期刊
ONCOLOGY REPORTS
卷 28, 期 6, 页码 2101-2106出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2012.2027
关键词
let-7a; enhancer of zeste homolog 2; proliferation; apoptosis; nasopharyngeal carcinoma
类别
资金
- China Natural Science Foundation [81000963]
- 333 Talent Program of Jiangsu Province [BRA2011046]
- Kunshan Social Development Foundation [KS1006, KS1009]
- Suzhou Social Development Foundation [SYS201063]
Let-7a is frequently downregulated in various types of human cancer including nasopharyngeal carcinoma. However, the underlying mechanism of let-7a action in nasopharyngeal carcinoma remains elusive. In this study, we show that the enhancer of zeste homolog 2 (EZH2) is a direct target of let-7a in human nasopharyngeal carcinoma cells. The inhibition of EZH2 in vitro by let-7a, EZH2 si RNA, attenuated nasopharyngeal carcinoma cell growth, inhibited cell proliferation and induced cell apoptosis. In addition, for each biological process we identified ontology-associated transcripts that significantly correlate with EZH2 expression. Finally, the expression of EZH2 significantly abrogated let-7a-mediated cell proliferation and apoptosis in the nasopharyngeal carcinoma cells. Taken together, our results suggest that let-7a and EZH2 may be potential therapeutic targets for nasopharyngeal carcinoma.
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