Article
Biochemistry & Molecular Biology
Ahmed M. Abu El-Asrar, Gert De Hertogh, Eef Allegaert, Mohd I. Nawaz, Sara Abouelasrar Salama, Priscilla W. Gikandi, Ghislain Opdenakker, Sofie Struyf
Summary: Inflammation and fibrosis are key features of proliferative vitreoretinal disorders. The process of macrophage-myofibroblast transition (MMT) may contribute to myofibroblast formation in epiretinal membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Paolo Carpineto, Arturo Maria Licata, Marco Ciancaglini
Summary: Proliferative vitreoretinopathy (PVR) is the main cause of failure after retinal detachment (RD) surgery. Despite advancements in technology, fibrocellular membrane growth in the vitreous cavity and on the retinal surface, as well as intraretinal fibrosis, can negatively impact surgical outcomes. While knowledge about the physiopathology and risk factors of PVR has been obtained, surgical skills remain the most effective way to manage PVR complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hirotsugu Hanazaki, Harumasa Yokota, Satoru Yamagami, Yoshikazu Nakamura, Taiji Nagaoka
Summary: This study investigated the effect of anti-autotaxin (ATX) aptamers on the development of proliferative vitreoretinopathy (PVR) in both in vivo and in vitro swine models. The results showed that the anti-ATX aptamer inhibited RPE cell proliferation and migration in vitro and prevented tractional retinal detachment caused by PVR in the in vivo model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shun-Hua Chen, Yu-Jheng Lin, Li-Chiu Wang, Hsien-Yang Tsai, Chang-Hao Yang, Yu-Ti Teng, Sheng-Min Hsu
Summary: The study suggests that doxycycline may be a potential treatment for PVR in the future, by suppressing cell migration, proliferation, and contraction as well as reducing the activity of relevant proteins to alleviate the severity of PVR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Ani Korhonen, Erika Gucciardo, Kaisa Lehti, Sirpa Loukovaara
Summary: This study identified overexpression of multiple pro-angiogenic processes in PDR fibrovascular tissue, as well as genes and pathways related to lymphatic development, epithelial to mesenchymal transition, fibrosis, and extracellular matrix composition. Targeting these mechanisms could lead to the development of novel treatments for PDR.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Mara Crispin, Jacquelyn Gerhart, Alison Heffer, Mark Martin, Fathma Abdalla, Arturo Bravo-Nuevo, Nancy J. Philp, Ajay E. Kuriyan, Mindy George-Weinstein
Summary: In this study, the response of Myo/Nog cells during ERM formation in a mouse model of PVR was examined. The results showed that the number of Myo/Nog cells increased with the progression of PVR and they were the largest subpopulation of cells in ERMs. Myo/Nog cells not only differentiate into myofibroblasts, but also synthesize muscle proteins. Therefore, targeting BAI1 to deplete Myo/Nog cells may be a pharmacological approach to prevent and treat PVR.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shuai Yang, Hui Li, Haipei Yao, Yao Zhang, Huiqian Bao, Liangjing Wu, Conghui Zhang, Min Li, Le Feng, Jingfa Zhang, Zhi Zheng, Guotong Xu, Fang Wang
Summary: The study revealed that lncRNA ERLR plays a role in TGF-beta 1-induced EMT in human RPE cells and is involved in the pathogenesis of PVR, providing new insights into the mechanism and treatment of the disease.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Ophthalmology
Friederike Schaub, Petra Schiller, Robert Hoerster, Daria Kraus, Frank G. Holz, Rainer Guthoff, Hansjurgen Agostini, Martin S. Spitzer, Peter Wiedemann, Albrecht Lommatzsch, Karl T. Boden, Spyridon Dimopoulos, Sebastian Bemme, Svenja Tamm, Mathias Maier, Johann Roider, Philip Enders, Lebriz Altay, Sascha Fauser, Bernd Kirchhof
Summary: The study aimed to examine the effect of adjuvant therapy with 5-FU and LMWH compared with placebo on the incidence of PVR in high-risk patients with primary RRD. The results showed that there was no significant difference in the rate of PVR between the adjuvant therapy group and the placebo group.
