Article
Engineering, Electrical & Electronic
Trinh Bich Hoang, Bjorn Torger Stokke, Ulrik Hanke, Erik Andrew Johannessen, Agne Johannessen
Summary: The study utilized a quartz crystal microbalance to investigate the mass and viscoelastic properties associated with the binding of ConcanavalinA (Con A) and dextran in an affinity assay with varying glucose concentrations. The results showed that the system demonstrated a resolution equivalent to +/- 0.4mM in the presence of 40 mM glucose, with the mass changes depending on the viscoelastic properties of the lectin layer. The assay was reversible with a higher sensitivity to lower glucose concentrations, but with a decreasing signal magnitude for each cycle.
IEEE SENSORS JOURNAL
(2021)
Article
Energy & Fuels
Krege M. Christison, Gregory B. Boursalian, Andreas H. Franz
Summary: Samples of QCM deposits were analyzed using pyrolysis gas chromatography/mass spectrometry to understand their composition. Several important compound classes were identified. Although one compound could not be conclusively identified, indirect evidence suggested its structure as a pentamethyl substituted cyclohexylpyridine, which was later confirmed through de novo synthesis. A spiking study was performed to investigate the effect of these compounds on QCM deposit formation, along with variations in sulfur compounds and alkyl phenols.
Article
Chemistry, Applied
Tian Liu, Yu Zhang, Xiaomin Lu, Peipei Wang, Xinyu Zhang, Jing Tian, Qingcheng Wang, Junlong Song, Yongcan Jin, Huining Xiao
Summary: CBM4 binds preferentially to both CNF and CNC, with different driving forces: hydrogen bonds for CNF resulting in favorable enthalpy but compensated by unfavorable entropy change, while favorable entropy for CNC but compensated by unfavorable enthalpic change due to water rearrangement.
CARBOHYDRATE POLYMERS
(2021)
Article
Nanoscience & Nanotechnology
Nils Luedecke, Marek Bekir, Stephan Eickelmann, Matthias Hartlieb, Helmut Schlaad
Summary: Inspired by mussel proteins, a platform for protein-repellent macromolecules based on poly(2-ethyl-2-oxazoline) carrying catechol and cationic functional groups was developed. The polymers with catechol units showed a strong tendency to form surface-bound layers on different substrates, while the ones with additional cationic units were able to form defined and durable polymer films. These coatings prevented the attachment of model proteins, offering a biomimetic approach to nonfouling surface coatings.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ester Canepa, Davide Bochicchio, Giorgia Brosio, Paulo Henrique Jacob Silva, Francesco Stellacci, Silvia Dante, Giulia Rossi, Annalisa Relini
Summary: Membrane fusion is essential for eukaryotic cell functionality and is regulated by specialized proteins, lipid composition, and ion environment. Liposomes decorated with amphiphilic Au nanoparticles (AuLips) have been shown to act as tunable fusion machinery, triggered by divalent ions and tunable by liposome cholesterol content. This research provides new mechanistic details on the fusogenic activity of AuNPs and demonstrates their potential as artificial fusogenic agents for biomedical applications.
Article
Environmental Sciences
Yang Lyu, Jie Yu, Minhui Guo, Kan Wang, Zhenxun Yu, Lingxiao Zhang, Ying Zhang, Leilei Chen
Summary: The study utilized QCM-D to investigate the binding properties of CIP on extracellular proteins from activated sludge, revealing that factors affecting the binding included CIP concentration, pH, and cations. The binding process followed Langmuir model, with two distinct binding periods based on viscoelastic properties of the CIP layer.
