Article
Biology
Beilei Zhang, Zhanghang Li, Kunqin Wang, Mingke Duan, Yidan Yin, Qirui Zhan, Fu Wang, Ruifang An
Summary: Ovarian cancer (OC) is a highly lethal tumor in women, and understanding the role of pyroptosis-related genes (PRGs) in prognosis can help develop new treatment approaches. In this study, a 9-genes based prognostic model was developed for OC patients, and an immune deficiency in the high-risk group was identified as a potential cause for decreased survival. Age, clinical stage, and the prognostic model were independent factors impacting OC prognosis, and a predictive nomogram was created for survival prediction. Additionally, the regulatory axis of lncRNA RP11-186B7.4/hsa-miR-449a/CASP8/ AIM2/ZBP1 was identified in OC, providing potential biomarkers and therapeutic targets.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shaoyi Yang, Jie Ji, Meng Wang, Jinfu Nie, Shujie Wang
Summary: In this study, a prognostic model based on ferroptosis-related lncRNAs was constructed to predict the prognosis and immune response in ovarian cancer patients. This model has the potential to improve our understanding of ferroptosis-related lncRNAs and provide a new tool for prognosis and immune response prediction in ovarian cancer patients.
Article
Reproductive Biology
Chong Wang, Chunxiao Zhang, Shimin Yang, Jiangdong Xiang, Dongmei Zhou, Xiaowei Xi
Summary: Ovarian cancer is a common malignant tumor that seriously threatens women's health. The lack of clinical prognostic predictors can be addressed by using m5c-related lncRNA as a basis to construct a risk model. The study successfully developed a reliable m5c-related prediction model for ovarian cancer, which can be used for prognosis assessment and the discovery of novel biomarkers.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yan-Ming Lu, Ya-Ru Guo, Meng-Ya Zhou, Yue Wang
Summary: The upregulation of lncRNA BC041954 is associated with the development and prognosis of ovarian cancer, suggesting its potential as a prognostic indicator for patients with this disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, General & Internal
Yan Li, Juan Wang, Fang Wang, Chengzhen Gao, Yuanyuan Cao, Jianhua Wang
Summary: This study developed an autophagy-related lncRNA signature for predicting clinical outcomes and therapeutic responses in ovarian cancer.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Yanping Lyu, Shuangfeng Yang, Xuejie Lyu, Yuan-Liang Wang, Shumi Ji, Shuling Kang, Yu Jiang, Jianjun Xiang, Chenzhou He, Peixin Li, Baoying Liu, Chuancheng Wu
Summary: This study reveals the association between genetic polymorphism of lncRNA and the prognosis of gastric cancer, suggesting that it can serve as a predictor for GC prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Kuniko Horie, Kiyoshi Takagi, Toshihiko Takeiwa, Yuichi Mitobe, Hidetaka Kawabata, Takashi Suzuki, Kazuhiro Ikeda, Satoshi Inoue
Summary: Recent advances in RNA studies have identified a novel estrogen-inducible antisense RNA, BNAT1, in ER-positive breast cancer. Silencing of BNAT1 inhibited the growth of tamoxifen-resistant breast cancer cells, repressed cell cycle progression, and promoted apoptosis. BNAT1 may play a critical role in ER-positive breast cancer biology by modulating ER alpha-dependent transcription regulation.