Article
Cell Biology
Zhoude Zheng, Jia Li, Ye Cui, Wei Wang, Mingqiang Zhang, Youming Zhang, Yan Bai, Sun Ying, Jinming Gao
Summary: Lung fibroblasts, expressing IRAK-M, have been shown to play a crucial role in subepithelial fibrosis and airway remodeling. In this study, the effect of IRAK-M on lung fibroblasts was investigated through silencing or overexpressing IRAK-M. The results revealed that silencing IRAK-M enhanced the proliferation, migration, and invasiveness of lung fibroblasts, while overexpression of IRAK-M inhibited these cellular phenotypes. Modulation of IRAK-M expression also affected the production of inflammatory and fibrotic cytokines by the fibroblasts. These findings suggest that targeting IRAK-M could be a potential strategy to slow down airway remodeling.
Review
Biochemistry & Molecular Biology
Fatima Milhano dos Santos, Sergio Ciordia, Joana Mesquita, Joao Paulo Castro de Sousa, Alberto Paradela, Candida Teixeira Tomaz, Luis Antonio Paulino Passarinha
Summary: Proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and neovascular age-related macular degeneration (nAMD) are leading causes of blindness. Proteomics studies have revealed the complexity and biological activity of the vitreous, which plays a central role in the onset and progression of vitreoretinal diseases. Understanding the vitreous proteome could provide insights into the pathological mechanisms underlying these diseases and identify potential pharmaceutical targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lijun Dong, Haote Han, Xionggao Huang, Gaoen Ma, Dong Fang, Hui Qi, Zhuo Han, Luping Wang, Jingkui Tian, Bart Vanhaesebroeck, Guoming Zhang, Shaochong Zhang, Hetian Lei
Summary: The specific inhibitor Idelalisib has shown potential in preventing proliferative vitroretinopathy (PVR) by inhibiting Akt activation, fibronectin expression, and collagen gel contraction in human RPE cells and an animal model.
LABORATORY INVESTIGATION
(2022)
Review
Ophthalmology
Lorenzo Ferro Desideri, Dmitri Artemiev, Souska Zandi, Martin S. Zinkernagel, Rodrigo Anguita
Summary: This review discusses the adjunctive treatment options for proliferative vitreoretinopathy (PVR), including current and emerging treatments, and their potential clinical application and benefits for patients in this subgroup.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jose A. Roca, Anali Yon-Mendoza, Nathaly Huaman, Lihteh Wu
Summary: The study indicated that weekly post-operative intravitreal methotrexate injections can improve the retinal re-attachment rate in eyes with grade C proliferative vitreoretinopathy. Methotrexate as an adjunct to surgical repair shows promise for the management of PVR.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Liangjing Wu, Shuai Yang, Hui Li, Yao Zhang, Le Feng, Conghui Zhang, Jiayi Wei, Xunyi Gu, Guotong Xu, Zhaoyang Wang, Fang Wang
Summary: In this study, the characteristics and functions of migrasomes in retinal pigmented epithelium (RPE) activation and proliferative vitreoretinopathy (PVR) development were investigated using ex vivo, in vitro, and in vivo models. The results showed that migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed in human PVR-associated clinical samples. TGF-beta 1 was found to increase the expression of TSPAN4 and promote migrasome production, which enhanced the migration and proliferation ability of RPE. Blocking TSPAN4 weakened the ability of RPE to initiate experimental PVR.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haiping Jiang, Yuning Chen, Zhengquan He, Jie Li, Qingqin Gao, Wei Li, Wenbin Wei, Ying Zhang
Summary: In this study, blebbistatin was found to inhibit the progression of PVR, prevent retinal function loss, and showed potential as a drug for the treatment of PVR.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)