Article
Oncology
Sen Li, Chenyang Zhao, Jinlan Gao, Xinbin Zhuang, Shuang Liu, Xuesha Xing, Qi Liu, Chen Chen, Shusen Wang, Yang Luo
Summary: Cyclin G2 serves as a potent tumor suppressor in glioma by inhibiting tumor growth and promoting apoptosis. Its mechanism involves suppressing LDHA phosphorylation, reversing immunosuppression, and enhancing responses to immunotherapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Kai Yu, Yulong Ji, Min Liu, Fugeng Shen, Xiaoxing Xiong, Lijuan Gu, Tianzhu Lu, Yingze Ye, Shi Feng, Jianying He
Summary: In this study, the researchers found that CKS2 is overexpressed in glioma and is associated with the prognosis of overall survival in patients. The methylation status of CKS2 is negatively correlated with its expression level, and CKS2 expression is closely related to tumor immunity. Silencing CKS2 can inhibit the proliferation and invasion of glioma cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Shigeo Ohba, Yongjian Tang, Tor-Christian Aase Johannessen, Joydeep Mukherjee
Summary: PKM2 interacts with and enhances the activation of the Cdk1-cyclin B complex, thereby directly controlling the progression of mitosis and the growth of brain tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Neurosciences
Ling-Kai Shih, Subhas Mukherjee, Daniel J. Brat
Summary: The relationship between glioma stem cells (GSCs) and normal neural stem cells (NSCs) has been established, and cyclin-dependent kinases (CDKs) play important roles in regulating cell cycle as well as neuronal survival, metabolism, differentiation, and self-renewal. Understanding the connection between cell cycle regulation and self-renewing division provides new opportunities for therapeutically targeting glioblastoma (GBM).
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Bin Liu, Gang Zhang, Shukun Cui, Guoliang Du
Summary: KIF11 is upregulated in glioma tumors and negatively correlated with overall survival outcomes; It promotes stemness in glioma cells, cell proliferation, and chemoresistance; KIF11 promotes cell cycle progression by upregulating cyclin expression.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Summary: Many psychiatric disorders are associated with deficits in cognitive functions and synaptic plasticity, which are linked to abnormal lipid modifications of neuronal proteins. Cyclin Y (CCNY), located in the postsynaptic compartment, plays an inhibitory role in synaptic plasticity and spatial learning through myristoylation and palmitoylation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Oncology
Yue Xiao, Xinyi Chen, Weiwei Hu, Wenjing Ma, Qianqian Di, Haimei Tang, Xibao Zhao, Guodong Huang, Weilin Chen
Summary: The research finds that USP39 interacts with Cyclin B1 and stabilizes its expression by deubiquitinating Cyclin B1. The overexpression of USP39 promotes the proliferation of human glioma cells and is positively correlated with the expression levels of Cyclin B1. The study suggests that USP39 is a novel deubiquitinating enzyme of Cyclin B1 and promotes tumor cell proliferation through Cyclin B1 stabilization.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Ki Sung Park, Ji Eun Park, Sung Soo Ahn, Inho Park, Ho Sung Kim, Jong Hee Chang, Seung-Koo Lee, Se Hoon Kim
Summary: Qualitative and quantitative MRI parameters, including infiltrative pattern, maximal diameter, and the 95th percentile of normalized cerebral blood volume (nCBV), were found to be independent predictors of CDKN2A/B homozygous deletion in IDH-mutant astrocytomas. The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may serve as useful MRI biomarkers for identifying CDKN2A/B homozygous deletion in these tumors.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meimei Li, Boliao Li, Qi Yang, Yanying Li, Junxiang Wu, Xiangli Xu
Summary: In this study, we identified 50 neuropeptides including neuropeptide Y (NPY) of Mythimna separata using transcriptome sequencing. The spatial and temporal expression profile of NPY indicated its important role in feeding regulation and energy metabolism. Knockdown of NPY significantly inhibited food uptake and body weight, delayed developmental duration, and altered energy storage in M. separata larvae.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Andrea Molinas, Stephanie Heil, Stefan Koch
Summary: While the CCNY gene has been implicated in the pathogenesis of inflammatory bowel disease, a study investigating the role of cyclin Y in intestinal epithelial cells found that its absence did not significantly affect cell proliferation or disease activity. The low expression of cyclin-Y-associated CDKs in IECs suggests that cyclin Y may not play a crucial role in intestinal epithelial homeostasis, casting doubt on CCNY mutations as causative factors in IBD.
Review
Cell Biology
Aleksandra Opacka, Agnieszka Zuryn, Adrian Krajewski, Klaudia Mikolajczyk
Summary: CCNY, as a member of the cyclin family, is involved in cell division and tumor transformation. It affects cell migration and invasion through mechanisms such as inhibition of protein activation and promotion of protein phosphorylation. This review aims to evaluate the expression of CCNY in physiological processes and compare its expression in cancer cells to understand its impact on tumor progression.
Article
Genetics & Heredity
Wenyi Zhang, Pengchao Wang, Yiwei Xiong, Tianyong Chen, Sufei Jiang, Hui Qiao, Yongsheng Gong, Yan Wu, Shubo Jin, Hongtuo Fu
Summary: This study investigated the regulatory roles of Cyclin B (CycB) in the reproductive development of male oriental river prawns. The results showed that CycB plays essential roles in both testis and ovary development in Macrobrachium nipponense. In males, Cyclin B expression was higher during the reproductive season and positively affected testis development. RNA interference analysis revealed that CycB positively affects testis development by influencing the expression of Mn-insulin-like androgenic gland hormone. This study highlights the functions of CycB in M. nipponense and its potential application in studying male reproductive development in other crustacean species.
Article
Neurosciences
Hongik Hwang, Young-Na Hur, Heesung Sohn, Jiyeon Seo, Jung-Hwa Hong, Eunsil Cho, Yuri Choi, Saebom Lee, Seongeun Song, A-Ram Lee, Suyeon Kim, Dong-Gyu Jo, Hyewhon Rhim, Mikyoung Park
Summary: The study reveals that CCNY negatively regulates plasticity-induced changes in spine morphology by controlling actin dynamics. By blocking the activation of cofilin, an actin-depolymerizing factor, CCNY directly binds to filamentous actin and interferes with LTP-induced actin polymerization and depolymerization, resulting in fewer plastic spines and impairment of structural LTP.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Cell Biology
Xiaoting Zhao, Mei Jiang, Yu Teng, Jie Li, Zhefeng Li, Wende Hao, Hongyu Zhao, Chenghong Yin, Wentao Yue
Summary: Cyclin Y (CCNY) plays a crucial role in tumor progression, especially in promoting cell motility and invasion through its CCNYc isoform which interacts with PFTK1 to regulate cell metastasis via TPM4 and F-actin formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Florian Heigwer, Christian Scheeder, Josephine Bageritz, Schayan Yousefian, Benedikt Rauscher, Christina Laufer, Sergi Beneyto-Calabuig, Maja Christina Funk, Vera Peters, Maria Boulougouri, Jana Bilanovic, Thilo Miersch, Barbara Schmitt, Claudia Blass, Fillip Port, Michael Boutros
Summary: This article reports a study that utilizes synthetic genetic interaction and cell morphology data to investigate gene function. They used machine learning to assign functions to genes in 47 modules and identified an interaction between Cdk2 and the Cop9 signalosome complex. These data provide a genome-scale resource for uncovering the mechanisms underlying genetic interactions and their plasticity at the single-cell level.
