Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Elham Badrlou, Atefe Abak, Mohammad Taheri
Summary: miRNAs play a significant role in CRC by influencing the expression and activity of CRC-related pathways and interacting with long non-coding RNAs. Levels of miRNAs can be used to distinguish CRC patients from healthy controls. Despite evaluation of therapeutic application of miRNAs in CRC in animal models, it has not been verified in clinical settings.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Review
Biochemistry & Molecular Biology
Rashidah Baharudin, Nurul Qistina Rus Bakarurraini, Imilia Ismail, Learn-Han Lee, Nurul Syakima Ab Mutalib
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, and microRNAs play a significant role in its occurrence and progression. However, the methylation profiles of microRNAs in colorectal cancer patients are still unknown. Methylation is an important factor in cancer detection, and this review aims to provide insight into the current understanding of microRNA methylation in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lucia Dansero, Fulvio Ricceri, Laura De Marco, Valentina Fiano, Ginevra Nesi, Lisa Padroni, Lorenzo Milani, Saverio Caini, Giovanna Masala, Claudia Agnoli, Carlotta Sacerdote
Summary: Colorectal cancer is a common cancer worldwide, and prevention is the key to reducing its burden. Certain miRNAs may be related to CRC diagnosis and could serve as biomarkers. However, there is inconsistency across studies and further validation is needed.
Review
Biochemistry & Molecular Biology
Daniela A. R. Santos, Cristiana Gaiteiro, Marlene Santos, Lucio Santos, Mario Dinis-Ribeiro, Luis Lima
Summary: Colorectal cancer (CRC) is the third most common cancer globally. Early detection is crucial for better prognosis and increased survival rate. MicroRNA biomarkers have emerged as a powerful tool for CRC screening, as they are highly expressed in CRC patients and easily detectable. This review evaluates the available data on microRNAs as promising biomarkers for early CRC screening, discusses their advantages, disadvantages, and optimal study characteristics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lui Ng, Ryan Wai-Yan Sin, David Him Cheung, Wai-Keung Leung, Abraham Tak-Ka Man, Oswens Siu-Hung Lo, Wai-Lun Law, Dominic Chi-Chung Foo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is increasing worldwide, and it is associated with colorectal polyps. This study aimed to investigate the potential of serum microRNAs (miRNAs) in identifying NAFLD in colorectal polyp patients. The results showed that a serum miRNA panel composed of four miRNA pairs significantly identified NAFLD in colorectal polyp patients, and its performance improved when patients with other concurrent metabolic disorders were removed from the analysis. The serum miRNA panel could be a potential diagnostic biomarker for screening NAFLD in colorectal polyp patients for early diagnosis and prevention of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Farah J. Nassar, Zahraa S. Msheik, Maha M. Itani, Remie El Helou, Ruba Hadla, Firas Kreidieh, Rachelle Bejjany, Deborah Mukherji, Ali Shamseddine, Rihab R. Nasr, Sally N. Temraz
Summary: CRC is the second leading cause of cancer deaths worldwide, with poor prognosis for Stage IV patients and liver metastasis as the main cause of mortality. miRNA shows potential as non-invasive diagnostic biomarkers for CRC, with specific panels of miRNA having diagnostic accuracy for advanced CRC and liver metastasis.
Article
Genetics & Heredity
Shengyong Zhai, Xiaoling Li, Yan Wu, Xiaoli Shi, Binbin Ji, Chun Qiu
Summary: This study proposes a new method, BNNRMDA, for identifying potential microRNA biomarkers for colon cancer and colorectal cancer. The method combines disease semantic similarity, Gaussian Association Profile Kernel (GAPK) similarity, microRNA function similarity, and a regularization model. Experimental results show that BNNRMDA has strong performance in microRNA-disease association identification and discovers several potential biomarkers.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
William Tzu-Liang Chen, Han-Bin Yang, Tao-Wei Ke, Wen-Ling Liao, Shih-Ya Hung
Summary: Colorectal cancer is a common cancer in Taiwan, and DJ-1 plays a crucial role in predicting TNM stage and promoting cancer progression in colorectal cancer. Therefore, DJ-1 inhibition may be a potential therapeutic strategy for colorectal cancer treatment.
