Article
Environmental Sciences
Marthandam Asokan Shibu, Yi-Ju Chen, Hong-Siang Yang, Yen-Hua He, Yun-Hsin Lo, Wan-Teng Lin
Summary: This study found that ethanol extract from pine needles has anti-tumor activity against liver cancer cells. A fraction containing pinocembrin, chrysin, and tiliroside can reduce autophagy and increase apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Diqi Yang, Ruiling Yin, Qianghui Lei, Jiandi Zhu, Sha Nan, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: Baicalin alleviates endometrial inflammatory injury by regulating autophagy and influencing the redistribution of TJ proteins, providing a new therapeutic approach for preventing embryo loss and endometritis.
Review
Biochemistry & Molecular Biology
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Summary: The pathogenesis of hepatocellular carcinoma (HCC) is a complex and multifactorial process that remains incompletely understood. Autophagy and apoptosis are two important cellular pathways that play critical roles in cell survival or death. Dysregulation of the balance between apoptosis and autophagy is commonly observed in HCC and other cancers. Autophagy can either inhibit or promote apoptosis, thereby influencing the fate of liver cancer cells. This review provides a concise overview of the pathogenesis of HCC, highlighting recent developments such as endoplasmic reticulum stress, microRNAs, and gut microbiota. The characteristics of HCC associated with specific liver diseases are discussed, and a brief introduction to autophagy and apoptosis is provided. The role of autophagy and apoptosis in HCC initiation, progression, and metastasis is reviewed, with extensive analysis of experimental evidence pointing to an interplay between these two processes. The role of ferroptosis, a recently described form of regulated cell death, is also presented. Finally, the potential therapeutic implications of autophagy and apoptosis in drug resistance are examined.
Article
Oncology
Giuseppa Augello, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Lucia Condorelli, Antonella Cusimano, Lydia Giannitrapani, James A. McCubrey, Juan Lucio Iovanna, Melchiorre Cervello
Summary: The study revealed that NUPR1 knock-down impaired autophagic flux, increasing cell sensitivity to sorafenib, and activated the p73 signaling pathway, enhancing the anti-tumor effects of the drug. Combined therapy with the p73 activator NSC59984 and sorafenib showed synergistic suppression of tumor growth, suggesting a novel approach for HCC treatment.
Article
Cell Biology
Zhi Yu, Dan Wang, Yingying Tang
Summary: In hepatocellular carcinoma, PKM2 promotes metastasis and inhibits autophagy through the activation of the JAK/STAT3 pathway. Knockdown of PKM2 induces cell apoptosis and autophagy, while also suppressing cell migration and proliferation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Ling Qiao, Siyuan Qin, Ningna Weng, Bowen Li, Maochao Luo, Zhe Zhang, Li Zhou, Dong Wang, Canhua Huang
Summary: Toceranib phosphate exhibits potent antitumor activity against human hepatocellular carcinoma (HCC) by stimulating apoptosis and inducing autophagy. The protective role of TOC-induced autophagy in HCC cell death is associated with the inactivation of the Akt/mTOR pathway. Additionally, the combination therapy of sorafenib and TOC shows pronounced synergistic effects on HCC cells.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Qinglian Hu, Liwang Xu, Xiaoyu Huang, Yuxuan Duan, Dongchang Sun, Zhengwei Fu, Yunfen Ge
Summary: In this study, a collaborative MOF system with dual-response properties was constructed for intelligent drug release. The system demonstrated excellent biocompatibility and synergistic efficacy, showing promising potential for biomedical applications.
Article
Biochemistry & Molecular Biology
Wen-Tsan Chang, Yung-Ding Bow, Yen-Chun Chen, Chia-Yang Li, Jeff Yi-Fu Chen, Yi-Ching Chu, Yen-Ni Teng, Ruei-Nian Li, Chien-Chih Chiu
Summary: The study demonstrates that the combination treatment of diTFPP and C-2-ceramide can significantly enhance cell death in HCC cells through disrupting sphingolipid metabolism, inhibiting cell cycle-related gene expression, inducing autophagy, and reactive oxygen species-responsive changes in gene expression.
