Article
Radiology, Nuclear Medicine & Medical Imaging
Guotao Wang, Xiaohua Xie, Huadong Chen, Zhihai Zhong, Wenying Zhou, Hong Jiang, Xiaoyan Xie, Luyao Zhou
Summary: The study included 130 lesions from 130 patients with a mean age of 36.0 months and a male predominance. The CEUS criterion showed high sensitivity and specificity in predicting hepatoblastoma and hemangioma. The malignancy rates in different CEUS categories and the incidence of hepatoblastoma in specific CEUS categories were highlighted.
EUROPEAN RADIOLOGY
(2021)
Article
Pediatrics
Richard S. Whitlock, Kalyani R. Patel, Tianyou Yang, HaiThuy N. Nguyen, Prakash Masand, Sanjeev A. Vasudevan
Summary: The study demonstrated the importance of intraoperative NIR-ICG guidance in assisting with identification and surgical resection of extrahepatic disease and multifocal liver tumors in children with primary liver cancer.
JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Oncology
Allison F. O'Neill, Rebecka L. Meyers, Howard M. Katzenstein, James Geller, Greg M. Tiao, Dolores Lopez-Terrada, Marcio Malogolowkin
Summary: Liver tumors, including hepatoblastoma (HB) and hepatocellular carcinoma (HCC), account for 1%-2% of all pediatric malignancies. Previous studies by the Children's Oncology Group have significantly contributed to the current understanding of disease pathophysiology and treatment, laying the foundation for ongoing international research on HB and HCC. Future research aims to uncover the biological mechanisms underlying these tumors, improve risk stratification, advance multidimensional care, and discover novel therapies.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Surgery
Julia M. Boster, Riccardo Superina, George Mazariegos, Gregory M. Tiao, Jonathan P. Roach, Mark A. Lovell, Brian S. Greffe, George Yanni, Daniel H. Leung, Scott A. Elisofon, Suzanne McDiarmid, Nitika A. Gupta, Steven J. Lobritto, Caroline Lemoine, Janis M. Stoll, Bernadette E. Vitola, James F. Daniel, Blayne A. Sayed, Dev M. Desai, Abigail E. Martin, Arpit Amin, Ravinder Anand, Sarah G. Anderson, Shikha S. Sundaram
Summary: Management of unresectable pediatric hepatoblastoma and hepatocellular carcinoma remains challenging. This study examined survival predictors in pediatric liver transplantation for these tumors using the SPLIT database. The results showed favorable outcomes after liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma, including salvage transplant. Unexpected numbers of transplants occurred in PRE/POST-TEXT I/II tumors. Judicious patient selection is critical to distinguish potentially resectable tumors and advocate for organ transplantation in patients with unresectable malignancies.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Pediatrics
Yu-Tong Zhang, Yu-Fei Zhao, Dian-Fei Yang, Jian Chang
Summary: This study found that HB tumor rupture may not predict poor prognosis, and peritoneal perfusion with interleukin-2 may improve prognosis.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Alessa L. Henneberg, Christiane A. Opitz
Summary: A recent study has revealed that hepatocellular carcinoma cells suppress the urea cycle enzymes and depend on the uptake of exogenous arginine and GCN2 kinase-induced cell-cycle arrest for survival. These findings present new possibilities for combination therapy in liver cancer.
Article
Medicine, General & Internal
Caroline P. Lemoine, Omid Madadi-Sanjani, Claus Petersen, Christophe Chardot, Jean de Ville de Goyet, Riccardo Superina
Summary: This study evaluated surgeons' practices in pediatric liver surgery and made recommendations for the management of children needing liver surgery. The findings suggest that pediatric liver surgery should be performed by specialized pediatric surgeons and centralized in regional centers of excellence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Jiliang Feng, Ruidong Zhu, Yu Yin, Shanshan Wang, Lei Zhou, Fudong Lv, Dawei Zhao
Summary: The primary epithelial tumors of the liver (PETL) exhibit heterogeneous cellular origins, with certain tumors in different categories sharing similar cell origins. Hepatic adenomas, hepatocellular carcinomas, and pure fetal hepatoblastomas share the same cellular origin spectrum, as do bile duct adenomas, peribiliary cysts, and intrahepatic cholangiocellular carcinomas. The cells-of-origin of embryonal HBs include liver stem cells, hepatoblasts, and transitional cells between them.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Review
Oncology
Janet Rae Julson, Raoud Marayati, Elizabeth Ann Beierle, Laura Lee Stafman
Summary: This review provides an in-depth summary of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. The currently available pharmaceutical agents targeting PIM kinases and existing clinical trials are also briefly summarized.
