Article
Gastroenterology & Hepatology
Linjie Hu, Hairenguli Maimaiti, Lu Zhou, Jie Gao, Yihan Lu
Summary: This study investigated the epidemiological characteristics of Hand, foot, and mouth disease (HFMD) and the serotypes of enterovirus (EV) in Shanghai, China, after the introduction of EV-A71 vaccines. The results showed that CV-A6 was the predominant EV serotype in the HFMD epidemic, followed by CV-A16 and EV-A71. The changing trends in EV serotypes influenced the periodicity of the HFMD epidemic. A minority of HFMD cases had comorbidities, but they were not correlated with EV serotypes. The use of EV-A71 vaccine had an impact on the HFMD epidemic, and it may promote vaccination in children infected with EV-A71.
Article
Biochemical Research Methods
Gabr F. El Bagoury, Rawan Elhabashy, Ayman H. Mahmoud, Naglaa M. Hagag, Mohamed E. El Zowalaty
Summary: This study developed a new real-time reverse transcription-polymerase chain reaction (RTqPCR) method for the rapid and accurate diagnosis of different lineages of SAT 2 and O serotypes of foot-and-mouth disease virus (FMDV) circulating in Egypt. The results showed that the developed assay had high sensitivity and specificity, making it suitable for routine surveillance and improving disease control measures.
JOURNAL OF VIROLOGICAL METHODS
(2022)
Article
Virology
Andrea Isabel Estevez Garcia, David J. Lefebvre, Lionel Nyabongo, Andy Haegeman, Canesius Nkundwanayo, Annebel De Vleeschauwer, Desire Ntakirutimana, Ilse De Leeuw, Deogratias Nsanganiyumwami, Pascal Niyokwizera, Thierry van den Berg, Alfred Niyokwishimira, Kris De Clercq
Summary: This study reports the occurrence of foot-and-mouth disease in Burundi and investigates the affected cattle herds. The study finds that the foot-and-mouth virus is widely spread in the affected regions, with different serotypes. Additionally, the isolated virus strains have similarities with strains from other countries in the region, suggesting possible transboundary transmission.
Article
Immunology
Seong Yun Hwang, Sung Ho Shin, Hyun Mi Kim, SeHee Shin, Min Ja Lee, Su-Mi Kim, Jong-Soo Lee, Jong-Hyeon Park
Summary: In this study, a potent vaccine strain was developed to provide complete protection against FMD type O viruses of Southeast Asia, Middle East-South Asia, and Cathay topotypes. Mice immunized with the experimental vaccines were fully protected against these viruses. PA2-VP1 showed higher neutralizing antibody titers than JC-VP1 in early vaccination phase in pigs.
Article
Immunology
Michael Puckette, Benjamin A. A. Clark, Jose Barrera, John G. G. Neilan, Max V. V. Rasmussen
Summary: We evaluated four DNA vaccine candidates for their ability to produce virus-like particles (VLPs) and elicit a protective immune response against Foot-and-mouth disease virus (FMDV) in cattle. However, none of the DNA vaccine candidates elicited protection from clinical disease when administered independently. Administration of pTarget O1P1-3C plasmid enhanced neutralizing antibody titers when used as a priming dose prior to administration of a conditionally licensed adenovirus-vectored FMD vaccine.
Review
Immunology
Zhimin Lu, Shu Yu, Weijun Wang, Wenxian Chen, Xinyan Wang, Keke Wu, Xiaowen Li, Shuangqi Fan, Hongxing Ding, Lin Yi, Jingding Chen
Summary: FMD is a serious disease that affects the global livestock industry, and the development of vaccines plays a key role in controlling outbreaks of FMD.
Article
Veterinary Sciences
Geoff Jones, Cord Heuer, Wes Johnson, Douglas Begg, Andrew McFadden, Ashish Sutar, Ronello Abila, Clare Browning, Ginette Wilsden, Anna B. Ludi, Syseng Khounsy, Supatsak Subharat
Summary: To control foot-and-mouth disease through vaccination, it is important to have sufficient population coverage and high vaccine efficacy in the field. Post-vaccination surveys can be conducted to monitor vaccine coverage and performance. Understanding the performance of serological tests is crucial for accurate interpretation of data.
