Article
Pharmacology & Pharmacy
Huang-Chi Chen, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Szu-Chia Chen, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chao-Hung Kuo
Summary: This study demonstrates that montelukast is effective at reducing arsenic-induced epithelial-mesenchymal transition (EMT) in human bronchial epithelial cells. By inhibiting arsenic-induced reactive oxygen species (ROS) generation and NF-kB activation, montelukast can suppress arsenic-induced cell migration and the expression of extracellular matrix proteins and EMT-regulating transcription factors. Combination treatment with fluticasone and montelukast can reverse the inhibitory effect of montelukast on arsenic-induced EMT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Xie, Qiwei Jiang, Xueji Wu, Lei Wang, Bing Gao, Zicheng Sun, Xiaomei Zhang, Lang Bu, Ying Lin, Qiang Huang, Jie Li, Jianping Guo
Summary: Research has revealed that IKBKE plays an oncogenic role in breast cancer metastasis by regulating the abundance of Snail. The findings suggest that targeting IKBKE could be a potential therapeutic strategy for metastatic breast cancer.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Agriculture, Dairy & Animal Science
Haokun Liu, Ying Zhao, Yanfang Wu, Yutong Yan, Xiaoe Zhao, Qiang Wei, Baohua Ma
Summary: Mastitis is a common and important clinical disease in ruminants, which may lead to inflammatory fibrosis if not promptly treated. This study found that Snail plays a critical role in LPS-induced EMT in GMECs, and the mechanism is dependent on the activation of the TLR4/NF-kappa B signaling pathway.
Article
Cell Biology
Yang Zhang, Weixing Ni, Lei Qin
Summary: In this study, the researchers aimed to investigate the role and mechanism of RUFY3 in hepatocellular carcinoma (HCC) progression. Results showed that high expression of RUFY3 was significantly associated with tumor size, microvascular invasion, clinical stage, and poor prognosis in HCC patients. Furthermore, RUFY3 was found to promote HCC cell growth, invasion, and metastasis through activating NF-kappa B-mediated epithelial-mesenchymal transition (EMT). These findings suggest that RUFY3 may serve as a novel target for HCC treatment.
Article
Biochemistry & Molecular Biology
Luis Arturo Palafox-Mariscal, Pablo Cesar Ortiz-Lazareno, Luis Felipe Jave-Suarez, Adriana Aguilar-Lemarroy, Maria Martha Villasenor-Garcia, Jose Roberto Cruz-Lozano, Karen Lilith Gonzalez-Martinez, Anibal Samael Mendez-Clemente, Alejandro Bravo-Cuellar, Georgina Hernandez-Flores
Summary: Cervical cancer is a common and deadly type of female cancer. Inflammation can lead to tumor metastasis and EMT. The anti-inflammatory compound PTX may disrupt EMT and reduce cell migration and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yang Zhang, Yujie Yang, Fan Yang, Xiaohan Liu, Ping Zhan, Jichao Wu, Xiaojie Wang, Ziying Wang, Wei Tang, Yu Sun, Yan Zhang, Qianqian Xu, Jin Shang, Junhui Zhen, Min Liu, Fan Yi
Summary: The upregulation of HDAC9 in fibrotic kidneys is found to promote epithelial cell cycle arrest at G2/M by regulating STAT1. Inhibition or knockdown of HDAC9 attenuates the loss of epithelial phenotype and fibroblasts activation, indicating its potential as a therapeutic target for kidney fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Huahua Tu, Wei Wang, Yanqing Feng, Linfei Zhang, Huadong Zhou, Caitao Cheng, Lei Ji, Qinghe Cai, Yong Feng
Summary: Beta-patchoulene (beta-PAE) is a compound extracted from patchouli with analgesic, anti-inflammatory, and antioxidant effects. This study found that beta-PAE can inhibit the growth, proliferation, migration, and epithelial-mesenchymal transition of hypoxia-induced hepatocellular carcinoma (HCC) cells, and promote apoptosis.
