Article
Biochemistry & Molecular Biology
Mengmeng Li, Qinglai Tang, Shisheng Li, Xinming Yang, Ying Zhang, Xiaojun Tang, Peiying Huang, Danhui Yin
Summary: The study found that Schisandrin B (Sch B) exerts anticancer effects on head and neck squamous cell carcinoma (HNSCC) by regulating apoptosis and autophagy. Sch B can induce apoptosis and autophagy in HNSCC cells, and inhibition of autophagy can enhance the apoptotic effect of Sch B. Additionally, Sch B-activated autophagy in HNSCC cells is dependent on the nuclear factor-kappa B (NF-kappa B) pathway, and reactive oxygen species (ROS) act as a regulator of the NF-B pathway. Therefore, inhibiting autophagy to enhance the anticancer effect of Sch B deserves further research.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yanting Wang, Xianyue Ren, Weiyu Li, Ruoyan Cao, Suyang Liu, Laibo Jiang, Bin Cheng, Juan Xia
Summary: SPDEF acts as a tumor suppressor in HNSCC by transcriptionally activating NR4A1, leading to inhibition of AKT, MAPK, and NF-kappa B signaling pathways. Low expression of SPDEF is associated with poor clinical outcomes in HNSCC patients, and restoration of SPDEF inhibits cell proliferation in HNSCC.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Junjie Huang, Bin Liang, Tianjiao Wang
Summary: FOXD1 is a potential oncogene in head and neck squamous cell carcinoma, with prognostic value for predicting patient survival. It plays an important role in tumor site, HPV infection, and immune cell infiltration. Additionally, FOXD1 is involved in cancer-related pathways and metabolism-related processes.
BIOSCIENCE REPORTS
(2021)
Article
Oncology
Charlotte Koetting, Linda Hofmann, Ramin Lotfi, Daphne Engelhardt, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Summary: Curcumin modulates the immune response and has anti-tumor effects by inhibiting NF-kappa B activation and reducing regulatory T-cell attraction, making it a promising adjuvant in cancer therapy for head and neck squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Ethan L. L. Morgan, Tiffany Toni, Ramya Viswanathan, Yvette Robbins, Xinping Yang, Hui Cheng, Sreenivasulu Gunti, Angel Huynh, Anastasia L. L. Sowers, James B. B. Mitchell, Clint T. T. Allen, Zhong Chen, Carter Van Waes
Summary: TNF alpha is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but several cancers display resistance to TNF alpha due to activation of the NF kappa B pro-survival pathway. In this study, we found that the expression of USP14, a proteasome-associated deubiquitinase, is increased in HNSCC and correlates with worse progression free survival. Inhibition or depletion of USP14 inhibited the proliferation and survival of HNSCC cells and reduced NF kappa B activity. Furthermore, we showed that the inhibitor b-AP15 sensitized HNSCC cells to TNF alpha-mediated cell death and radiation-induced cell death, and delayed tumor growth in vivo.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Multidisciplinary
Jiabin Xu, Hong Liu, Tao Wang, Zhenfu Wen, Haolin Chen, Zeyu Yang, Liyan Li, Shan Yu, Siyong Gao, Le Yang, Kan Li, Jingyuan Li, Xiang Li, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang
Summary: Immunotherapy, particularly dendritic cell (DC) vaccines, has shown promise in treating head and neck squamous cell carcinoma (HNSCC). However, the low immunogenicity and poor lymph node (LN) targeting efficiency have hindered the therapeutic efficacy. To overcome these limitations, a hybrid nanovaccine (Hy-M-Exo) was developed by combining tumor-derived exosome (TEX) and dendritic cell membrane vesicle (DCMV). The Hy-M-Exo nanovaccine displayed enhanced LN targeting efficiency and activated antigen presenting cells (APCs), resulting in a robust T-cell response. In a mouse model of HNSCC, the Hy-M-Exo nanovaccine demonstrated significant therapeutic efficacy, making it a promising strategy for antitumor immunotherapy.
