Total synthesis of 3-epi-(+)-lycoricidine from Gamer aldehyde via intramolecular aldol cyclization

A highly efficient total synthesis of 3-epi-(+)-lycoricidine has been described for the first time from easily available (S)-Garner aldehyde with an overall yield of 7% in 20 steps. Stereoselective nucleophilic addition, Sharpless asymmetric dihydroxylation, Dess-Martin periodinane oxidation, intramolecular aldol cyclization, and Luche reduction are the salient features of this approach. (C) 2014 Elsevier Ltd. All rights reserved.