This study evaluated the patterns of subretinal fluid in eyes with non-neovascular AMD and found that SRF may be a result of RPE decompensation and RPE pump failure.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Pierre-Henry Gabrielle, Vuong Nguyen, Jennifer J. Arnold, Sanjeeb Bhandari, Francesco Viola, Odette A. M. Tigchelaar-Besling, Gonzaga Garay-Aramburu, Louise O'Toole, Chui Ming Gemmy Cheung, Daniel Barthelmes, Catherine Creuzot-Garcher, Mark Gillies
Summary: This study reported the 36-month treatment outcomes of eyes with nAMD receiving VEGF inhibitors in real-world practice who did not develop SRFi or MA. The findings suggest that eyes without these complications can maintain their initial vision improvement over three years.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tobias Strunz, Michael Poellmann, Maria-Andreea Gamulescu, Svenja Tamm, Bernhard H. F. Weber
Summary: Anti-VEGF treatment has been effective in preserving vision for nAMD patients, but response to treatment varies. Criteria such as visual acuity and retinal thickness can separate patients into responders and non-responders, but even non-responders show changes in retinal thickness. Genetic association studies have not yielded significant findings, suggesting the need for larger phenotyping studies to assess anti-VEGF treatment responses in nAMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Reem H. ElSheikh, Muhammad Z. Chauhan, Ahmed B. Sallam
Summary: Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly population, with neovascular AMD (nAMD) being the main contributor to visual loss. Currently approved anti-VEGF agents have shown favorable prognosis for nAMD but come with a substantial financial burden for patients and the healthcare system due to their high cost and the need for repeated treatments and visits. Emerging therapies aim to prolong treatment intervals and introduce new modalities for better results.
Review
Biochemistry & Molecular Biology
Alexander G. Marneros
Summary: Current anti-VEGF-A therapies can inhibit CNV in some patients with NV-AMD, but long-term treatment may impair the normal functions of the retina and choroid. Therefore, there is an urgent need for novel therapies that can specifically target the disease mechanisms without affecting the normal physiological functions. Inflammasome activation, which plays a role in pathologic angiogenesis, has become an area of interest in the field of AMD. However, the role of the inflammasome in AMD pathogenesis is still unclear, and more research is needed to understand its significance.
Review
Medicine, General & Internal
Prem Patel, Veeral Sheth
Summary: AMD is a common cause of vision loss, with two main types, neovascular and non-neovascular, treated primarily through inhibition of VEGF. Discrepancies between clinical trial results and real-world outcomes exist, indicating the potential for new treatments to improve therapeutic efficacy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh. Fursova, Anna S. Derbeneva, Ida F. Nikulich, Vasiliy A. Devyatkin, Nataliya G. Kolosova
Summary: This study aimed to evaluate the association between polymorphic markers of MTOR, SQSTM1, ULK1, MAP1LC3A, and ATG5 genes and the development of nAMD and the response to anti-VEGF therapy. The study found that MTOR gene polymorphisms are associated with the risk of nAMD, and SQSTM1-rs10277 and ULK1-rs3088051 may influence the short-term response to anti-VEGF treatment.
Article
Biochemistry & Molecular Biology
Oyuna S. Kozhevnikova, Anzhella Zh Fursova, Anna S. Derbeneva, Ida F. Nikulich, Mikhail S. Tarasov, Vasiliy A. Devyatkin, Yulia Rumyantseva, Darya Telegina, Nataliya G. Kolosova
Summary: The study evaluated the association between polymorphisms in genes related to the complement system and neovascular age-related macular degeneration (nAMD) and its treatment response biomarkers. The results showed that certain gene polymorphisms were associated with the risk of nAMD and treatment response.
Review
Cell Biology
Louis Tenbrock, Julian Wolf, Stefaniya Boneva, Anja Schlecht, Hansjuergen Agostini, Peter Wieghofer, Guenther Schlunck, Clemens Lange
Summary: Age-related macular degeneration is a progressive disease that can lead to irreversible blindness. The formation of subretinal fibrosis is a key mechanism in the most aggressive form of this disease. While understanding of the cellular and molecular mechanisms involved is limited, potential therapeutic approaches are being explored to inhibit subretinal fibrosis in the future.