Review
Oncology
Qiu-Luo Liu, Huijie Zhou, Zong-Guang Zhou, Hai-Ning Chen
Summary: Colorectal cancer (CRC) patients often suffer from liver metastases, resulting in high mortality rates. The molecular basis and management of colorectal liver metastases (CRLMs) pose significant challenges in the clinic. Recent genomic evidence has revealed liver tropism in CRC and a stricter evolutionary bottleneck in the liver compared to lymph nodes. This organ-specific bottleneck challenges CRC cells and necessitates adaptation at both the genetic and phenotypic levels to interact with the hepatic microenvironment. Here, we review emerging evidence on the clonal evolution of CRLM and discuss recent insights into the molecular mechanisms behind the bidirectional interactions between metastatic CRC cells and the unique liver microenvironment.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Computer Science, Artificial Intelligence
Yoo Jung Kim, Hyungjoon Jang, Kyoungbun Lee, Seongkeun Park, Sung-Gyu Min, Choyeon Hong, Jeong Hwan Park, Kanggeun Lee, Jisoo Kim, Wonjae Hong, Hyun Jung, Yanling Liu, Haran Rajkumar, Mahendra Khened, Ganapathy Krishnamurthi, Sen Yang, Xiyue Wang, Chang Hee Han, Jin Tae Kwak, Jianqiang Ma, Zhe Tang, Bahram Marami, Jack Zeineh, Zixu Zhao, Pheng-Ann Heng, Ruediger Schmitz, Frederic Madesta, Thomas Roesch, Rene Werner, Jie Tian, Elodie Puybareau, Matteo Bovio, Xiufeng Zhang, Yifeng Zhu, Se Young Chun, Won-Ki Jeong, Peom Park, Jinwook Choi
Summary: PAIP is a free research platform supporting pathological artificial intelligence, aiming to construct high-quality pathology learning dataset for accessibility. The PAIP challenge this year evaluated new algorithms for automated liver cancer detection and required participants to use data and statistical metrics for performance evaluation.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Oncology
Xiaoran Li, Zheng Wang, Dongpo Zhang, Di Zhao, Jindong Ye, Weihong Duan, Liuxin Duan, Quanda Liu
Summary: This study retrospectively evaluated the clinical data and outcomes of 18 patients with recurrent hepatoblastoma who underwent repeat hepatectomy. The results showed that this procedure can be performed safely, but only a specific subgroup of patients might actually benefit from it.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Quirino Lai, Gianluca Mennini, Zoe Larghi Laureiro, Massimo Rossi
Summary: ALPPS is mainly used for common liver cancers, with limited knowledge on its efficacy and safety for rare liver pathologies, requiring further research. Among the rare indications, neuroendocrine tumor and gallbladder cancer have the highest number of cases.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Oncology
Ran Yang, Yong Zhan, Yi Li, Shu-Yang Dai, Shi-Wei He, Chun-Jing Ye, Ling-Du Meng, De-Qian Chen, Chen-Bin Dong, Lian Chen, Gong Chen, Kui-Ran Dong, Kai Li, Shan Zheng, Jun Li, Wei Yao, Rui Dong
Summary: This article reports a case of a 6-month-old infant diagnosed with synchronous SBL and HB, and analyzes the cellular heterogeneity and adaptive changes of tumor cells after chemotherapy, revealing insights into the mechanisms leading to synchronous pediatric tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ambre Giguelay, Evgenia Turtoi, Lakhdar Khelaf, Guillaume Tosato, Ikrame Dadi, Tommy Chastel, Marie-Alix Poul, Marine Pratlong, Stefan Nicolescu, Dany Severac, Antoine Adenis, Olivia Sgarbura-Popescu, Sebastien Carrere, Philippe Rouanet, Marc Ychou, Francois Quenet, Didier Pourqier, Pierre-Emmanuel Colombo, Andrei Turtoi, Jacques Colinge
Summary: This study confirms the heterogeneity of CRC-LM CAFs through single-cell transcriptomic analysis and proposes a model for recruiting different origins of CAFs to the liver in different liver malignancies. Additionally, the study finds that targeting LTBP2 with antibodies may help deplete ECM-remodeling CAFs in CRC-LMs.
