Article
Biochemistry & Molecular Biology
Zhenlin Wang, Yuping Shi, Chenting Ying, Yang Jiang, Jiangfeng Hu
Summary: PLOD1 is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer, particularly associated with the progression of the most malignant mesenchymal subtype in GBM. Molecular experiments and tumor xenograft models demonstrated that PLOD1 overexpression promotes tumor viability, proliferation, migration, and mesenchymal transition, with an association to the NF-kappa B signaling pathway. High PLOD1 expression may be a potential treatment target for mesenchymal GBM or even all GBM by enhancing tumor invasiveness.
Article
Multidisciplinary Sciences
Xuehua Zhang, Guoyan Wang, Yujiao Gong, Leilei Zhao, Ping Song, He Zhang, Yurui Zhang, Huanyu Ju, Xiaoyu Wang, Bin Wang, Huan Ren, Xiao Zhu, Yucui Dong
Summary: The interaction between TGF-beta and EGFRvIII induces the expression and secretion of IGFBP3, promoting the development of GBM. Blocking IGFBP3 may be an additional target in the therapeutic strategy for EGFRvIII-expressing GBM.
Article
Oncology
Hongzhi Li, Xiang Li, Shanshan Yu, Yanling Hu, Licheng Xu, Tianhe Wang, Xiaohong Yang, Xinyi Sun, Binghai Zhao
Summary: NAFLD is the most common liver disease globally, especially in developing countries. Hepatic MicroRNAs have been found to play a crucial role in NAFLD by controlling lipid metabolism, inflammation, and fibrosis. This study discovered that MicroRNA-23b may regulate lipid metabolism in NAFLD through its interaction with Acot4.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Penghui Song, Jianjun Wu, Jianbing Chen, Fang Wang, Jingmei Chen, Guanyu Wang
Summary: This study clarifies the role and molecular mechanisms of circ-ADAM9 in breast cancer. It shows that inhibition of circ-ADAM9 impairs proliferation, migration, and invasion of breast cancer cells, and increases radiosensitivity. Circ-ADAM9 regulates the behavior of breast cancer cells through the miR-383-5p/PFN2 axis.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Cell Biology
Yinan Wang, Chuan He Yang, Andrew P. Schultz, Michelle M. Sims, Duane D. Miller, Lawrence M. Pfeffer
Summary: BRG1 promotes invasion and migration, and decreases chemotherapy sensitivity in GBM cells, indicating its oncogenic role in this deadly form of brain cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Longzhou Zhang, Zengjin Liu, Yang Dong, Lingchang Kong
Summary: Epigenetic abnormalities, particularly in histone acetylation, are closely linked to cancer initiation. In this study, researchers found that the downregulation of SLC30A3 and the overexpression of HDAC1 in glioblastoma tissues play crucial roles in tumor growth and metastasis. Targeting SLC30A3 by HDAC1 and SE could potentially serve as a therapeutic strategy for glioblastoma.
Article
Biochemistry & Molecular Biology
Ming Chen, Bryan Kim, Neil Robertson, Sujan Kumar Mondal, Zdravka Medarova, Anna Moore
Summary: Recent studies have shown that inhibition of miR-10b can enhance the cytotoxicity of conventional glioblastoma multiforme (GBM) chemotherapy. This study explored the potential of using MN-anti-miR10b to inhibit miR-10b expression in glioblastoma cells and enhance the cytotoxic effect of temozolomide (TMZ) chemotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Wei Zhang, Kai Liao, Dongning Liu
Summary: miR-744-5p, frequently downregulated in colorectal cancer, inhibits proliferation and promotes apoptosis of CRC cells by targeting SEPT2, suggesting its potential as a therapeutic target for CRC patients.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Lihang Wang, Yun Wang, Tingsheng Lu, Chunshan Luo, Bing Qiu, Shishu Huang, Yunfeng Lin
Summary: In the treatment of rheumatoid arthritis, tetrahedral framework nucleic acid loaded miR-23b (T-23b) inhibits systemic and synovial inflammation by suppressing the production of multiple inflammatory cytokines. It also prohibits osteoclastic activity and cartilage matrix degradation to help protect joint structure by regulating the expression of related genes at the transcriptional level.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Oncology
Jiahui Zhao, Qiankun Li, Bingfu Feng, Dechao Wei, Yili Han, Mingchuan Li, Yongxing Wang, Yong Luo, Yongguang Jiang
Summary: The study revealed that miR-149 acts as a tumor suppressor in CRPC by inhibiting AR expression, inducing apoptosis and cell cycle arrest, and reducing the functional activity of the PI3K/Akt1 signaling pathway by targeting Akt1 protein. These findings suggest that the miR-149/Akt1/AR regulatory pathway may serve as a novel therapeutic target for prostate cancer.
