Article
Cardiac & Cardiovascular Systems
Hannah N. Marmor, Michael N. Kammer, Stephen A. Deppen, Maren Shipe, Valerie F. Welty, Khushbu Patel, Caroline Godfrey, Ehab Billatos, James G. Herman, David O. Wilson, Amanda K. Kussrow, Darryl J. Bornhop, Fabien Maldonado, Heidi Chen, Eric L. Grogan
Summary: The study aimed to compare different methods in diagnosing indeterminate pulmonary nodules, and the results showed that the integrated biomarker model had higher diagnostic accuracy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Sheng Wu, Hsin-Yi Wu, Pin-Hsuan Wang, Ting-Yu Chen, Kuan-Ru Chen, Chih-Wei Chang, Dong-En Lee, Bo-Heng Lin, William Chih-Wei Chang, Pao-Chi Liao
Summary: Lung cancer is a major cause of cancer-related death worldwide, and research is needed to dissect its pathogenic mechanisms and discover specific biomarkers. LCMD is the first database to provide information on lung cancer-related metabolites, aiming to promote the discovery of biomarkers for lung cancer.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Oncology
Jingwei Li, Qiran Zhang, Decheng Jiang, Jun Shao, Weimin Li, Chengdi Wang
Summary: Lung cancer has the highest mortality rate among malignancies worldwide. Circular RNAs (circRNAs), a type of covalently closed molecules, show potential clinical application prospects in lung cancer. This review explains the biogenesis, biological functions, and pathophysiology of circRNAs, and highlights their forefront in the diagnosis, prognosis, and therapy of lung cancer.
Article
Oncology
Jiaqi Li, Man Liu, Xue Zhang, Longtao Ji, Ting Yang, Yutong Zhao, Zhi Wang, Feifei Liang, Liping Dai
Summary: This study investigated the expression of anti-PD1/PDL1 autoantibodies in lung cancer patients and normal controls. The results showed that the expression of anti-PD1/PDL1 IgG was significantly higher in lung cancer samples compared to normal controls. It was also found that plasma anti-PD1/PDL1 IgG and IgM could potentially serve as biomarkers and risk predictors for lung cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Marcel E. Dinger, Parichehr Maleki, Mohammad Taheri, Mohammadreza Hajiesmaeili
Summary: circRNAs have been proposed as molecular markers for lung cancer due to their stability in blood, showing potential value in disease detection. Dysregulation of circRNAs in lung cancer tissues suggests their potential involvement in carcinogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Median Zhao, Jianguo Feng, Liling Tang
Summary: CeRNAs can regulate biological processes through complex networks, potentially leading to cancer when imbalanced; Dysregulated RNAs in lung cancer may serve as ceRNAs to regulate various biological functions; CeRNAs are also being explored as potential prognostic and diagnostic biomarkers in lung cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Oncology
Hong Huang, Yongfeng Yang, Yihan Zhu, Hongyu Chen, Ying Yang, Li Zhang, Weimin Li
Summary: Lung cancer is the leading cause of cancer-related mortality, often diagnosed at advanced stages. Early detection and intervention are crucial to reducing mortality, and circulating biomarkers offer noninvasive and cost-effective real-time information. This review focuses on the research progress of three common types of blood protein biomarkers in lung cancer for potential clinical translation.
Article
Medicine, General & Internal
Roberto Gasparri, Giulia Sedda, Valentina Caminiti, Patrick Maisonneuve, Elena Prisciandaro, Lorenzo Spaggiari
Summary: Lung cancer is the leading cause of cancer deaths worldwide, and early detection is crucial for reducing the burden of the disease. Current diagnostic techniques have limitations, highlighting the need for reliable biomarkers for early identification. Urine could be a non-invasive alternative matrix, with potential for discovering diagnostic biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Xiangxiao Hu, Lina Wang, Bin Shang, Junren Wang, Jian Sun, Bin Liang, Lili Su, Wenjie You, Shujuan Jiang
Summary: Immune checkpoint inhibitors have revolutionized cancer treatment but also brought about immune-related adverse events. It is important to understand and predict which patients are susceptible to these toxicities.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yihong Ren, Yuxin Zhao, Yanan Shan, Sixuan Li, Nan Su, Zhigang Cui, Zhihua Yin
Summary: This study found that hsa_circ_0049657, a circular RNA derived from the NFIX gene, was down-regulated in NSCLC tissues and cells. In addition, we could suppress the proliferation and invasion abilities and promote apoptosis of NSCLC cells by up-regulating hsa_circ_0049657.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Jennifer W. Carlisle, Ticiana Leal
Summary: Small cell lung cancer (SCLC) is a rapidly progressive neuroendocrine carcinoma that has limited effective treatments. Advances in DNA sequencing and whole transcriptomics have identified key subtypes, leading to the development of chemoimmunotherapy as the standard of care for advanced disease. Ongoing research is focused on incorporating immunotherapy into limited stage settings and exploring combination strategies with radiation.