Article
Chemistry, Medicinal
Jialing Sun, Xuemei Yang, Haitao Sun, Shaohui Huang, Haiyan An, Wei Xu, Weicong Chen, Wenting Zhao, Chunyu He, Xiaodan Zhong, Tong Li, Yang Liu, Bin Wen, Qingfeng Du, Songqi He
Summary: Baicalin, derived from Scutellaria baicalensis Georgi, has been found to inhibit hepatocellular carcinoma (HCC) growth and metastasis. This study showed that Baicalin suppressed HCC cell proliferation, invasion, and metastasis, induced cell cycle arrest and apoptosis. In vivo experiments demonstrated that Baicalin inhibited HCC growth. Mechanistically, Baicalin inhibited the expressions of ROCK1, p-GSK-3β, and β-catenin, while up-regulating GSK-3β and p-β-catenin expressions. Baicalin also regulated the expressions of various proteins involved in HCC progression. Molecular docking studies revealed a binding interaction between Baicalin and ROCK1. Suppression of ROCK1 expression enhanced the inhibitory effects of Baicalin on HCC, while restoration of ROCK1 expression reduced Baicalin's efficacy. These findings suggest that Baicalin suppresses HCC proliferation and metastasis through the ROCK1/GSK-3β/β-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Junli Zhang, Ling Shang, Wendi Jiang, Wenjuan Wu
Summary: This study investigates the effects of Shikonin (SK) and Pyrroline-5-carboxylate reductase 1 (PYCR1) on apoptosis and autophagy in hepatocellular carcinoma. The results demonstrate that SK and siPYCR1 can inhibit the malignant phenotype of HCC cells and induce apoptosis and autophagy in a dose-dependent manner. Additionally, the study shows that SK and siPYCR1 together can downregulate the expression of PI3K/Akt/mTOR signal pathway proteins in HCC cells.
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Yusuf Hussain, Jyoti Singh, Abha Meena, Rohit Anthony Sinha, Suaib Luqman
Summary: The therapeutic potential of combining escin and sorafenib for liver cancer treatment has been established in this study, and the underlying mechanism involving the up-regulation of p62 to block autophagy and induce late apoptosis in liver cancer cells has been elucidated.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Xiaodong Wang, Chunyue Wang, Huimin Tian, Yichi Chen, Bolin Wu, Wen Cheng
Summary: This study investigated the combination therapy of sonodynamic therapy (SDT) and MG-132 for liver cancer and found that this combination treatment could effectively induce apoptosis and autophagy in HCC cells, thereby achieving anti-tumor therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fangnan Wu, Chaoyong Tu, Kun Zhang, Hanyang Che, Qiaomei Lin, Zhuokai Li, Qingyun Zhou, Bufu Tang, Yang Yang, Minjiang Chen, Chuxiao Shao
Summary: This study found that PKMYT1 is overexpressed in HCC patients and is associated with poor prognosis. Knockdown of PKMYT1 inhibited proliferation and migration of HCC cell lines, inhibited autophagy, and induced apoptosis. These findings suggest that PKMYT1 may function as an oncogene and could be a new target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Juan Yi, Xia Gong, Xiao-Yang Yin, Li Wang, Jin-Xia Hou, Jing Chen, Bei Xie, Gang Chen, Li-Na Wang, Xiao-Yuan Wang, Da-Chun Wang, Hu-Lai Wei
Summary: This study demonstrates that combination therapy with parthenolide (PTL) and arsenic trioxide (ATO) synergistically inhibits the proliferation of hepatocellular carcinoma (HCC) cells by suppressing stemness and self-renewal ability and inducing apoptosis. The study also reveals that the USP7-HUWE1-p53 pathway is involved in PTL enhancing ATO-induced apoptosis of HCC cell lines, and that PTL and ATO induce autophagic activity by inhibiting the PI3K/Akt/mTOR pathway.
FRONTIERS IN ONCOLOGY
(2022)
