Article
Oncology
Weidan Ji, Zhangxiao Peng, Bin Sun, Lei Chen, Qin Zhang, Minggao Guo, Changqing Su
Summary: The study confirmed that high expression of LpCat1 in HCC cells promoted cancer cell invasion, playing a crucial role in the progression and metastasis of HCC by interacting with STAT1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Jin Kim, Nayeong Yuk, Hee Jeong Shin, Hye Jin Jung
Summary: Violacein has shown promising therapeutic potential in effectively suppressing hepatocellular carcinoma (HCC) by inhibiting the proliferation and stemness of HCC cells. Its antiproliferative effect is attributed to cell cycle arrest at the sub-G1 phase and induction of apoptotic cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Theresa H. Wirtz, Alena Saal, Irina Bergmann, Petra Fischer, Daniel Heinrichs, Elisa F. Brandt, Maria T. Koenen, Sonja Djudjaj, Kai M. Schneider, Peter Boor, Richard Bucala, Ralf Weiskirchen, Jurgen Bernhagen, Christian Trautwein, Marie-Luise Berres
Summary: The study identified a pro-tumorigenic role of MIF in the proliferation and therapy-induced apoptosis of HCC cells, mediated through the MIF cognate receptor CD74.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Environmental Sciences
Etimad Huwait, Seham M. Awaji, Taha A. Kumosani, Elie K. Barbour, Khalid O. Abulnaja, Said S. Moselhy
Summary: The study found that the ethanol extract of Ruthana date has cytotoxic effects on human hepatocellular carcinoma cells, which is achieved through DNA fragmentation and activation of the proapoptotic BAX gene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Federica Ragusa, Nadia Panera, Silvia Cardarelli, Marco Scarsella, Marzia Bianchi, Stefano Biagioni, Mauro Giorgi, Anna Alisi, Mara Massimi
Summary: The study found that PDE4D gene/protein were over-expressed in HCC samples compared to normal livers, and silencing or pharmacological inhibition of PDE4D activity showed anti-tumorigenic effects by reducing cell proliferation and increasing apoptosis. Over-expression of PDE4D in human HCCs correlated with up-regulated pro-oncogenic genes, suggesting a new potential molecular network for further investigation. PDE4D depletion/inhibition may serve as a novel biomarker for diagnosis and a potential adjuvant target for HCC therapy.
Article
Biochemistry & Molecular Biology
Luhao Li, Suxin Li, Haohao Wang, Lin Li, Peiju Wang, Dongqi Shen, Xiaowei Dang
Summary: The study revealed that GSG2 is overexpressed in HCC tissues, and knockdown of GSG2 can inhibit the progression of HCC, promote cell apoptosis, and potentially participate in the oncogenesis of HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Medicine, Research & Experimental
Hui Liu, Junya Li, Wenwen Yuan, Shengyu Hao, Meng Wang, Fei Wang, Hongzhuan Xuan
Summary: The study found that the bioactive components in poplar propolis extract CP were mainly flavonoids and esters. CP induced HepG2 apoptosis through a mitochondrial-dependent intrinsic pathway, as well as through the regulation of various signaling pathways and molecules to achieve anti-proliferation and pro-apoptosis effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Isaacson B. Adelani, Oluwakemi A. Rotimi, Emmanuel N. Maduagwu, Solomon O. Rotimi
Summary: Vitamin D deficiency may aid HCC progression and play vital roles in skeletal mineralization and cell cycle regulation. Studies have shown that Vitamin D plays crucial roles in the anticancer effects in HCC and can serve as therapeutic targets. Research advancements have revealed the multifaceted mechanisms of Vitamin D in HCC development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fangnan Wu, Chaoyong Tu, Kun Zhang, Hanyang Che, Qiaomei Lin, Zhuokai Li, Qingyun Zhou, Bufu Tang, Yang Yang, Minjiang Chen, Chuxiao Shao
Summary: This study found that PKMYT1 is overexpressed in HCC patients and is associated with poor prognosis. Knockdown of PKMYT1 inhibited proliferation and migration of HCC cell lines, inhibited autophagy, and induced apoptosis. These findings suggest that PKMYT1 may function as an oncogene and could be a new target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Jing-ru Yang, Xiao-ling Ling, Quan-lin Guan
Summary: The study revealed that Rap-related protein Rap-2a (RAP2A) is upregulated in hepatocellular carcinoma (HCC) tissues and cells, and plays a role in promoting tumor cell proliferation and apoptosis resistance, potentially through activating the mTOR signaling pathway.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Environmental Sciences
Dongqin Niu, Dong Wang, Limei Fan, Zixin Liu, Ming Chen, Weiran Zhang, Yuchen Liu, Jinhua Xu, Yunyi Liu
Summary: In this study, the effectiveness of the copper (II) complex of salicylate phenanthroline [Cu(sal)(phen)] against hepatocellular carcinoma (HCC) was investigated. Cu(sal)(phen) inhibited HCC cell proliferation and induced apoptosis by increasing mitochondrial reactive oxygen species (ROS) production. The expression of antiapoptotic proteins survivin and Bcl-2 decreased, while DNA damage marker gamma-H(2)AX and apoptotic marker cleaved PARP expression increased with Cu(sal)(phen) treatment. In vivo studies showed that Cu(sal)(phen) greatly attenuated the growth of HCC xenograft tumors. Cu(sal)(phen) was also found to be relatively safe based on toxicity experiments with mice. These findings suggest that Cu(sal)(phen) has potential as a therapeutic drug for HCC.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Genetics & Heredity
Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran
Summary: This review summarizes the role and potential efficacy of miRNAs in promoting and inhibiting cell proliferation and apoptosis in HCC, as well as the role of miRNAs in therapy resistance in HCC.
Article
Cell Biology
Hui Tong, Xiaohui Liu, Chenghong Peng, Baiyong Shen, Zhecheng Zhu
Summary: This study demonstrates the significant role of KNTC1 in hepatocellular carcinoma (HCC) development and its correlation with poor prognosis. KNTC1 affects the biological activity of HCC cells through the PI3K/Akt signaling pathway.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Haina Wang, Rui Wang, Dan Huang, Sihan Li, Beibei Gao, Zhijie Kang, Bo Tang, Jiajun Xie, Fanzhi Yan, Rui Liang, Hua Li, Jinsong Yan
Summary: The study demonstrates that HHT can inhibit the growth and spread of HCC cells through various pathways, including reducing cell proliferation, inhibiting colony formation, preventing cell invasion and migration, inducing cell cycle arrest, and promoting apoptosis. The apoptosis induced by HHT is mainly achieved through the activation of the Hippo pathway.
FRONTIERS IN PHARMACOLOGY
(2021)