Review
Biochemistry & Molecular Biology
Vladimir Baran, Alexandra Mayer
Summary: After fertilization, the remodeling of the oocyte and sperm genome is crucial for the successful initiation of mitotic activity in the fertilized oocyte and subsequent proliferation of the early embryo. The specific nature of gene totipotency in early cleavage embryos leads to differences in cell cycle control mechanisms compared to somatic cells. This review focuses on the Chk1 kinase as an important factor in monitoring DNA integrity during early embryogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xinyu Yang, Xinjie Chen, Shaosen Zhang, Wenyi Fan, Ce Zhong, Tianyuan Liu, Guoyu Cheng, Liang Zhu, Qingyi Liu, Yiyi Xi, Wen Tan, Dongxin Lin, Chen Wu
Summary: This study investigates the mechanisms driving radioresistance in esophageal squamous-cell carcinoma (ESCC) by analyzing patient-derived xenografts (PDXs). The findings reveal the enrichment of collagen type 1 (Col1) derived from cancer-associated fibroblasts (CAF) and CXCL1 derived from tumor cells in non-responsive PDXs. Col1 not only promotes radioresistance by enhancing DNA repair capacity but also induces CXCL1 secretion in tumor cells. Additionally, CXCL1 further activates CAFs via the CXCR2-STAT3 pathway, establishing a positive feedback loop. Interfering with tumor-cell-derived CXCL1 or inhibiting the CXCL1-CXCR2 pathway effectively restores the radiosensitivity of radioresistant xenografts in vivo.
Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mateusz Kciuk, Adrianna Gieleci, Somdutt Mujwar, Mariusz Mojzych, Renata Kontek
Summary: The cyclin-dependent kinase (CDK) family plays a critical role in regulating transcription and cell-cycle progression. Recent studies have revealed their involvement in DNA damage response (DDR) and repair, impacting the fidelity of cell division and maintenance of genomic integrity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Michal Zaluski, Izabela Gutowska
Summary: Cyclin-dependent kinases are crucial in various cellular processes and their dysregulation can lead to diseases, making them potential drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pathology
Sami G. Almalki
Summary: The cell cycle consists of interphase and mitosis, with interphase further divided into G1, S, and G2 phases. The cell grows and prepares for DNA synthesis during G1, undergoes DNA synthesis in S phase, and continues to grow and prepare for mitosis in G2. After mitosis, cytokinesis occurs, resulting in two daughter cells. Dysregulation of the cell cycle is a hallmark of cancer and can contribute to its development and progression. Cyclin inhibitors and checkpoint activators show promise in cancer treatment, especially in combination with other therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yu-Hsueh Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang
Summary: The study showed that the expressions of WEE1 and phosphorylated CDK1 in specimens of OSCC are important for predicting the recurrence and progression of OSCC. Low WEE1 expression is associated with OSCC recurrence, while low phosphorylated CDK1 expression is associated with larger tumor size and more advanced clinical stages of OSCC.
JOURNAL OF DENTAL SCIENCES
(2022)
Review
Cell Biology
Rustem Uzbekov, Claude Prigent
Summary: All living organisms are composed of cells, which undergo cell division to reproduce and form a whole organism. Cell division is a highly regulated process that follows a sequence of events known as the cell cycle. The universality of the cell cycle is attributed to the shared genetic information encoded by the DNA double helix in all organisms.
Review
Cell Biology
Aleksandra J. Pluta, Cecilia Studniarek, Shona Murphy, Chris J. Norbury
Summary: This article discusses the important roles of structurally related cyclin-dependent protein kinases (CDKs) in eukaryotic cell function, highlighting their roles in cell cycle regulation and transcriptional regulation, and the overlap between these processes.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Cell Biology
Sargun Sokhi, Cody W. Lewis, Amirali B. Bukhari, Joanne Hadfield, Edric J. Xiao, Jeremy Fung, Yea Jin Yoon, Wen-Hsin Hsu, Armin M. Gamper, Gordon K. Chan
Summary: Cell cycle checkpoint kinases are important targets for cancer therapy, and their inhibition can induce cell death or increase sensitivity to other genotoxic therapies. In this study, the researchers found that the overexpression of Myt1, a kinase regulating cell cycle progression, confers resistance to inhibitors of other kinases. Elevated Myt1 levels compensate for Cdk1 inhibition and lead to reduced premature mitotic entry and decreased length of mitosis, ultimately increasing cell survival rates. The findings suggest that Myt1 overexpression is a common mechanism by which cancer cells acquire resistance to drugs targeting the G2/M checkpoint.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucie Knoblochova, Tomas Duricek, Michaela Vaskovicova, Chrysoula Zorzompokou, Diana Rayova, Ivana Ferencova, Vladimir Baran, Richard M. Schultz, Eva R. Hoffmann, David Drutovic
Summary: Checkpoint kinase CHK1 regulates cell cycle progression in early mouse embryos by restraining CDK1 kinase activity through CDC25A phosphatase degradation. It also ensures the long G2 phase needed for genome activation and reprogramming gene expression in two-cell stage mouse embryos. Depletion of CHK1 leads to DNA damage and chromosome segregation errors, resulting in aneuploidy and infertility.
