期刊
TETRAHEDRON
卷 71, 期 18, 页码 2708-2718出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.03.033
关键词
Fungus; Truncatella angustata; Truncateols A-N; Structural elucidation; Inhibition of influenza-A virus
资金
- National Natural Science Foundation of China [30672607]
- NSFC-Shangdong Join Fund for Marine Science [U1406402]
- National Hi-Tech 863-Projects [2010DFA31610, 2011AA090701, 2013AA092902]
- COMRA [DY125-15-T-01]
- Sino-German Project [GZ816]
Fourteen new isoprenylated cyclohexanols namely truncateols A-N (1-14) were isolated from the solid culture of the sponge-associated fungus Truncatella angustata. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD, as well as X-ray diffraction for the assignment of absolute configurations. The structures of truncateols are characterized by the presence of unique alkynyl or allenyl groups. Truncateol M (13) exerted potent inhibitory effect against influenza-A viral infection by targeting virion assembly/release step. (C) 2015 Elsevier Ltd. All rights reserved.
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