PREVENTIVE VETERINARY MEDICINE
(2023)
Article
Veterinary Sciences
Gerelmaa Ulziibat, Eran Raizman, Amarsanaa Lkhagvasuren, Chris J. M. Bartels, Orgikhbayar Oyun-Erdene, Bodisaikhan Khishgee, Clare Browning, Donald P. King, Anna B. Ludi, Nicholas A. Lyons
Summary: Vaccines are crucial in controlling foot-and-mouth disease outbreaks in Mongolia, but logistical challenges make delivering a two-dose primary vaccination course difficult in nomadic pastoralist systems. While highly potent vaccines have shown prolonged immunity, their effectiveness in field conditions with commercially available vaccines has not been confirmed. This study compared neutralizing titres in Mongolian sheep and cattle vaccinated with either a two-dose primary course or a single double-dose vaccine over a 6-month period. The results suggest that the single double-dose regimen may be a cost-effective approach for FMD control in Mongolia.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Biao Wang, Sijin Liu, Haoting Li, Weidong Dong, Haiyun Liu, Jun Zhang, Chao Tian, Suwei Dong
Summary: This study demonstrates the potential of self-assembling glycopeptide conjugates (GPCs) as vaccine adjuvants. The GPCs are capable of promoting receptor-mediated endocytosis and inducing immune cell maturation, leading to enhanced antibody production. The findings highlight the versatility and biological functions of carbohydrates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Immunology
Kay Childs, Yongjie Harvey, Ryan Waters, Timothy Woma, Ginette Wilsden, Hualu Sun, Peng Sun, Julian Seago
Summary: Foot-and-mouth disease is a highly contagious viral disease of livestock that has a severe economic impact on the agriculture industry in many regions. Current vaccines are not effective against the contemporary strains of the disease, particularly in East Africa. Researchers have identified stable strains of the virus and developed a quadrivalent vaccine that generates high neutralizing antibody titers and provides good cross-protection against regional strains.
Article
Multidisciplinary Sciences
Aiguo Zhang, Deyin Li, Chao Song, Huiyuan Jing, Hongfei Li, Junxian Mi, Guizhi Zhang, Shuangxing Jin, Xiaoli Ren, Heping Huangfu, Dongmei Shi, Ruiai Chen
Summary: The combination of TLR ligands pam2CSK4, poly (I:C) and imiquimod can effectively enhance immune responses to H9N2 avian influenza virus in duck. This finding is of great importance for the development of waterfowl vaccines.
Article
Immunology
Romina Cecilia Russi, Diego del Balzo, Ivana Gabriela Reidel, Mariano Alonso Bivou, Noelia Flor, Agustin Lujan, Diego Sanchez, Maria Teresa Damiani, Carolina Veaute
Summary: This study evaluated a vaccine based on a fragment of the Polymorphic membrane protein D (FPmpD) of C. trachomatis as an immunogen using a DNA prime-protein boost strategy. The results showed that both free recombinant FPmpD and recombinant FPmpD formulated with adjuvants increased the titers of anti-rFPmpD antibodies in mice and induced a rapid and robust humoral immune response upon Ct challenge. However, the adjuvant-containing vaccine formulations were more effective in reducing Ct shedding and preventing immunopathology compared to the vaccine with free rFPmpD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yun-Jung Hwang, Kyung-Kwan Lee, Jong-Won Kim, Kwang-Hyo Chung, Sang-Jick Kim, Wan-Soo Yun, Chang-Soo Lee
Summary: The study introduces an optical and electrochemical dual-modal approach for the specific detection of foot-and-mouth disease virus serotypes O and A, offering high sensitivity and accuracy.
Article
Cell Biology
Lei Feng, Yong-Yu Gao, Mingwei Sun, Zi-Bin Li, Qiang Zhang, Jie Yang, Cui Qiao, Hang Jin, Hong-Sheng Feng, Yu-Han Xian, Jianxun Qi, George F. F. Gao, William J. J. Liu, Feng-Shan Gao
Summary: This study identifies a series of T-cell epitopes with high binding capacity, which can be used for the development of universal vaccines.
Article
Virology
Naoko Uno, Ted M. Ross
Summary: The study developed four independent DENV envelope glycoproteins using COBRA methodology to induce broadly neutralizing antibodies against all four serotypes, demonstrating a broad protective immune response in rhesus macaques.
JOURNAL OF VIROLOGY
(2021)