CELL AND TISSUE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lucia Mundo, Gian Tosi, Stefano Lazzi, Grazia Pertile, Barbara Parolini, Giovanni Neri, Matteo Posarelli, Elena De Benedetto, Tommaso Bacci, Ennio Silvestri, Maria Siciliano, Stefano Barbera, Maurizio Orlandini, John Greenwood, Stephen Moss, Federico Galvagni
Summary: LRG1 is a potential therapeutic target for treating neovascular age-related macular degeneration (nvAMD). High expression of LRG1 was found in the eyes of treatment-naive nvAMD patients, and the LRG1 concentration in the aqueous humor of these patients was significantly higher compared to controls. These findings support the development of an anti-LRG1 monoclonal antibody for clinical trials in patients with nvAMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Shinichiro Chujo, Hisashi Matsubara, Yoshitsugu Matsui, Masahiko Sugimoto, Mineo Kondo
Summary: The purpose of this study was to determine if atrophy of the retinal pigment epithelium (RPE) in eyes with neovascular age-related macular degeneration (nAMD), which meets the criteria for suspension of anti-vascular endothelial growth factor (anti-VEGF) treatment, is associated with anti-VEGF treatments. The results indicated that the expansion rate of RPE atrophy did not differ significantly between eyes that continued anti-VEGF treatment and those that suspended treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Levon M. Khachigian, Gerald Liew, Kelvin Y. C. Teo, Tien Y. Wong, Paul Mitchell
Summary: Neovascular age-related macular degeneration (nAMD) is a leading cause of visual impairment and blindness, but current anti-VEGF therapies have limitations. This article discusses the need for new and improved therapies for nAMD and explores the efficacy of multi-targeted therapies that target both the VEGF pathway and other pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Michelle Prasuhn, Caroline Hillers, Felix Rommel, Gabriela Riemekasten, Harald Heidecke, Khaled Nassar, Mahdy Ranjbar, Salvatore Grisanti, Aysegul Tura
Summary: Analyzing levels of autoantibodies against AT1 receptor, PAR1, VEGF-A, VEGF-B, and VEGF receptor 2 in nAMD patients did not show statistically significant results that correspond to the clinical five-year course. Larger, prospective studies are needed to reevaluate different and more autoantibodies to gain deeper insights.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Ophthalmology
Divya Alex, Anantharaman Giridhar, Mahesh Gopalakrishnan, Swati Indurkhya, Shivam Madan
Summary: The presence of subretinal hyperreflective material (SHRM) in eyes with neovascular age-related macular degeneration is associated with poorer visual outcomes, with higher SHRM height, width, and area leading to decreased visual acuity. However, decreasing reflectivity of SHRM lesions and resolution of SHRM may correlate with better vision. Persistent SHRM is associated with scar and GA formation in the long term. Therefore, SHRM can serve as a surrogate OCT biomarker for predicting visual outcomes in neovascular AMD.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Editorial Material
Ophthalmology
Andreas Berlin, Ling Chen, Jeffrey Messinger, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Claudio Iovino, Adrian Au, Prithvi Ramtohul, Tommaso Bacci, Abdullah AlBahlal, Abdullah M. Khan, Abdulelah A. Al-Abdullah, Robert Wendel, Jay Chhablani, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: This study analyzed the imaging characteristics and clinical course of patients with coincident lesions of PAMM and AMN in the same eye, and found that this phenomenon may be associated with retinal vein impairment and hypoperfusion in the deep retinal capillary plexus.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Xiaofei Wang, Stanley Chang, Jack Grinband, Lawrence A. Yannuzzi, K. Bailey Freund, Quan Hoang, Michael J. A. Girard
Summary: The axial length is longer in highly myopic eyes and the adjusted tortuosity of the optic nerve is lower, suggesting higher traction forces during eye movements. Optic nerve displacements differ significantly between adduction and abduction, with smaller displacements in highly myopic eyes. Additionally, posterior segment displacements are smaller in highly myopic eyes in both gaze directions, with larger displacements in the anterior-most segment during adduction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Max Brinkmann, Tommaso Bacci, Deepayan Kar, Jeffrey D. Messinger, Kenneth R. Sloan, Ling Chen, Timothy Hamann, Maximilian Wiest, K. Bailey Freund, Sandrine Zweifel, Christine A. Curcio
Summary: This study evaluated the role of acquired vitelliform lesion (AVL) in age-related macular degeneration pathophysiology and analyzed the histological and clinical features of AVL. The results showed that AVL deposits have low levels of retinal pigment epithelium (RPE) organelles and outer segments. The growth rates of collapsing and non-collapsing AVLs were different, suggesting dysregulation of lipid transfer pathways specific to cone photoreceptors and supporting cells in the formation of AVL deposits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ling Chen, Dongfeng Cao, Jeffrey D. Messinger, Thomas Ach, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
