Article
Gastroenterology & Hepatology
Romain Desert, Wei Chen, Xiaodong Ge, Roselyne Viel, Hui Han, Dipti Athavale, Sukanta Das, Zhuolun Song, Daniel Lantvit, Luis Cano, Alexandra Naba, Orlando Musso, Natalia Nieto
Summary: A study found that there are extracellular matrix (ECM) deposits in liver cancer tumors with high intratumor fibrosis, which contain components such as collagen and growth factors. These deposits are associated with poor patient outcomes.
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ester Sanchez-Tillo, Leire Pedrosa, Ingrid Vila, Yongxu Chen, Balazs Gyorffy, Lidia Sanchez-Moral, Laura Siles, Juan J. Lozano, Anna Esteve-Codina, Douglas S. Darling, Miriam Cuatrecasas, Antoni Castells, Joan Maurel, Antonio Postigo
Summary: Mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 has opposite functions in KRAS- and BRAF-mutant CRCs. In KRAS-mutant CRCs, ZEB1 is associated with worse prognosis and more undifferentiated tumors, while in BRAF-mutant CRCs, ZEB1 is associated with better prognosis and more differentiated tumors. ZEB1 is positively correlated with gene signatures for EMT, cell proliferation and survival, and ERK signaling in KRAS-mutant CRC cells, but negatively correlated in BRAF-mutant CRC cells. ZEB1 may function as a tumor suppressor in BRAF-mutant CRCs.
Article
Biochemistry & Molecular Biology
Sema Bilgin, Secil Erden Tayhan, Asli Yildirim, Esra Koc
Summary: The aim of this study was to investigate the anticancer effects of isoeugenol based compounds 1, 2 on HT29 colorectal cancer cell line in vitro. Results indicated that 1 and 2 inhibited HT29 cell proliferation and induced apoptosis. These compounds also suppressed the mRNA expressions of metastasis-related genes such as Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor 1 alpha.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemical Research Methods
Kristina Lietz, Babak Saremi, Lena Wiese
Summary: This study developed a web application that simplifies the analysis of microarray data and allows for the comparison of results from different technologies and organisms. The application provides a convenient and customizable analysis process and allows users to gain further insights from existing study data.
BMC BIOINFORMATICS
(2023)
Article
Multidisciplinary Sciences
Tsinat Berhane, Anja Holm, Kasper Thystrup Karstensen, Andreas Petri, Mirolyuba Simeonova Ilieva, Henrik Krarup, Mogens Vyberg, Marianne Bengtson Lovendorf, Sakari Kauppinen
Summary: In this study, it was found that the overexpression of lncRNA PURPL in HCC inhibits cell proliferation, induces apoptosis, and increases the sensitivity of HCC cells to the chemotherapeutic agent doxorubicin.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nan Li, Ming Liu, Xiaohui Cao, Wei Li, Yunfang Li, Zongmao Zhao
Summary: In this study, differentially expressed genes in NSCLC tissues with or without bone metastases were identified, with COL6A1 being chosen as the target gene. Functional experiments demonstrated that overexpression of COL6A1 promoted the proliferation and invasion of NSCLC cells, while knockdown inhibited these processes. Moreover, COL6A1 also affected the adhesion ability of cancer cells to osteoblasts. These findings suggest that COL6A1 may serve as a potential diagnostic marker and therapeutic target for bone metastasis in NSCLC.
Article
Biochemistry & Molecular Biology
Qiangwei Zhou, Pengpeng Guan, Zhixian Zhu, Sheng Cheng, Cong Zhou, Huanhuan Wang, Qian Xu, Wing-kin Sung, Guoliang Li
Summary: DNA methylation is a stable epigenetic modification that plays crucial roles in cell differentiation, development, X chromosome inactivation, and disease. Allele-specific DNA methylation (ASM) is an established mechanism in genomic imprinting, closely related to tumorigenesis and plant development. The establishment of a comprehensive ASM database and in-depth analysis across multiple species revealed potential ASM-related genes in cancer and provided valuable insights into the functions of ASM in diseases and development.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Virology
Serdal Arslan, Mehmet Bakir, Burcu Bayyurt, Eylem Aydemir, Kenan Kinaci, Aynur Engin
Summary: This study investigated the lncRNA gene expression profiles in CCHF using microarray for the first time. Several lncRNAs were found to be significantly regulated in both case and fatal case groups. These lncRNAs could be considered as important therapeutic targets for further studies on CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Jiexi Li, Zhengdao Lan, Wenting Liao, James W. W. Horner, Xueping Xu, Jielin Liu, Yohei Yoshihama, Shan Jiang, Hong Seok Shim, Max Slotnik, Kyle A. A. LaBella, Chang-Jiun Wu, Kenneth Dunner Jr, Wen-Hao Hsu, Rumi Lee, Isha Khanduri, Christopher Terranova, Kadir Akdemir, Deepavali Chakravarti, Xiaoying Shang, Denise J. J. Spring, Y. Alan Wang, Ronald A. A. DePinho
Summary: Sex plays an important role in cancer incidence, spectrum, and outcomes, particularly in colorectal cancer (CRC) where men have higher metastases and mortality rates. A study using a murine CRC model revealed that oncogenic mutant KRAS (KRAS*) CRC in males showed higher metastases and worse outcomes. Further analysis found that the Y-chromosome gene histone demethylase KDM5D, driven by KRAS*-mediated activation of the STAT4 transcription factor, contributed to the sex differences in KRAS* CRC. Deletion of Kdm5d in cancer cells improved tight junction integrity, reduced invasiveness, and enhanced cancer cell killing by CD8(+) T cells. On the contrary, mice with a Kdm5d transgene had a higher propensity for invasive tumors. Therefore, the upregulation of Y chromosome KDM5D via KRAS*-STAT4 pathway disrupts cancer cell adhesion properties and tumor immunity, providing a potential therapeutic strategy for reducing metastasis risk in men with KRAS* CRC.