Article
Chemistry, Analytical
Lianjie Zhou, Fumihito Kato, Masumi Iijima, Tomoyuki Nonaka, Shun'ichi Kuroda, Hirotsugu Ogi
Summary: Quartz-crystal-microbalance (QCM) biosensor is a label-free biosensor that can achieve higher sensitivity by removing electrodes and wires attached to the surfaces of the quartz resonator. A wireless-electrodeless QCM biosensor using a microelectro-mechanical systems (MEMS) process was developed, which improved the electro-mechanical coupling efficiency. The sensitivity of the MEMS QCM biosensor was confirmed by the detection of immunoglobulin G (IgG) and C-reactive protein (CRP), achieving a detection limit of 1 ng mL-1 or less.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yongheng Zhu, Xuhua Dong, Jinsheng Cheng, Lumin Wang, Cheng Zhao, Yonghui Deng, Siqi Xie, Yingjie Pan, Yong Zhao, Gengzhi Sun, Tianjun Ni
Summary: To achieve real-time monitoring of humidity, facile and ultra-thin CoAl layered double hydroxide (CoAl LDH) nanosheets were used to engineer quartz crystal microbalances (QCM). The CoAl LDH nanosheets exhibited good humidity sensing performance due to their large specific surface area and abundant hydroxyl groups. The QCM sensor showed ultrahigh sensitivity, fast response and recovery time, low hysteresis, good linearity, stability, and selectivity, as well as superior self-recovery ability under high humidity. The sensor also demonstrated excellent properties in distinguishing respiratory states, wetting degree of fingers, and monitoring humidity in vegetable packaging.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
H. Vovusha, R. G. Amorim, H. Bae, S. Lee, T. Hussain, H. Lee
Summary: By using density functional theory calculations, the sensing of sulfur containing gases (H2S and SO2) on double transition metal carbide MXenes was investigated. The adsorption of H2S and SO2 on M2TiC2Tx (M = Mo, Cr; Tx = O, S, OH) mono-layers was found to be strong. H2S exhibited stronger adsorption on oxygen-terminated (Mo2TiC2O2, Cr2TiC2O2) monolayers, while SO2 had stronger adsorption on sulfur-terminated (Mo2TiC2S2, Cr2TiC2S2) monolayers. The sensitivities of H2S and SO2 on the Mo2TiC2S2 monolayer were found to be 16.3% and 10.3% respectively, indicating promising sensing characteristics.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Physical
Mengnan Cui, Zhihui Zheng, Jiacheng Wang, Youwei Wang, Xiaolin Zhao, Ruguang Ma, Jianjun Liu
Summary: This study establishes surface electron affinity as a quantitative screening principle for cathode materials, finding that materials with specific surface electron affinities can prevent the dissolving of LiPSs and exhibit good electronic conductivity. The design principle is verified through experimental characterizations of different materials, and the optimal binding strength of LiPSs on cathodes is identified. Differential atom electronegativity is defined as a universal descriptor for screening high-performance cathodes of Li-S batteries, showing that certain metal oxides and transition metal compounds can promote battery performance. These findings provide valuable insight for future cathode design and improved battery performance.
ENERGY STORAGE MATERIALS
(2021)
Article
Agricultural Engineering
Shuwen Hou, Buzhen Shen, Daihui Zhang, Ruoyan Li, Xin Xu, Kai Wang, Chenhuan Lai, Qiang Yong
Summary: This study employed lignin blockers, including non-catalytic protein and surfactants, to enhance the enzymatic digestibility of pretreated poplars. Among them, Tween 80 showed the most significant improvement, increasing glucose yield and reducing the required enzyme loading. Quartz crystal microbalance analysis revealed that Tween 80 had a higher binding rate on lignin surfaces compared to enzymes and significantly reduced the enzyme-lignin binding capacity and rate. These findings contribute to understanding the mechanism of surfactant promotion in enzymatic hydrolysis.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guoqiang Yu, Gehui Liu, Tianyi Liu, Ethan H. Fink, Alan R. Esker
Summary: Changes in mass and viscoelasticity of fungal chitin layers during chitinase attack were studied using regenerated chitin (RChitin) thin films as a mimic. The degradation of RChitin films by family 18 chitinases and family 19 chitinases with chitin-binding domains (CBDs) was monitored in real time. The results showed that chitinase adsorption significantly affected the degradation of RChitin films, and CBDs played an important role in the degradation of insoluble substrates.
Article
Engineering, Multidisciplinary
Amara Nasrullah, Sumaira Roshan, Usman Latif, Adnan Mujahid, Ghulam Mustafa, Sadia Z. Bajwa, Adeel Afzal
Summary: This study develops a gravimetric sensor using molecularly imprinted polymer (MIP) layers fabricated with ZnO nanoparticles for the detection of very-low-density lipoprotein (VLDL) in blood. The sensor exhibits high sensitivity and selectivity for VLDL, and shows potential for reliable analysis of VLDL in complex biofluids.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bhargava Nemmaru, Nicholas Ramirez, Cindy J. Farino, John M. Yarbrough, Nicholas Kravchenko, Shishir P. S. Chundawat
Summary: This study investigates the role of carbohydrate-binding modules (CBMs) in nonproductive enzyme binding, finding that reduced CBM equilibrium binding affinity towards cellulose I is correlated with improved endocellulase activity.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
J. Tucker Andrews, Kirstyn E. Baker, Jacob T. Handloser, Natalie Bridges, Alexis A. Krone, Peter J. N. Kett
Summary: This study used a quartz crystal microbalance to investigate the effect of salt on the formation of phosphatidylcholine SLBs on a silicon dioxide surface, finding that the influence of different cations on SLB formation varies at different salt concentrations.
