Review
Chemistry, Multidisciplinary
Mingyu Liu, Xingwang Zhang, Guoqiang Li
Summary: This review presents a comprehensive summary of 243 hot-spot marine natural products reported from 2012 to 2021, providing important chemical and biological inspirations for marine natural product study and marine drug development. It also introduces some general rules regarding these outstanding compounds.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Pankaj Garg, Rachana Garg, David Horne, Sanjay Awasthi, Ravi Salgia, Sharad S. Singhal
Summary: Cancer is a widespread and constantly evolving disease that poses a significant public health concern. Despite advancements in treatment strategies, such as surgery, radiation, and pharmaceutical therapies, there has been little improvement in cancer-related death rates. As a result, natural product-based therapeutic discoveries are being considered as an alternative approach. Primary prevention plays a crucial role in global cancer control, and this review provides an overview of the mechanisms by which bioactive ingredients in natural dietary products may contribute to the prevention and management of various malignancies.
Article
Chemistry, Multidisciplinary
Kosheli Thapa Magar, George Frimpong Boafo, Xiaotong Li, Zhongjian Chen, Wei He
Summary: Biological drugs are limited in their application due to their inherent properties, but liposome-based drug delivery systems provide a promising solution to improve drug delivery.
CHINESE CHEMICAL LETTERS
(2022)
Article
Health Care Sciences & Services
Richard G. Frank, Thomas G. Mcguire, Ian Nason
Summary: Concerns have arisen in recent policy debates about generic drug markets, with changes in regulations, purchasing structure, and drug supply chains affecting market dynamics. While effective price competition remains in larger markets, smaller markets and injectable products face less competition and more supply disruptions. The image of generic drugs as a commodity in competitive markets is simplistic, with increasing evidence of price spikes, sustained high margins, and market instabilities.
Article
Management
Yujie Zhao, Hong Zhou, Roel Leus
Summary: This paper investigates recovery strategies for supply chain enterprises under uncertain demand. It proposes financing strategies and recovery strategies for retailers to mitigate the negative impact of disruptions. The analysis considers the potential impact on regret, bankruptcy risk, and profit for different financing and recovery strategies.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Review
Food Science & Technology
Yu-Hsuan Liu Yi-Shuo, Ting Tseng, Min-Lin Jiang, Churn-Shiouh Gau, Lin-Chau Chang
Summary: The Non-Biological Complex Drug (NBCD) Working Group defines NBCDs as medicinal products that are not biological medicines and have complex structures that cannot be fully characterized using physicochemical analytical means. This study compares the regulatory requirements for developing generic NBCDs in the EU and the US, focusing on nanoparticle albumin-bound paclitaxel (nab-paclitaxel) injections, liposomal injections, glatiramer acetate injections, iron carbohydrate complexes, and sevelamer oral dosage forms. It emphasizes the importance of demonstrating pharmaceutical comparability between generic and reference products through comprehensive characterization. While the approval pathways and requirements may differ, it is anticipated that harmonization of regulatory requirements will be achieved through collaboration between the EMA and FDA.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Economics
Jia Shi, Qiang Li, Lap Keung Chu, Yuan Shi
Summary: This study suggests that retailers should accept trade credit when demand uncertainty is high, trade credit risk premium is moderate, and wholesale price is low. Retailers should only adopt trade credit when both demand uncertainty and production cost are not high, and wholesale price is endogenously determined. Research also finds that most results still hold when relaxing the assumption on the bank's risk attitude.
TRANSPORTATION RESEARCH PART E-LOGISTICS AND TRANSPORTATION REVIEW
(2021)
Article
Biotechnology & Applied Microbiology
Ruili Huang, Miao Xu, Hu Zhu, Catherine Z. Chen, Wei Zhu, Emily M. Lee, Shihua He, Li Zhang, Jinghua Zhao, Khalida Shamim, Danielle Bougie, Wenwei Huang, Menghang Xia, Mathew D. Hall, Donald Lo, Anton Simeonov, Christopher P. Austin, Xiangguo Qiu, Hengli Tang, Wei Zheng
Summary: The biological activity-based modeling approach uses compound activity profiles to predict activity across different assays or targets, aiding in the discovery of potential antiviral drug candidates. This method successfully identified compounds with potential activity against Zika, Ebola, and SARS-CoV-2 viruses, demonstrating its effectiveness in predicting antiviral compounds. The confirmed anti-SARS-CoV-2 compounds show promise as potential therapies, with a focus on viral entry inhibition and autophagy modulation.
NATURE BIOTECHNOLOGY
(2021)
Article
Engineering, Industrial
Omar Alhawari, Gursel A. Suer, M. Khurrum S. Bhutta
Summary: This paper explores the decision-making process for manufacturers in the supply chain when facing uncertain market demands, with a focus on designing manufacturing systems to save time and effort while maximizing profits. The research shows that using a cellular manufacturing system can effectively design optimal production models for product families, but decision-making must take into account different demand coverage restrictions to generate maximum profits.
