Article
Plant Sciences
Xue Wei, Jing Wang, Yu-Ying Deng, Bing-Hao Shao, Ze-Feng Zhang, Hui-Hui Wang, Chun -Mei Wang
Summary: The application of Tubechong patching therapy can promote fracture healing in rats by regulating angiogenesis through the VEGF/ERK1/2 signaling pathway. It has been found to have the potential to promote cell proliferation, migration, and wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wen-Bo Zhang, Si-Yi Feng, Zhan-Xiang Xiao, You-Fei Qi, Zhao-Fan Zeng, Hao Chen
Summary: In this study, the down-regulation of MFN2 in the aortic tissues of AS patients and mice was observed. Silencing of MFN2 promoted the occurrence of VC and mediated this process through a series of signal transduction pathways. In addition, E2F1 was found to promote the expression of MFN2 and inhibit ox-LDL-induced VSMC calcification.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Pediatrics
Zhen Ding, Fei Yu, Yan Sun, Ning Jiao, Lina Shi, Jinghong Wan, Qinghua Liu
Summary: This study found that ORMDL3 promotes angiogenesis in chronic asthma by upregulating VEGF and MMP-9. Asthmatic mice showed more severe airway angiogenesis, while budesonide alleviated this phenomenon.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Shenjian Luo, Zhi Yang, Ruxin Chen, Danming You, Fei Teng, Youwen Yuan, Wenhui Liu, Jin Li, Huijie Zhang
Summary: Cardiac fibrosis, a major cause of mortality and morbidity in heart disease, is poorly understood. This study investigated the role of CRLF1 in cardiac fibrosis and found that it promotes fibrosis by activating the ERK1/2 signaling pathway. CRLF1 may serve as a potential target for therapeutic intervention in cardiac fibrosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Pharmacology & Pharmacy
Aline Zaparte, Angelica R. Cappellari, Caroline A. Brandao, Julia B. de Souza, Thiago J. Borges, Luiza W. Kist, Mauricio R. Bogo, Luiz F. Zerbini, Luis Felipe Ribeiro Pinto, Talita Glaser, Maria Carolina B. Goncalves, Yahaira Naaldijk, Henning Ulrich, Fernanda B. Morrone
Summary: Esophageal cancer is a global disease with two main subtypes, esophageal squamous cell carcinoma and esophageal adenocarcinoma. Research shows that P2Y(2) receptor activation in esophageal cancer cells promotes cell proliferation and colony formation, while its blockade reduces these effects. Targeting P2Y(2) receptors may have therapeutic potential for esophageal cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Mian Wu, Lifeng Chen, Yuhan Qi, Hai Ci, Shan Mou, Jie Yang, Qiaoyu Yuan, Weiqi Yao, Zhenxing Wang, Jiaming Sun
Summary: Using umbilical cord mesenchymal stem cells (hUCMSCs) as seed cells for tissue-engineered breast construction has shown significant advantages, promoting adipose tissue regeneration and enhancing angiogenesis. The transplantation of hUCMSCs was found to increase fat tissue content, reduce macrophage numbers, and exhibit good differentiation capability in adipose tissue.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Qinglan Wang, Feng Zhang, Yang Lei, Ping Liu, Chenghai Liu, Yanyan Tao
Summary: The study investigated the effects and mechanism of miR-322/424 in liver fibrosis, revealing that miR-322/424 plays a crucial role in targeting Cullin2 and enhancing HIF-1 alpha-mediated hepatic angiogenesis. The results showed that miR-322/424 levels were increased in liver cirrhosis patients and animal models, with its agonist exacerbating fibrosis while the antagonist had the opposite effect.
Article
Cell Biology
Shuang-Shuang Dong, Dan-Dan Dong, Zhang-Fu Yang, Gui-Qi Zhu, Dong-Mei Gao, Jie Chen, Yan Zhao, Bin-Bin Liu
Summary: The study demonstrated that exosomal miR-3682-3p derived from HCC cells attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling, providing novel potential targets for liver cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haiping Zhang, Ziliang Yu, Bingbing Wu, Farui Sun
Summary: In this study, circFOXP1 was found to promote angiogenesis in osteosarcoma by regulating the miR-127-5p/CDKN2AIP signaling pathway. It upregulated CDKN2AIP expression to enhance tumor angiogenesis, and could directly bind to miR-127-5p to indirectly affect CDKN2AIP expression. These findings highlight the role of circFOXP1 in osteosarcoma metastasis and provide insights into potential therapeutic targets for this aggressive cancer.
Article
Biochemistry & Molecular Biology
Peina He, Jianyun Sheng, Jinxu Qi, Xianguang Bai, Jiaxin Li, Fubao Wang, Yamin Yuan, Xinhua Zheng
Summary: NCK1 plays a key role in extracellular matrix degradation and metastatic progression of triple-negative breast cancer (TNBC). High expression of NCK1 is associated with poor prognosis in lymph node-positive metastatic TNBC patients, and promotes migration and activity of MMPs in a STAT3-dependent manner. NCK1 may serve as a diagnostic and prognostic marker for metastatic TNBC.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Yujie Jia, Qi Wang, Minglu Liang, Kai Huang
Summary: This study found that KPNA2 promotes angiogenesis under hypoxia by promoting the binding of STAT3 and JAK1 and regulating STAT3 phosphorylation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Yang Gao, Hui Zheng, Liangdong Li, Mingtao Feng, Xin Chen, Bin Hao, Zhongwei Lv, Xiaoyan Zhou, Yiqun Cao
Summary: This study found that high expression of PSMA in GBM is associated with poor prognosis, promoting angiogenesis in GBM by enhancing proliferation, invasion, and tube formation ability of HUVECs. PSMA may promote angiogenesis in GBM by interacting with ITGB4 and activating the NF-kappa B signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Datong Sun, Shenghui Yang, Xufeng Zhang, Sai Li, Lin Wang, Junmin Chen, Chun Qiu, Ke Xu
Summary: This study shows that in resistant GBM cells, FoxO3a modulates the nuclear accumulation of beta-catenin by regulating MMP9 expression, thereby increasing cellular resistance to TMZ.
Article
Biochemistry & Molecular Biology
Shiyu Hao, Chunyan Yang, Peng Song, Hewen Shi, Ying Zou, Meiyang Chen, Xingli Wu, Yancun Yin, Zhenhai Yu, Weiwei Zhu, Minjing Li
Summary: The tight junction protein CLDN4 is closely related to the development of acute myeloid leukemia (AML). Up-regulated expression of CLDN4 in AML cells is associated with decreased cell growth and increased apoptosis. Knockdown of CLDN4 inhibits the expression of PIK3R3 and MAP2K2, suppressing the activation of AKT and ERK1/2. Higher expression of CLDN4 is correlated with worse survival and shorter disease-free survival in AML patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Shijie Shao, Lianhua Piao, Jiangsong Wang, Liwei Guo, Jiawen Wang, Luhui Wang, Lei Tong, Xiaofeng Yuan, Xu Han, Sheng Fang, Junke Zhu, Yimin Wang
Summary: This study investigates the molecular role of Tspan9 in osteosarcoma and reveals its association with signaling pathways involved in tumor metastasis. Inhibition of Tspan9 suppresses migration and invasion of OS cells, while its overexpression has the opposite effect.
FRONTIERS IN ONCOLOGY
(2022)