Article
Cell Biology
Lixu Zhu, Wenzhi Guo
Summary: This study identified the methylation characteristics of PD-1-negative HCC samples and proposed a prognostic model based on DMEGs. The tumor samples showed significantly lower ESTIMATE scores compared to normal samples, and 31 DMEGs were identified as able to distinguish PD-1-negative samples from normal samples. Functional enrichment analysis revealed the involvement of these genes in tumor-related and immune-related pathways, and potential therapeutic drugs were identified through DrugBank screening. The prognostic model based on three DMEGs demonstrated good predictive power for HCC prognosis and was validated in an independent cohort.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiao Wang, Mengke Chen, Xiong Liang, Yu Bai, Judeng Zeng, Xiaoyi Xu, Hao Li, Jing Wang, Keyu Fan, Guijun Zhao
Summary: This study reveals that RNF135 is regulated by promoter hypermethylation and its decreased expression is associated with poor prognosis in hepatocellular carcinoma (HCC). Functional analysis demonstrates that RNF135 plays a crucial role in suppressing HCC cell migration and is involved in tumor immune microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Rongfeng Shi, Hui Zhao, Suming Zhao, Hongxin Yuan
Summary: This study comprehensively integrated the transcriptome profiling of DNA methylation regulators in hepatocellular carcinoma, identifying three distinct DNA methylation regulator-related molecular subtypes and constructing a prognostic and immunotherapeutic relevant gene signature. These findings contribute to the advancement of individualized immunotherapy for hepatocellular carcinoma.
Article
Cell Biology
Lixu Zhu, Wenzhi Guo
Summary: This study identified the methylation characteristics of PD-1-negative HCC samples and potential therapeutic drugs, and proposed a prognostic model based on UBD, CD5L, and CD213A2 methylation expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Yingyun Guo, Binglu Huang, Ruixue Li, Jiao Li, Shan Tian, Cheng Peng, Weiguo Dong
Summary: In patients with hepatocellular carcinoma (HCC), APOA-1 mRNA expression is negatively regulated by DNA methylation. Low APOA-1 expression may serve as a potential risk biomarker for predicting survival in HCC patients. Additionally, high APOA-1 transcription correlates with better overall survival, and APOA-1 hypermethylation is associated with progress-free survival in HCC sufferers.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Huimin Shen, Hao Wu, Fengkai Sun, Jianni Qi, Qiang Zhu
Summary: This study identified key prognostic factors of iron metabolism-related and methylated genes for HCC, and constructed a prognostic model to predict overall survival of patients. The risk score calculated using gene expression of specific DEGs was found to be an independent variable correlated with HCC prognosis, providing a potential treatment strategy for HCC.
Article
Gastroenterology & Hepatology
Claudia Maccali, Aline L. Chagas, Ilka Boin, Emilio Quinonez, Sebastian Marciano, Mario Vilatoba, Adriana Varon, Margarita Anders, Sergio Hoyos Duque, Agnaldo S. Lima, Josemaria Menendez, Martin Padilla-Machaca, Jaime Poniachik, Rodrigo Zapata, Martin Maraschio, Ricardo Chong Menendez, Linda Munoz, Diego Arufe, Rodrigo Figueroa, Alejandro Soza, Martin Fauda, Simone R. Perales, Rodrigo Vergara Sandoval, Carla Bermudez, Oscar Beltran, Isabel Arenas Hoyos, Lucas McCormack, Francisco Juan Mattera, Adrian Gadano, Jose H. Parente Garcia, Claudia Megumi Tani, Luiz Augusto Carneiro D'Albuquerque, Flair J. Carrilho, Marcelo Silva, Federico Pinero
Summary: This study evaluated the post-recurrence survival (PRS) of HCC patients after liver transplantation, finding that early recurrence, sorafenib therapy, and surgery/TACE treatment were associated with improved survival rates. Any treatment, sorafenib therapy, and surgery/TACE treatment all significantly improved PRS.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Yuan Fang, Weiqiang Tang, Dan Zhao, Xiaoli Zhang, Na Li, Yang Yang, Li Jin, Zhitao Li, Benkai Wei, Yinglei Miao, Zhong Zeng, Hanfei Huang
Summary: The study reveals that HELLS is associated with poorer prognosis in liver hepatocellular carcinoma (LIHC) and is positively correlated with tumor-infiltrating lymphocytes and immune checkpoint genes. The DNA methylation of HELLS may be involved in immune response. These findings highlight the important role of HELLS in promoting LIHC malignancy and suggest its potential as a biomarker for LIHC.