Article
Neurosciences
Kemeng Pan, Song Chen, Yue Wang, Wenbing Yao, Xiangdong Gao
Summary: The study investigates the potential therapeutic effects of microRNA-23b (miR-23b) on Alzheimer's disease by targeting GnT-III, highlighting its role in improving cognitive impairment, neurotoxicity, tau, and amyloid pathology. The research also shows that miR-23b can inhibit tau lesion formation by activating the Akt/GSK-3 beta signaling pathway and reduce oxidative stress by altering Aβ precursor protein processing. Overall, overexpression of miR-23b can disrupt the pathogenesis of AD.
Article
Biochemistry & Molecular Biology
Susanne Flor, Claudia R. Oliva, Md Yousuf Ali, Kristen L. Coleman, Jeremy D. Greenlee, Karra A. Jones, Varun Monga, Corinne E. Griguer
Summary: Glioblastoma, the deadliest form of brain cancer, often becomes resistant to standard treatments due to the upregulation of antioxidant catalase (CAT) which enhances resistance to chemotherapy and radiation, decreases survival rates, and enriches glioma stem cell populations.
Article
Oncology
Yibing Li, Jianing Huo, Junjian He, Xiaoxin Ma
Summary: This study found that MONC inhibits the malignant phenotypes of ECSCs and ECCs by regulating the miR-636/GLCE axis. The MONC/miR-636/GLCE axis may provide novel treatment avenues for human EC. The tumor suppressive effect of MONC in nude mice was also verified in this study, with miR-636 rescuing the effect of overexpressing MONC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yu-Qi Liu, Min Luo, Yu Shi, Ying Guo, Hua Zhang, Kai-Di Yang, Tian-Ran Li, Liu-Qing Yang, Ting-Ting Liu, Bo Huang, Qing Liu, Zhi-Cheng He, Xiao-Ning Zhang, Wen-Ying Wang, Shuai Wang, Hui Zeng, Qin Niu, Xia Zhang, You-Hong Cui, Zhi-Ren Zhang, Xiu-Wu Bian, Yi-Fang Ping
Summary: This study found that the genetic deletion of miRNA-processing enzyme Dicer in macrophages can inhibit the growth of glioblastoma and prolong the survival of tumor-bearing mice. The deletion of Dicer in macrophages can change their phenotype, promoting a proinflammatory activation state with enhanced phagocytosis and interferon production, thus improving the ability to eliminate tumor cells.
