Article
Multidisciplinary Sciences
Alanna B. Chan, Gian Carlo G. Parico, Jennifer L. Fribourgh, Lara H. Ibrahim, Michael J. Bollong, Carrie L. Partch, Katja A. Lamia
Summary: Disruption of circadian rhythms can increase the risk of various cancers. Mutations in the CRY2 gene found in human cancers have been shown to accelerate cell growth in mouse fibroblasts expressing high levels of c-MYC. These mutations also have divergent effects on circadian rhythms and interaction with SCFFBXL3.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Zaofeng Yang, Marianne M. M. Lee, Michael K. Chan
Summary: The study demonstrates that Pos3Aa crystals can serve as an efficient vehicle for delivering proteins into cells, reversing the inactivation of potential cancer therapeutics and making them more sensitive to chemotherapy drugs.
Review
Chemistry, Multidisciplinary
Jerson L. Silva, Debora Foguel, Vitor F. Ferreira, Tuane C. R. G. Vieira, Mayra A. Marques, Giulia D. S. Ferretti, Tiago F. Outeiro, Yraima Cordeiro, Guilherme A. P. de Oliveira
Summary: Biomolecular condensates, arising from liquid-liquid phase separation, have dual roles in health and disease. This review focuses on their role in cancer, particularly in relation to the p53 tumor suppressor. Mutations in the TP53 gene, present in over half of malignant tumors, have significant implications for future cancer treatment strategies. Targeting the phase transitions of mutant p53 offers a promising direction for innovative cancer diagnostics and therapeutics.
Article
Biochemistry & Molecular Biology
Sun Hee Lee, Do Young Hyeon, Soo-Hyun Yoon, Ji-Hak Jeong, Saeng-Myung Han, Ju-Won Jang, Minh Phuong Nguyen, Xin-Zi Chi, Sojin An, Kyung-gi Hyun, Hee-Jung Jung, Ji-Joon Song, Suk-Chul Bae, Woo-Ho Kim, Daehee Hwang, You Mie Lee
Summary: Under hypoxic conditions, G9a-mediated methylation regulates the inactivation of RUNX3, promoting cancer cell proliferation and suppressing immune response and apoptosis, thereby facilitating tumor growth during early tumorigenesis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pariyakorn Udomwan, Chamsai Pientong, Panwad Tongchai, Ati Burassakarn, Nuchsupha Sunthamala, Sittiruk Roytrakul, Supawadee Suebsasana, Tipaya Ekalaksananan
Summary: The study showed that Androg could disrupt E6-mediated p53 degradation in HPV16-positive cervical cancer cells, leading to the restoration of intracellular p53 levels and induction of apoptosis. The anti-tumor activity of Androg relied on reducing host cell proteins associated with ubiquitin-mediated proteolysis pathways, particularly HERC4 and SMURF2. This disruption of E3 ubiquitin ligase activity by Androg may serve as an alternative treatment for HPV-associated epithelial lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Aidan J. Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B. Barney, Lauren N. Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A. Fedak, Tanner Wright, Carlo C. Maley, Wendy K. Kiso, Dennis Schmitt, David Malkin, Joshua D. Schiffman, Lisa M. Abegglen
Summary: There are approximately 20 TP53 retrogenes in the African and Asian elephant genomes, along with a conserved TP53 gene that encodes a full-length protein. The elephant TP53-RETROGENE 9 (TP53-R9) encodes a truncated p53 protein (p53-R9) that lacks important functional domains. The expression of this truncated elephant p53 retrogene protein induces apoptosis in human cancer cells, suggesting its potential use in therapeutic development.
CELL DEATH DISCOVERY
(2023)
Article
Biochemistry & Molecular Biology
Keisuke Omori, Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Masahiro Umeda, Kosei Ito
Summary: Osteosarcoma is a disease in humans characterized by TP53 mutations. In mice, loss of p53 triggers OS development, and osteoprogenitor-specific p53-deleted mice are widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms underlying the initiation or progression of OS following or parallel to p53 inactivation remain largely unknown. This study reveals a novel tumor suppressive mechanism mediated by C/ebp alpha in p53-deficient osteosarcomagenesis, highlighting the importance of the Runx-Myc oncogenic axis as a therapeutic target for OS.