Article
Oncology
Xiaoyan Wang, Yiwen Wang, Fusheng Sun, Yang Xu, Zhaocong Zhang, Chang Yang, Lijie Zhang, Ge Lou
Summary: The upregulated expression of lncRNA ZFHX4-AS1 in ovarian cancer is associated with poor prognosis. Functional and pathway analyses reveal its involvement in cell metabolism, protein synthesis, cell proliferation, and cell cycle. The expression of lncRNA ZFHX4-AS1 affects the infiltration of immune cells such as M2 macrophages, memory B-cells, naive B cells, and activated NK cells. Furthermore, lncRNA ZFHX4-AS1 and its related genes are significantly correlated with immune checkpoints. Knockdown of lncRNA ZFHX4-AS1 inhibits proliferation, invasion, and migration of ovarian cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Lin, Xian Xu, Kelie Chen, Zhiqin Fu, Shengchao Wang, Yaqing Chen, Honghe Zhang, Yuequn Niu, Hanwen Chen, Hongfei Yu, Jian-zhong Shao, Weiguo Lu, Yihua Wu, Dajing Xia
Summary: This paper explores the functional role and molecular mechanism of long noncoding RNA CASC15 in ovarian cancer. In vitro and in vivo experiments validate CASC15 as an oncogenic gene that enhances metastasis in ovarian cancer. It is shown that miR-23b-3p and miR-24-3p directly target CASC15 and CASC15 regulates SMAD3 expression through these microRNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Li Meng, Qianqian Zhang, Xianghua Huang
Summary: This study revealed the presence of dysregulated m5C modifications in human high-grade serous ovarian cancer, which may impact cell proliferation and metabolic pathways in cancer cells. High expression of COL4A3 gene was correlated with poor prognosis in ovarian cancer, indicating its potential as a prognostic marker.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Computer Science, Information Systems
Guoqing Bao, Ran Xu, Xiuying Wang, Jianxiong Ji, Linlin Wang, Wenjie Li, Qing Zhang, Bin Huang, Anjing Chen, Di Zhang, Beihua Kong, Qifeng Yang, Cunzhong Yuan, Xinyu Wang, Jian Wang, Xingang Li
Summary: This study proposed a 5-lncRNA signature for pan-cancer prognosis prediction, which showed better performance in long-term prognostic estimation and was validated in external cohorts. The identified lncRNAs associated with overall survival of pan-cancer patients and may serve as viable molecular targets common among diverse cancers.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Article
Reproductive Biology
Chun Wai Ng, Kwong-Kwok Wong
Summary: This study conducted an updated meta-analysis to investigate the prognostic value of estrogen receptor (ER) subtypes ER alpha and ER beta in ovarian cancer. The findings suggest that higher expression of ER alpha and ER beta is significantly associated with better survival in ovarian cancer patients. However, the choice of specific ER antibody clones used in immunohistochemistry analysis significantly affects the results.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xue Chen, Jian-cheng Ding, Guo-sheng Hu, Xing-yi Shu, Yan Liu, Jun Du, Zi-jing Wen, Jun-yi Liu, Hai-hua Huang, Guo-hui Tang, Wen Liu
Summary: This study identifies a highly expressed estrogen-induced lncRNA, LINC02568, in ER-positive breast cancer, which plays important roles in cell growth, tumorigenesis, and endocrine therapy drug resistance. Mechanistically, LINC02568 regulates estrogen/ERα-induced gene transcriptional activation by stabilizing ESR1 mRNA through sponging miR-1233-5p in the cytoplasm. Additionally, LINC02568 contributes to tumor-specific pH homeostasis by regulating carbonic anhydrase CA12 in the nucleus. The dual functions of LINC02568 contribute to breast cancer progression and drug resistance.
