Article
Biochemistry & Molecular Biology
Weiming Ouyang, David M. Frucht
Summary: This study reveals that the Erk1/2 inactivation-triggered and COP1-mediated c-Jun degradation is regulated by protein phosphatases, UBE2 enzymes, and an intrinsic motif of c-Jun. The C-terminus of c-Jun protein plays a critical role in facilitating its degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hana Lee, Won-Jin Kim, Hyeon-Gu Kang, Jun-Ho Jang, Il Ju Choi, Kyung-Hee Chun, Seok-Jun Kim
Summary: The study found that LAMB1 is upregulated in gastric cancer and contributes to cell growth and motility. The expression level of LAMB1 is closely associated with the prognosis of patients with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yongxu Jia, Qian Yan, Yinli Zheng, Lei Li, Baifeng Zhang, Zhiwei Chang, Zehua Wang, Hong Tang, Yanru Qin, Xin-Yuan Guan
Summary: This study identified a key molecular mechanism that influences lymph node metastasis. RPRD1B was found to promote lymph node metastasis by regulating the c-Jun/c-Fos/SREBP1 axis, and NEAT1 enhanced the activity of this axis through a positive feedback loop. These findings provide a potential therapeutic target for the treatment of gastric cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Shu Liu, Yewei Zhang, Shien Cui, Dajiang Song, Bo Li, Qian Chen, Guangyu Yao, Bin Gong
Summary: This study reveals the upregulation of NAP1L1 in breast cancer and its interaction with HDGF to recruit c-Jun, leading to cell growth. NAP1L1 may serve as a potential oncogene with therapeutic implications for breast cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Hidekazu Hirano, Yuichi Abe, Yosui Nojima, Masahiko Aoki, Hirokazu Shoji, Junko Isoyama, Kazufumi Honda, Narikazu Boku, Kenji Mizuguchi, Takeshi Tomonaga, Jun Adachi
Summary: This study conducted a phosphoproteomic analysis using endoscopically collected tumor samples and revealed molecular changes in HER2-positive gastric cancer patients after treatment. It identified potential predictive or resistant biomarkers and therapeutic targets.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Tao Shen, Bingning Dong, Yanling Meng, David D. Moore, Feng Yang
Summary: GATA2 degradation driven by COP1 is a direct mechanism for regulating AR expression and activation, PCa growth, and castration resistance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Xiaodong Zhang, Fangyu Hu, Baiwang Zhu, Xueli Jiao, Yun Li, Shuang Wu, Ganglin Ren, Jizhen Li, Qipeng Xie, Yifei Pan, Hongyan Li, Lingling Zhao
Summary: This study investigates the role of TEX11 gene in colorectal cancer (CRC). The results show that TEX11 expression is significantly downregulated in clinical samples and cell lines, and is associated with poor prognosis in CRC patients. Further experiments demonstrate that TEX11 can inhibit the proliferative capacity of CRC cells. Mechanistically, TEX11 promotes COP1 transcription by upregulating FOXO3a expression, thus accelerating the degradation of the negative transcriptional regulator c-Jun and enhancing p21 transcription, leading to inhibition of CRC cell proliferation.
Article
Cell Biology
Susu Guo, Yuxin Chen, Yueyue Yang, Xiao Zhang, Lifang Ma, Xiangfei Xue, Yongxia Qiao, Jiayi Wang
Summary: This study demonstrates that TRIB2 reduces Ub levels by stimulating proteasome degradation and interacts with PCBP2 to modulate PSMB5 activity, which is crucial for liver cancer cell viability and tumor growth. The interaction between TRIB2 and PCBP2 also protects liver cancer cells from oxidative damage through the function of glutathione peroxidase 4. Targeting TRIB2 may enhance the effectiveness of therapeutic agents for liver cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Xiaohua Zhu, YingYing Xie, Wenyan Huang, Zigui Chen, SuiQun Guo
Summary: Our data demonstrated that NAP1L1 could act as a prognostic biomarker in OC and can interact with HDGF to mediate the proliferation of OC, and this process of triggered proliferation may contribute to the activation of HDGF/C-JUN signaling in OC cells.
