期刊
ONCOLOGIST
卷 14, 期 10, 页码 1039-1049出版社
WILEY
DOI: 10.1634/theoncologist.2009-0122
关键词
Delirium; Neoplasms; Palliative care; Diagnostic techniques and procedures; Antipsychotic agents
类别
资金
- National Institutes of Health [RO1NR010162-01A1, RO1CA122292-01, RO1CA124481-01]
Delirium remains the most common and distressing neuropsychiatric complication in patients with advanced cancer. Delirium causes significant distress to patients and their families, and continues to be underdiagnosed and undertreated. The most frequent, consistent, and, at the same time, reversible etiology is drug-induced delirium resulting from opioids and other psychoactive medications. The objective of this narrative review is to outline the causes of delirium in advanced cancer, especially drug-induced delirium, and the diagnosis and management of opioid-induced neurotoxicity. The early symptoms and signs of delirium and the use of delirium-specific assessment tools for routine delirium screening and monitoring in clinical practice are summarized. Finally, management options are reviewed, including pharmacological symptomatic management and also the provision of counseling support to both patients and their families to minimize distress. The Oncologist 2009; 14: 1039-1049
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