Article
Biochemistry & Molecular Biology
Sigrid Uxa, Paola Castillo-Binder, Robin Kohler, Konstanze Stangner, Gerd A. Mueller, Kurt Engeland
Summary: Ki-67, a marker for cancer, is controlled by the expression of the MKI67 gene during the cell cycle. The interaction between DREAM, B-MYB-MuvB, FOXM1-MuvB, and RB plays a role in cell cycle-dependent transcription and transcriptional repression following p53 activation.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Pharmacology & Pharmacy
Jessica L. Phillips, Christiane Loehr, Bach D. Nguyen, Andrew B. Buermeyer, Siva K. Kolluri
Summary: The aryl hydrocarbon receptor (AhR) acts as a tumor suppressor in the absence of p53 signaling, and its loss can lead to increased tumorigenesis and altered tumor spectrum. These findings support the development of anti-cancer therapeutics that enhance the tumor suppressive actions of AhR.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Leon F. McSwain, Claire E. Pillsbury, Ramona Haji-Seyed-Javadi, Sandip Kumar Rath, Victor Chen, Tiffany Huang, Shubin W. Shahab, Haritha Kunhiraman, James Ross, Gabrielle A. Price, Abhinav Dey, Dolores Hambardzumyan, Tobey MacDonald, David S. Yu, Christopher C. Porter, Anna M. Kenney
Summary: Y-box binding protein 1 (YBX1 or YB1) plays a crucial role in driving proliferation, stemness, and resistance to platinum-based therapies in medulloblastoma (MB). This study focuses on investigating the role of YB1 in mediating radiation resistance in MB. The findings demonstrate that depleting YB1 in combination with radiation sensitizes MB cells to radiation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Stanley Teleka, Marju Orho-Melander, Fredrik Liedberg, Olle Melander, Karin Jirstrom, Tanja Stocks
Summary: This study found a potential additive interaction between genetic susceptibility for bladder cancer, blood pressure, and the risk of aggressive urothelial cancer in men. If replicated, these findings may provide insights for preventing aggressive urothelial cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Alberta Palazzo, Hector Hernandez-Vargas, Delphine Goehrig, Jean-Jacques Medard, David Vindrieux, Jean-Michel Flaman, David Bernard
Summary: Cancer cells arising from senescent cells display more aggressive features and resistance to drugs. A molecular signature of these cells can serve as a prognostic marker for several human cancers.
Review
Cell Biology
Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng
Summary: Hypoxia is crucial in solid tumors, with HIF and p53 signaling pathways playing key roles in regulating cellular responses to hypoxia. The interplay between hypoxia and p53 pathways can impact cancer progression, with p53 regulating hypoxia and HIF signaling in various ways, while mutant p53 can promote cancer progression through interaction with hypoxia and HIF signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biology
Julian M. Rozenberg, Svetlana Zvereva, Aleksandra Dalina, Igor Blatov, Ilya Zubarev, Daniil Luppov, Alexander Bessmertnyi, Alexander Romanishin, Lamak Alsoulaiman, Vadim Kumeiko, Alexander Kagansky, Gerry Melino, Carlo Ganini, Nikolai A. Barlev
Summary: During oncogenesis, cells undergo unrestricted proliferation, altering tissue homeostasis and possibly due to dysregulation of p53 family proteins p63 and p73. While p63 and p73 can compensate for loss of p53 in some cases, their overlap with p53 functions is strongest in regulating p53-dependent gene expression. Surprisingly, p73 is rarely lost or mutated in cancers, with its inactive isoforms often overexpressed and promoting cancer growth by repressing cell death mediated by p73.
Article
Neurosciences
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Akiko Tokinobu, Masashi Arakawa
Summary: The study suggests that higher maternal magnesium intake during pregnancy is inversely associated with hyperactivity problems in Japanese children, while there were no evident associations observed between maternal intake of other metal elements and childhood behavioral problems.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Pediatrics
Maoka Yamada, Keiko Tanaka, Masashi Arakawa, Yoshihiro Miyake
Summary: Our study found an association between maternal depression during pregnancy and postpartum and childhood behavioral problems. Specifically, maternal depressive symptoms during these periods were linked to emotional symptoms, conduct problems, hyperactivity, and peer problems in children, highlighting the impact of perinatal maternal depression on childhood development.
PEDIATRIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Atsushi Nishikawa, Keiko Tanaka, Yoshihiro Miyake, Chisato Nagata, Shinya Furukawa, Akira Andoh, Tetsuji Yokoyama, Naoki Yoshimura, Kenichiro Mori, Tomoyuki Ninomiya, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Mitsuru Saito, Katsuhisa Ohashi, Hirotsugu Imaeda, Kazuki Kakimoto, Kazuhide Higuchi, Hiroaki Nunoi, Yuji Mizukami, Seiyuu Suzuki, Sakiko Hiraoka, Hiroyuki Okada, Keitarou Kawasaki, Masaaki Higashiyama, Ryota Hokari, Hiromasa Miura, Teruki Miyake, Teru Kumagi, Hiromasa Kato, Naohito Hato, Koji Sayama, Yoichi Hiasa
Summary: This Japanese case-control study found that ever smoking was associated with an increased risk of ulcerative colitis (UC), especially among former smokers. However, no significant association was observed between current smoking and UC risk. Passive smoking exposure at home was also found to be significantly associated with an increased risk of UC.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Satomi Tanaka, Junji Uchino, Takashi Yokoi, Takashi Kijima, Yasuhiro Goto, Yoshifumi Suga, Yuki Katayama, Ryota Nakamura, Kenji Morimoto, Akira Nakao, Makoto Hibino, Nozomi Tani, Takayuki Takeda, Hiroyuki Yamaguchi, Yusuke Tachibana, Chieko Takumi, Noriya Hiraoka, Masafumi Takeshita, Keisuke Onoi, Yusuke Chihara, Ryusuke Taniguchi, Takahiro Yamada, Yohei Matsui, Osamu Hiranuma, Yoshie Morimoto, Masahiro Iwasaku, Shinsaku Tokuda, Yoshiko Kaneko, Tadaaki Yamada, Koichi Takayama
Summary: Combination therapy with immune checkpoint inhibitors and cytotoxic chemotherapies is more effective than cytotoxic chemotherapies alone in advanced NSCLC patients. The prognostic nutritional index (PNI) and lung immune prognostic index (LIPI) may serve as prognostic markers for chemoimmunotherapy.
Article
Endocrinology & Metabolism
Hiroshi Kumon, Yoshihiro Miyake, Yuta Yoshino, Jun-ichi Iga, Keiko Tanaka, Hidenori Senba, Eizen Kimura, Takashi Higaki, Bunzo Matsuura, Ryuichi Kawamoto, Shu-ichi Ueno
Summary: This is the first study to show significant associations between AGXT2 SNP rs37369, the CTA haplotype, and the CCA haplotype and DM. No interaction with regard to the risk of DM was observed between rs37369 and smoking.
CANADIAN JOURNAL OF DIABETES
(2022)
Article
Biochemistry & Molecular Biology
Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Shinya Furukawa, Akira Andoh, Tetsuji Yokoyama, Naoki Yoshimura, Kenichiro Mori, Tomoyuki Ninomiya, Yasunori Yamamoto, Eiji Takeshita, Yoshio Ikeda, Mitsuru Saito, Katsuhisa Ohashi, Hirotsugu Imaeda, Kazuki Kakimoto, Kazuhide Higuchi, Hiroaki Nunoi, Yuji Mizukami, Seiyuu Suzuki, Sakiko Hiraoka, Hiroyuki Okada, Keitarou Kawasaki, Masaaki Higashiyama, Ryota Hokari, Hiromasa Miura, Teruki Miyake, Teru Kumagi, Hiromasa Kato, Naohito Hato, Koji Sayama, Yoichi Hiasa
Summary: The IL12B gene SNP rs6887695 is significantly associated with the risk of UC, with individuals carrying the GG genotype having an increased risk. The influence of alcohol consumption on UC risk may depend on rs6887695.
Article
Allergy
Maoka Yamada, Keiko Tanaka, Chisato Nagata, Masashi Arakawa, Yoshihiro Miyake
Summary: Prenatal and postnatal smoking exposure is associated with an increased prevalence of wheeze and asthma among 3-year-old Japanese girls, but not boys. Girls exposed to both prenatal maternal smoking and postnatal household smoking have a significantly higher prevalence of wheeze and physician-diagnosed asthma. Significant interactions between sex and smoking exposure affecting wheeze and asthma were found.
Article
Biochemistry & Molecular Biology
Rei Noguchi, Akihiro Yoshimura, Junji Uchino, Takayuki Takeda, Yusuke Chihara, Takayo Ota, Osamu Hiranuma, Hiroshi Gyotoku, Koichi Takayama, Tadashi Kondo
Summary: EGFR mutations are strong predictive markers for EGFR-TKI therapy in NSCLC patients. Comprehensive kinase activity analysis identified specific kinase features in NSCLC patients with sensitizing EGFR mutations. Network analysis revealed highly phosphorylated kinases, and pathway analysis showed enrichment of the PI3K-AKT and RAF/MAPK pathways in patients with poor prognosis.
