Article
Medicine, Research & Experimental
Wei Liu, Dunwei Wang, Lidi Liu, Lin Wang, Ming Yan
Summary: The study revealed the important role of miR-140 in osteosarcoma development, inhibiting tumor cell proliferation, migration, and invasion, as well as promoting cell apoptosis by targeting USP22.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Lu Ding, Rongxin Sun, Qi Yan, Chengwei Wang, Xiaoping Han, Yong Cui, Rong Li, Jiwen Liu
Summary: In osteosarcoma, miR-506 directly targets Skp2 to inhibit cell proliferation, induce apoptosis, and reduce migration and invasion abilities. Upregulation of Skp2 reverses the tumor suppressive effects of miR-506, while downregulation of Skp2 enhances the anticancer activity of miR-506 mimic transfection in osteosarcoma cells.
Article
Chemistry, Medicinal
Angela De Luca, Daniele Bellavia, Lavinia Raimondi, Valeria Carina, Viviana Costa, Milena Fini, Gianluca Giavaresi
Summary: Resveratrol (RSV) exhibits multiple tumor-suppressing activities on osteosarcoma (OS) cell lines, including inhibition of cell growth, promotion of cell differentiation, inhibition of cell migration, and enhancement of cytotoxic effect in combination with chemotherapy.
Article
Oncology
Wacili Da, Lin Tao, Yue Zhu
Summary: This study demonstrates that CTAB inhibits the proliferation and metastasis of osteosarcoma cells, induces apoptosis through the PI3K/AKT signaling pathway, and does not inhibit the growth of human osteoblasts.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yan Xue, Hongmiao Liu, Guangchen Nie, Xiaoping Ren
Summary: This study firstly suggests that DARS-AS1 acts as an oncogene in osteosarcoma by regulating the miR-532-3p/CCR7 pathway.
Article
Medicine, General & Internal
Feng Gao, Feng Xu
Summary: This study analyzed the role of LncRNA GAL1 in osteosarcoma cancer proliferation, migration and invasion of cancer cells. The results showed that GASL1 exhibits lower expression in osteosarcoma tissues and cell lines than normal surroundings tissues and osteoblasts respectively. GASL1 overexpression resulted in a decline of cancer cell viability and decreased migration and invasion of cancer cells.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Environmental Sciences
Chin-Yin Lin, Yih-Shou Hsieh, Shu-Chen Chu, Li-Sung Hsu, Shih-Chien Huang, Pei-Ni Chen
Summary: This study found that ethanoic Cinnamomum cassia extracts (CCE) have inhibitory effects on the invasion, migration, and cancer stemness of osteosarcoma cells. CCE can reverse epithelial-to-mesenchymal transition and suppress the expression of stemness genes, leading to reduced proliferation and induced apoptosis in the cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Junyi Wang, Lichan Yuan, Xiaohong Xu, Zhongyin Zhang, Yuhuan Ma, Leilei Hong, Junqing Ma
Summary: This study found that Trio is highly expressed in osteosarcoma and promotes the proliferation and invasion of tumor cells. Trio inhibits osteogenic differentiation of osteosarcoma cells and accelerates tumor growth.
