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Biochemistry & Molecular Biology
Ruo Yu Meng, Hua Jin, Thi Van Nguyen, Ok-Hee Chai, Byung-Hyun Park, Soo Mi Kim
Summary: UA potentiates the anti-tumor efficacy of PTX by inhibiting cell proliferation and migration in esophageal squamous cell carcinoma, potentially through targeting the Akt/FOXM1 cascade. This combination treatment shows significantly enhanced anti-tumor potential both in vitro and in vivo, suggesting a new strategy for curing esophageal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Food Science & Technology
Xiangsheng Zhang, Huan Kan, Yun Liu, Wu Ding
Summary: Plumbagin shows potential medicinal properties, including anticancer activities. It inhibits cell proliferation, blocks cell cycle, induces apoptosis and autophagy in endometrial cancer cells. The anticancer effects of PLB may be mediated by abrogating the PI3K/Akt pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Ming Wang, Xin Xu, Jian Tang, Zhi-Yong Sun, Yu-Jie Fu, Xiao-Jing Zhao, Xiu-Mei Ma, Qing Ye
Summary: Apatinib was shown to induce ER stress, autophagy, and apoptosis in ESCC cells, with inhibiting autophagy enhancing apatinib-induced apoptosis. The combination of apatinib and CQ sensitized ESCC cells to paclitaxel through the IRE-1 alpha-AKT-mTOR signaling pathway, suggesting its potential use in innovative anticancer therapeutic strategies.
CELL AND BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Puja Patel, Vinita Manimaran Nadar, Devan Umapathy, Selvambigai Manivannan, Rajiu Venkatesan, Velanganni Antony Joseph Arokiyam, Srinivasan Pappu, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jabir, Balazs Gulyas, Parasuraman Padmanabhan, Subramanian Tamil Selvan, Ponnuchamy Kumar
Summary: This study reports a theranostic platinum nanoparticle platform conjugated with an anticancer drug, which induces apoptosis in breast cancer cells by activating a specific signaling pathway. These findings suggest that this platform may serve as a promising agent for cancer nanomedicine.
ACS APPLIED NANO MATERIALS
(2021)
Article
Oncology
Jun Peng, Ke Ma, Hao Rong, Bo Xiao, Jiang Zhu, Jin-Tao He
Summary: The study suggests that GBAS may play a role in esophageal cancer by regulating cell viability, apoptosis, and cell cycle progression.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Meng-Yun Zhao, Pan Liu, Chen Sun, Li-Jian Pei, Yu-Guang Huang
Summary: The study found that propofol and paclitaxel inhibit the viability of cervical cancer cells and have synergistic effects when used in combination at certain concentrations. In addition, propofol promotes paclitaxel-induced apoptosis of cervical cancer cells and affects ROS levels and Fe2+ concentrations under different drug treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinbing Sui, Xuemeng Han, Peng Chen, Qibiao Wu, Jiao Feng, Ting Duan, Xiaying Chen, Ting Pan, Lili Yan, Ting Jin, Yu Xiang, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Ruonan Zhang, Bi Chen, Mingming Zhang, Zuyi Yang, Na Kong, Tian Xie, Xia Ding
Summary: Baicalin, a natural active ingredient from Scutellaria baicalensis Georgi, has shown potential antitumor effects against various cancer types. The study revealed that baicalin exerts its antitumor activity mainly by inducing Akt-dependent cell cycle arrest and promoting apoptosis in lung cancer cells, suggesting it may be a promising candidate for developing new drugs for lung cancer treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Plant Sciences
Tianshu Yang, Yi Xiao, Shuo Liu, Fazhen Luo, Dongyun Tang, Yilin Yu, Yan Xie
Summary: The study found that isorhamnetin (IS) can enhance the chemosensitivity of drug-resistant breast cancer cells. IS inhibits cell proliferation and migration, and enhances the antitumor effects of doxorubicin (DOX) against resistant breast cancer cells. IS regulates the cell cycle and induces the production of reactive oxygen species, leading to inhibition of cell proliferation and DNA damage, thus enhancing the antitumor effects of DOX.
Article
Oncology
Mengmeng Wang, Mingjun Gao, Yong Chen, Jun Wu, Xiaolin Wang, Yusheng Shu
Summary: This study found that PLCD3 is highly expressed in ESCC tissues and cell lines, and its expression is correlated with pathological stage and lymphatic metastasis. PLCD3 knockdown inhibits cell proliferation, migration, and invasion, promotes apoptosis, and arrests the cell cycle in the G1 phase. PLCD3 overexpression, on the other hand, promotes cell proliferation, migration, and invasion. Xenograft models also suggest that PLCD3 promotes tumorigenesis in ESCC. Finally, overexpression of PLCD3 activates the PI3K/AKT/P21 signaling pathway.
Article
Oncology
Zhiqiang Hu, Hui Wang, Yan Fu, Kang Ma, Xiaoyan Ma, Jing Wang
Summary: Gentiopicroside (GPS) shows anticancer effects on HeLa cells by inhibiting cell proliferation, inducing apoptosis, arresting cell migration, and promoting cell death through the mitochondrial apoptotic pathway. Additionally, GPS has minimal effects on normal cells and regulates tumor cell migration through the MAPK and Akt signaling pathways, with MAPK1 being a potential target against HeLa cells.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhang, Shan Li, Xiangguo Cui, Yiliang Wang
Summary: This study explored the molecular mechanism of miR-944 mediated SPP1 in breast cancer progression and its regulatory effect on the PI3K/Akt pathway. The expression of miR-944 was decreased while that of SPP1 was increased in breast cancer tissues and cells. miR-944 negatively regulated the expression of SPP1 and inhibited breast cancer cell proliferation by blocking the PI3K/Akt pathway.
Article
Biochemistry & Molecular Biology
Ji Yoon Lee, Jihwa Chung, Yeongju Byun, Kyoung Hwa Kim, Shung Hyun An, Kihwan Kwon
Summary: The study demonstrates that MSC-sEVs have protective effects against DOX-induced cardiomyopathy by upregulating survivin expression, which is mediated by the regulation of Akt activation by miRNAs in MSC-sEVs. This suggests that MSC-sEVs may be a novel therapy for the prevention of DOX-induced cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang
Summary: This study reveals that matrine, an alkaloid from the medicinal plant Sophora flavescens, has strong anticancer effects and can be explored as a new therapeutic agent for triple-negative breast cancer (TNBC). Through bioinformatics analysis and network pharmacology, researchers found that matrine inhibits the PI3K/AKT pathway, suppresses cell proliferation and invasion, induces apoptosis and autophagy, effectively inhibiting the growth and spread of TNBC.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Jiang, Xu Zhi, Peixia Zhang, Zhongmei Zhou, Jinxiang Ye, Yu Gao, Xinye Wang, Chuanyu Yang, Haijun Chen, Rong Liu, Ceshi Chen
Summary: The study identified that the isochromanoindolenine derivative FZU-0025-065 inhibits TNBC by suppressing the AKT signaling pathway, showing potential for TNBC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)