Article
Neurosciences
Jueqiong Wang, Huanhuan Sun, Ruoyi Guo, Jiangyuan Guo, Xinyi Tian, Jinli Wang, Shichao Sun, Yusen Han, Ying Wang
Summary: Recent studies have shown that exosomes obtained from bone marrow mesenchymal stem cells (BMSCs) have promising therapeutic potential in treating multiple sclerosis (MS). This study investigated the mechanism of BMSC-exos containing miR-23b-3p in both LPS-stimulated BV2 microglia and an animal model for MS. The results demonstrated that BMSC-Exos containing miR-23b-3p reduced microglial pyroptosis and alleviated the severity of EAE, providing new insights into the therapeutic potential of BMSC-Exos for MS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Xingliang Dai, Yunfei Wang, Xuchen Dong, Minfeng Sheng, Haiyang Wang, Jia Shi, Yujing Sheng, Liang Liu, Qianqian Jiang, Yanming Chen, Bingshan Wu, Xuejun Yang, Hongwei Cheng, Chunsheng Kang, Jun Dong
Review
Immunology
Na Zhang, Li Wei, Meng Ye, Chunsheng Kang, Hua You
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ying Cai, Eryan Yang, Xiuhua Yao, Xuebin Zhang, Qixue Wang, Yunfei Wang, Ji Liu, Weijia Fan, Kaikai Yi, Chunsheng Kang, Jialing Wu
Summary: tPA exerts neuroprotective effects by increasing phosphorylation of AMPK and expression of FUNDC1, thereby inhibiting apoptosis and improving mitochondrial function.
Review
Oncology
Luyue Chen, Kai Huang, Kaikai Yi, Yanlin Huang, Xinhua Tian, Chunsheng Kang
Review
Oncology
Tao Jiang, Do-Hyun Nam, Zvi Ram, Wai-Sang Poon, Jiguang Wang, Damdindorj Boldbaatar, Ying Mao, Wenbin Ma, Qing Mao, Yongping You, Chuanlu Jiang, Xuejun Yang, Chunsheng Kang, Xiaoguang Qiu, Wenbin Li, Shaowu Li, Ling Chen, Xuejun Li, Zhixiong Liu, Weimin Wang, Hongmin Bai, Yu Yao, Shouwei Li, Anhua Wu, Ke Sai, Guilin Li, Kun Yao, Xinting Wei, Xianzhi Liu, Zhiwen Zhang, Yiwu Dai, Shengqing Lv, Liang Wang, Zhixiong Lin, Jun Dong, Guozheng Xu, Xiaodong Ma, Wei Zhang, Chuanbao Zhang, Baoshi Chen, Gan You, Yongzhi Wang, Yinyan Wang, Zhaoshi Bao, Pei Yang, Xing Fan, Xing Liu, Zheng Zhao, Zheng Wang, Yiming Li, Zhiliang Wang, Guanzhang Li, Shengyu Fang, Lianwang Li, Yanwei Liu, Shuai Liu, Xia Shan, Yuqing Liu, Ruichao Chai, Huimin Hu, Jing Chen, Wei Yan, Jinquan Cai, Hongjun Wang, Lingchao Chen, Yuan Yang, Yu Wang, Lei Han, Qixue Wang
Summary: The joint guideline committee of Chinese Glioma Cooperative Group, Society for Neuro-Oncology of China, and Chinese Brain Cancer Association has updated the clinical practice guideline to provide recommendations for the diagnosis and management of diffuse gliomas. The guidelines focus on molecular and pathological diagnostics, as well as main treatment modalities including surgery, radiotherapy, and chemotherapy. Additionally, the guidelines integrate results from clinical trials of immune therapies and target therapies as future directions.
Article
Oncology
Jixing Zhao, Shixue Yang, Xiaoteng Cui, Qixue Wang, Eryan Yang, Fei Tong, Biao Hong, Menglin Xiao, Lei Xin, Can Xu, Yanli Tan, Chunsheng Kang
Summary: Researchers have discovered a small-molecule inhibitor called EPIC-0412 that enhances the effectiveness of the chemotherapy drug TMZ in treating GBM. By disrupting DNA damage repair pathways and targeting MGMT, EPIC-0412 sensitizes GBM cells to TMZ and induces cell cycle arrest and apoptosis. The study also shows that EPIC-0412 epigenetically silences MGMT through specific pathways.