Article
Oncology
D. Gareth Evans, Kelly-Anne Phillips, Roger L. Milne, Robert Fruscio, Cezary Cybulski, Jacek Gronwald, Jan Lubinski, Tomasz Huzarski, Zerin Hyder, Claire Forde, Kelly Metcalfe, Leigha Senter, Jeffrey Weitzel, Nadine Tung, Dana Zakalik, Maria Ekholm, Ping Sun, Steven A. Narod
Summary: This study aimed to estimate the impact of different treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation. The results indicated that bilateral oophorectomy was associated with a reduced risk of death from breast cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Yuanfu Zhang, Peng Han, Qiuyan Guo, Yangyang Hao, Yue Qi, Mengyu Xin, Yafang Zhang, Binbin Cui, Peng Wang
Summary: This study characterized the role of lncRNA somatic mutations in the ceRNA regulatory network in 33 cancers, revealing the impact of high and low-frequency mutations on oncogenic gene expression levels. Experimental verification showed the importance of these mutations in tumor heterogeneity. The study also identified that lncRNAs perturbing ceMs associated with patient survival may serve as biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Oncology
Jun-jun Qiu, Yan Wang, Jing-xin Ding, Hong-yan Jin, Gong Yang, Ke-qin Hua
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yu Deng, He Huang, Jiangcheng Shi, Hongyan Jin
Summary: This study identified several genes, including CCNE2, that may play a role in MHT-related breast cancer development. CCNE2 may serve as a sensitive risk indicator for breast cancer in women using MHT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Tao Ming, Jinping Luo, Yu Xing, Yan Cheng, Juntao Liu, Shuai Sun, Fanli Kong, Shihong Xu, Yuchuan Dai, Jingyu Xie, Hongyan Jin, Xinxia Cai
Summary: Devices for continuous in-vivo testing (CIVT) can detect target substances in real time, providing valuable insights into a patient's condition and treatment response. However, the detection of many key markers remains challenging. This review summarizes the key technologies and methodologies of CIVT and discusses future development directions.
MATERIALS TODAY BIO
(2022)
Article
Business
Xingtai Zhang, Hongyan Jin
Summary: This study conducted two scenario-based experiments to examine the potential influence of smart technology, artificial intelligence, automation, robotics, and algorithms (STAARA) on hotel employees' career perceptions in the hospitality services industry. It found that negative awareness of STAARA leads to higher job insecurity and mobility for hotel employees. However, high-level career progression attenuates the impact of STAARA on job insecurity and mobility.
JOURNAL OF HOSPITALITY MARKETING & MANAGEMENT
(2023)
Article
Automation & Control Systems
Xi-mei Zhao, Yun-wei Gong, Hong-yan Jin, Chi Xu
Summary: In this study, an adaptive super-twisting-based nonsingular fast terminal sliding mode control (AST-NFTSMC) scheme is proposed to reduce the impact of PMLSM servo system on interferences. The mathematical model of PMLSM with uncertainties is established, and a control law is developed to asymptotically converge position signal to a given state. The super-twisting algorithm is introduced to weaken the chattering caused by nonlinear switching function. An adaptive law is further introduced to adjust the switching gains online and weaken chattering. The practicability of AST-NFTSMC is proved in theory and verified by system experiments, which demonstrate its ability to significantly reduce chattering and achieve robust control performance.
TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
(2023)
Article
Chemistry, Multidisciplinary
Fanli Kong, Jinping Luo, Luyi Jing, Yiding Wang, Huayu Shen, Rong Yu, Shuai Sun, Yu Xing, Tao Ming, Meiting Liu, Hongyan Jin, Xinxia Cai
Summary: A sensitive electrochemical aptasensor for detecting the concentration of Doxorubicin (DOX) was developed. The sensor utilized a gold wire as the working electrode and was modified with reduced graphene oxide (rGO)/gold nanoparticles (AuNPs) to enhance sensitivity. An aptamer was used as the recognition element and changes in electron transfer rate induced by the aptamer-DOX binding resulted in current changes correlated with DOX concentration. The aptasensor exhibited good linearity in the concentration range of 0.3 μM to 6 μM with a detection limit of 0.1 μM. Moreover, the aptasensor demonstrated good recovery in real samples, indicating its potential for DOX detection.