Article
Gastroenterology & Hepatology
Saray Duran-Sanchon, Lorena Moreno, Javier Gomez-Matas, Josep M. Auge, Miquel Serra-Burriel, Miriam Cuatrecasas, Leticia Moreira, Anna Serradesanferm, Angels Pozo, Jaume Grau, Maria Pellise, Meritxell Gironella, Antoni Castells
Summary: The miRFec algorithm can effectively identify individuals at highest risk for advanced colorectal neoplasia and differentiate patients with colorectal cancer from those with non-advanced adenomas or normal colonoscopy. By incorporating this algorithm, 34% of colonoscopies could be avoided, increasing the effectiveness and efficiency of FIT-based CRC screening programs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Longhai Li, Lihua Zhang, Ting Zhang, Xiaowei Qi, Gang Cheng, Lingxia Xia
Summary: The study suggests that CXCL7 may serve as a potential biomarker for both diagnosis and prognosis of OCRC patients, with higher concentrations in OCRC compared to non-OCRC patients. The sensitivity and specificity of CXCL7 in diagnosing OCRC were 86.54% and 81.87%, respectively. Additionally, high levels of CXCL7 in serum were independently associated with poor overall survival in OCRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biophysics
Wenhui Chen, Tingting Li, Chengbo Chen, Jinghui Zhang, Ziyu Ma, Weilin Hou, Yao Yao, Wei Mao, Chang Liu, Dezhao Kong, Sheng Tang, Wei Shen
Summary: Precise and early screening of colorectal cancer is crucial for its treatment. In this study, a three-dimensional ordered DNA network was used to detect a colorectal cancer-related biomarker pair, miRNA-211 and H2S. This method allows for simultaneous detection of biomolecules and inorganic gases, overcoming the limitations of single type detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biotechnology & Applied Microbiology
Lin Li, Andre Gorgens, Veronika Mussack, Elena Pepeldjiyska, Anne Sophie Hartz, Andreas Rank, Jorg Schmohl, Doris Kra''mer, Samir El Andaloussi, Michael W. Pfaffl, Helga Schmetzer
Summary: Extracellular Vesicles (EVs) play a crucial role in hematological malignancies, affecting bone marrow environment, immune system, drug resistance, and therapies. EVs collected from serum of leukemia samples have potential as biomarkers for disease pattern distinctions. This study aims to investigate the potential role and methodology of serum-derived EVs as biomarkers in leukemic versus healthy samples.
CANCER GENE THERAPY
(2022)
Article
Pharmacology & Pharmacy
Lei Shen, Wei Zong, Wei Feng, Erlin Chen, Shuo Ma, Jie Yuan, Guihua Wang, Xinliang Gu, Xianjuan Shen, Shaoqing Ju
Summary: The study indicates that serum Linc01836 has significant value in the diagnosis and prognosis of CRC, serving as a promising biomarker. Its high expression is closely associated with pathological features of CRC and can be utilized for early screening and clinical surveillance of CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Monica Milian, Eduardo Targarona, Eduardo Garcia-Granero, Xavier Serra-Aracil
Summary: Currently, most surgical departments in Spanish hospitals are organized into specialized surgical units, focusing on different subspecialties within General and Digestive Surgery (GDS). These units have specific structures, human resources, organization, teaching, and research. Some of them also offer specialized fellowship-like training programs in the respective subspecialties, although they are not officially funded. However, there has been no model for accreditation or recognition of these units or fellowship programs. The AEC has developed a regulation for the accreditation of specialized surgical units in GDS, which will serve as a model for defining subspecialty training in these areas. The accreditation process involves various quality indicators, including unit structure, process quality, and outcome indicators.
Article
Surgery
Xavier Serra-Aracil, Manel Armengol Carrasco, Joan Morote Robles, Eloy Espin Basany, Natalia Amat-Lefort, Alvaro Serra-Gomez, Salvador Navarro-Soto
Summary: This study investigates the variations in requirements of doctoral programs in different surgery departments at Spanish public universities and proposes the establishment of a quality scale. The findings reveal a wide variability in the requirements of these programs, highlighting the need for standardized regulations to promote and protect higher-level doctorates.
Editorial Material
Surgery
Xavier Serra Aracil, Oriol Pino Perez
Article
Gastroenterology & Hepatology
Laura Mora Lopez, Anna Pallisera Lloveras, Anna Serracant Barrera, A. Garcia-Nalda, M. Caraballo Angeli, Oriol Pino Perez, Salvador Navarro Soto, Xavier Serra Aracil
Summary: This study describes the robot-assisted intracorporeal anastomosis technique in left colon surgery (rLCS) and reports the initial results. The results show that this technique is safe and feasible, with low postoperative mortality rate.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Xavier Serra-Aracil, Victoria Lucas-Guerrero, Laura Mora-Lopez
Summary: Transanal endoscopic microsurgery (TEM) allows the local excision of rectal tumors and achieves lower morbidity and mortality rates than total mesorectal excision. TEM can treat lesions up to 18 to 20 cm from the anal verge, obtaining good oncological results in T1 stage cancers and preserving sphincter function. However, TEM is technically demanding, especially for large lesions, those with high risk of perforation, those in the upper rectum or rectosigmoid junction, and those in the anal canal.