Article
Environmental Sciences
Yuexiao Ma, Qingqing Liang, Fenghong Wang, Kanglin Yan, Mengqi Sun, Lisen Lin, Tianyu Li, Junchao Duan, Zhiwei Sun
Summary: In this study, we found that subacute exposure to silica nanoparticles (SiNPs) can trigger autophagy dysfunction and pulmonary inflammation, leading to epithelial-to-mesenchymal transition (EMT) through activation of the p62/NF-kappa B signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Obstetrics & Gynecology
Xinxin Lin, Nobuhisa Yoshikawa, Wenting Liu, Tetsuya Matsukawa, Kae Nakamura, Masato Yoshihara, Yoshihiro Koya, Mai Sugiyama, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Yusuke Shimizu, Hiroaki Kajiyama
Summary: This study aimed to identify and elucidate the functional and prognostic roles of a novel metastasis-promoting molecule in cervical cancer called DDIT4 (DNA-damage-inducible transcript 4). The study involved analyzing multiple microarray databases, evaluating the correlation between DDIT4 expression and clinicopathological characteristics, conducting in vitro assays to determine cell migration and invasion, exploring potential downstream pathways of DDIT4, and determining in vivo metastatic capability using a mouse model. The results showed that high expression of DDIT4 was significantly related to short overall survival and lymph node metastasis in early-stage cervical cancer patients. Knockdown of DDIT4 attenuated migration and invasion activity in tumor cells, reduced the expression of EMT-related proteins and the NF-κB pathway, and promoted tumor progression in the mouse model.
REPRODUCTIVE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiao-ming Jiang, Yu-lian Xu, Luo-wei Yuan, Le-le Zhang, Mu-yang Huang, Zi-han Ye, Min-xia Su, Xiu-ping Chen, Hong Zhu, Richard D. Ye, Jin-jian Lu
Summary: The study elucidated the resistance mechanisms in osimertinib-resistant cells, involving EMT and activation of the NF-kappa B pathway. TGF beta 2 plays a crucial role in osimertinib-resistant cells and is associated with cell death and NF-kappa B pathway activation.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Genetics & Heredity
Zhong-Fang Shi, Guan-Zhang Li, You Zhai, Chang-Qing Pan, Di Wang, Ming-Chen Yu, Chi Liu, Wei Zhang, Xiao-Guang Yu
Summary: This study found that EGFRvIII activated the NF-κB pathway and regulated the expression of ALDH1A3, promoting the proneural-mesenchymal transition of GBM and reducing its sensitivity to TMZ. This provides an experimental basis for the selection of clinical drugs for GBM patients with EGFRvIII (+).
Review
Cell Biology
Amy Oh, Makayla Pardo, Anaelena Rodriguez, Connie Yu, Lisa Nguyen, Olin Liang, Anna Chorzalska, Patrycja M. Dubielecka
Summary: NF-kappa B transcription factors play critical roles in immune regulation and inflammatory signaling, and their dysregulation is associated with cancer development and metastasis. Understanding the involvement of NF-kappa B in epithelial to mesenchymal transition can contribute to optimized therapeutic strategies in cancer.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Dehu Chen, Qinghong Liu, Gan Cao
Summary: ERCC6L is upregulated in gastric cancer tissues and associated with tumor size, clinical stage, and patient prognosis. It promotes gastric cancer cell proliferation and metastasis by activating NF-kappa B signaling pathway.
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Biochemical Research Methods
Yingxin Zhao, Jing Zhang, Hong Sun, Allan R. Brasier
Summary: IKK regulates essential signaling pathways in TGF beta-induced EMT, and a new crosstalk pathway involving IKK, XBP1s and HBP was identified. This pathway controls N-glycosylation of the extracellular matrix in EMT and may hold therapeutic potential for preventing ECM remodeling in lung fibrosis and other airway remodeling diseases.
JOURNAL OF PROTEOME RESEARCH
(2021)