Article
Gastroenterology & Hepatology
Jeffrey S. Morris, Manal M. Hassan, Ye Emma Zohner, Zeya Wang, Lianchun Xiao, Asif Rashid, Abedul Haque, Reham Abdel-Wahab, Yehia I. Mohamed, Karri L. Ballard, Robert A. Wolff, Bhawana George, Liang Li, Genevera Allen, Michael Weylandt, Donghui Li, Wenyi Wang, Kanwal Raghav, James Yao, Hesham M. Amin, Ahmed Omar Kaseb
Summary: The HepatoScore system proposes a novel approach for risk assessment in hepatocellular carcinoma (HCC) patients, providing a global biological characterization of individual patient's disease. It significantly improves prognostic assessments, therapeutic decision making, and patient stratification within existing staging systems and prognostic factors, demonstrating strong potential for clinical application.
Article
Pathology
Deepika Kumar, Omeed Hafez, Dhanpat Jain, Xuchen Zhang
Summary: This study compared the histomorphologic features and phenotypic heterogeneity between primary and metastatic hepatocellular carcinoma (HCC) using 39 cases with both primary and metastatic tissues. The findings revealed significant intratumoral heterogeneity and histomorphologic discordance between primary and metastatic HCCs, with certain histologic patterns and subtypes being closely associated with metastasis. Further studies on a larger cohort are needed to better understand the mechanisms of HCC metastasis.
Review
Medicine, General & Internal
Hai-Yi Long, Tong-Yi Huang, Xiao-Yan Xie, Jian-Ting Long, Bao-Xian Liu
Summary: This review highlights the significance of extrahepatic metastasis in the treatment of hepatocellular carcinoma, emphasizing the roles of systemic agents and locoregional management while discussing the potential of immunotherapy in HCC treatment.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Endocrinology & Metabolism
Juerong Lu, Jintang Liao, Yunhao Chen, Jie Li, Xinyue Huang, Huajun Zhang, Bo Zhang
Summary: By analyzing ultrasound characteristics and clinical data, we identified clinical factors associated with lymph node metastasis in patients with papillary thyroid carcinoma (PTC), and developed a personalized nomogram for predicting lymph node metastasis. The nomogram showed excellent discrimination, calibration, and clinical practicability, and may assist clinicians in predicting lymph node metastasis prior to surgery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Surgery
Yan-Yan Wang, Bang-De Xiang, Liang Ma, Jian-Hong Zhong, Jia-Zhou Ye, Kun Wang, Bao-Cai Xing, Le-Qun Li
Summary: The study developed a nomogram to estimate the risk of SPLD and long-term survival in HCC patients before hepatectomy. Independent preoperative predictors of SPLD were identified, including total bilirubin and albumin. The nomogram showed good performance in predicting both SPLD and overall survival, outperforming other existing algorithms.
Article
Multidisciplinary Sciences
Ji Won Han, Pil Soo Sung, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon
Summary: Elevated diastolic whole blood viscosity (WBV) is associated with distant metastases and poor survival in patients with hepatocellular carcinoma (HCC). High diastolic WBV is an independent risk factor for poor survival and may be predictive of future distant metastases.
Article
Surgery
Jae Seok Bae, Dong Ho Lee, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Haeryoung Kim, Kyung Bun Lee, Yunhee Choi
Summary: This study compared the performances of MRE and TE in predicting severe complications after liver resection in HCC patients. The results showed that MRE had better predictive accuracy than TE for high comprehensive complication index (CCI) and diagnosing liver fibrosis. MRE measurement of liver stiffness was independently associated with high CCI after liver resection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ningbin Luo, Xiangyang Huang, Yinan Ji, Guanqiao Jin, Yunying Qin, Bangde Xiang, Danke Su, Weizhong Tang
Summary: This study found that the functional liver imaging score (FLIS) based on preoperative gadoxetic acid-enhanced MRI can predict posthepatectomy liver failure (PHLF) in hepatocellular carcinoma (HCC) patients. FLIS has a higher predictive power than the MELD score, ALBI score, and ICG-R15 clearance.
EUROPEAN RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Qiang Sun, Xiangda Zhang, Xueyi Gong, Zhipeng Hu, Qiao Zhang, Weiming He, Xiaojian Chang, Zemin Hu, Yajin Chen
Summary: This study compared the survival outcomes of LH and OH in the treatment of HCC based on reconstructed time-to-event data from high-quality propensity-score matching studies. The results indicated that LH can improve RFS in patients with HCC undergoing minor hepatectomy, and may benefit long-term RFS in overall patients.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Feng Xia, Qiao Zhang, Jun Zheng, Zhiyuan Huang, Elijah Ndhlovu, Hengyi Gao
Summary: This study establishes a clinical model to predict R1 resection after hepatectomy for resectable ruptured hepatocellular carcinoma (rHCC), which can be used to better plan perioperative strategies.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Wei Xu, Yonggang Wang, Zhanwei Yang, Jingdong Li, Ruineng Li, Fei Liu
Summary: In this study, we developed and validated a MVI prediction model for patients with hepatocellular carcinoma (HCC) that differentiates MVI classification and may provide useful guidance for treatment planning.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Liu, Hang Zheng, Xinzi Sui, Bo Liu, Min Meng, Yuemin Feng, Qiang Zhu, Xinya Zhao
Summary: There were no significant differences in long-term outcomes between microwave ablation and surgical resection for subcapsular hepatocellular carcinoma. Microwave ablation may be an alternative curative option for subcapsular hepatocellular carcinoma.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.
Article
Biochemical Research Methods
Xusheng Zhang, Yongxin Ma, Kejun Liu, Long Chen, Lin Ding, Weihu Ma, Bendong Chen
Summary: This study identified 5 new potential predictive targets for hepatocellular carcinoma in patients with dermatomyositis, and found that these targets are associated with immune cell infiltration and immune checkpoints in hepatocellular carcinoma.
BMC BIOINFORMATICS
(2023)
Article
Oncology
Yifan Chen, Jianxing Zeng, Pengfei Guo, Jinhua Zeng, Jingfeng Liu
Summary: This study revealed that high PLR is an independent risk factor for extrahepatic metastasis in HCC patients after liver resection. Patients with high PLR have a higher rate of extrahepatic metastasis.
CANCER MANAGEMENT AND RESEARCH
(2021)