Summary: Melanotic cells with large spherical melanosomes, possibly originating from retinal pigment epithelium, were found in eyes with neovascular age-related macular degeneration. These cells exhibit molecular differences from RPE, suggesting a process of transdifferentiation. Studying detailed histology of eyes affected by nvAMD may lead to the development of new therapies for fibrosis.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Meira Fogel-Levin, SriniVas R. Sadda, Philip J. Rosenfeld, Nadia Waheed, Giuseppe Querques, Bailey K. Freund, David Sarraf
Summary: Imaging is crucial in the evaluation and management of retinal disorders, and different imaging modalities have unique capabilities to show different aspects of the disease. Multimodal retinal imaging provides abundant and insightful information, but integrating the complex data can be overwhelming. This article discusses the applications, strengths, and limitations of various retinal imaging tools, including color fundus photography, widefield imaging, fundus autofluorescence, near infrared reflectance, optical coherence tomography angiography, and en face optical coherence tomography, as well as the advantages and disadvantages of a multimodal approach.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marc J. Sirks, Elon H. C. van Dijk, Noa Rosenberg, Carla E. M. Hollak, Stamatios Aslanis, Chui Ming Gemmy Cheung, Itay Chowers, Chiara M. Eandi, K. Bailey Freund, Frank G. Holz, Peter K. Kaiser, Andrew J. Lotery, Kyoko Ohno-Matsui, Giuseppe Querques, Yousif Subhi, Ramin Tadayoni, Charles C. Wykoff, Dinah Zur, Roselie M. H. Diederen, Camiel J. F. Boon, Reinier O. Schlingemann
Summary: Since July 2021, there has been a worldwide shortage of verteporfin (Visudyne (R)), which has had a significant impact on the care of ophthalmic patients worldwide and may result in serious and irreversible vision loss.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
K. Bailey Freund, Giovanni Staurenghi, Jesse J. Jung, Sandrine A. Zweifel, Mariano Cozzi, Lauren Hill, Steven Blotner, Min Tsuboi, Shamika Gune
Summary: The study aimed to investigate the relationship between the Consensus on Neovascular Age-Related Macular Degeneration (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab therapy in patients with neovascular age-related macular degeneration (nAMD). Results showed that the different lesion types had varying effects on best-corrected visual acuity (BCVA) outcomes, supporting the use of an anatomic classification system to evaluate and predict visual responses to anti-vascular endothelial growth factor therapy for nAMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Diogo Cabral, Prithvi Ramtohul, Ana C. Fradinho, K. Bailey Freund
Summary: The purpose of this study was to characterize and distinguish non-neovascular deep retinal age-related microvascular anomalies (DRAMA) from type 3 macular neovascularization (MNV) using volume rendering of OCT and OCTA. Two types of capillary dilations were identified in DRAMA, and their characteristics were analyzed. This study provides important insights into the pathological features of non-neovascular AMD.
OPHTHALMOLOGY RETINA
(2022)
Article
Ophthalmology
Riccardo Sacconi, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
Summary: This study investigated the association between nascent geographic atrophy (GA) and the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). The results showed that 22.7% of the patients had nascent GA preceding exudative type 3 MNV. Therefore, the detection of nascent GA in AMD patients may require closer surveillance to identify early exudative type 3 MNV warranting treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, Daniel Oh, Daniel Galhoz, K. Bailey Freund
Summary: The purpose of this study was to investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate distinctive features of choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Patients diagnosed with CSC underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging. The results showed that en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA in eyes with CSC.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Ariane Malcles, Edward Gigon, K. Bailey Freund, Ugo Introini, Francesco Bandello, Maria Vittoria Cicinelli
Summary: The study evaluated the clinical characteristics, multimodal imaging features, and long-term treatment outcomes of eyes with neovascular age-related macular degeneration (nAMD) and bacillary layer detachment (BALAD) treated with intravitreal anti-VEGF therapy. The findings showed that BALAD was associated with all types of MNV in nAMD patients, and there was a high risk of subretinal fibrosis leading to poor functional outcomes.
OPHTHALMOLOGY RETINA
(2022)
Letter
Ophthalmology
Yu Qiang Soh, Quan V. Hoang, K. Bailey Freund, Jesse J. Jung
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