Article
Pharmacology & Pharmacy
Sarayut Radapong, Kelvin Chan, Satyajit D. Sarker, Kenneth J. Ritchie
Summary: Oxyresveratrol (OXY) alters key gene expression and biological pathways in MCF-7 breast cancer cells, inducing apoptosis and inhibiting cell cycle control. These changes were validated through quantitative PCR analysis and protein assays.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanjing Wang, Siyi Wang, Yuchen Niu, Buyong Ma, Jingjing Li
Summary: CXCL14 is a tumor suppressor gene in colorectal carcinoma that is initially activated and then silenced during tumor occurrence and deterioration. Its silencing is primarily caused by promoter hypermethylation. The methylation level of CXCL14 is associated with the anatomical site of tumor occurrence and is correlated with patient age and prognosis. Reversing the hypermethylation of CXCL14 may serve as an epigenetic therapy for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jorge Baquero, Xiao-Han Tang, Theresa Scognamiglio, Lorraine J. Gudas
Summary: Oral squamous cell carcinoma is an aggressive disease with low survival rates. Knockout of EZH2 in basal stem cells of tongue epithelia results in more aggressive carcinomas.
Article
Clinical Neurology
Delphine Boche, Marcia N. Gordon
Summary: The review explores the diversity of microglial phenotypes in healthy brains, aging, and Alzheimer's disease, identifies knowledge gaps, and suggests areas for further research. Comparisons between human samples and mouse models are made to understand the molecular complexity of microglial response repertoire, which could lead to new therapeutic avenues for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Cell Biology
Tiancheng Zhao, Yezhou Li, Kexin Shen, Quan Wang, Jiayu Zhang
Summary: This study investigates the mechanism underlying the OLR1/c-MYC/SULT2B1 axis in regulating glycolytic metabolism, cell proliferation, and chemoresistance in colon cancer cells. The findings suggest that knockdown of OLR1 can inhibit glycolytic metabolism, as well as cell proliferation and chemoresistance, by downregulating c-MYC and SULT2B1 expression.
CELL DEATH & DISEASE
(2022)
Article
Surgery
Jong Min Lee, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
Summary: The study investigated the learning curve of robotic rectal cancer surgery and found that surgical outcomes improved after the 177th case. After matching, patients in phase 2 had lower rates of surgical failure overall, including conversion to open surgery, severe complications, and insufficient harvested lymph nodes. Further studies by other robotic surgeons are needed to validate these results.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Seo-Hyeon Hwang, Dong-Woo Kang, Mi-Kyung Lee, Ji Yong Byeon, Hanui Park, Dong-Hyuk Park, Kyung-Chul Kim, Seung-Tae Lee, Sang Hui Chu, Nam Kyu Kim, Justin Y. Jeon
Summary: This study aimed to explore genome-wide DNA methylation changes after 6-week exercise training in colorectal cancer survivors. Results showed significant methylation changes in 756 CpG sites in the exercise group, linked to biological processes such as immune response and transcription. These findings suggest that exercise intervention may have positive effects on epigenetic markers in colorectal cancer survivors.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Ho Seung Kim, Han-Gil Kim, Seung Yoon Yang, Yoon Dae Han, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim, Min Soo Cho
Summary: This study retrospectively analyzed the medical records of patients who underwent surgery for appendiceal mucocele between 2010 and 2018, comparing the perioperative and short-term outcomes of single-incision laparoscopic surgery (SILS) and conventional laparoscopic surgery (CLS), as well as evaluating the oncological safety of SILS. The results showed that SILS for appendiceal mucocele is feasible and safe perioperatively and in the short-term, with favorable oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Letter
Gastroenterology & Hepatology
Nam Kyu Kim, Sung Uk Bae
DISEASES OF THE COLON & RECTUM
(2021)
Article
Surgery
Seung Yoon Yang, Min Soo Cho, Nam Kyu Kim
Summary: PELM is a sphincter-preserving alternative for patients with low rectal cancer invading the ipsilateral LAM, achieving good surgical margins and a 3-year local recurrence rate of 14.4% during a median follow-up of 44 months.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2021)
Editorial Material
Gastroenterology & Hepatology
Cristopher Varela, Manar Mohammed Nassr, Nam-Kyu Kim
DISEASES OF THE COLON & RECTUM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jaeseung Shin, Nieun Seo, Song-Ee Baek, Nak-Hoon Son, Joon Seok Lim, Nam Kyu Kim, Woong Sub Koom, Sungwon Kim
Summary: This study evaluated radiomics models based on T2-weighted imaging and diffusion-weighted MRI for predicting pCR after nCRT in LARC and compared their performance with visual assessment by radiologists. The results showed that the MRI-based radiomics model had better classification performance than experienced radiologists for diagnosing pathologic complete response in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
Article
Gastroenterology & Hepatology
Cristopher Varela, Manar Nassr, Azharuddin Razak, Nam Kyu Kim
Summary: Hand-sewn anastomosis is a crucial skill for surgeons, especially in complex surgical circumstances. Our step-by-step procedure for hand-sewn double-layered anastomosis provides a tension-free, well-perfused, and sealed anastomosis that allows gastrointestinal continuity and reduces complications.
