期刊
ONCOGENE
卷 34, 期 9, 页码 1116-1125出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2014.58
关键词
-
资金
- Human Frontier Science Program long-term fellowship
- National Science Council [NSC99-2628-B-006-031-MY3, NSC101-2325-B-006-018, NSC100-2321-B-002-071, NSC101-2321-B-002-068, NSC102-2811-B-002-069]
- National Taiwan University [101R7601-2]
The transcriptional repressor Slug is best known to control epithelial-mesenchymal transition (EMT) and promote cancer invasion/metastasis. In this study, we demonstrate that Slug is temporally regulated during cell cycle progression. At G1/S transition, cyclin E-cyclin-dependent kinase 2 mediates the phosphorylation of Slug at Ser-54 and Ser-104, resulting in its ubiquitylation and degradation. Non-phosphorylatable Slug is markedly stabilized at G1/S transition compared with wild-type Slug and greatly leads to downregulation of DNA synthesis and checkpoint-related proteins, including TOP1, DNA Ligase IV and Rad17, reduces cell proliferation, delays S-phase progression and contributes to genome instability. Our results indicate that Slug has multifaceted roles in cancer progression by controlling both EMT and genome stability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据