INTERNATIONAL JOURNAL OF PRODUCTION ECONOMICS
(2021)
Article
Pharmacology & Pharmacy
Barbara Fuezi, Jana Gurinova, Henning Hermjakob, Gerhard F. Ecker, Rahuman Sheriff
Summary: This study introduces a computational technique to connect drugs to biological pathways through drug-protein interactions. By retrieving drug target proteins and conducting enrichment tests, potential pathways affected by drugs can be identified. The developed tool is open-source and customizable for other systems biology analyses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Energy & Fuels
Rui Qiu, Yong-Tu Liang, Qi Liao, Ying-Qi Jiao, Bo-Hong Wang, Yi Guo, Hao-Ran Zhang
Summary: This paper addresses the primary logistics planning of oil products under the imbalance of supply and demand. A mathematical programming model is developed to achieve supply-demand balance and optimize logistics schemes. The model considers various constraints and adjustment rules and is tested on a large-scale logistics scenario, proving its effectiveness and applicability.
Article
Medicine, Research & Experimental
Tereza Buchtova, Lucie Beresova, Katarina Chroma, Tomas Pluhacek, Tibor Beres, Dominika Kaczorova, Petr Tarkowski, Jiri Bartek, Martin Mistrik
Summary: Cannabinoids derived from Cannabis sativa L. have become more accessible for public consumption in the form of cannabis products. Some cannabis-derived drugs have been approved for managing diseases and chemotherapy-induced nausea and vomiting. Preclinical data using human cell culture models suggests that cannabidiol and cannabis extracts may counteract the anticancer effects of platinum-based drugs commonly used in therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Electrical & Electronic
Shenbo Yang, Hongyu Lin, Liwei Ju, Jie Ma
Summary: This study addresses the uncertainty in supply and demand of off-grid microgrids and proposes a chance-constrained bi-level optimal dispatching model, along with a benefit allocation strategy for both sides of supply and demand. Using scenario generation and an improved genetic algorithm, the research effectively reduces energy supply deviation and achieves demand-supply interaction to reduce load shedding. The results suggest that increasing installed capacity, implementing demand response, or adding energy conversion units can enhance supply-demand matching and clean energy utilization efficiency.
INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS
(2023)
Review
Pharmacology & Pharmacy
Rodrigo dos A. Miguel, Amanda S. Hirata, Paula C. Jimenez, Luciana B. Lopes, Leticia V. Costa-Lotufo
Summary: Nature is a rich source of medicinal compounds like doxorubicin (DOX) and paclitaxel (PTX). Nanoformulations of these drugs are cost-effective and offer improved pharmacokinetic properties and targeted delivery, resulting in reduced side effects. They can also overcome drug resistance and allow for multi-drug encapsulation for combined chemotherapy.
Article
Biodiversity Conservation
Yuhan Huang, Rongrong Ma, Wei Zhou, Yuan Yuan, Jun Ren, Yingui Cao
Summary: This study constructed a framework for retrospective assessment and optimal regulation of supply-demand risks of ecological products (EPs) to guide risk management. By conducting a case study in Qinghai Province, China, it was found that different types of EPs had a surplus supply, with significant spatial differences in supply-demand risk levels, mainly in urban concentrated development areas. For different levels of supply-demand risk, intra-regional and cross-regional optimization regulation strategies were proposed to improve the efficiency of EPs allocation and policy formulation at a regional scale.