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fan Yang, Chunlan Ma, Jing Qiu, Xiaoli Feng, Kai Yang
Summary: This study identified 114 circRNAs that were differentially expressed in NSCLC tissue compared to paracancerous tissue levels, with 77 downregulated and 37 upregulated. CircRNA_001846 may serve as a promising diagnostic biomarker for NSCLC, associated with tumor differentiation, lymph node metastasis, and node metastasis stage.
Review
Medicine, Research & Experimental
Weihua Zhan, Song Zhang
Summary: TRIM proteins play key roles in various biological processes and are closely related to tumor development; Alterations in TRIM gene and protein levels frequently emerge in tumors and affect tumor progression; TRIM proteins maintain the balance between tumor suppressive and tumor promoting genes through ubiquitylation events.
Review
Biochemistry & Molecular Biology
Heather L. Rossi, Jorge F. Ortiz-Carpena, Devon Tucker, Andrew E. Vaughan, Nilam S. Mangalmurti, Noam A. Cohen, De'Broski R. Herbert
Summary: This review discusses the important role of TFF family members in healthy and diseased airways. TFF peptides maintain and restore homeostasis in the airways through their regulation of the mucous layer, cell motility, cell differentiation, and immune function. Differences in TFF member tracks between humans and mice pose a challenge for research. New evidence suggests that TFF proteins interact with receptor binding partners in mediating biological effects in mouse models of repair and infection. TFF peptides may be reasonable therapeutic targets in the treatment of airway diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Fujing Wang, Jia'er Fan, Tingting Pei, Zhuo'en He, Jiaxing Zhang, Liliang Ju, Zhongxiao Han, Mingqing Wang, Wei Xiao
Summary: Diabetic nephropathy is the leading cause of end-stage renal disease. Shenkang pills, a traditional Chinese medicine prescription, can effectively treat early-stage diabetic nephropathy and improve renal podocyte dysfunction. The therapeutic effects of Shenkang pills may involve down-regulation of the AURKB/RacGAP1/RhoA pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Jiehua Deng, Wei Xiao, Zheng Wang
Summary: The expression level of FAM46C is correlated with the prognosis of tumors, and low expression suggests a poor prognosis. FAM46C is positively correlated with immune cell abundance in the tumor microenvironment and has associations with immunomodulatory pathways, factors, and markers. Additionally, FAM46C expression is related to certain tumor characteristics.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Dao Qi Zhu, Ying Liu, Zhi Jian Yu, Ru Hua Zhang, Ai Wu Li, Feng Ying Gong, Wei Wang, Wei Xiao, Qin Fan
Summary: The study reveals the association between KRAS mutation and radioresistance in non-small cell lung cancer (NSCLC). KRAS mutation could serve as a biomarker for radioresistance and a potential target to enhance radiosensitivity.
WORLD JOURNAL OF ONCOLOGY
(2022)
Article
Microbiology
Zhuoen He, Yunong Zeng, Shuyu Li, Lizhen Lin, Ruisi Zhou, Fangzhao Wang, Wenjiao Yang, Yuhao Wu, Junhao Yang, Ali Chen, Zhang Wang, Hong Yang, Xiaoshan Zhao, Wei Xiao, Lei Li, Shenhai Gong
Summary: This study highlights the significance of gut commensal fungi in hepatic inflammation and oxidative stress in APAP-induced liver injury and suggests a promising therapeutic strategy targeting Cyp2a5 for DILI treatment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Organic
Xia Cheng, Fo-Pei Ma, Yong-Ming Yan, Wen-Li Zhao, Jin Shi, Wei Xiao, En-Guang Bi, Qi Luo
Summary: A novel polyketide Aspertaichunol A (1) was isolated from medicinal insect-derived endophytic Aspergillus taichungensis SMU01, possessing a unique structure and potential immunomodulatory activity.
