期刊
TETRAHEDRON
卷 71, 期 7, 页码 1132-1135出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.12.005
关键词
Luche reduction; alpha,beta-unsaturated carbonyl; Er (III) triflate; 2-MeTHF; Green chemistry
An operationally simple and environmentally benign catalytic procedure has been developed to selectively reduce different alpha,beta-unsaturated ketones. The corresponding allylic alcohols are obtained with high chemo- and diastereoselectivity using Er(OTf)(3) and NaBH4 in 2-MeTHF. This protocol reduces the amount of catalyst and NaBH4 needed, compared to classical procedures and the stages of extraction/purification are carried out in aqueous solutions avoiding the use of toxic solvents. Taking into account that Er(OTf)(3) can be considered even less toxic than table salt and the 'greenness' of 2-MeTHF as a solvent, the system Er(OTf)(3)/2-MeTHF can be proposed as a cheap, efficient, and environmentally sustainable reduction system for the synthesis of allylic alcohols. (C) 2014 Elsevier Ltd. All rights reserved.
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