Article
Oncology
Dakui Luo, Min Chen, Qingguo Li, Kangjunjie Wang, Kaihua Wang, Junqiang Li, Guoxiang Fu, Zezhi Shan, Qi Liu, Yufei Yang, Lei Liang, Yanlei Ma, Yi Qin, Jun Qin, Daming Gao, Xinxiang Li
Summary: This study reveals that UTX promotes colorectal cancer (CRC) progression through downregulation mediated by the CUL4B-DDB1-COP1 complex. Utx deletion in mice increases susceptibility to tumorigenesis, but this effect can be alleviated by the EZH2 inhibitor GSK126. Furthermore, the CUL4B-DDB1-COP1 complex is identified as the functional E3 ligase responsible for targeting UTX for degradation in CRC cells. Patient cohort analysis also shows that UTX expression is negatively correlated with clinical stage, favorable disease outcomes, and COP1 expression.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Oncology
Ping Zhu, Guoping Liu, Xue Wang, Jingjing Lu, Yue Zhou, Shuyi Chen, Yabiao Gao, Chaofu Wang, Jerry Yu, Yangbai Sun, Ping Zhou
Summary: The study revealed that GLUT1 mRNA expression is significantly increased in breast cancer tissues, which is associated with metastasis and poor prognosis. The transcription factor c-Jun may regulate GLUT1 gene expression by binding to its promoter, thereby affecting glycolysis and breast cancer metastasis.
Article
Cell Biology
Yijing Ren, Cheng Lv, Jing Zhang, Beibei Zhang, Bei Yue, Xiaoping Luo, Zhilun Yu, Hao Wang, Junyu Ren, Zhengtao Wang, Wei Dou
Summary: Alantolactone (ATL) exhibits inhibitory effects on cell activities, induces apoptosis, and inhibits colony formation in colorectal cancer. It also reduces cell migration and invasion capabilities. Furthermore, ATL demonstrates significant anti-tumor effects in vivo models.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Wenxue Liu, Zhiyan Zhan, Meiying Zhang, Bowen Sun, Qiqi Shi, Fei Luo, Mingda Zhang, Weiwei Zhang, Yanli Hou, Xiuying Xiao, Yanxin Li, Haizhong Feng
Summary: The study reveals that KAT6A is upregulated in ovarian cancer and correlates with patient survival. Downregulation of KAT6A inhibits proliferation and migration of ovarian cancer cells, induces apoptosis, and enhances sensitivity to cisplatin. Additionally, KAT6A interaction with COP1 leads to impaired function, accumulation, and enhanced activity of beta-catenin, suggesting a critical role of the KAT6A/COP1/beta-catenin signaling axis in ovarian cancer progression. Targeting this signaling axis could be a novel strategy for ovarian cancer treatment.
Article
Biochemistry & Molecular Biology
Ye Ji Jeon, Sang Ah Yi, Jaecheol Lee, Jeung-Whan Han
Summary: S6K1 plays a crucial role in regulating cell proliferation and growth in the mTOR signaling pathway. Our study demonstrates the dynamic distribution of S6K1 in the cytoplasm and nuclei of human cervical cancer cells and reveals its additional role as a gene transcription regulator. These findings provide important insights into the mechanisms of tumorigenesis and potential therapeutic strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Qingjiang Hu, Takaaki Masuda, Shotaro Kuramitsu, Taro Tobo, Kuniaki Sato, Shinya Kidogami, Sho Nambara, Masami Ueda, Yusuke Tsuruda, Yosuke Kuroda, Shuhei Ito, Eiji Oki, Masaki Mori, Koshi Mimori
Editorial Material
Oncology
Takaaki Masuda, Atsushi Nonami, Fumiaki Tanaka, Yuki Ando, Masatoshi Eto, Koshi Mimori
Article
Genetics & Heredity
Shotaro Sakimura, Satoshi Nagayama, Mitsuko Fukunaga, Qingjiang Hu, Akihiro Kitagawa, Yuta Kobayashi, Takanori Hasegawa, Miwa Noda, Yuta Kouyama, Dai Shimizu, Tomoko Saito, Atsushi Niida, Yusuke Tsuruda, Hajime Otsu, Yoshihiro Matsumoto, Hiroki Uchida, Takaaki Masuda, Keishi Sugimachi, Shin Sasaki, Kazutaka Yamada, Kazuki Takahashi, Hideki Innan, Yutaka Suzuki, Hiromi Nakamura, Yasushi Totoki, Shinichi Mizuno, Masanobu Ohshima, Tatsuhiro Shibata, Koshi Mimori
Summary: This study revealed the significant role of copy number aberrations in cancer evolution, as well as the importance of neoantigens and diverse T cell receptor repertoire in postoperative recurrence. The comparison of driver mutations and immune response-related molecules between early and metastatic sites showed differences, and the postoperative recurrence was associated with neoantigen levels and TCR diversity in the metastatic sites.