CELL DEATH & DISEASE
(2021)
Article
Oncology
GuangDuo Zhu, XiaoWei Yang, WeiWei Zhou, Xu Lian, YingJie Hao
Summary: Excessive apoptosis of nucleus pulposus (NP) cells is the key factor in intervertebral disc degeneration (IVDD) progression. Pleomorphic adenoma gene like-2 (PLAGL2) has been found to play a crucial role in cell apoptosis. In this study, the researchers established mouse IVDD models and investigated the effect of PLAGL2 on NP cells' viability, apoptosis, and mitochondria function. They found that PLAGL2 was upregulated in IVDD disc tissues and stimulated NP cells. Knockdown of PLAGL2 inhibited apoptosis and mitochondria damage in NP cells. Furthermore, PLAGL2 was found to transcriptionally activate RASSF5, a downstream apoptosis-related factor. Overall, this study suggests that PLAGL2 induces apoptosis in NP cells and exacerbates IVDD progression, providing a potential therapeutic target for IVDD treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Ming Luo, Mingyang Huang, Ningning Yang, Yufan Zhu, Peng Huang, Zhujun Xu, Wengang Wang, Lin Cai
Summary: Osteosarcoma (OS) is a pediatric bone tumor with high heterogeneity. The discrepancy in tumorigenicity among OS cell lines is not fully understood. In this study, we investigated the potential role of mechanotransduction in OS tumorigenicity using in vitro and in vivo models. We found impaired mechanosensing and downregulation of rigidity-sensing proteins in transformed OS cells, as well as a novel TP53 mutation (R156P) that inhibits rigidity sensing. Our findings suggest that rigidity-sensing components play a fundamental role in OS tumorigenicity and mutant TP53 serves as an executor for malignant programs.
Article
Cell Biology
Yuan Gao, Lunhao Bai, Guanning Shang
Summary: The study demonstrates that the Notch-1 signaling pathway plays a critical role in regulating the viability, apoptosis, migration, and invasion abilities of osteosarcoma cells. Mechanistically, Notch-1 overexpression increases Cdc20 expression, contributing to enhanced cell survival and invasion in osteosarcoma. This research provides a promising treatment strategy for osteosarcoma by targeting Notch-1.
Article
Biochemistry & Molecular Biology
Ju Yeong Kim, Hun Hee Park, Tai-Soon Yong, Soung-Hoo Jeon
Summary: The study showed that LiCl and EGF treatments have different effects on osteosarcoma cells, with LiCl reducing cell migration and proliferation, while EGF promoting cell migration and proliferation. Additionally, it was found that LiCl can interfere with the translocation of pERK from the cytoplasm to the nucleus.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yue Xi, Jianlin Liu, Gufeng Shen
Summary: By using the GEO database and bioinformatics analysis, we identified IGFBP4 and TAGLN as key genes in osteosarcoma. Osteosarcoma patients with high expression levels of IGFBP4 and TAGLN had better overall survival times. Correlation analysis showed significant associations between IGFBP4 and tumor metastasis, Enneking stage, and TAGLN. Experimental verification demonstrated down-regulation of IGFBP4 and TAGLN expression in osteosarcoma tissue. Support Vector Machine analysis revealed a strong relationship among the expression of IGFBP4, TAGLN, and osteosarcoma.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Yan Gao, Ting Zou, Wentong Liang, Zhijun Zhang, Mingrong Qie
Summary: The study revealed the crucial regulatory role of HAND2-AS1 in cervical cancer, which upregulated TIMP3 expression through competitive binding to miR-21-5p, leading to suppression of cell proliferation, migration, invasion, and promotion of apoptosis. HAND2-AS1 may serve as a potential target for cervical cancer therapy.