CLINICS IN COLON AND RECTAL SURGERY
(2022)
Article
Surgery
X. Serra-Aracil, V Lucas-Guerrero, A. Garcia-Nalda, L. Mora-Lopez, A. Pallisera-Lloveras, A. Serracant, S. Navarro-Soto
Summary: This study aims to determine the optimal time and distance for evaluating the fluorescence saturation of indocyanine green (ICG). The results showed that the fluorescence intensity was highest and relatively stable between 1.5 and 3.5 minutes after ICG administration, making it suitable for assessing vascularization. Additionally, the results obtained were most accurate when the distance between the camera and the tissue was 5 cm.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Editorial Material
Gastroenterology & Hepatology
X. Serra-Aracil, A. Cidoncha-Secilla, J. Badia-Closa, A. Pallisera-Lloveras, A. Garcia-Nalda, M. Caraballo-Angeli, L. Mora-Lopez
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Article
Multidisciplinary Sciences
X. Serra-Aracil, A. Garcia-Nalda, B. Serra-Gomez, A. Serra-Gomez, L. Mora-Lopez, A. Pallisera-Lloveras, V. Lucas-Guerrero, S. Navarro-Soto
Summary: This study presents a new system, SERGREEN software, for quantifying ICG fluorescence intensity. The experimental results show that SERGREEN software can detect differences in ICG fluorescence intensity between normal and ischemic situations, and a reduction of 32.6% or more is correlated with tissue ischemia.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
X. Serra-Aracil, C. Pericay, J. Badia-Closa, T. Golda, S. Biondo, P. Hernandez, E. Targarona, N. Borda-Arrizabalaga, A. Reina, S. Delgado, F. Vallribera, A. Caro, J. Gallego-Plazas, M. Pascual, C. alvarez-Laso, H. G. Guadalajara-Labajo, L. Mora-Lopez
Summary: This study compared the effectiveness of chemoradiotherapy combined with minimally invasive surgery and traditional surgery in the treatment of T2-T3ab,N0,M0 rectal cancer. The study found that chemoradiotherapy combined with minimally invasive surgery can reduce postoperative complications and hospitalization rates, and achieve a high rate of pathological complete response.
ANNALS OF ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xavier M. Serra-Aracil, Jose Hidalgo, Arturo Dominguez, Helena Vallverdu, Monica Millan, Aleidis Caro-Tarrago, Salvadora Delgado, C. Gomez, Nuria Llorach, Laura Mora-Lopez
Summary: The aim of this study is to provide a rationale for reducing catheterization time while avoiding acute urine retention in patients undergoing scheduled laparoscopic colon surgery. The study is a multicenter, prospective, controlled, randomized non-inferiority study, with patients randomized into two groups: experimental group (with immediate catheter removal after surgery) and control group (with catheter removal 24 hours post-surgery). The main outcome is the development of acute urine retention, with secondary outcomes being urinary infection and hospital stay.
COLORECTAL DISEASE
(2023)
Article
Surgery
X. Serra-Aracil, L. Mora-Lopez, I. Gomez-Torres, A. Pallisera-Lloveras, A. Serracant, A. Garcia-Nalda, O. Pino-Perez, A. Torrecilla, S. Navarro-Soto
Summary: The purpose of this study was to analyze the safety and feasibility of laparoscopic and robotic surgery in upper rectum, sigmoid, and left colon resection and anastomosis, and to compare the short-term differences between these two approaches. The results showed that both laparoscopic and robotic intracorporeal resection and anastomosis were feasible and safe, and achieved similar surgical, postoperative, and pathological outcomes as described in the literature. However, there seemed to be more complications in the laparoscopic group.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Surgery
M. Lopez-Cano, M. Adell-Trape, M. Verdaguer-Tremolosa, V. Rodrigues-Goncalves, J. Badia-Closa, X. Serra-Aracil
Summary: This study aimed to evaluate the long-term occurrence of parastomal hernia (PH) after the use of a prophylactic synthetic non-absorbable mesh in elective end colostomy. Long-term data from three randomized controlled trials were collected and analyzed. The results showed that the presence of a prophylactic mesh did not significantly reduce the development of PH in the overall study population, but the open retromuscular technique had a higher reduction in PH occurrence.
Letter
Surgery
Xavier Serra-Aracil, Laura Mora-Lopez
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Xavier Serra-Aracil, Alba Zarate, Josep Bargallo, Anna Gonzalez, Anna Serracant, Jordi Roura, Salvadora Delgado, Laura Mora-Lopez
Summary: This study suggests that laparoscopic TaTME can avoid conversion to open surgery and has a significantly lower conversion rate compared to laparoscopic total mesorectal excision (LaTME), especially when performed by experienced surgeons. There were no significant differences in postoperative recovery and complications between the two groups, but laparoscopic TaTME had a lower incidence of anastomotic leakage.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Oncology
Xavier Serra-Aracil, Carles Pericay, Jesus Badia-Closa, Thomas Golda, Sebastiano Biondo, Pilar Hernandez, Eduardo Tarragona, Nerea Borda-Arrizabalaga, Angel Reina, Salvadora Delgado, Francesc Vallribera, Aleidis Caro, Javier Gallego Plazas, Marta Pascual, Carlos Alvarez-Laso, Damian Garcia, Laura Mora-Lopez
JOURNAL OF CLINICAL ONCOLOGY
(2022)