Article
Chemistry, Organic
Jian Lv, Jia-Jia Zhu, Yu Liu, Hai Dong
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Xingxian Gu, Jibin Zhao, Like Chen, Yunzhong Li, Bo Yu, Xiangguang Tian, Zhongcheng Min, Su Xu, Huijuan Gu, Junjie Sun, Xiaoquan Lu, Meng Chang, Xufan Wang, Liqun Zhao, Shengqing Ye, Hongwei Yang, Yingtao Tian, Feng Gao, Yu Gai, Guanghua Jia, Jingjing Wu, Yan Wang, Jianghua Zhang, Xuesong Zhang, Weichun Liu, Xin Gu, Xi Luo, Hai Dong, Huaimin Wang, Berthold Schenkel, Francesco Venturoni, Paolo Filipponi, Bertrand Guelat, Thomas Allmendinger, Bernhard Wietfeld, Pascale Hoehn, Nikola Kovacic, Luca Hermann, Thierry Schlama, Thomas Ruch, Nadine Derrien, Philippe Piechon, Florian Kleinbeck
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Tao Luo, Ying Zhang, Jiafeng Xi, Yuchao Lu, Hai Dong
FRONTIERS IN CHEMISTRY
(2020)
Article
Chemistry, Analytical
Xueming Li, QuanQuan Song, Yuxin Pei, Hai Dong, Teodor Aastrup, Zhichao Pei
Summary: The study examines the attachment property of suspension cells on PDA surfaces, finding that suspension cells can directly attach to PDA coatings without secondary modifications. A novel PDA-based suspension-cell QCM biosensor was fabricated, demonstrating high repeatability, stability, and low nonspecific binding. Real-time evaluation of lectin binding on suspension cells indicates glycosylation variations on cell surfaces, offering a new strategy for complex molecular recognition studies.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Organic
Guang-Jing Feng, Shuang-Shuang Wang, Jian Lv, Tao Luo, Yuzhou Wu, Hai Dong
Summary: An improved method for synthesizing 1-glycosyl thioacetates was developed, which efficiently synthesized two thioglucoside gliflozin analogues for the first time in high yields. This method overcomes the disadvantages of traditional methods and does not require isolation of intermediate products during the synthesis process.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Guang-Jing Feng, Tao Luo, Yang-Fan Guo, Chun-Yang Liu, Hai Dong
Summary: A green method using sodium alkanethiolates instead of alkyl mercaptans and trifluoromethanesulfonic acid in nonpolar solvents is developed for synthesizing 1-thioalkyl glycosides and 1,2-cis-alpha-thioglycosides under mild conditions.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jian Lv, Chun-Yang Liu, Yang-Fan Guo, Guang-Jing Feng, Hai Dong
Summary: A one-pot strategy based on SnCl2-catalyzed acetalation and selective benzoylation was developed to efficiently synthesize orthogonally protected glycosyl acceptors with 2-OH/3-OH. Subsequently, 2-OBz or 3-OBz 4,6-O-benzylidene galactosides and glucosides were prepared in moderate to high yields from free galactosides and glucosides, and were used as valuable glycosyl acceptors for the synthesis of blood group antigens O and B analogues in this study.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Tao Luo, Qiang Zhang, Yang-Fan Guo, Zhi-Chao Pei, Hai Dong
Summary: Efficient strategies were developed in this study to synthesize 2-deoxysugars with exclusive alpha/beta-configuration. Four methyl 2-SAc glycosides were synthesized through the double serial inversion strategy and further converted into corresponding glycosyl donors. Glycosylation and synthesis of 2-deoxysugars were also investigated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Engineering, Environmental
Tengyang Zhu, Shutong Liu, Qing Xia, Ming Yi, Huan Liu, Hai Dong, Yan Wang
Summary: Polyamide-based thin film composite membranes have been widely used in membrane-based separations. This research focuses on improving the hydrophilicity and chain packing density of the PA selective layer by metal-assisted multiple crosslinking strategy. The resulting TFC-Fe3+-PhA membrane exhibits excellent water/ethanol separation performance, making it a promising candidate for bioethanol purification.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yang-Fan Guo, Tao Luo, Guang-Jing Feng, Chun-Yang Liu, Hai Dong
Summary: An improved method for efficiently synthesizing 2-OH thioaryl glycosides from per-protected glycals was developed. The method involved the oxidation of glycals with oxone to prepare 1,2-anhydro sugars, followed by reaction with NaBH4 and aryl disulfides. This method was also used in a one-pot reaction to synthesize glycosyl donors with both armed and NGP effects.