Article
Genetics & Heredity
Ti-Wei Miao, Fang-Ying Chen, Long-Yi Du, Wei Xiao, Juan-Juan Fu
Summary: An RBP-related signature was successfully constructed to predict prognosis in NSCLC, serving as a reference for individualized therapy. Through bioinformatics analysis and experimental validation, the signature revealed correlations between the high-risk group and immune infiltration, gene mutation frequency, chemotherapy response, and other factors.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Piao Luo, Jiayun Chen, Qian Zhang, Fei Xia, Chen Wang, Yunmeng Bai, Huan Tang, Dandan Liu, Liwei Gu, Qingfeng Du, Wei Xiao, Chuanbin Yang, Jigang Wang
Summary: This study used advanced single-cell RNA sequencing (scRNA-seq) and proteomics techniques to uncover the cellular and molecular mechanisms of aristolochic acid I (AAI)-induced hepatotoxicity. The results showed that AAI activated multiple signaling pathways in hepatocytes and liver sinusoidal endothelial cells (LSECs), leading to inflammatory response and cell apoptosis. In addition, AAI induced infiltration of inflammatory cells and aggravated inflammation.
PRECISION CLINICAL MEDICINE
(2022)
Article
Cell Biology
Tingting Pei, Daoqi Zhu, Sixia Yang, Rong Hu, Fujing Wang, Jiaxing Zhang, Shihua Yan, Liliang Ju, Zhuoen He, Zhongxiao Han, Jinyue He, Yangtian Yan, Mingqing Wang, Wei Xiao, Yun Ma
Summary: Chronic kidney disease affects muscle atrophy, and the gut microbiome is related to protein consumption. This study found that Bacteroides plebeius may combat muscle atrophy by modulating the gut microbiome.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Tingting Pei, Rong Hu, Fujing Wang, Sixia Yang, Haitong Feng, Qiye Li, Jiaxing Zhang, Shihua Yan, Liliang Ju, Zhuoen He, Zhongxiao Han, Aicheng Yang, Wei Xiao, Yun Ma, Mingqing Wang
Summary: This study investigated the effects of Akkermansia muciniphila (AKK) bacteria on kidney damage and the renal interstitium in rats with chronic kidney disease (CKD). The results showed that AKK administration could significantly reduce renal interstitial fibrosis and may be a novel therapeutic strategy for treating CKD.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Sixia Yang, Tingting Pei, Linshuang Wang, Yi Zeng, Wenxu Li, Shihua Yan, Wei Xiao, Weidong Cheng
Summary: The study found that Salidroside has a protective effect in aging-related renal fibrosis. It can reduce renal dysfunction, decrease mesangial hyperplasia, and regulate proteins related to ferroptosis.
Article
Multidisciplinary Sciences
Wei Zhang, Siyu Xia, Wei Xiao, Yali Song, Li Tang, Min Cao, Jing Yang, Shuang Wang, Zhijie Li, Chengchao Xu, Jianqiao Liu, Shanchao Zhao, Chuanbin Yang, Jigang Wang
Summary: This study focuses on the reproductive issues of advanced paternal age and analyzes the molecular and cellular changes associated with aging in the testes of mice. The study discovers various aging-related biological processes and identifies an increased subtype of aging-specific macrophages that contribute to a proinflammatory environment during testicular aging.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Immunology
Xia Chen, Rong Wu, Lei Li, Yunong Zeng, Jingrui Chen, Mingyuan Wei, Yinglin Feng, Guiming Chen, Yuhang Wang, Lizhen Lin, Haihua Luo, Ali Chen, Zhenhua Zeng, Fangjie He, Yang Bai, Siyou Zhang, Yubing Han, Zhang Wang, Xiaoshan Zhao, Wei Xiao, Yong Jiang, Shenhai Gong
Summary: The changes in gut microbiome during pregnancy are associated with increased susceptibility to sepsis. Through experiments on mice and humans, it was found that reduced abundance of Parabacteroides merdae during pregnancy leads to decreased levels of formononetin (FMN) and increased macrophage death. Further investigation revealed that FMN inhibits macrophage pyroptosis by suppressing nuclear accumulation of hnRNPUL2 and subsequent binding to the Nlrp3 promoter. Treatment with FMN or deletion of hnRNPUL2 protected against septic inflammation. The levels of P. merdae and FMN in the gut were inversely correlated with sepsis progression in patients.
Article
Biochemistry & Molecular Biology
Jiangpeng Wu, Xiuping Sun, Chunyi Wu, Xiaoping Hong, Lulin Xie, Zixu Shi, Liang Zhao, Qingfeng Du, Wei Xiao, Jichao Sun, Jigang Wang
Summary: This study used single-cell RNA sequencing to analyze the liver tissues of mice exposed to GLY, the active ingredient of a widely used herbicide. The results showed that GLY can induce changes in cell composition, upregulate oxidative stress and inflammatory response, and affect the functionality of macrophages and hepatic stellate cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)