CANCER GENE THERAPY
(2021)
Article
Endocrinology & Metabolism
Dong-Jie Li, Yong-Hua Li, Hong-Bin Yuan, Le-Feng Qu, Pei Wang
METABOLISM-CLINICAL AND EXPERIMENTAL
(2017)
Article
Neurosciences
Qing Ou Yang, Wen-Jing Yang, Jian Li, Fang-Ting Liu, Hongbin Yuan, Yue-Ping Ou Yang
Article
Cell Biology
Hai-Jing Sun, Yan Lu, Hao-Wei Wang, Hao Zhang, Shuang-Ran Wang, Wen-Yun Xu, Hai-Long Fu, Xue-Ya Yao, Feng Yang, Hong-Bin Yuan
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Anesthesiology
Jian Li, Qing Ouyang, Cheng-wen Chen, Qian-bo Chen, Xiang-nan Li, Zheng-hua Xiang, Hong-bin Yuan
Article
Biochemistry & Molecular Biology
Xiaofeng Liu, Zhengqing Zhao, Ruihua Ji, Jiao Zhu, Qian-Qian Sui, Gillian E. Knight, Geoffrey Burnstock, Cheng He, Hongbin Yuan, Zhenghua Xiang
PURINERGIC SIGNALLING
(2017)
Article
Oncology
Mei Yang, Wei Chen, Yu Zhang, Rui Yang, Yiru Wang, Hongbin Yuan
MOLECULAR MEDICINE REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ruihua Ji, Jiao Zhu, Dan Wang, Qian-Qian Sui, Gillian E. Knight, Geoffrey Burnstock, Hongbin Yuan, Zhenghua Xiang
PURINERGIC SIGNALLING
(2018)
Article
Cell Biology
Xiaodi Yan, Wendian Li, Liye Yang, Wenwen Dong, Wei Chen, Yanfei Mao, Pingbo Xu, Dongjie Li, Hongbin Yuan, Yonghua Li
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Mouli Tian, Mei Yang, Zhenjie Li, Yiru Wang, Wei Chen, Liye Yang, Yonghua Li, Hongbin Yuan
BIOSCIENCE REPORTS
(2019)
Article
Health Care Sciences & Services
Kun-ming Tao, Sann Sokha, Hong-bin Yuan
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Cell Biology
Jian Li, Mouli Tian, Tong Hua, Haowei Wang, Mei Yang, Wenqian Li, Xiaoping Zhang, Hongbin Yuan
Summary: The impaired autophagy flux mainly occurs in astrocytes during the maintenance of neuropathic pain. Activation of autophagy can relieve pain, while inhibition of autophagy can aggravate pain and alter levels of neuroinflammation and reactive oxygen species. Further study shows that inhibition of autophagy can slow the induction of neuroinflammatory responses but increase their maintenance.
Article
Neurosciences
Yu Zhang, Qianbo Chen, Dashuang Chen, Wenqi Zhao, Haowei Wang, Mei Yang, Zhenghua Xiang, Hongbin Yuan
Summary: SerpinA3N is expressed in astrocytes and penumbra neurons after stroke in mice. It reduces brain damage possibly via interacting with clusterin and inhibiting neuronal apoptosis and neuroinflammation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Cell Biology
Erliang Kong, Yongchang Li, Peng Ma, Yixuan Zhang, Ruifeng Ding, Tong Hua, Mei Yang, Hongbin Yuan
Summary: This study aimed to explore the mechanism of Lyn-mediated glycolysis enhancement of microglia in neuropathic pain. Chronic constriction injury (CCI) model was established to induce neuropathic pain, and it resulted in upregulation of Lyn expression and glycolysis enhancement in microglia of the spinal dorsal horn. Intrathecal administration of Lyn inhibitor Bafetinib or siRNA-lyn knockdown alleviated pain hyperalgesia, suppressed glycolysis enhancement, and inhibited nuclear translocation of IRF5 in CCI mice. Furthermore, IRF5 was found to promote the binding of transcription factors SP1 and PU.1 to glycolytic gene promoters, and the enhanced glycolysis facilitated the proliferation and pro-inflammatory phenotype transition of microglia, contributing to neuropathic pain. Lyn-mediated glycolysis enhancement of microglia contributes to neuropathic pain by facilitating IRF5 nuclear translocation in the spinal dorsal horn.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Neurosciences
Mei Yang, Wenyun Xu, Yiru Wang, Xin Jiang, Yingke Li, Yajuan Yang, Hongbin Yuan
Article
Biochemistry & Molecular Biology
Xingguang Liu, Hao Cao, Jian Li, Bo Wang, Peng Zhang, Xu Dong Zhang, Zhongmin Liu, Hongbin Yuan, Zhenzhen Zhan
CELL DEATH AND DIFFERENTIATION
(2017)