Article
Oncology
Zhenwang Zhang, Wu Liu, Xiajun Bao, Tian Sun, Jiawei Wang, Mengxi Li, Chao Liu
Summary: This study reveals the role of deubiquitinating enzyme USP39 in promoting breast cancer cell proliferation and tumor growth through deubiquitination and stabilization of FOXM1. Elevated USP39 expression reduces FOXM1 ubiquitination levels, enhancing its transcriptional activity and regulating the expression of downstream genes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
John J. Kim, Wenchuan Liang, Chi-Chih Kang, Mark D. Pegram, Amy E. Herr
Summary: A newly developed single-cell analysis tool can accurately identify different isoforms of the nuclear estrogen receptor alpha protein, revealing the presence of ER-alpha 46 in 5.5% of hormone-sensitive and 4.2% of hormone-insensitive breast cancer cells. Single-cell immunoblotting shows potential in capturing cellular responses to hormones.
Article
Oncology
Hetakshi Kurani, Seyedeh Fatemeh Razavipour, Kuzhuvelil B. Harikumar, Matthew Dunworth, Andrew J. Ewald, Apsra Nasir, Gray Pearson, Derek Van Booven, Zhiqun Zhou, Diana Azzam, Claes Wahlestedt, Joyce Slingerland
Summary: This study identified DOT1L as a key regulator of cancer stem cells (CSCs) in triple-negative breast cancer (TNBC). Inhibition of DOT1L suppressed the growth and metastasis of TNBC CSCs, suggesting that DOT1L inhibitors may be a potential therapeutic option for targeting stem cell-enriched TNBC.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Zhen Zhang
Summary: This study identified high expression of POLD2 in TNBC and poor clinical outcomes in patients with high POLD2 expression. Functional and mechanistic studies revealed the involvement of the E2F1-POLD2 axis in TNBC proliferation, suggesting POLD2 as a potential therapeutic target for TNBC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S. S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Summary: Increased levels and diversity of HERV transcription are characteristic of most cancer types and are linked with disease outcomes. In lung squamous cell carcinoma (LUSC), elevated transcription of HERVH proviruses predicted survival and an isoform of CALB1 driven by an upstream HERVH provirus was identified as the mediator. HERVH-CALB1 expression was associated with tumor progression and showed pleiotropic effects, promoting tumor growth and suppressing senescence while controlling the secretion of CXCL8 and other chemoattractants.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cell Biology
Mengqin Shen, Ruixue Zhang, Wenzhi Jia, Zongping Zhu, Li Zhao, Gang Huang, Jianjun Liu
Summary: This study reveals the association of nuclear EGFR with RNA-binding proteins (RBPs) and identifies NONO as a key RBP in TNBC. NONO is upregulated in TNBC tissues and enhances EGFR transcriptional activity by increasing its stability and recruiting specific proteins. Moreover, the nuclear EGFR/NONO complex plays a critical role in tumorigenesis and chemotherapy resistance in TNBC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Luana S. Lenz, Juliano L. Faccioni, Paula A. Bracco, Jephesson A. F. Santos, Luiza C. Pereira, Julieti H. Buss, Mauricio T. Tamborindeguy, Daphne Torgo, Thayana Monteiro, Giovana B. Mantovani, Carolina N. Santo, Julia C. Marcolin, Eloisa Dalsin, Alvaro Vigo, Sidia M. Callegari-Jacques, Andrew O. Silva, Giovana R. Onzi, Karine R. Begnini, Guido Lenz
Summary: The fitness of cancer cells in colony formation is dynamic, influenced by factors such as ERK activity, cell-cycle duration, and DNA repair capacity. Colonies exhibit dynamic resistance to drugs, indicating an adaptability to drug presence.
Article
Pathology
Anchen Su, Kun Yao, Hanru Zhang, Yiqing Wang, Haibo Zhang, Jianming Tang
Summary: A study identified DANCR, a long noncoding RNA, as a promoter of cisplatin chemoresistance in triple-negative breast cancer cells. It was found that DANCR binds to KLF5 and induces acetylation of KLF5, resulting in down-regulation of KLF5 and hypersensitivity to cisplatin through the DANCR/KLF5/p27 signaling pathway.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li-Ming Xu, Jiao Zhang, Yue Ma, Ya-Jing Yuan, Hao Yu, Jun Wang, Xu-Chen Cao, Li Zhu, Ping Wang
Summary: This study found that the miR-135/ZNF217/METTL3/NANOG axis plays a significant role in the progression of breast cancer. Modulating the expression of this axis can effectively inhibit the malignant behavior of breast cancer cells, highlighting the potential value of ZNF217 silencing and miR-135 upregulation in the prevention and treatment of breast cancer.
Article
Chemistry, Multidisciplinary
Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You
Summary: This study reveals that OTUD7B regulates LSD1 binding partner specificity and cellular homeostasis through deubiquitination, impacting breast cancer metastasis. Dysregulation of OTUD7B and LSD1 expression in breast cancer is associated with tumor characteristics and prognosis.
Article
Multidisciplinary Sciences
Mahdieh Rojhannezhad, Bahram M. Soltani, Mohammad Vasei, Nassim Ghorbanmehr, Seyed Javad Mowla
Summary: HER-2/neu gene encodes a protein called HER2 that plays an important role in some cancers. This study used the CRISPR/Cas9 method to knockout a potential enhancer called Her2-Enhancer1 located within the HER2 gene, and investigated its regulatory effects on HER2 and HER2-interacting genes. The findings revealed significant alterations in the expression of HER2 and other target genes, as well as an increase in apoptosis rate. These results suggest the potential of this enhancer as a target for therapy in HER2-positive cancers.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Cyrinne Achour, Devi Prasad Bhattarai, Paula Groza, angel-Carlos Roman, Francesca Aguilo
Summary: This study identifies a specific alternative splicing (AS) signature associated with breast tumorigenesis and reveals the role of METTL3 in modulating breast cancer-associated AS programs. It also demonstrates that m(6)A deposition in splice site boundaries and in splicing and transcription factor transcripts can directly regulate AS switches of specific breast cancer-associated transcripts. Furthermore, the study suggests that five validated AS events in vitro are associated with a poor overall survival rate for patients with breast cancer, indicating their potential as novel prognostic biomarkers.
Article
Multidisciplinary Sciences
Jianchen Yang, Jack Virostko, David A. Hormuth, Junyan Liu, Amy Brock, Jeanne Kowalski, Thomas E. Yankeelov
Summary: This study developed a mathematical model to predict how glucose dynamics influence metabolism and tumor cell growth. Through experiments and model construction, the accuracy of the model was validated.
Article
Cell Biology
Hsing-Hua Chao, Jun-Liang Luo, Ming-Hsuan Hsu, Li-Han Chen, Tzu-Pin Lu, Mong-Hsun Tsai, Eric Y. Chuang, Li-Ling Chuang, Liang-Chuan Lai
Summary: This study reveals novel regulatory mechanisms of NDRG1-OT1 in breast cancer cells, promoting tumor growth and migration through the actions of HIF-1 alpha and miR-875-3p.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Ka Ming Wong, Jiaxing Song, Yung H. Wong
Summary: Nm23-H1 is a metastasis suppressor protein whose expression is regulated by transcription factors like CTCF and EGR1, potentially affecting the invasion and metastasis of breast cancer.
SCIENTIFIC REPORTS
(2021)