Article
Biochemistry & Molecular Biology
Tao Luo, Tian-Tian Xu, Yang-Fan Guo, Hai Dong
Summary: Acetalization and deacetalation are common methods used in the synthesis of glycosyl building blocks to protect and deprotect the 4- and 6-hydroxyl groups of glycosides. This study demonstrates that SnCl4, in the presence of water in CH2Cl2, can catalyze the deacetalization of various carbohydrates with acetal/ketal groups, yielding almost quantitative deacetalization products. Additionally, the selective cleavage of p-methoxylbenzyl groups was observed when using a catalytic amount of SnCl4, while the acetal/ketal groups remained intact. This finding allows for the convenient conversion of 4,6-benzylidene glycosides to 4,6-OAc or 4-OH, 6-OAc glycosides.
Article
Chemistry, Organic
Tao Luo, Yang-Fan Guo, Tian-Tian Xu, Hai Dong
Summary: In this study, a visible-light-promoted desulfurization method was successfully used to synthesize deoxysugars, particularly 1-deoxyglycose, 2,4-deoxyglycosides, and 2-deoxyglycosides with exclusive alpha-configuration. Compared to desulfurization under UV light, this method under visible light is easy to operate, does not require a dedicated photochemical reactor, occurs under mild conditions, and avoids many side reactions.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Guang-Jing Feng, Yang-Fan Guo, Yuming Tang, Min Li, Yufei Jia, Zhimeng Li, Shuangshuang Wang, Hongmei Liu, Yuzhou Wu, Hai Dong
Summary: The potential of thioglucoside analogues as antidiabetic drugs was investigated in this study. The analogues showed good stability, low toxicity, and high inhibitory activity, making them promising candidates for new gliflozin drugs. Additionally, the synthesis of these analogues is simple, efficient, and cost-effective.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Yang-Fan Guo, Tao Luo, Hai Dong
Summary: This study presents a SnCl2/Me2SnCl2-catalyzed carbamoylation reaction of carbohydrates with high selectivity and yields. The SnCl2 catalyst selectively carbamoylates the axial hydroxyl groups of glycoside substrates containing cis-diols, while the Me2SnCl2 catalyst selectively carbamoylates the equatorial hydroxyl groups. The SnCl2 method has a broader substrate scope, including glycosides with 1,3-diols, while the Me2SnCl2 method can include glycosides with trans-diols.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Jian Lv, Yu Liu, Jia-Jia Zhu, Dapeng Zou, Hai Dong
Article
Chemistry, Organic
Fuying Zhu, Yamei Lin
Summary: In this study, a low-metal iron-supported catalyst (Fe20/NC-Mg) was reported for the efficient synthesis of quinoxaline compounds, using water as a solvent and without additional bases. The synergistic effect of FeNx site and Mg (OH)2 nanorods in the catalyst played a key role in achieving high yields (82-91%) in 16 examples. The gram-level synthesis and reusability of the catalysts after four cycles demonstrated its industrial application potential.
Article
Chemistry, Organic
Mikhail Kozlov, Alexey Tyurin, Andrey Dmitrenok, Vyacheslav Rusak, Aleksander Fedorov, Igor Zavarzin, Yulia Volkova
Summary: This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
Article
Chemistry, Organic
Jisna Jose, Thomas Mathew
Summary: 2-Cyclopentenone and its derivatives are highly esteemed synthetic intermediates with exceptional utility in organic synthesis. They are favored structural motifs in numerous pharmaceutical drugs and natural products, highlighting their significance. The review discusses the various methods used to synthesize cyclopentenones from 2016 to 2023.