Article
Immunology
Songping Cui, Shuang Cao, Qing Chen, Qiang He, Ren Lang
Summary: This study found that the preoperative inflammatory status plays a crucial role in the long-term prognosis of hepatocellular carcinoma (HCC) patients after liver transplantation (LT). Specifically, the preoperative inflammatory biomarkers SIRI and PLR can be used to predict the prognosis of HCC patients after LT.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Yunhua Tang, Tielong Wang, Weiqiang Ju, Fangcong Li, Qi Zhang, Zhitao Chen, Jinlong Gong, Qiang Zhao, Dongping Wang, Maogen Chen, Zhiyong Guo, Xiaoshun He
Summary: The study demonstrated that IFLT significantly reduces the risk of HCC recurrence, decreases IRI damage, and lowers the incidence of early allograft dysfunction after liver transplantation when compared to conventional liver transplantation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Qian Yan, Ying Tang, Fan He, Jiao Xue, Ruisheng Zhou, Xiaoying Zhang, Huiyan Luo, Daihan Zhou, Xiongwen Wang
Summary: This study investigated alterations in DNA methylation patterns in hepatocellular carcinoma (HCC) using whole-genome bisulfite sequencing technology. The research identified a genome-wide hypomethylation pattern in HCC, with hyper-DMGs mainly involved in metabolism pathways and hypo-DMGs mainly involved in cell adhesion. By constructing a prognostic model based on aberrantly methylated genes, the study provided insights into the epigenetic mechanisms of HCC development.
Article
Oncology
Qi Zhang, Yuxuan Wei, Yihu Li, Xingyuan Jiao
Summary: The study found that the macrophage receptor with collagenous structure (MARCO) is downregulated in hepatocellular carcinoma (HCC) and is associated with poor prognosis in patients. Low MARCO expression is correlated with high alpha-fetoprotein levels, high incidence of microvascular invasion, and a higher number of patients exceeding Milan criteria. MARCO could potentially serve as a prognostic marker and therapeutic target in post-liver transplantation HCC.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Weiwei Cao, Yu Chen, Wei Han, Juzheng Yuan, Weimin Xie, Kun Liu, Yan Qiu, Xudan Wang, Xiao Li
Summary: This study found that patients with normal or normalized AFP and sICAM-1 levels in liver cancer had lower tumor recurrence rates and better survival rates, while those with elevated levels of both markers had poorer outcomes. AFP and ICAM-1 play crucial roles in the diagnosis, prognostic prediction, and immunotherapy of HCC, and their combined application can improve predictive accuracy.
Article
Biochemistry & Molecular Biology
Junhai Pan, Duguang Li, Xiaoxiao Fan, Jiaxi Cheng, Shengxi Jin, Peng Chen, Hui Lin, Yirun Li
Summary: This study used MassARRAY EpiTYPER technology to investigate the methylation differences of DLC1 in HCC tissues and adjacent noncancerous tissues, and explored the functional correlation between epigenetic modifications and DLC1 gene regulation using modified CRISPR-Cas9 system and DNMTi. The methylation levels of DLC1 isoforms in HCC samples were significantly lower than those in adjacent noncancerous tissues, and the expression of DLC1 could be bidirectionally regulated. Hypomethylation of DLC1 in HCC samples was associated with satellite lesions and incomplete tumor capsule. DLC1 methylation levels could be used as a potential biomarker for HCC.
DNA AND CELL BIOLOGY
(2023)
Article
Oncology
Ganji Purnachandra Nagaraju, Begum Dariya, Prameswari Kasa, Sujatha Peela, Sujatha Peela Bassel F. El-Rayes
Summary: HCC is the most common primary malignancy of the liver, with a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC, including chromatin remodeling, histone alterations, DNA methylation, and ncRNA expression. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies, improving overall survival, and predicting therapeutic outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)