Article
Rheumatology
Yusuke Kashiwado, Yasutaka Kimoto, Kenji Oku, Mari Yamamoto, Shiro Ohshima, Satoshi Ito, Takahiko Horiuchi, Tsutomu Takeuchi
Summary: This study evaluated the treatment and prognosis of COVID-19 in patients with rheumatic diseases based on the time of onset and dominant strain. Data from a nationwide COVID-19 registry in Japan were analyzed, and the primary endpoints were hypoxemia incidence and mortality. The study found that the prognosis of COVID-19 improved over time in patients with rheumatic diseases, particularly during the Omicron BA.5-dominant period. Vaccination history and onset during the Omicron BA.5-dominant period were negatively associated with hypoxemia.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Sho Fujimoto, Yojiro Arinobu, Kohta Miyawaki, Masahiro Ayano, Hiroki Mitoma, Yasutaka Kimoto, Nobuyuki Ono, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: This study examined the role of basophils and anti-double-stranded DNA (dsDNA) IgE in the pathogenesis of SLE using human samples. The results showed that the serum levels of anti-dsDNA IgE in SLE patients were correlated with disease activity. Basophils were found to promote B cell differentiation through dsDNA-specific IgE, similar to the process observed in mouse models.
Article
Oncology
Takayuki Takeda, Tadaaki Yamada, Yusuke Kunimatsu, Keiko Tanimura, Kenji Morimoto, Shinsuke Shiotsu, Yusuke Chihara, Asuka Okada, Shigeto Horiuchi, Makoto Hibino, Kiyoaki Uryu, Ryoichi Honda, Yuta Yamanaka, Hiroshige Yoshioka, Takayasu Kurata, Koichi Takayama
Summary: Chemoimmunotherapy was found to improve overall survival (OS) and progression-free survival (PFS) in patients with extensive-stage small cell lung cancer (ES-SCLC) in previous phase III trials. However, the efficacy and safety of this treatment in elderly patients aged 75 years and older in Japan need to be evaluated using real-world evidence. A study evaluated 225 Japanese patients with SCLC, with 155 receiving chemoimmunotherapy. The study found that the dose reduction at the initiation of the first cycle was higher in elderly patients and that there were no significant differences in PFS and OS between non-elderly and elderly patients.
Article
Peripheral Vascular Disease
Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Ryuichi Kawamoto
Summary: In women, higher intake of fish and n-3 and n-6 polyunsaturated fatty acids may be associated with a lower prevalence of carotid wall thickening and a decrease in maximum carotid intima-media thickness. However, no significant associations were found between intake of fish and other fatty acids and carotid wall thickening or maximum carotid intima-media thickness in men.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Oncology
Keiko Tanimura, Takayuki Takeda, Akihiro Yoshimura, Ryoichi Honda, Shiho Goda, Shinsuke Shiotsu, Mototaka Fukui, Yusuke Chihara, Kiyoaki Uryu, Shota Takei, Yuki Katayama, Makoto Hibino, Tadaaki Yamada, Koichi Takayama
Summary: A prognostic risk classification combining pre-chemoradiotherapy (CRT) modified Glasgow Prognostic Score (mGPS) and post-CRT C-reactive protein (CRP) level helps predict progression-free survival (PFS) and overall survival (OS) of durvalumab consolidation after CRT in locally advanced non-small cell lung cancer (NSCLC) patients.
Article
Oncology
Keiko Tanimura, Takayuki Takeda, Nobutaka Kataoka, Akihiro Yoshimura, Kentaro Nakanishi, Yuta Yamanaka, Hiroshige Yoshioka, Ryoichi Honda, Kiyoaki Uryu, Mototaka Fukui, Yusuke Chihara, Shota Takei, Hayato Kawachi, Tadaaki Yamada, Nobuyo Tamiya, Naoko Okura, Takahiro Yamada, Junji Murai, Shinsuke Shiotsu, Takayasu Kurata, Koichi Takayama
Summary: This study found that first-line chemoimmunotherapy significantly improved overall survival and progression-free survival in patients with non-small cell lung cancer who had PD-L1 expression within the range of 1-49%. However, the benefits of chemoimmunotherapy were limited for patients with PD-L1 expression less than 1%.
Article
Rheumatology
Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura, Yoshifumi Tada, Hiroaki Niiro, Koichi Akashi, Takahiko Horiuchi
Summary: Discontinuation of biologic therapy after hospitalization for infections may lead to flares in rheumatoid arthritis. Continuing biologic therapy reduces the risk of rheumatoid arthritis flares, especially in patients without immunodeficiency.
ARTHRITIS RESEARCH & THERAPY
(2022)