Article
Microbiology
Yanfei Zhang, Matteo Barberis
Summary: Coordination between cell cycle and metabolism is important for cell division and new cell construction. Cyclin-dependent kinases (Cdks) play a crucial role in this coordination, regulating cell division. This study reveals the possible impact of cell cycle mechanisms on cellular metabolism, finding that certain metabolic enzymes may be phosphorylated by Cdks, affecting their activities and metabolic regulation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Irena Baranowska-Bosiacka, Katarzyna Kulczycka, Izabela Gutowska
Summary: Recent studies have shown that small molecule drugs targeting CDK inhibitors have become attractive options for treating cancer and neurodegenerative disorders. Most CDK inhibitors target the ATP binding pocket, but the similarity in structure among CDK kinases makes achieving selectivity challenging. Therefore, inhibitors binding outside the ATP binding site have attracted great interest for their potential applications in the biomedical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Fatemeh Sadoughi, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Forough Alemi, Bahman Yousefi
Summary: Our genome undergoes tens of thousands of harms and damages daily, and cells have sophisticated mechanisms to repair them to maintain genome stability; Cells must sustain the integrity of genetic content, and mediators play a crucial role in transmitting DNA damage signals to prevent defective DNA replication.
Article
Chemistry, Medicinal
James F. Blake, Nicholas C. Kallan, Dengming Xiao, Rui Xu, Josef R. Bencsik, Nicholas J. Skelton, Keith L. Spencer, Ian S. Mitchell, Richard D. Woessner, Susan L. Gloor, Tyler Risom, Stefan D. Gross, Matthew Martinson, Tony H. Morales, Guy P. A. Vigers, Barbara J. Brandhuber
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2010)
Article
Chemistry, Medicinal
Nicholas C. Kallan, Keith L. Spencer, James F. Blake, Rui Xu, Justin Heizer, Josef R. Bencsik, Ian S. Mitchell, Susan L. Gloor, Matthew Martinson, Tyler Risom, Stefan D. Gross, Tony H. Morales, Wen-I Wu, Guy P. A. Vigers, Barbara J. Brandhuber, Nicholas J. Skelton
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Chemistry, Medicinal
Rui Xu, Anna Banka, James F. Blake, Ian S. Mitchell, Eli M. Wallace, Josef R. Bencsik, Nicholas C. Kallan, Keith L. Spencer, Susan L. Gloor, Matthew Martinson, Tyler Risom, Stefan D. Gross, Tony H. Morales, Wen-I Wu, Guy P. A. Vigers, Barbara J. Brandhuber, Nicholas J. Skelton
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Oncology
Kurtis D. Davies, P. LouAnn Cable, Jennifer E. Garrus, Francis X. Sullivan, Ira von Carlowitz, Yvan Le Huerou, Eli Wallace, Richard D. Woessner, Stefan Gross
CANCER BIOLOGY & THERAPY
(2011)
Article
Oncology
B. Z. Carter, D. H. Mak, R. Woessner, S. Gross, W. D. Schober, Z. Estrov, H. Kantarjian, M. Andreeff
Article
Oncology
Amir T. Fathi, Omotayo Arowojolu, Ian Swinnen, Takashi Sato, Trivikram Rajkhowa, Donald Small, Fredrik Marmsater, John E. Robinson, Stefan David Gross, Matthew Martinson, Shelley Allen, Nicholas C. Kallan, Mark Levis
Article
Chemistry, Medicinal
Steve Wenglowsky, Li Ren, Kateri A. Ahrendt, Ellen R. Laird, Ignacio Aliagas, Bruno Alicke, Alex J. Buckmelter, Edna F. Choo, Victoria Dinkel, Bainian Feng, Susan L. Gloor, Stephen E. Gould, Stefan Gross, Janet Gunzner-Toste, Joshua D. Hansen, Georgia Hatzivassiliou, Bonnie Liu, Kim Malesky, Simon Mathieu, Brad Newhouse, Nicholas J. Raddatz, Yingqing Ran, Sumeet Rana, Nikole Randolph, Tyler Risom, Joachim Rudolph, Scott Savage, LeAnn T. Selby, Michael Shrag, Kyung Song, Hillary L. Sturgis, Walter C. Voegtli, Zhaoyang Wen, Brandon S. Willis, Richard D. Woessner, Wen-I Wu, Wendy B. Young, Jonas Grina
ACS MEDICINAL CHEMISTRY LETTERS
(2011)
Article
Oncology
Tammie C. Yeh, Vivienne Marsh, Bryan A. Bernat, Josh Ballard, Heidi Colwell, Ron J. Evans, Janet Parry, Darin Smith, Barbara J. Brandhuber, Stefan Gross, Allison Marlow, Brian Hurley, Joe Lyssikatos, Patrice A. Lee, James D. Winkler, Kevin Koch, Eli Wallace
CLINICAL CANCER RESEARCH
(2007)
Article
Cell Biology
JL Maller, MS Schwab, SD Gross, FE Taieb, BT Roberts, BJ Tunquist
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2002)
Article
Biochemistry & Molecular Biology
SD Gross, AL Lewellyn, JL Maller
JOURNAL OF BIOLOGICAL CHEMISTRY
(2001)
Review
Cell Biology
JL Maller, MS Schwab, BT Roberts, SD Gross, FE Taieb, BJ Tunquist
BIOLOGY OF THE CELL
(2001)
Article
Biochemistry & Molecular Biology
FE Taieb, SD Gross, AL Lewellyn, JL Maller
Article
Biochemistry & Molecular Biology
MS Schwab, BT Roberts, SD Gross, BJ Tunquist, FE Taieb, AL Lewellyn, JL Maller
Article
Biochemistry & Molecular Biology
SD Gross, MS Schwab, FE Taieb, AL Lewellyn, YW Qian, JL Maller