Review
Oncology
Nuhad K. Ibrahim
Summary: The epothilone drug class, including ixabepilone, has shown efficacy and safety in the treatment of metastatic breast cancer, demonstrating improved progression-free survival and overall response rates in patients who have progressed during chemotherapy. Additionally, ixabepilone's clinical benefit in special populations has been characterized, with evidence supporting its use in specific patient groups such as those with triple-negative breast cancer. Dose reductions do not appear to impact the efficacy of ixabepilone, making it a valuable option for individualized treatment plans in patients with unmet needs.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yousheng Mo, Wei Liu, Piaoxue Liu, Qiao Liu, Zhongyu Yuan, Qi Wang, Dongsheng Yuan, Xiao-Jia Chen, Tongkai Chen
Summary: A multifunctional graphene oxide tumor-targeting drug delivery system was developed, which improved the delivery of paclitaxel, reversed multi-drug resistance, and increased the therapeutic efficacy of breast cancer treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Review
Biochemistry & Molecular Biology
Ji He, Erika Fortunati, Dong-Xu Liu, Yan Li
Summary: Chemotherapeutics are a main therapy for metastatic breast cancers, but multidrug resistance due to ABC transporters remains a challenge. Targeting ABCB1 to reverse drug resistance in clinical trials has been disappointing, but ABC transporters may play roles in breast cancer development and metastasis beyond efflux function. Understanding the functions and regulations of ABC transporters in breast cancer biology may lead to more targeted and novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Stanton Tam, Yassir Al-Zubaidi, Md Khalilur Rahman, Kirsi Bourget, Fanfan Zhou, Michael Murray
Summary: This study evaluated the efficacy of clinically approved EGFR inhibitors in combination with the cytotoxic agent ixabepilone in TNBC cells. The combination of ixabepilone and vandetanib showed synergistic effects on cell proliferation and apoptosis, while the combination of ixabepilone and gefitinib exhibited antagonism.
PHARMACOLOGICAL REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Shiwen Yu, Jinling Zheng, Yan Zhang, Dandan Meng, Yujue Wang, Xiaoyu Xu, Na Liang, Shayibai Shabiti, Xu Zhang, Zixi Wang, Zehua Yang, Pengbing Mi, Xing Zheng, Wenjun Li, Hongfei Chen
Summary: Chemotherapy is the primary treatment for breast cancer, but side effects and multidrug resistance (MDR) are major challenges. Research is focused on finding new drugs and understanding the mechanisms and inhibition of MDR.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Paras Famta, Saurabh Shah, Naitik Jain, Kondasingh Charan Kumar, Deepkumar Bagasariya, Dharmendra Kumar Khatri, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: Chemotherapy is crucial in the treatment of solid tumors like breast cancer, but drug-induced tumor-free survival may not be long-lasting. Factors such as multidrug resistance and microenvironment remodeling play a role in tumor relapse and resistance.
Article
Chemistry, Applied
Qiang Chen, Chaochao Jia, Yingran Xu, Zhuanzhuan Jiang, Ting Hu, Conghu Li, Xu Cheng
Summary: Efficient dual-pH responsive chitosan nanoparticles were fabricated to treat MDR tumors, showing high toxicity and strong antitumor efficiency in vivo.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyuan Ji, Daoxia Guo, Jia Ma, Min Yin, Yun Yu, Chang Liu, Yanfeng Zhou, Jinli Sun, Qian Li, Nan Chen, Chunhai Fan, Haiyun Song
Summary: The hydrogel patch designed to modulate the plasticity of T-ICs in TNBC shows promising results in improving chemosensitivity, enhancing tumor immunogenicity, and increasing T-cell infiltration. Additionally, the patch efficiently suppresses tumor growth, postsurgical relapse, and metastasis with a single dose, demonstrating superior efficacy against multidrug resistance.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ingrid Fatima Zattoni, Thales Kronenberger, Diogo Henrique Kita, Lais Danciguer Guanaes, Matheus Murmel Guimaraes, Larissa de Oliveira Prado, Melanie Ziasch, Luis C. Vesga, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Marcos Brown Goncalves, Miguel D. Noseda, Diogo R. B. Ducatti, Antti Poso, Robert W. Robey, Suresh Ambudkar, Vivian Rotuno Moure, Alan Guilherme Goncalves, Glaucio Valdameri
Summary: A newly discovered porphyrin derivative (4B) was identified as an inhibitor of the ABCG2 transporter, capable of overcoming multidrug resistance in vitro and showing selective inhibition towards ABCG2 without being transported by it.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Lili Chen, Ahmed Nabil, Nanami Fujisawa, Emiho Oe, Kai Li, Mitsuhiro Ebara
Summary: A universal vector system for drug-resistant breast cancer was designed to reverse multidrug resistance, achieve thermo-chemotherapy, and enable long-term drug release. The system showed therapeutic effects and could provide personalized treatment options for different breast malignancies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Medicinal
Ingrid Fatima Zattoni, Leticia Carani Delabio, Julia de Paula Dutra, Diogo Henrique Kita, Gustavo Scheiffer, Marina Hembecker, Giovana da Silva Pereira, Vivian Rotuno Moure, Glaucio Valdameri
Summary: The primary source of failure in cancer therapies is multidrug resistance (MDR) caused by overexpression of ABC transporters, particularly the breast cancer resistance protein (BCRP/ABCG2). Inhibiting ABCG2 function and modulating its expression are promising strategies to overcome MDR. This review provides an overview of various ABCG2 inhibitors and discusses their chemical aspects, experimental methods used for identification and characterization, as well as the biological requirements for preclinical tests. Additionally, the potential use of ABCG2 inhibitors in cancer stem cells (CSC) to improve treatment response and the mechanism of ABCG2 modulators at the transcriptional and protein expression levels are discussed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Bo Peng, Si-Yuan Zhang, Ka Iong Chan, Zhang-Feng Zhong, Yi-Tao Wang
Summary: Breast cancer is a common cancer in women worldwide, and the challenges in its treatment include abnormal metabolism, immunosuppression, and drug resistance. AMPK can regulate metabolic reprogramming, inhibit breast cancer cell growth and metastasis, and stimulate immune cell responses. However, the role of AMPK in breast cancer progression is still controversial.