期刊
TETRAHEDRON LETTERS
卷 56, 期 1, 页码 247-251出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.11.083
关键词
Notoamide; Aspergillus sp.; Bioconversion; Alkaloid
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23108518, 25108719, 24710252]
- Nagase Science and Technology Foundation
- National Institutes of Health (United States) [R01 CA070375]
- NATIONAL CANCER INSTITUTE [R01CA070375] Funding Source: NIH RePORTER
We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (-)-Notoamide B, which suggested that Versicolamide B (8) is biosynthesized from 6-epi-Notoamide T (10) via 6-epi-Stephacidin A. Here we report that [C-13](2)-10 was incorporated into isotopically enriched 8 and seven new metabolites, which were not produced under normal culture conditions. The results suggest that the addition of excess precursor activated the expression of dormant tailoring genes giving rise to these structurally unprecedented metabolites. (C) 2014 Elsevier Ltd. All rights reserved.
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