Article
Gastroenterology & Hepatology
Shin-ei Kudo, Yuta Kouyama, Yushi Ogawa, Katsuro Ichimasa, Tsuyoshi Hamada, Kazuki Kato, Koki Kudo, Takaaki Masuda, Hajime Otsu, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Hideyuki Miyachi, Naruhiko Sawada, Toshiro Sato, Tatsuhiro Shibata, Shigeharu Hamatani, Tetsuo Nemoto, Fumio Ishida, Atsushi Niida, Satoru Miyano, Masanobu Oshima, Shuji Ogino, Koshi Mimori
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2020)
Article
Oncology
Atsushi Fujii, Takaaki Masuda, Michio Iwata, Taro Tobo, Hiroaki Wakiyama, Kensuke Koike, Keisuke Kosai, Takafumi Nakano, Shotaro Kuramitsu, Akihiro Kitagawa, Kuniaki Sato, Yuta Kouyama, Dai Shimizu, Yoshihiro Matsumoto, Tohru Utsunomiya, Takao Ohtsuka, Yoshihiro Yamanishi, Masafumi Nakamura, Koshi Mimori
Summary: The study identified ASAP2 as a novel driver gene in PDAC, with high expression contributing to a poor prognosis and promoting tumor growth by facilitating cell cycle progression. Niclosamide, repositioned as a drug targeting the ASAP2 pathway, suppresses PDAC growth by inhibiting ASAP2 expression.
Article
Oncology
Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Summary: A study sequencing 52 tumor samples from 33 ESCC patients who received radiotherapy combined with 5-fluorouracil/platinum revealed the impact of chemoradiotherapy on clonal evolution, with MYC gain potentially serving as a marker for therapy resistance. The findings enhance understanding of therapeutic resistance and support the rationale for precision chemoradiotherapy.
Article
Oncology
Kuniko Sunami, Hideaki Bando, Yasushi Yatabe, Yoichi Naito, Hideaki Takahashi, Katsuya Tsuchihara, Shinichi Toyooka, Koshi Mimori, Shinji Kohsaka, Hiroyuki Uetake, Ichiro Kinoshita, Keigo Komine, Masayuki Takeda, Tetsu Hayashida, Kenji Tamura, Kazuto Nishio, Noboru Yamamoto
Summary: Comprehensive genomic profiling (CGP) is increasingly used in Japan for the clinical management of solid cancers, with some restrictions such as patient eligibility and opportunities for testing. The implementation of CGP based on plasma circulating tumor DNA (ctDNA) may raise issues regarding the selection and use of tissue DNA and ctDNA CGP.
Article
Oncology
Takaaki Masuda, Osamu Niizeki, Takashi Niizeki, Kenji Fujiyoshi, Yuki Ando, Hiroshi Niizeki, Koshi Mimori
Summary: This case describes a MBC patient with predominant liver metastases who declined systemic therapy and opted for hepatic arterial infusion chemotherapy (HAIC), showing partial response or stable disease in the liver and slow progression in other sites, surviving for 1 year and 3 months. The study suggests that HAIC may be a therapeutic option for advanced breast cancer patients with liver metastases who cannot tolerate systemic therapy.