Editorial Material
Oncology
Xing Liu, Chunsheng Kang
Article
Oncology
Lei Xin, Yanli Tan, Yuanxue Zhu, Xiaoteng Cui, Qixue Wang, Jixing Zhao, Shaohui Tian, Can Xu, Menglin Xiao, Biao Hong, Jianglong Xu, Xiaoye Yuan, Changsheng Wang, Chunsheng Kang, Chuan Fang
Summary: This study identified a potential small-molecule inhibitor, EPIC-0307, that selectively disrupted the PRADX-EZH2 interaction to upregulate expressions of tumor suppressor genes, thereby exerting its antitumor effects on GBM cells. EPIC-0307 treatment also increased the chemotherapeutic efficacy of TMZ by epigenetically downregulating DNA repair-associated genes and MGMT expression in GBM cells.
Review
Oncology
Xiaoteng Cui, Yunfei Wang, Junhu Zhou, Qixue Wang, Chunsheng Kang
Summary: Malignant gliomas are difficult to diagnose and treat due to their infiltrative growth pattern, rapid progression, and poor prognosis. Temozolomide (TMZ) is the only first-line chemotherapeutic drug for malignant gliomas that can cross the blood-brain barrier, but some patients are insensitive to TMZ and can develop acquired resistance during treatment.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Oncology
Kaikai Yi, Qi Zhan, Qixue Wang, Yanli Tan, Chuan Fang, Yunfei Wang, Junhu Zhou, Chao Yang, Yansheng Li, Chunsheng Kang
Summary: This study revealed that PTRF promotes GBM tumor proliferation and suppresses immune responses through a lipid remodeling pathway involving cPLA2. The overexpression of PTRF alters the metabolism of cells, affecting the growth and immune infiltration of GBM tumors. These findings highlight new therapeutic targets for GBM treatment.
Article
Engineering, Multidisciplinary
Long LiXia, Cheng LinJie, Hou JingJing, Wang LiMei, Wang Xu, He LiGang, Li SiDi, Zhao Jin, Hou Xin, Kang ChunSheng, Yuan XuBo
Summary: Increasing the branching degree of star-branched copolymers can improve the blood circulation and tumor-targeting effects of polymeric nanovehicles in vivo, allowing the payload to persist longer in the bloodstream.
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lin Wang, Junhu Zhou, Qixue Wang, Yunfei Wang, Chunsheng Kang
Summary: This study proposes a potential anti-SARS-CoV-2 strategy based on the CRISPR-Cas13a system, identifying a specific RNA segment of the spike protein and designing an efficient crRNA sequence for cleavage. It provides a rapid design pipeline for an antiviral tool against SARS-CoV-2 and introduces a novel approach for anti-virus study.
Article
Nanoscience & Nanotechnology
Yadan Zheng, Zhanzhan Zhang, Qi Liu, Yu Zhao, Chunxiong Zheng, Jialei Hao, Kaikai Yi, Ying Wang, Chun Wang, Xinzhi Zhao, Linqi Shi, Chunsheng Kang, Yang Liu
ACS APPLIED BIO MATERIALS
(2020)
Article
Medicine, Research & Experimental
Qi Zhan, Kaikai Yi, Hongzhao Qi, Sidi Li, Xueping Li, Qixue Wang, Yunfei Wang, Chaoyong Liu, Mingzhe Qiu, Xubo Yuan, Jin Zhao, Xin Hou, Chunsheng Kang
Article
Medicine, Research & Experimental
Yansheng Li, Xing Liu, Xiaoteng Cui, Yanli Tan, Qixue Wang, Yunfei Wang, Can Xu, Chuan Fang, Chunsheng Kang
Summary: The study identified a novel cancer driver lncRNA named PRADX in glioblastoma and colon adenocarcinoma, which is highly expressed in tumor cells and tissues. Through various experiments, PRADX was found to interact with EZH2 protein, increase H3K27 trimethylation in the UBXN1 gene promoter, and promote NF-KB activity by suppressing UBXN1. Knockdown of PRADX inhibited tumor cell viability and growth both in vitro and in vivo, suggesting its potential as a therapeutic target for these cancers.