Article
Chemistry, Physical
Yue Zhao, Shujie Jiao, Shuo Liu, Yimin Jin, Song Yang, Xianghu Wang, Tong Liu, Hongyan Jin, Dongbo Wang, Shiyong Gao, Jinzhong Wang
Summary: Using thioacetamide additive as a defect passivation agent can greatly improve the quality of CsPbBr3 perovskite films, reducing defect state density and non-radiative recombination, which leads to enhanced performance of the photodetectors.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Physical
Yue Zhao, Shujie Jiao, Shuo Liu, Yimin Jin, Song Yang, Xianghu Wang, Tong Liu, Hongyan Jin, Dongbo Wang, Shiyong Gao, Jinzhong Wang
Summary: A surface passivation strategy based on interface engineering is reported to achieve high-quality CsPbBr3 perovskite films by introducing thioacetamide (TAA) as interface materials, which enhances the photodetection performance and stability.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Obstetrics & Gynecology
He Huang, Guowei Ding, Mei Li, Yu Deng, Yan Cheng, Hongyan Jin
Summary: This study aimed to investigate the prevalence of stress urinary incontinence (SUI) and the associated risk factors in Chinese perimenopausal and postmenopausal women. The results showed that obesity, vaginal delivery, climacteric symptoms, and diabetes were identified as the most notable risk factors for SUI in this population.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Oncology
Xinyu Qu, Yumeng Wang, Qian Jiang, Tingting Ren, Chenyan Guo, Keqin Hua, Junjun Qiu
Summary: This study investigates the mechanism of cervical cancer immune remodeling and explores the potential therapeutic targets. The research suggests that a combination treatment targeting IDO1 and ICB agent could improve the therapeutic efficacy of current cervical cancer immunotherapies.
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Huizhen Huang, Zhiheng Li, Yue Xia, Zhenhua Zhao, Dandan Wang, Hongyan Jin, Fang Liu, Ye Yang, Liyijing Shen, Zengxin Lu
Summary: This study aimed to explore the correlation between tumor-infiltrating CD8(+) and CD4(+) T cells and the quantitative pharmacokinetic parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with advanced gastric cancer. The data of 103 patients with histopathologically confirmed advanced gastric cancer were retrospectively analyzed. The results showed that the radiomics features of DCE-MRI are associated with the expression of tumor-infiltrating CD8(+) and CD4(+) T cells in advanced gastric cancer patients.
PATHOLOGY & ONCOLOGY RESEARCH
(2023)
Article
Obstetrics & Gynecology
Yan Ding, Xuyin Zhang, Junjun Qiu, Chunbo Li, Keqin Hua
Summary: This study evaluated the association between preoperative conization and recurrences after laparoscopic radical hysterectomy for early-stage cervical cancer. The results showed that preoperative conization and the absence of residual tumor were associated with a lower risk of recurrence.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, Research & Experimental
Xiaotong Yu, Jing Yu, Hong Dai, Chenyun Deng, Xudong Sun, Sijie Long, Zhujun Jiang, Hongyan Jin, Zhu Guan, Zhenjun Yang
Summary: The newly developed and optimized delivery system consisting of neutral cytidinyl lipid DNCA/cationic lipid CLD (Mix) effectively enhanced the anti-tumor immunity of cDNs and significantly altered T cell exhaustion (Tex) in tumor-burden mice.
Article
Genetics & Heredity
Kaixin Cao, Hongyan Jin, Haoxin Li, Mengmeng Tang, Jianhong Ge, Zekang Li, Xiaoyun Wang, Xuetao Wei
Summary: The study collected and analyzed clinical data of 7974 singleton, high-risk pregnant women in Peking University First Hospital from 2014 to 2018. It found that exposure to high-level (>= 75 mu g/m(3)) of PM2.5 during the third trimester of pregnancy increases the risk of PTB and ETB. Each 10ug/m(3) increase in PM2.5 significantly affects PTB and ETB during the third trimester and the entire pregnancy in the high-level exposure group.
GENES AND ENVIRONMENT
(2022)
Review
Oncology
Yu Deng, Hongyan Jin
Summary: Menopausal hormone therapy (MHT) is commonly used for treating symptoms associated with menopause in women, but its exact relationship with increased risk of breast cancer remains unclear. Current research indicates that estrogen monotherapy is associated with a lower incidence of breast cancer, while estrogen-progesterone combined therapy is linked to an elevated risk.
CANCER BIOLOGY & MEDICINE
(2022)
