Article
Plant Sciences
Maria Stephanie Cid-Gallegos, Cristian Jimenez-Martinez, Xariss M. Sanchez-Chino, Eduardo Madrigal-Bujaidar, Veronica R. Vasquez-Garzon, Rafael Baltierrez-Hoyos, Isela Alvarez-Gonzalez
Summary: This study evaluates the chemopreventive effect of chickpea on colon carcinogenesis in a mice model. The results show that a 20% chickpea diet significantly reduces tumors and biomarkers of proliferation and inflammation in AOM/DSS-induced colon cancer mice. Both diets of 10% and 20% chickpea exert a chemopreventive effect.
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Akanksha Esmeeta, Subhamay Adhikary, V Dharshnaa, P. Swarnamughi, Z. Ummul Maqsummiya, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Summary: Colon cancer, the third most common cancer, can be inhibited by plant-based compounds through various mechanisms. However, there are challenges in using these compounds, such as poor solubility, absorption, and intellectual property issues. Traditional medicines have advantages and limitations in treating cancer. This review focuses on the benefits and challenges of using bioactive compounds derived from plants for colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Abdulrazaq Yusuf, Ochai Emmanuel Odeh, Solomon Oguche Alhassan, Sunday Ene-Ojo Atawodi
Summary: The study evaluated the preventive effect of Hyphaene thebaica fruit on colon carcinogenesis in rats. The fruit protected against lipid peroxidation and early biomarkers of colon carcinogenesis. It also prevented severe inflammations and damage to the MLH1 gene. The results validate the use of H. thebaica fruit for the management of colorectal disorders.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Blassan P. George, Rahul Chandran, Heidi Abrahamse
Summary: Cancer chemoprevention involves using external agents to slow down or suppress cancer growth, and the occurrence of global cancer types varies depending on factors such as environmental, lifestyle, and genetic factors. Developed countries can prevent cancer with advanced treatment modalities, while developing countries often see it as a painful death sentence.
Article
Chemistry, Multidisciplinary
Kewei Wang, Xuan Xiao, Maolin Jiang, Jisi Li, Jielian Zhou, Youyong Yuan
Summary: The near-infrared dye CyNH2 can selectively induce pyroptosis in cancer cells through NQO1 response, leading to systemic activation of antitumor immunity.
Article
Biology
Malgorzata Klosek, Dagmara Jaworska, Grazyna Pietsz, Ewelina Szliszka
Summary: This study examined the apoptotic effect of santin in combination with TRAIL on colon cancer cells. Flow cytometry and fluorescence microscopy were used to observe apoptosis and death receptor expression. It was found that santin synergized with TRAIL to induce apoptosis in colon cancer cells. This synergistic effect was achieved by increasing the expression of death receptors TRAIL-R1 and TRAIL-R2 and altering the mitochondrial membrane potential.
Article
Oncology
Cody J. Schmidlin, Aryatara Shakya, Matthew Dodson, Eli Chapman, Donna D. Zhang
Summary: NRF2 plays a complex role in cancer by regulating genes involved in cell function and survival, and its activation mode determines its effects in cancer. The discovery of pharmacological modulators targeting NRF2 provides potential breakthroughs in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Plant Sciences
Bushra Ansari, Michael Aschner, Yaseen Hussain, Thomas Efferth, Haroon Khan
Summary: The research focuses on evaluating the inhibitory effects of naringin in citrus fruits on colorectal cancer, as well as its potential mechanistic pathways, including multiple signaling pathways such as NF-Kappa B/IL-6/STAT3, PI3K/AKT/mTOR, apoptosis, NF-Kappa B-COX-2-iNOS, and beta-catenin pathways.
Article
Plant Sciences
Marcelo Augusto Altieri, Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Nelci Antunes de Moura, Luis Fernando Barbisan
Summary: The study found that dietary capsaicin can reduce the development of urothelial lesions in rats, demonstrating a protective effect.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Geum-Lan Hong, Kyung-Hyun Kim, Chul-Ho Lee, Tae-Won Kim, Ju-Young Jung
Summary: NQO1 deficiency impairs autophagy and increases pro-fibrotic markers in renal cells, while NQO1 overexpression enhances autophagy and reduces the expression of pro-fibrotic markers. In vivo studies on Nqo1 knockout mice further confirmed that NQO1 deficiency exacerbates renal fibrosis by dysregulating autophagy.
Article
Biochemistry & Molecular Biology
Lucia Palumbo, Salvatore Genovese, Chiara Collevecchio, Francesco Epifano, Serena Fiorito
Summary: This manuscript investigates the biomolecular mechanism of action of 4'-geranyloxyferulic acid, a natural colon cancer chemopreventive agent, in cultured Caco-2 cells. The application of this phytochemical leads to a time- and dose-dependent decrease in cell viability, accompanied by the generation of reactive oxygen species and induction of caspases 3 and 9, ultimately causing apoptosis. Key pro-apoptotic targets, including CD95, DR4 and 5, cytochrome c, Apaf-1, Bcl-2, and Bax, undergo significant modifications, explaining the observed apoptosis in Caco-2 cells treated with 4'- geranyloxyferulic acid.
Review
Biochemistry & Molecular Biology
Samuel E. Weinberg, Le Yu Sun, Allison L. Yang, Jie Liao, Guang Yu Yang
Summary: Chronic inflammation is a common risk factor for human cancer, including colon cancer. Patients with inflammatory bowel disease have a significantly increased risk for colorectal carcinoma. Inositol and its phosphates play important roles in cancer prevention through cellular metabolic and signal transduction pathways.
Article
Medicine, Research & Experimental
Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Summary: The study demonstrates that NQO1 plays a protective role against oxidative stress and apoptosis in diabetic nephropathy by regulating Sirt1 and increasing intracellular NAD+/NADH levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Maarten C. Bosland, Lori Horton
Summary: This study examined the impact of arsenic exposure on prostate carcinogenesis in a rat model. The results showed that drinking water containing sodium arsenite did not affect the induction of prostate cancer or survival in the rats, nor did it affect their growth or water intake.