CASE REPORTS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hajime Otsu, Sho Nambara, Qingjiang Hu, Yuichi Hisamatsu, Takeo Toshima, Kazuki Takeishi, Yusuke Yonemura, Takaaki Masuda, Eiji Oki, Koshi Mimori
Summary: The study aimed to identify individuals at high risk of gastric cancer by detecting microRNAs (miRNA) in the blood as biomarkers. Specific miRNA combinations may serve as promising biomarkers for precancerous lesions in gastric cancer.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Satoshi Nagayama, Yuta Kobayashi, Mitsuko Fukunaga, Shotaro Sakimura, Keishi Sugimachi, Shin Sasaki, Takaaki Masuda, Ken-ichi Mafune, Masanobu Oshima, Tatsuhiro Shibata, Yutaka Suzuki, Koshi Mimori
Summary: The detection and sequencing of mutated ctDNA is essential in postoperative management of colorectal cancer (CRC). This study conducted target resequencing of ctDNA and found that mutated genes in ctDNA indicated immune-resistance traits due to the loss of neoantigen presentation in primary CRC tumors. Therefore, ctDNA mutations can be frequently detected postoperatively to identify recurrence, but they come from immune-tolerated clones.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou, Mituko Fukunaga, Ayako Gamachi, Kiyomi Imamura, Yuta Kuze, Junko Zenkoh, Ayako Suzuki, Atsushi Niida, Haruka Hirose, Shuto Hayashi, Jun Koseki, Eiji Oki, Satoshi Fukuchi, Kazunari Murakami, Taro Tobo, Satoshi Nagayama, Mamoru Uemura, Takeharu Sakamoto, Masanobu Oshima, Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori, Takeshi Iwasaki, Yoshinao Oda, Tatsuhiro Shibata, Yutaka Suzuki, Teppei Shimamura, Koshi Mimori
Summary: The cellular interactions in the tumor microenvironment of colorectal cancer (CRC) remain poorly understood. This study investigates the importance of events occurring at the invasion front for CRC treatment strategies. The findings highlight the signaling between CRC cell populations and stromal cell populations, specifically at the invasion front.
Review
Gastroenterology & Hepatology
Masaaki Iwatsuki, Chihiro Matsumoto, Koshi Mimori, Hideo Baba
Summary: Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare familial gastric cancer syndrome caused by a mutation in the APC gene. Treatment involves standard methods for gastric cancer, with prognosis depending on the presence of distant metastasis and the use of total gastrectomy. Prophylactic total gastrectomy is recommended in cases of dysplasia, but careful consideration of the patient's background is necessary. Currently, there are no guidelines for screening, timing of prophylactic total gastrectomy, or endoscopic surveillance for GAPPS.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Editorial Material
Gastroenterology & Hepatology
Koshi Mimori
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Oncology
Hirofumi Ohmura, Taro Tobo, Koshi Mimori, Eishi Baba, Takahiko Horiuchi
Summary: We report a case of colon neuroendocrine carcinoma (NEC) that developed Trousseau's syndrome. The patient experienced disease progression after multiple lines of therapy and ultimately died due to worsening condition.
CASE REPORTS IN ONCOLOGY
(2023)
Article
Oncology
Akihiro Kitagawa, Takaaki Masuda, Junichi Takahashi, Taro Tobo, Miwa Noda, Yosuke Kuroda, Qingjiang Hu, Yuta Kouyama, Yuta Kobayashi, Shotaro Kuramitsu, Kuniaki Sato, Atsushi Fujii, Yukihiro Yoshikawa, Hiroaki Wakiyama, Dai Shimizu, Yusuke Tsuruda, Hidetoshi Eguchi, Yuichiro Doki, Koji Mori, Koshi Mimori
CANCER GENOMICS & PROTEOMICS
(2020)
