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Medicine, Research & Experimental
Yunxia Liu, Xia Liu, Yanhua Zhou, Tingting Liu, Jie Li
Summary: The study revealed that high expression of miR-27a in cholangiocarcinoma patients is associated with lymph node metastasis, TNM stages, and poorer overall survival. Overexpression of miR-27a promotes cell proliferation, migration, and invasion in CCA, while knockdown suppresses these processes. These findings suggest the potential utility of miR-27a in prognosis and progression of CCA.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Lili Zhang, Huixiao Chen, Fengxi He, Shiqian Zhang, Aihua Li, Aifeng Zhang, Anqi Zhang
Summary: miR-320a plays an important role in ovarian cancer progression and infiltration, promoting the proliferation, migration, and invasion of EOC cells by targeting RASSF8.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Gang Peng, Yi Liu, Chenxing Yang, Chenfu Shen
Summary: This study found that miR-25 is significantly upregulated in glioma and promotes the proliferation, migration, and invasion of glioma cells by directly targeting CADM2.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Qiang Yan, Chenming Ni, Yingying Lin, Xu Sun, Zhenhua Shen, Minjie Zhang, Shuwen Han, Jiemin Shi, Jing Mao, Zhe Yang, Weilin Wang
Summary: The study revealed a new mechanism in which ELK1 promoted the progression of pancreatic cancer via LGMN, and the two were positively correlated with clinical stage, degree of differentiation, and lymph node infiltration, identified as independent prognostic factors for overall survival.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Weiyang Lou, Wenlong Wang, Jing Chen, Shuqian Wang, Yuan Huang
Summary: This study utilized various analytical methods to identify SEMA3F as a potential oncogene in hepatocellular carcinoma, along with determining the noncoding RNAs influencing its overexpression. Additionally, a significant association was found between SEMA3F and tumor immune cell infiltration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Gastroenterology & Hepatology
Lina Li, Jie Liu, Wei Huang
Summary: This study confirmed for the first time the upregulation of E2F5 in gastric cancer and discovered that E2F5 can directly upregulate UBE2T transcription, thereby promoting malignant progression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Anatomy & Morphology
Yu Chen, Biling Wang, Zihao Zhao, Ming Li, Fei Wang
Summary: Overexpression of PRSS2 in gastric cancer is associated with poor prognosis and can serve as a potential biomarker for assessing the prognosis of gastric cancer. Knockdown of PRSS2 reduces the proliferation, migration, and invasion of GC cells.
Article
Cell Biology
Xiaosheng Wu, Hao Wang, Danping Zhu, Yixia Chai, Jing Wang, Weiyu Dai, Yizhi Xiao, Weimei Tang, Jiaying Li, Linjie Hong, Miaomiao Pei, Jieming Zhang, Zhizhao Lin, Jide Wang, Aimin Li, Side Liu
Summary: This study reveals the mechanism of how deubiquitinating enzyme USP3 promotes tumor progression and metastasis in gastric cancer. The downstream targets of USP3, COL9A3 and COL6A5, are identified using isobaric tags technique. The results show that USP3 interacts with and stabilizes COL9A3 and COL6A5 through deubiquitination, playing a crucial role in the oncogenic activity of USP3 both in vitro and in vivo.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Shangfa Gao, Peng Shi, Zhishuai Tian, Xingwang Yang, Ning Liu
Summary: MiR-1225 is significantly upregulated in breast cancer tissues and associated with poor prognosis, potentially promoting cancer progression by enhancing cell proliferation, migration, and invasion. It targets JAK1 and may serve as a biomarker and therapeutic target for breast cancer treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jialin Wang, Zhendong Liu, Cheng Zhang, Hongbo Wang, Ang Li, Binfeng Liu, Xiaoyu Lian, Zhishuai Ren, Wang Zhang, Yanbiao Wang, Bo Zhang, Bo Pang, Yanzheng Gao
Summary: High expression of HOXD11 is significantly associated with survival and clinical characteristics of glioma patients, serving as a potential biomarker for targeted therapy and prognostic assessment. Knockout of HOXD11 can inhibit proliferation and invasion of glioma cells, altering cell behavior.
Article
Multidisciplinary Sciences
Xiangke Cao, Qinghua Ma, Bin Wang, Qingqiang Qian, Yinan Xi
Summary: Circ-E2F3 is upregulated in cervical cancer tissues and cell lines, correlating with clinicopathological features and poor prognosis of patients. It promotes proliferation, invasion, migration of cancer cells, and tumor growth in vivo, by inhibiting miR-296-5p to facilitate nuclear translocation of STAT3 and affect cyclin D1 expression.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Oncology
Liao Chen, Huirong Tang, Guobin Liu, Shufeng Xiao, Daoming Liang, Jun Ma, Yanlong Yang, Haibo Luo, Yong Zhu, Fujia Xie, Xi Cheng, Junlin Chi, Xuesong Wu
Summary: The upregulation of miR-196b and downregulation of ECRG4 were observed in gastric cancer tissues and cells. Inhibition of miR-196b suppressed cell proliferation, migration, and invasion, while ECRG4 was identified as a target of miR-196b. In vivo, miR-196b inhibition also led to decreased tumor volume and weight, suggesting its potential as a therapeutic target for gastric cancer.
Article
Biochemistry & Molecular Biology
Guofeng Zhang, Yonglin Zhu, Chengzhen Jin, Qingpeng Shi, Xiaochun An, Licheng Song, Fengguang Gao, Shanhui Li
Summary: Circular RNA (circRNA) associated ceRNA network plays a critical role in the initiation and progression of osteosarcoma by upregulating CDK14 in a miR-330-3p-dependent manner.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun Ping, Song Xiaoling, Weng Hao, Gu Jun
Summary: Proliferation is a significant hallmark of gallbladder cancer, a relatively rare but fatal malignancy. This study identified KIF11 as a major upregulated regulator of proliferation in gallbladder cancer, potentially promoting GBC cell proliferation through the ERBB2/PI3K/AKT signaling pathway. The findings provide insights into the mechanisms underlying GBC cancer development and may contribute to the development of novel diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Yongmeng Li, Yanfei Liu, Kai Jin, Rui Dong, Cun Gao, Libo Si, Zitong Feng, Huiying Zhang, Hui Tian
Summary: MTFR1 is upregulated in LUAD and associated with poor clinicopathologic features and prognosis. Overexpression of MTFR1 promotes proliferation, invasion, migration, glycolytic capacity, and inhibits apoptosis of LUAD cells. MTFR1 may exert its functions through the AMPK/mTOR signaling pathway and is targeted by miR-29c-3p. Targeting MTFR1 could be an effective therapeutic strategy for LUAD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)