ECOLOGICAL INDICATORS
(2023)
Article
Hematology
A. Iorio, J. S. Stonebraker, M. Brooker, J. M. Soucie
Article
Hematology
J. S. Stonebraker, J. Hajjar, J. S. Orange
Article
Immunology
Jeffrey S. Stonebraker, Albert Farrugia, Benjamin Gathmann, Jordan S. Orange
JOURNAL OF CLINICAL IMMUNOLOGY
(2014)
Article
Medicine, General & Internal
Chatree Chai-Adisaksopha, Mark W. Skinner, Randall Curtis, Neil Frick, Michael B. Nichol, Declan Noone, Brian O'Mahony, David Page, Jeffrey Stonebraker, Lehana Thabane, Mark Crowther, Alfonso Iorio
Article
Hematology
Chatree Chai-Adisaksopha, Mark W. Skinner, Randall Curtis, Neil Frick, Michael B. Nichol, Declan Noone, Brian O'Mahony, David Page, Jeffrey Stonebraker, Lehana Thabane, Mark A. Crowther, Alfonso Iorio
Article
Hematology
Chatree Chai-Adisaksopha, Mark W. Skinner, Randall Curtis, Neil Frick, Michael B. Nichol, Declan Noone, Brian O'Mahony, David Page, Jeffrey Stonebraker, Lehana Thabane, Mark A. Crowther, Alfonso Iorio
Article
Medicine, General & Internal
Alfonso Iorio, Jeffrey S. Stonebraker, Herve Chambost, Michael Makris, Donna Coffin, Christine Herr, Federico Germini, Jeffrey S. Stonebraker, Alfonso Iorio, Vanessa Byams, Magdy El-Ekiaby, Michael Makris, Jamie O'Hara, Glenn F. Pierce, Alain Weill
ANNALS OF INTERNAL MEDICINE
(2019)
Article
Hematology
Jeffrey S. Stonebraker, Paula H. B. Bolton-Maggs, Mark Brooker, Bruce Evatt, Alfonso Iorio, Michael Makris, Brian O'Mahony, Mark W. Skinner, Donna Coffin, Glenn F. Pierce, Ellia Tootoonchian
Article
Hematology
Chatree Chai-Adisaksopha, Declan Noone, Randall Curtis, Neil Frick, Michael B. Nichol, Federico Germini, Brian O'Mahony, David Page, Jeffrey S. Stonebraker, Mark W. Skinner, Alfonso Iorio
Summary: This study aimed to evaluate the health status of people living with mild or moderate hemophilia and found that hemophilia has a significant impact on patients' quality of life, especially in terms of bleeding-related issues. The research suggests that future studies are needed to identify optimal care management for patients with mild and moderate hemophilia.
Article
Hematology
Jeffrey S. Stonebraker, Jonathan M. Ducore
Summary: The increased use of emicizumab in the United States is projected to have a significant impact on the usage and cost of standard half-life and extended half-life products for treating hemophilia A. By 2025, with a 59% increase in the number of HA patients, factor and emicizumab usage is expected to rise, leading to a total cost of $650 million.
Article
Hematology
Federico Germini, Chatree Chai-Adisaksopha, Drashti Pete, Randall Curtis, Neil Frick, Michael B. Nichol, Declan Noone, Brian O'Mahony, David Page, Jeffrey S. Stonebraker, Lehana Thabane, Mark A. Crowther, Mark W. Skinner, Alfonso Iorio
Summary: The study found that sexual difficulty is more prevalent in people living with hemophilia compared to those without bleeding disorders, and is associated with markers of disease severity. It is recommended that sexual health issues be incorporated into comprehensive hemophilia care, future research, and hemophilia-related health policy.
Article
Hematology
Jeffrey S. Stonebraker, Brian O'Mahony, Declan Noone, Alfonso Iorio
Summary: This study aimed to develop and validate a method for converting IU of SHL or EHL, and milligrams of emicizumab into a single metric. By generating robust estimates of conversion factors for current treatment options for prophylaxis in haemophilia, this study will facilitate benchmarking across different countries or longitudinally.
Article
Hematology
Jamie M. M. O'Sullivan, Ellia Tootoonchian, Baiba Ziemele, Michael Makris, Augusto B. B. Federici, Claudia Khayat Djambas, Magdy El Ekiaby, Dawn Rotellini, Robert F. F. Sidonio, Alfonso Iorio, Donna Coffin, Glenn F. F. Pierce, Jeffrey Stonebraker, Paula D. D. James, Michelle Lavin
Summary: Recent guidelines for von Willebrand Disease (VWD) highlighted the challenges in diagnosis and management. Identifying the number of persons with VWD (PwVWD) internationally will help target support to aid diagnosis of PwVWD. Registration rates of PwVWD vary internationally and are influenced by national income status.
Review
Hematology
Jeffrey S. Stonebraker, Alfonso Iorio, Michelle Lavin, Suely M. Rezende, Alok Srivastava, Glenn F. Pierce, Donna Coffin, Ellia Tootoonchian, Michael Makris
Summary: This study analyzed the reported prevalence of von Willebrand disease (VWD) worldwide in relation to income classification. The results showed that the prevalence of VWD was significantly higher in high-income countries compared to other income classifications, and the prevalence was higher in females than males. The detection and diagnosis of type 1 VWD presented challenges in forming a consistent prevalence value across countries and income classifications.
Article
Materials Science, Paper & Wood
Camilla Abbati de Assis, Antonio Suarez, Jeffrey P. Prestemon, Jeffrey Stonebraker, Carlos Carrillo, Sudipta Dasmohapatra, Hasan Jameel, Ronalds Gonzalez
Summary: The study found that organizations in the bio-based industry commonly utilize some form of risk analysis in capital investment decision-making, with qualitative and deterministic assessment methods dominating over probabilistic methods. Risk assessment is mostly conducted in the later stages of a project, with financial, market and sales, and technology uncertainties being the main sources considered. Additionally, Internal Rate of Return, Return on Investment, and Net Present Value are the preferred financial indicators used for evaluating capital investments, consistent with previous studies in other industry sectors.