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2,4,6-Trichloro-1,3,5-triazine and N,N′-dimethylformamide as an effective Vilsmeier-Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides

TETRAHEDRON LETTERS (2015)

期刊

TETRAHEDRON LETTERS

卷 56, 期 37, 页码 5164-5167

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PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.tetlet.2015.07.056

关键词

2,4,6-Trichloro-1,3,5-triazine/N,N '-dimethylformamide; Vilsmeier-Haack type reagent; Acetanilides; 2-Chloro-3-formyl quinolines; Sonication; Rate acceleration

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Chemistry, Organic

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摘要

TCTA-DMF (2,4,6-trichloro-1,3,5-triazine/N,N'-dimethylformamide) adduct has been used as a Vilsmeier-Haack type reagent for effective synthesis of 2-chloro-3-formyl quinolines from acetanilides under conventional and ultrasonically assisted conditions. The reaction times under sonication are quite significantly shorter than conventional methods even though the yields obtained under sonication are comparable with those obtained under reflux conditions. (C) 2015 Elsevier Ltd. All rights reserved.

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Article Chemistry, Organic

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2,4,6-Trichloro-1,3,5-triazine and N,N′-dimethylformamide as an effective Vilsmeier-Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides

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TETRAHEDRON LETTERS

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PERGAMON-ELSEVIER SCIENCE LTD

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Recent Advances in the Synthesis and Application of C-2-Formyl Glycals

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2,4,6-Trichloro-1,3,5-triazine and N,N′-dimethylformamide as an effective Vilsmeier-Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides

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PERGAMON-ELSEVIER SCIENCE LTD

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