ANNALS OF COLOPROCTOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jihee Min, Ki-yong An, Hyuna Park, Wonhee Cho, Hye Jeong Jung, Sang Hui Chu, Minsoo Cho, Seung Yoon Yang, Justin Y. Jeon, Nam Kyu Kim
Summary: This study aimed to investigate the effects of postoperative exercise on the recovery of colorectal cancer patients. The results indicated that patients in the postoperative exercise group had shorter hospital stay, greater readiness for discharge, and increased muscle mass. Therefore, postoperative inpatient exercise may facilitate faster recovery and discharge after colorectal cancer surgery.
BMC GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Chinock Cheong, Jeonghyun Kang, Byung Soh Min, Nam Kyu Kim, Joong Bae Ahn, Kang Young Lee
Summary: This study investigated the impact of neoadjuvant imatinib on rectal GIST. The results showed that imatinib treatment can reduce tumor size, increase resectability, and help preserve the sphincter. The neoadjuvant group had a higher rate of levator ani muscle displacement and larger radiologic tumor size compared to the control group. However, there was no significant difference between the two groups in terms of postoperative complications, hospital stay, local recurrence, and disease-free survival.
Article
Medicine, General & Internal
Cristopher Varela, Manar Nassr, Nam Kyu Kim
Summary: Controversial surgical anatomical landmarks in the deep pelvis can be visualized and identified using current technologies. Performing the gate approach technique during deep lateral dissection for total mesorectal excision facilitates visualization of the pelvic neurovascular structures following simple dissection steps to preserve the pelvic autonomic nerves and avoid accidental vascular injuries.
YONSEI MEDICAL JOURNAL
(2022)
Article
Surgery
Sun-Ho Kwon, Yea-Il Joo, Seon Hahn Kim, Dae Ho Lee, Jeong-Heum Baek, Soon Sup Chung, Ji-Yeon Shin, Chang Soo Eun, Nam Kyu Kim
Summary: This meta-analysis aimed to assess the safety and efficacy of TaTME for rectal cancer in South Korea. Results showed comparable outcomes between TaTME and LaTME, with the benefit of low conversion rate for TaTME.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Radwan Torky, Mohammed Alessa, Ho Seung Kim, Ahmed Sakr, Eman Zakarneh, Fozan Sauri, Heejin Bae, Nam Kyu Kim
Summary: The study found a low rate of metastases in patients with locally advanced rectal cancer after receiving CRT, but these patients often showed positive magnetic resonance circumferential resection margin, extramural vascular invasion, and lymph node involvement, indicating the need for further research to improve survival rates.
ANNALS OF COLOPROCTOLOGY
(2021)
Article
Oncology
Dae-Ro Lim, Dong-Hyun Kang, Jung-Chul Kuk, Tae-Hyung Kim, Eung-Jin Shin, Tae-Sung Ahn, Hyeong-Joo Kim, Dong-Jun Jeong, Moo-Jun Baek, Nam-Kyu Kim
Summary: The study investigated the role of GPR56 in CRC and found that its downregulation affected cell proliferation, invasion, and migration abilities, as well as inhibited colony-forming. High expression of GPR56 was negatively correlated with the overall survival rate of CRC patients, suggesting its potential as a prognostic indicator.
Review
Medicine, General & Internal
Nam Kyu Kim, Ho Seung Kim, Mohmmed Alessa, Radwan Torky
Summary: Surgery for rectal cancer aims to achieve radical resection with safe margins for improved oncologic and functional outcomes. Minimally invasive surgery allows for better visualization of nerve structures and meticulous dissection, leading to improved surgical quality.
YONSEI MEDICAL JOURNAL
(2021)