Article
Ophthalmology
You Na Kim, Joong Won Shin, Yu Jeong Park, Joo Yong Lee, June Gone Kim, Young Hee Yoon, Yoon Jeon Kim
Summary: In patients with CRVO, pre-existing glaucoma was associated with poorer visual and anatomical outcomes, and played as a significant risk factor for the development and conversion to ischaemic CRVO with lower vision and presence of DRIL at early phase of CRVO.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Jiwon Baek, Hae-Young Lopilly Park, Seong Ah Kim, Kyung Euy Hong, Soo Ji Jeon, Da Young Shin, Younhea Jung, Chan Kee Park
Summary: By using OCT-A, the study investigated parapapillary choroidal microvasculature dropout (MvD) in BRVO and OAG patients. It was found that the frequency of MvD was higher in OAG patients. The effect of MvD on VF change differed between BRVO and OAG, suggesting potential differences in underlying pathogenesis.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Jayoung Ahn, Daniel Duck-Jin Hwang
Summary: This study evaluated longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in eyes affected with branch and central retinal vein occlusion (BRVO and CRVO, respectively) and fellow eyes. It found that the global pRNFL thickness of fellow eyes in the BRVO and CRVO groups decreased significantly at 24 months compared to baseline, while the fellow eyes of patients with CRVO had significantly lower pRNFL thickness at 12 and 24 months compared to those of the BRVO and normal control groups. These results suggest that fellow eyes of patients with BRVO and CRVO are susceptible to pRNFL damage.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Pasquale Loiudice, Giuseppe Covello, Michele Figus, Chiara Posarelli, Maria Sole Sartini, Giamberto Casini
Summary: This study aimed to evaluate the choroidal vascularity change in eyes with central and branch retinal vein occlusion (RVO). By analyzing the records of 47 patients, it was found that RVO eyes had higher choroidal vascularity index, total choroidal area, and luminal area compared to unaffected eyes. The changes varied according to the type of macular edema.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Dan Calugaru, Mihai Calugaru
Summary: In patients with acute central/hemicentral retinal vein occlusions, intraocular pressure (IOP) may be reduced due to decreased aqueous humor secretion, gradually increasing until 3 months after occlusion onset, while IOP increases can lead to ocular hypertension and glaucoma. The correlations between ocular hypertension/glaucoma and acute RVOs can be classified into three groups based on the sequence of events and age-related vascular alterations.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yingying Chen, Yi Du, Lu Qiu, Jing Zheng
Summary: We present a rare case of an elderly man who experienced central retinal vein occlusion (CRVO) and cerebral infarction after oral intake of the anti-cancer drug anlotinib, likely due to a drug-related complication.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Yixiang Zhan, Weipeng Zhao, Kemin Ni, Zhaoce Liu, Yanjun Su, Xichuan Li, Heng Zhang, Chunze Zhang
Summary: Immunotherapy is a revolutionary cancer treatment, but it can lead to rare ocular side effects. This case report highlights a patient who developed central retinal vein occlusion and vitreous hemorrhage, resulting in blindness, after receiving anti-PD-1 therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Madhu Bhoot, Julie Pegu, Shayana Bhumbla, Suneeta Dubey, Manisha Agarwal, Saptarshi Mukherjee, H. S. Harish
Summary: The study aimed to determine the association between primary angle-closure disease (PACD) and retinal vein occlusion (RVO). The results showed that 40% of RVO patients had PACD, with a higher risk in patients with central retinal vein occlusion (CRVO) compared to branch retinal vein occlusion (BRVO). Additionally, RVO patients with diabetes and CAD had a higher probability of developing PACD.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Medicine, General & Internal
Yi Tang, Yan Cheng, Shuo Wang, Yongjie Wang, Pengjia Liu, Hong Wu
Summary: This article reviews the classification, pathogenesis, risk factors, cytokines, and complications of retinal vein occlusion (RVO). Risk factors and cytokines play important roles in exploring the mechanisms and potential treatment targets for RVO. The interrelation of risk factors adds complexity to the understanding of RVO mechanisms. Cytokines act as mediators in various pathological conditions associated with RVO, such as inflammation, neovascularization, and macular edema. The review aims to provide valuable insights into managing RVO through summarizing the updated knowledge on risk factors, cytokines, and signaling.
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Ingrid U. Scott, Neal L. Oden, Paul C. Vanveldhuisen, S. Michael, B. A. Blodi
Summary: There is a nonlinear association between central subfield thickness (CST) on spectral-domain OCT and concurrent visual acuity letter score (VALS) in eyes treated initially with afli-bercept or bevacizumab for macular edema associated with central retinal vein occlusion (CRVO) or hemiretinal vein occlusion (HRVO). The best expected VALS is observed when post-treatment CST is close to the estimated inflection points.
Review
Ophthalmology
Sohan Singh Hayreh
Summary: This article discusses the role of photocoagulation in the treatment of retinal vein occlusion, emphasizing its importance in managing NV and macular edema. Research shows that photocoagulation can prevent and treat NV-related complications in CRVO and BRVO, and recent advancements in treatment options have drastically changed the role and management of photocoagulation in these conditions.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Article
Ophthalmology
Anibal Francone, Andrea Govetto, Lisa Yun, Juliet Essilfie, Kouros Nouri-Mahdavi, David Sarraf, Jean-Pierre Hubschman
Summary: Eyes with retinal vein occlusion and concurrent glaucoma have a higher prevalence of microcystoid macular abnormalities and poorer visual acuity compared to eyes without glaucoma. Additionally, the number of anti-VEGF injections is significantly higher in eyes with glaucoma.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lasse Jorgensen Cehofski, Anders Kruse, Alexander Norgaard Alsing, Benn Falch Sejergaard, Jonas Ellegaard Nielsen, Anders Schlosser, Grith Lykke Sorensen, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: This study investigated the proteomic changes in the retina following aflibercept intervention in a central retinal vein occlusion (CRVO) model. The findings showed that aflibercept mainly acted through VEGF receptor modulation, and several other proteins also exhibited changes. These results provide insights into the mechanism of action of aflibercept and are of clinical importance for cases with aflibercept-resistant macular edema secondary to CRVO.
Review
Biochemistry & Molecular Biology
Sandrine Laurance, Mickael Marin, Yves Colin
Summary: Central retinal vein occlusion (CRVO) is a common retinal disorder leading to blindness, but the primary cause and treatment remain unidentified. This review aims to provide an overview of CRVO pathophysiology, specifically focusing on the role of red blood cells (RBCs). The review explores the functions of RBCs beyond oxygen transport and their potential involvement in CRVO occurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Manuel Casselholm de Salles, Charlotte Lindberg, David Epstein
Summary: In an ordinary clinical setting, many patients with NE already show evidence of NE at the first visit. A substantial proportion of patients develop NE a long time after presentation, typically a few months after discontinuation of intravitreal therapy for ME. The visual prognosis is similar between patients presenting with NE and those developing NE during follow-up. A high baseline IOP predicts the need for subsequent pressure-lowering procedures.
ACTA OPHTHALMOLOGICA
(2021)