Review
Medicine, General & Internal
Lanxin Hu, Jinwei Hu, Yanlin Huang, Sihan Zheng, Ji Yin, Xiaohui Li, Daiying Li, Caifeng Lv, Sen Li, Wenjian Hu
Summary: Since the 1950s, hypoxia has been identified as a crucial characteristic of cancer cells and their microenvironment, promoting cancer growth, survival, and metastasis. In the early 1990s, the activation of hypoxia-inducible factor-1 alpha (HIF1 alpha) was discovered as a key process in hypoxia, influencing angiogenesis and contributing to tumorigenesis, development, immune escape, and recurrence.
Article
Oncology
Libo Wang, Kejun Chen, Siyuan Weng, Hui Xu, Yuqing Ren, Quan Cheng, Peng Luo, Jian Zhang, Zaoqu Liu, Xinwei Han
Summary: This study investigates the role of PI3K pathway mutation in clinical prognosis prediction and its relationship with the immune microenvironment and response rate to immunotherapy in head and neck squamous cell carcinoma (HNSC) patients. The results show that PI3K pathway mutation predicts prolonged overall survival and better immunotherapy outcomes. The mutation group exhibits higher tumor mutation burden, activated immune-related pathways, and richer abundance of immune cells and immunomodulators.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Gyeong-Je Lee, Hyang Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Jae-Seek You, Ji-Su Oh, Yo-Seob Seo, Jae-Sung Kim
Summary: The study demonstrated that DMC can induce apoptosis in FaDu cells by modulating the cellular signaling pathway, suggesting its therapeutic potential for head and neck squamous cell carcinoma.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Oncology
Yuting Xue, Xuejiao Jiang, Junrong Wang, Yuxuan Zong, Zhennan Yuan, Susheng Miao, Xionghui Mao
Summary: Head and neck cancer, especially head and neck squamous cell carcinoma (HNSCC), is a highly lethal cancer with late diagnosis, high recurrence and metastasis rates, and poor prognosis. Recent studies on cell death regulation have shed light on the biology and therapeutic response of HNSCC, including various forms of cell death such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis. Regulatory cell death (RCD), controlled by specific signaling pathways, offers a new strategy for tumor therapy.
BIOMARKER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yi An, Jun Jeon, Lillian Sun, Adeeb Derakhshan, Jianhong Chen, Sophie Carlson, Hui Cheng, Christopher Silvin, Xinping Yang, Carter Van Waes, Zhong Chen
Summary: This study identified distinct alterations in cell death-related genes in HPV(+) HNSCC cells, which were associated with HPV status, tumor staging, and anatomic locations. Combination therapies, especially involving TRAIL and birinapant, showed increased drug sensitivity in these cells, highlighting the importance of targeting death pathways in HPV(+) HNSCC. Further research in this area may lead to improved treatment strategies for HNSCC and other squamous cancer types.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Article
Biochemistry & Molecular Biology
Lina Gu, Yang Sang, Xixi Nan, Yang Zheng, Fei Liu, Lingjiao Meng, Meixiang Sang, Baoen Shan
Summary: The up-regulated circCYP24A1 activates the NF-kappa B pathway by binding to PKM2, promoting the secretion of CCL5, and accelerating the malignant progression of ESCC.
Review
Oncology
Soudeh Ghafouri-Fard, Ali Noie Alamdari, Yashar Noee Alamdari, Atefe Abak, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali
Summary: This review summarizes the crucial role of the PI3K/AKT pathway in the development of squamous cell carcinomas, its impact on patient survival, the effectiveness of targeted therapies against this pathway, and the potential diagnostic markers for different types of SCCs.
CANCER CELL INTERNATIONAL
(2022)
Review
Toxicology
L. B. Alves, A. C. Moura, J. Amorim dos Santos, G. A. Borges, E. N. S. Guerra
Summary: This systematic review investigated the effects of PI3K inhibitors on HNSCC in vitro and in vivo. The results showed reduced cell proliferation and enhanced apoptosis after treatment with PI3K inhibitors. Combination therapy with PI3K inhibitors and other drugs had a stronger anticancer effect compared to single-drug treatments. These findings support the potential use of PI3K inhibitors in clinical trials for HNSCC.
TOXICOLOGY IN VITRO
(2023)